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The Unofficial Guide to Prescribing e-book

The Unofficial Guide to Prescribing e-book

Zeshan Qureshi | Simon R J Maxwell

(2014)

Additional Information

Book Details

Abstract

The Unofficial Guide to Prescribing lays out the practical steps of how to assess, investigate and manage a patient, with a focus on what to prescribe and how to prescribe it. Its aim is to empower newly graduated junior doctors to excel at dealing with emergencies and handling complex prescribing scenarios.

Prescribing errors cost healthcare systems millions annually, so early training in prescribing has become an urgent priority of medical education and now forms an essential part of teaching and assessment.

The Unofficial Guide to Prescribing (from the same stable as The Unofficial Guide to Passing OSCEs) is a new book designed to address this requirement. It is written by junior doctors still close to the transition from theory to practice, overseen by a review panel of senior clinicians to ensure accuracy, and designed to help medical students practise and learn as much as possible about prescribing, in actual clinical scenarios, before they have to do it for real.

Each scenario is presented as you would see it in the hospital setting and covers:

  • Initial step-by-step assessment of the patient: how to assess, assessment findings, and immediate management
  • Initial investigations
  • Initial management
  • Reassessment
  • Treatment
  • Handing over the patient
  • 'Prescribe' alerts throughout
  • Written-up drug charts
  • Blank drug charts for copying and practice

