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Book Details
Abstract
Editors Kimberly Brown and Celia Chao and authors review the latest in Melanoma. Articles will include Epidemiology, Risk Factors, Prevention, and Early Detection; Work-up and Staging of Malignant Melanoma; Principles of Surgical Treatment of Malignant Melanoma; Surviving Cutaneous Melanoma; Locoregional Therapies; Melanoma Vaccines; The Role of Radiation Therapy in Melanoma; Systemic Therapy in Melanoma; Unusual Presentations of Melanoma; Surgical Treatment Options for Stage IV Melanoma; Head and Neck Melanoma; Melanoma in Non-Caucasian Populations and more!
Table of Contents
| Section Title | Page | Action | Price |
|---|---|---|---|
| Front Cover | Cover | ||
| Melanoma\r | i | ||
| Copyright\r | ii | ||
| Contributors | iii | ||
| Contents | vii | ||
| Surgical Clinics Of North America\r | x | ||
| Foreword\r | xi | ||
| Preface\r | xv | ||
| Epidemiology, Risk Factors, Prevention, and Early Detection of Melanoma | 945 | ||
| Key points | 945 | ||
| Introduction | 945 | ||
| Epidemiology and impact | 946 | ||
| Global Incidence | 946 | ||
| Economic Impact | 946 | ||
| Demographics and Trends | 946 | ||
| Race | 946 | ||
| Gender | 947 | ||
| Age | 947 | ||
| Melanoma in young persons | 947 | ||
| Melanoma in older persons | 948 | ||
| Risk factors | 948 | ||
| Host Factors | 948 | ||
| Personal cancer history | 948 | ||
| Predisposing skin lesions | 950 | ||
| Select phenotypes: hair and eye color | 950 | ||
| Family history and genetics | 950 | ||
| Epigenetics | 951 | ||
| Exposures | 951 | ||
| Ultraviolet light | 951 | ||
| Mechanism | 951 | ||
| Exposure and anatomic location | 951 | ||
| Artificial tanning | 951 | ||
| Immunosuppression | 952 | ||
| Socioeconomic status | 952 | ||
| Other Factors | 953 | ||
| Prevention and early detection | 953 | ||
| Prevention | 953 | ||
| Early Detection | 954 | ||
| Education | 954 | ||
| Early detection | 955 | ||
| Summary | 956 | ||
| References | 957 | ||
| Workup and Staging of Malignant Melanoma | 963 | ||
| Key points | 963 | ||
| Introduction | 963 | ||
| Principles of biopsy | 964 | ||
| Pathologic analysis | 965 | ||
| Role of sentinel lymph node biopsy | 966 | ||
| Sentinel lymph node procedure | 967 | ||
| Imaging workup | 967 | ||
| Chest X-Ray | 967 | ||
| Ultrasound | 967 | ||
| 18-Fluoro-Deoxyglucose Positron Emission Tomography/Computed Tomography | 968 | ||
| Laboratory tests | 969 | ||
| Summary staging | 970 | ||
| References | 970 | ||
| Principles of Surgical Treatment of Malignant Melanoma | 973 | ||
| Key points | 973 | ||
| Introduction | 973 | ||
| Management of primary cutaneous melanoma | 974 | ||
| Background | 974 | ||
| Thin Melanoma (<1 mm) | 974 | ||
| Intermediate-Thickness Melanoma (1–4 mm) | 975 | ||
| Thick Melanoma (﹥4 mm) | 976 | ||
| Melanoma in Situ | 976 | ||
| WLE: Technical Points | 976 | ||
| Management of the regional lymph nodes | 976 | ||
| Background | 976 | ||
| Elective Lymphadenectomy | 977 | ||
| SLN Biopsy | 978 | ||
| Clinical Evidence for SLN Biopsy | 979 | ||
| Indications | 980 | ||
| Thick melanomas | 980 | ||
| Thin melanomas | 980 | ||
| SLN Biopsy Technical Points | 981 | ||
| Lymphoscintigraphy | 981 | ||
| Sentinel node biopsy | 981 | ||
| LND Lymph Node Dissection | 983 | ||
| Completion lymph node dissection | 983 | ||
| TLND | 984 | ||
| Technical points | 984 | ||
| Summary | 985 | ||
| References | 985 | ||
| Surviving Cutaneous Melanoma | 989 | ||
| Key points | 989 | ||
| Introduction | 989 | ||
| Prognostic factors for melanoma survival | 990 | ||
