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Clinical Applications of Functional MRI, An Issue of Neuroimaging Clinics, E-Book

Clinical Applications of Functional MRI, An Issue of Neuroimaging Clinics, E-Book

Jay J. Pillai

(2014)

Abstract

Editor Jay J. Pillai and authors review important areas in Clinical Applications of Functional MRI. Articles will include: Blood Oxygen Level Dependent Functional Magnetic Resonance Imaging for Presurgical Planning; Visual Mapping Using Blood Oxygen Level Dependent Functional MRI; Applications of BOLD fMRI and DTI in Epilepsy; Pretherapeutic fMRI in Children; BOLD fMRI for Presurgical Planning; Brain Tensor Imaging for Brain Malformations: Does it Help?; Technical Considerations for fMRI Analysis; Special Considerations/Technical Limitations of BOLD fMRI; The Economics of Functional MRI: Clinical and Research; Memory Assessment in the Clinical Context Using fMRI: A Critical Look at the State of the Field; Resting State BOLD fMRI for Pre-surgical Planning, and more!

Table of Contents

Section Title Page Action Price
Front Cover Cover
Clinical Applications ofFunctional MRI\r i
Copyright\r ii
Neuroimaging Clinics Of North America\r v
Contributors vii
Contents xi
Foreword xv
Preface\r xvii
Blood Oxygen Level Dependent Functional Magnetic Resonance Imaging for Presurgical Planning 557
Key points 557
Introduction 557
Anatomic organization of the sensorimotor system 558
The Primary Sensorimotor Cortex 558
Secondary Motor Areas 560
Supplementary Motor Area 561
Why functional MR imaging? 562
Paradigms 563
Paresis 564
Artifacts 564
Effect of tumor on functional MR imaging 565
Combination of methods 565
Magnetoencephalography 565
Electroencephalography 566
Positron Emission Tomography 566
Diffusion Tractography 566
Intraoperative mapping 567
Real-Time Functional MR Imaging 568
Summary and future directions 568
References 568
Visual Mapping Using Blood Oxygen Level Dependent Functional Magnetic Resonance Imaging 573
Key points 573
Introduction 573
Visual mapping paradigm and analysis 574
Clinical application 576
Resting-state functional MR imaging of the visual cortex 577
Neurovascular uncoupling in the visual cortex 579
Summary 581
References 582
Memory Assessment in the Clinical Context Using Functional Magnetic Resonance Imaging 585
Key points 585
Transitions in translational imaging 585
The goals of clinical functional MR imaging for memory 586
The pragmatics of clinical functional MRI for memory 586
Memory in temporal lobe epilepsy: activation tasks and correspondence with clinical memory data 587
Challenges to the link between activation magnitude and functional integrity 589
Resting-state fMRI and memory 591
The added value of fMRI in diagnosis and prediction 592
Final conceptual and methodological caveats in imaging memory 593
References 593
Preoperative Diffusion Tensor Imaging 599
Key points 599
Introduction 599
Rationale for brain tumor surgery and preoperative diffusion tensor imaging 600
Understanding white matter anatomy 600
Functional localization sources 601
Diffusion tensor imaging acquisition and visualization 607
Color-Coded Fractional Anisotropy Maps 607
Fiber Tracking 611
Diffusion tensor imaging interpretation 614
Future directions 615
Summary 615
References 615
Diffusion Tensor Imaging for Brain Malformations 619
Key points 619
Introduction 619
Basics of diffusion-weighted imaging and diffusion tensor imaging 620
White matter exploration from Andreas Vesalius to Josef Klingler and beyond 623
Applications of diffusion tensor imaging in pediatric brain malformations 626
Corpus Callosum or Commissural Malformations 626
Posterior Fossa Malformations, Including Joubert Syndrome 629
Anomalous Decussations in Many Malformations 630
Final remarks and 2 illustrative cases to think about 635
It Is All About Connecting the Dots 635
Illustrative Case 636
Nonsolved Case 636
Summary 637
References 637
Pretherapeutic Functional Magnetic Resonance Imaging in Children 639
Key points 639
Introduction 639
How to perform functional MR imaging in children 640
Blood-Oxygen-Level-Dependent Contrast in the Developing Brain 640
Which Paradigm Design? 640
Block or event? 640
Choosing tasks adapted to the child’s age and performance 640
Controlling performances 641
Technical Issues 641
Hardware 641
Acoustic noise 642