Table of Contents

Section Title Page Action Price
Front Cover Cover
The Unofficial Guide to Prescribing iii
Copyright Page iv
Contents v
Preface vii
Acknowledgements viii
Contributors ix
Panel of reviewers x
How to use this book xi
Prescribing xi
List of abbreviations xvii
1 Introduction to prescribing 1
The Characteristics of a Good Prescriber 1
Basic Principles of Clinical Pharmacology 2
Pharmacodynamics 2
Dose–response relationships 3
Agonists and antagonists 4
Efficacy and potency 4
Therapeutic index 5
Desensitization and withdrawal 5
Pharmacokinetics 5
Drug absorption 5
Drug distribution 7
Volume of distribution 7
Drug metabolism 7
Drug excretion 7
Concentration–time relationships 8
Repeated doses 8
Inter-Individual Variation 9
Adverse Drug Reactions 10
Definition 10
Prevalence 11
Frequency of ADRs 11
Classification 11
Reproductive ADRs 13
Detecting ADRs 13
Suspecting an ADR 13
Prevention of ADRs 13
Drug Interactions 13
Pharmacodynamic Interactions 14
Pharmacokinetic Interactions 14
Avoiding Drug Interactions 14
Medication Errors 15
Types and Causes of Prescribing Errors 15
Responding to Error 15
Prevention of Prescribing Errors 16
Rational Prescribing 16
Making a Diagnosis 16
Establishing the Therapeutic Goal 16
Choosing the Therapeutic Approach 17
Choosing a Drug 17
Choosing a Dosage Regimen 17
Writing a Prescription 18
Informing the Patient 18
Monitoring Treatment Effects 18
Stopping Drug Therapy 18
Prescribing for Patients with Special Requirements 19
Prescribing for Patients with Renal Disease 19
Prescribing for Patients with Hepatic Disease 20
Prescribing for Elderly Patients 20
Prescribing for Women who are Pregnant or BreastFeeding 20
Prescribing for Children 21
Getting Information about Medicines 21
British National Formulary (BNF) 21
Other Information Resources for Prescribers 22
Writing a Prescription 23
Hospital Prescribing 23
General Considerations before Prescribing 23
Writing the Prescription 25
Other Considerations after Prescribing 27
Hospital Discharge (‘to take out’) Medicines 27
General Practice Prescribing 27
Prescribing Intravenous (IV) Fluids 28
Normal Fluid Requirements 28
Making an Assessment of Fluid Requirements 28
Types of Fluids 28
Prescribing an IV Fluid 29
Monitoring Fluid Therapy 29
Potential Complications of Fluid Therapy 29
Monitoring Drug Therapy 31
Clinical and Surrogate Endpoints 31
Plasma Drug Concentration 31
Further reading and information 32
2 Cardiology 33
Station 2.1: Acute pericarditis 33
Initial Assessment 33
Airway 33
Breathing 33
Circulation 34
Disability 34
Exposure 34
Initial Investigations 34
Initial Management 35
Reassessment 35
Definitive Treatment 35
Handing over the Patient 35
Station 2.2: Acute left ventricular failure 38
Initial Assessment 38
Airway 38
Breathing 38
Circulation 38
Disability 39
Exposure 39
Initial Investigations 39
Initial Management 40
Reassessment 40
Handing over the Patient to ITU 41
Definitive Management 41
Station 2.3: Acute coronary syndrome 45
Initial Assessment 45
Airway 45
Breathing 45
Circulation 45
Disability 46
Exposure 46
Initial Investigations 46
Initial Management 47
Reassessment 47
Handing over the Patient 47
Definitive Management 48
Station 2.4: Bradycardia 52
Initial Assessment 52
Airway 52
Breathing 52
Circulation 52
Disability 52
Exposure 52
Initial Investigations 53
Initial Management 53
Reassessment 53
Definitive Management 54
Handing over to the Ward Doctor 54
Station 2.5: Tachycardia 56
Initial Assessment 56
Airway 56
Breathing 56
Circulation 56
Disability 56
Exposure 56
Initial Investigations 57
Initial Management 57
Reassessment 57
Definitive Management 58
Handing over the Patient 58
Station 2.6: Warfarin prescribing 60
Background Information 60
Initiating Warfarin 60
Warfarin counselling 61
Starting warfarin in a hospitalized patient 62
Starting warfarin in the community 63
Adjusting maintenance warfarin dose 64
Management of over-coagulation 64
What should you do if a patient taking warfarin is bleeding? 64
Major bleeding (i.e. requiring hospitalisation and blood transfusion, potentially life-threatening) 64
Minor bleeding with INR > 8.0 64
Minor bleeding INR 5.0–8.0 64
No bleeding with INR > 8.0 64
No bleeding with INR 5.0–8.0 64
Additional example scenarios 65
References 65
3 Respiratory medicine 67
Station 3.1: Acute exacerbation of asthma 67
Initial Assessment 67
Airway 67
Breathing 67
Circulation 68
Disability 68
Exposure 68
Initial Investigations 68
Initial Management 69
Reassessment 70
Definitive Management 70
Handing over the Patient 70
Station 3.2: Exacerbation of COPD 73
Initial Assessment 73
Airway 73
Breathing 73
Circulation 73
Disability 73
Exposure 74
Initial Investigations 74
Initial Management 74
Reassessment 75
Definitive Management 75
Handing over the Patient 76
Station 3.3: Community-acquired pneumonia (CAP) 79
Initial Assessment 79
Airway 79
Breathing 79
Circulation 79
Disability 79
Exposure 79
Initial Investigations 80
Initial Management 80
Reassessment 81
Definitive Management 81
Handing over the Patient 81
Station 3.4: Hospital-acquired pneumonia 85
Initial Assessment 85
Airway 85
Breathing 85
Circulation 85
Disability 85
Exposure 85
Initial Investigations 86