| Survival Related to Localized Melanoma (Stages I and II) | 990 | ||
| Survival Related to Regional Metastasis (Stage III) | 990 | ||
| Survival Related to Distant Metastasis (Stage IV) | 991 | ||
| Additional Prognostic Survival Factors | 991 | ||
| On-line Melanoma Prognosis Calculators | 992 | ||
| Melanoma surveillance | 992 | ||
| Variation in Follow-up Practices | 993 | ||
| NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) for Melanoma: Follow-up | 993 | ||
| Tailoring Surveillance Schedules to Individual Patient Needs | 996 | ||
| Patient Education and Risk Factor Modification | 996 | ||
| Evaluation of Psychosocial Distress and Coping Mechanisms | 997 | ||
| Diagnosis and management of melanoma recurrence | 997 | ||
| Local Scar Recurrence | 997 | ||
| Local, Satellite, and In-transit Recurrence | 998 | ||
| Regional Recurrence | 998 | ||
| Metastatic Recurrence | 998 | ||
| Summary | 999 | ||
| References | 999 | ||
| Locoregional Therapies in Melanoma | 1003 | ||
| Key points | 1003 | ||
| Surgical resection | 1003 | ||
| Intra-arterial regional perfusion therapies | 1004 | ||
| Hyperthermic Isolated Limb Perfusion | 1004 | ||
| Isolated Limb Infusion | 1006 | ||
| Intralesional and topical therapies | 1008 | ||
| Bacille Calmette-Guerin | 1008 | ||
| Interleukin-2 | 1008 | ||
| PV-10/Rose Bengal | 1009 | ||
| Talimogene Laherparepvec | 1009 | ||
| Topical agents | 1010 | ||
| Systemic therapy | 1010 | ||
| Radiation therapy | 1010 | ||
| Summary | 1012 | ||
| References | 1012 | ||
| Melanoma Vaccines | 1017 | ||
| Key points | 1017 | ||
| Introduction | 1017 | ||
| Autologous Melanoma Vaccines | 1018 | ||
| Allogeneic Vaccines | 1021 | ||
| Ganglioside Vaccines | 1023 | ||
| Peptide Vaccines | 1023 | ||
| Immune adjuvants and immunomodulators | 1024 | ||
| Intralesional immunotherapy: tumor (in situ) as vaccine | 1026 | ||
| Future | 1026 | ||
| References | 1027 | ||
| The Role of Radiation Therapy in Melanoma | 1031 | ||
| Key points | 1031 | ||
| Introduction | 1031 | ||
| Radiation for local control | 1032 | ||
| Lentigo Maligna | 1032 | ||
| High-Risk Cutaneous Melanoma | 1032 | ||
| Desmoplastic and Neurotropic Melanoma | 1033 | ||
| Head and Neck Mucosal Melanoma | 1034 | ||
| Anorectal Melanoma | 1035 | ||
| Radiation for nodal basin control | 1035 | ||
| Risk Factors for Nodal Basin Recurrence | 1035 | ||
| Adjuvant Radiation to Reduce Nodal Basin Recurrence | 1036 | ||
| Morbidity of Adjuvant Nodal Basin Radiation | 1041 | ||
| General morbidity | 1041 | ||
| Cervical basin morbidity | 1042 | ||
| Axillary basin morbidity | 1042 | ||
| Ilioinguinal basin morbidity | 1042 | ||
| Morbidity of adjuvant interferon and radiation | 1043 | ||
| Summary | 1043 | ||
| References | 1043 | ||
| Indications and Options for Systemic Therapy in Melanoma | 1049 | ||
| Key points | 1049 | ||
| Introduction | 1049 | ||
| Relevant biology behind current and new melanoma treatments | 1050 | ||
| Immunotherapy | 1050 | ||
| Molecularly Targeted Therapies | 1051 | ||
| An algorithm for treating stage IV melanoma | 1051 | ||
| BRAF-Mutant or Wild-Type Melanoma | 1052 | ||
| Adjuvant therapy of high-risk melanoma | 1053 | ||
| Definition of High-Risk Melanoma | 1053 | ||
| Results of Adjuvant Therapy with Interferon | 1054 | ||
| Clinical Trials of New Adjuvant Therapy Agents | 1055 | ||
| Summary | 1056 | ||
| References | 1056 | ||
| Unusual Presentations of Melanoma | 1059 | ||
| Key points | 1059 | ||
| Introduction | 1060 | ||
| Unknown primary melanoma in regional nodes | 1060 | ||
| Initial Evaluation | 1060 | ||