Temporal and spatial resolution 642
Feasibility of Fuctional MR Imaging in Children 642
Cooperation 642
Scan duration 642
Data Analysis 643
Mapping eloquent cortex in focal epilepsies and brain tumors in children 643
Motor Mapping 644
Language Mapping in Children 644
How to perform language fuctional MR imaging in children 644
Language dominance 645
Language mapping in children 648
Reading 649
Memory 649
Resting State Fuctional MR Imaging: An Emerging Technique for Pretherapeutic Mapping in Children: A Bright Future? 649
Acknowledgments 651
References 651
Resting-State Blood Oxygen Level–Dependent Functional Magnetic Resonance Imaging for Presurgical Planning 655
Key points 655
Introduction 655
Background 655
Resting-State Networks 656
Default mode network 656
Sensory and motor resting-state networks 656
Attention and cognitive-control resting-state networks 657
Application to presurgical planning 657
Review of the Literature 657
Overview of Processing Methods 658
Preoperative Sensorimotor Mapping in Brain Tumor Patients Using Seed-Based Approach 660
Preoperative Mapping of Functional Cortex Using Multilayered Perceptron 662
Preoperative resting-state functional MR imaging analysis 662
Electrode MR imaging coregistration in subjects monitored for seizure 662
Electrocortical stimulation mapping 662
Comparison of multilayer perceptron–based resting state network mapping to electrocortical stimulation mapping 662
Results in subjects with epilepsy 662
Minimization of false negatives 662
Illustrative Cases 664
Case example 1 664
Case example 2 665
Case example 3 666
Case example 4 666
Summary 667
Acknowledgments 667
References 667
Applications of Blood-Oxygen-Level-Dependent Functional Magnetic Resonance Imaging and Diffusion Tensor Imaging in Epilepsy 671
Key points 671
Applications of functional magnetic resonance imaging in epilepsy 671
Language-Related Blood-Oxygen-Level-Dependent Networks in Epilepsy 672
Statistical threshold 672
Localization of language networks 672
Prognostic value 673
Postoperative findings 673
Effect of epileptic activity and antiepileptic drugs 675
Memory-Related Blood-Oxygen-Level-Dependent Networks in Epilepsy 675
Autobiographical memory-related networks 675
Episodic memory-related networks 675
Working memory-related networks 676
Prognostic value 676
Postoperative findings 676
Simultaneous Electroencephalography-Functional Magnetic Resonance Imaging in Epilepsy 678
Scalp electroencephalography-functional magnetic resonance imaging 678
Intracranial electroencephalography-functional magnetic resonance imaging 678
Applications of diffusion tensor imaging in epilepsy 678
Detecting Unseen Changes and Understanding the Mechanism of Epilepsy 679
Detecting Postoperative Changes 680
Localizing Seizure Focus and Propagation 680
Localizing Language Networks 683
Diffusion Tensor Imaging and Memory Networks 683
Role of Diffusion Tensor Imaging for Localizing Optic Radiation 683
Multimodal image integration 685
Summary 685
References 685
Technical Considerations for Functional Magnetic Resonance Imaging Analysis 695
Key points 695
Learning objectives 695
Introduction 695
Data acquisition 697
Neurovascular uncoupling 698
BOLD data preprocessing steps before statistical analysis 698
Distortion correction 698
Realignment 698
Slice timing correction 699
Coregistration 699
Segmentation 700
Normalization 700
Smoothing 701
Statistical testing 701
Statistical inference 702
Summary 703
References 703
Special Considerations/Technical Limitations of Blood-Oxygen-Level-Dependent Functional Magnetic Resonance Imaging 705
Key points 705
Introduction 705
Image acquisition 705
Susceptibility Artifacts 705
Geometric Distortions 707
Image analysis and interpretation: false-positive and false-negative activation 708
Venous Effects 708
Physiologic Noise and Motion 709
Neurovascular Uncoupling 711
Summary 713
References 713
The Economics of Functional Magnetic Resonance Imaging 717
Key points 717
Introduction 717
Valuation of functional MRI: The resource-based relative value scale system 717
Professional Fees 718
Technical Fees 719
Functional MRI CPT codes and RVUs 719
Functional MRI charges and payments 720
Expenses 722
3T scanner purchase 722
Display and paradigm packages 722
Analysis packages 722
MR injector 723
Research Scanner Considerations 723
Summary 724
References 724
Index 725