Initial Management 86
Reassessment 87
Definitive Management 87
Handing over the Patient 87
Station 3.5: Pulmonary embolism 91
Initial Assessment 91
Airway 91
Breathing 91
Circulation 91
Disability 91
Exposure 91
Initial Investigations 92
Initial Management 93
Reassessment 93
Definitive Management 93
Handing over the Patient 93
References 94
4 Gastroenterology 97
Station 4.1: Severe ulcerative colitis 97
Initial Assessment 97
Airway 97
Breathing 97
Circulation 98
Disability 98
Exposure 98
Initial Investigations 98
Initial Management 99
Reassessment 99
Definitive Management 100
Handing over the Patient 100
Station 4.2: Spontaneous bacterial peritonitis 104
Initial assessment 104
Airway 104
Breathing 104
Circulation 104
Disability 105
Exposure 105
Initial Investigations 105
Initial Management 106
Reassessment 107
Handing over the Patient 107
Station 4.3: Paracetamol overdose 111
Initial Assessment 111
Airway 111
Breathing 111
Circulation 111
Disability 111
Exposure 112
Initial Investigations 112
Initial Management 113
N-Acetylcysteine (NAC) Administration 113
Monitoring for liver failure 114
Reassessment 114
Additional management 114
Handing over the Patient 114
Station 4.4: Abdominal sepsis 116
Initial Assessment 116
Airway 116
Breathing 116
Circulation 116
Disability 116
Exposure 117
Initial Investigations 117
Initial Management 118
Reassessment 118
Definitive Management 118
Handing over the Patient 118
Station 4.5: Acute upper GI bleed 122
Initial Assessment 122
Airway 122
Breathing 122
Circulation 122
Disability 123
Exposure 123
Initial Investigations 123
Initial Management for all Severe UGI Bleeds 125
Reassessment 125
Definitive Management for Oesophageal Variceal Bleeding 125
Handing over the Patient 126
References 126
5 Neurology 131
Station 5.1: Meningitis 131
Initial Assessment 131
Airway 131
Breathing 131
Circulation 132
Disability 132
Exposure 133
Initial Investigations 133
Initial Management 134
Reassessment after Investigation Results 135
Interpreting lumbar puncture results 135
Handing over the Patient (in this case would likely be to intensive care) 135
Station 5.2: Seizures 139
Initial Assessment 139
Airway 139
Breathing 139
Circulation 140
Disability 140
Exposure 140
Initial Investigations 140
Initial Management 141
Reassessment once the Seizure has Stopped 142
Phenytoin therapy 142
Handing over the Patient 143
Station 5.3: Subarachnoid haemorrhage 147
Initial Assessment 147
Airway 147
Breathing 147
Circulation 147
Disability 148
Exposure 148
Initial Investigations 148
Initial Management 149
Management Following Diagnosis of Subarachnoid Haemorrhage 150
Care of a patient following subarachnoid haemorrhage 150
Fluid prescribing in patients with subarachnoid haemorrhage 151
Handing over the Patient 151
Station 5.4: Ischaemic stroke 155
Initial Assessment 155
Airway 155
Breathing 155
Circulation 155
Disability 156
Exposure 156
Initial Investigations 156
Initial Management 157
Care of a Patient Following an Acute Stroke 158
Handing over the Patient 158
Station 5.5: Myasthenia gravis 162
Initial Assessment 162
Airway 162
Breathing 162
Circulation 162
Disability 163
Exposure 163
Initial Investigations 163
Initial Management 164
Handing over the Patient 165
References 165
6 Endocrinology 171
Station 6.1: Diabetic ketoacidosis 171
Initial Assessment 171
Airway 171
Breathing 172
Circulation 172
Disability 172
Exposure 172
Initial Investigations 172
Initial Management 173
Reassessment 173
Definitive Management 174
Handing over the Patient 174
Station 6.2: Hyperosmolar hyperglycaemic state (HHS) 178
Initial Assessment 178
Airway 178
Breathing 178
Circulation 178
Disability 178
Exposure 178
Initial Investigations 179
Initial Management 180
IV fluids 180
Reassessment 180
Definitive Management 181
Handing over the Patient 181
Station 6.3: Hypoglycaemia 185
Initial Assessment 185
Airway 185
Breathing 185
Circulation 185
Disability 185
Exposure 186
Initial Investigations 186
Initial Management 187
Reassessment 187
Definitive Management 187
Handing over the Patient 187
Station 6.4: Insulin prescribing 189
Types of Insulin 189
Scenario 1: Starting a Basal—Bolus 189
7 Obstetrics and gynaecology 227
Station 7.1: Preterm labour 227
Initial Assessment 227
Airway, breathing, circulation 227
History 228
Examination 228
Initial Investigations 228
Management 229
Outcome 229
Handing over to the Night Team 229
Station 7.2: Bleeding in pregnancy 232
Initial Assessment 232
Airway 232
Breathing 232
Circulation 232
Disability 233
Exposure 233
Initial Investigations 233
Initial Management 234
Fluid resuscitation 234
Reduce the blood loss 234
Handing over the Patient 235
Station 7.3: Pre-eclampsia 239
Initial Assessment 239
Airway 239
Breathing 239
Circulation 239
Disability 239
Exposure 240
Initial Investigations 240
Diagnosis 241
Management 241
Antenatal corticosteroids 243
Symptom management 243
Fetal monitoring 243
Presenting your Findings to the On-Call Obstetric Consultant 243
Outcome 243
Station 7.4: Hyperemesis gravidarum 246
Initial Assessment Aims 246
History 246
Examination 247
Initial Investigations 247
Diagnosis 247
Initial Management 247
Rehydration 248
Antiemetics 248
Refeeding complications 249
Encourage oral intake 250
Return of normal metabolism 250
VTE prophylaxis 250
Handing over the Patient to Primary Care: Discharge Summary 250
Station 7.5: Urinary tract infection in pregnancy 254
Initial Assessment 254
History 254
Examination 254
Investigations 255
Management 255
Prescribing analgesia 255
Prescribing antibiotics 255
Referring the patient for specialist opinion–consultant microbiologist 256
References 258
8 General surgery 259
Station 8.1: Venous thromboembolism (VTE) prophylaxis 259
Thromboprophylaxis 259
Assessment of venous thrombosis risk factors 259
General measures to reduce VTE risk 260
Mechanical thromboprophylaxis 260
Prescribing mechanical thromboprophylaxis 260
Contraindications to mechanical VTE prophylaxis 260
Pharmacological thromboprophalaxis 260
Risk of bleeding on VTE prophylaxis 260
Prescribing pharmacological thromboprophylaxis 261
Nicole’s Risk Factors and Bleeding Risk 261
Additional VTE prophylaxis examples: See prescribe boxes in margin (drug charts not shown) 261
Station 8.2: Acute pancreatitis 264
Initial Assessment 264
Airway 264
Breathing 264
Circulation 264
Disability 265
Exposure 265
Initial Investigations 265
Initial Management 266
Reassessment 267
Handing over the Patient 267
Station 8.3: Intestinal obstruction 271
Initial Assessment 271
Airway 271
Breathing 271
Circulation 271
Disability 271
Exposure 272
Initial Investigations 272
Initial Management 273
Reassessment 273
Handing over the Patient 274
Station 8.4: Diabetes in the surgical patient 278
Airway 278
Breathing 278
Circulation 278
Disability 278
Exposure 279
Initial Investigations 279
Initial Management 280
Reassessment 281
Handing over the Patient 281
Station 8.5: Postoperative fluid loss 285
Initial Assessment 285
Airway 285
Breathing 285
Circulation 285
Disability 286
Exposure 286
Initial Investigations 286
Initial Management 287
Reassessment 287
Handing over the Patient 287
References 293
9 Paediatrics 295
Station 9.1: Acute bronchiolitis 295
Initial Assessment 295
Airway 295
Breathing 295
Circulation 296
Disability 296
Exposure 296
Initial Investigations 296
Initial Management 297
Reassessment 298
Handing over the Patient 298
Station 9.2: Respiratory distress in the newborn 302
Initial Assessment 302
Airway 302
Breathing 302
Circulation 302
Disability 303
Exposure 303
Initial Investigations 303
Initial Management 304
Reassessment 304
Handing over the Patient 305
Station 9.3: Viral-induced wheeze 310
Initial Assessment 310
Airway 310
Breathing 310
Circulation 310
Disability 310
Exposure 311
Initial Investigations 311
Initial Management 311
Reassessment 312
Handing over the Patient 312
Station 9.4: Infective exacerbation of cystic fibrosis 315
Initial Assessment 315
Airway 315
Breathing 315
Circulation 315
Disability 316
Exposure 316
Initial Investigations 316
Initial Management 317
Reassessment 318
Handing over the Patient 318
Station 9.5: Gastroenteritis 322
Initial Assessment 322
Airway 322
Breathing 322
Circulation 322
Disability 322
Exposure 323
Initial Investigations 323
Initial Management 323
Reassessment 324
Handing over the Patient 324
Station 9.6: Sickle cell chest crisis 326
Initial Assessment 326
Airway 326
Breathing 326
Circulation 326
Disability 327
Exposure 327
Initial Investigations 327
Initial Management 328
Reassessment 328
Handing over the Patient 329
Station 9.7: Idiopathic nephrotic syndrome 333
Initial Assessment 333
Airway 333
Breathing 333
Circulation 333
Disability 334
Exposure 334
Initial Investigations 334
Initial Management 335
Reassessment 336
Handing over the Patient 336
References 336
10 Additional important scenarios 339
Station 10.1: Discharge prescribing 339
Prescribing Regular Medications 339
Prescribing PRN (As Required) Medication 340
Example 340
Prescribing Controlled Drugs 340
Station 10.2: Analgesia 341
Non-Opioids 341
Weak Opioids 341
Strong Opioids 341
Adjuvants 341
Prescribing Morphine 341
Station 10.3: Dealing with a medication error 343
Station 10.4: Reporting an adverse drug reaction 344
Medicines and Healthcare Products Regulatory Agency 344
Station 10.5: Blood product prescribing 346
Initial Assessment 346
Airway, breathing, circulation, disability, exposure 346
Initial Investigations 346
Initial Management 347
Blood Products that can be Prescribed 348
Less Commonly Prescribed Blood Products 348
Reassessment 348
Handing over the Patient 348
Station 10.6: Anaphylaxis 352
Initial Assessment 352
Airway 352
Breathing 352
Circulation 352
Disability 352
Exposure 352
Initial Investigations 353
Initial Management 353
Reassessment 354
Handing over the Patient 354
Station 10.7: Alcohol withdrawal 358
Initial Assessment 358
Airway 358
Breathing 358
Circulation 358
Disability 358
Exposure 358
Initial Investigations 359
Initial Management 359
Reassessment 360
Handing over the Patient 360
Station 10.8: Vancomycin and gentamicin prescribing 364
Vancomycin 365
Background information 365
1. Initiating vancomycin 365
2. Monitoring regimen 365
3. Subsequent dose adjustments 365
Gentamicin 366
Background information 366
1. Initiating gentamicin 366
2. Monitoring regimen 366
3. Subsequent dose adjustments 366
References 367
Index 373