| Relevant Biology | 1061 | ||
| Surgical Management | 1061 | ||
| Adjuvant Therapy | 1061 | ||
| Unknown primary melanoma in the dermis and subcutaneous tissue | 1062 | ||
| Unknown primary melanoma in visceral organs | 1063 | ||
| Cutaneous melanoma arising in childhood | 1064 | ||
| Initial Evaluation | 1064 | ||
| Relevant Biology | 1064 | ||
| Operative Management | 1065 | ||
| Adjuvant Therapy | 1065 | ||
| Melanoma arising on mucosal surfaces | 1065 | ||
| Site-Specific Differences | 1066 | ||
| Initial Evaluation | 1066 | ||
| Relevant Biology | 1066 | ||
| Operative Management | 1067 | ||
| Adjuvant Therapy | 1067 | ||
| Melanoma arising in the eye | 1067 | ||
| Site-Specific Differences | 1068 | ||
| Relevant Biology | 1068 | ||
| Operative Management | 1069 | ||
| Adjuvant Therapy and Operative Management of Metastatic Disease | 1069 | ||
| Summary | 1069 | ||
| Acknowledgments | 1070 | ||
| References | 1070 | ||
| Surgical Treatment Options for Stage IV Melanoma | 1075 | ||
| Key points | 1075 | ||
| Introduction | 1075 | ||
| Preoperative planning | 1076 | ||
| Surgery for M1a Disease | 1078 | ||
| Surgery for M1b Disease | 1079 | ||
| Surgery for M1c Disease | 1079 | ||
| Gastrointestinal tract | 1079 | ||
| Central nervous system | 1080 | ||
| Liver | 1080 | ||
| Surgical resection | 1080 | ||
| Regional therapies | 1081 | ||
| Other sites of disease | 1081 | ||
| Surgery as adjuvant therapy | 1082 | ||
| Summary | 1083 | ||
| References | 1083 | ||
| Head and Neck Melanoma | 1091 | ||
| Key points | 1091 | ||
| Introduction | 1091 | ||
| Epidemiology | 1091 | ||
| Clinical presentation | 1092 | ||
| History | 1092 | ||
| Physical Examination | 1092 | ||
| Classification and staging | 1093 | ||
| Morphology | 1093 | ||
| Histology | 1093 | ||
| Clinical Staging | 1093 | ||
| Investigations | 1093 | ||
| Biopsy | 1093 | ||
| Imaging Recommendations | 1094 | ||
| Treatment and pathologic staging | 1094 | ||
| Treatment of Primary Lesion | 1094 | ||
| Wide local excision | 1094 | ||
| Sentinel Node Biopsy and Lymphatic Drainage Patterns | 1095 | ||
| Indications for SLNB | 1095 | ||
| SLNB technique | 1096 | ||
| Histologic evaluation | 1096 | ||
| ELND | 1097 | ||
| Parotid Management | 1097 | ||
| Neck Dissection | 1097 | ||
| Technical aspects | 1097 | ||
| Indications | 1099 | ||
| Clinically positive lymph nodes—therapeutic neck dissection | 1099 | ||
| Positive SLNB in the neck—therapeutic neck dissection | 1099 | ||
| Positive parotid SLN—therapeutic neck dissection and parotidectomy | 1099 | ||
| Extensive invasive lymph node disease—therapeutic neck dissection including nonlymphatic structures | 1099 | ||
| No known lymph node disease—elective neck dissection | 1099 | ||
| Adjuvant therapy | 1100 | ||
| Radiotherapy | 1100 | ||
| Chemotherapy | 1100 | ||
| Reconstruction | 1100 | ||
| Reconstruction Timing | 1100 | ||
| Techniques | 1101 | ||
| Location Specific Reconstructive Options | 1102 | ||
| Scalp | 1102 | ||
| Forehead | 1103 | ||
| Eyelids | 1104 | ||
| Cheek | 1104 | ||
| Lips | 1105 | ||
| Nose | 1106 | ||
| Ears | 1106 | ||
| Mohs Surgery | 1108 | ||
| Summary | 1108 | ||
| References | 1108 | ||
| Melanoma in Non-Caucasian Populations | 1115 | ||
| Key points | 1115 | ||
| Introduction | 1115 | ||
| Epidemiology | 1116 | ||
| Anatomy | 1116 | ||
| Clinical Presentation | 1116 | ||
| Histologic Type | 1117 | ||
| Stage at Diagnosis | 1119 | ||
| Etiology | 1120 | ||
| Subtype | 1120 | ||
| UV Radiation | 1120 | ||
| Genetics | 1121 | ||
| Outcomes | 1122 | ||
| Interventions | 1123 | ||
| Summary | 1124 | ||
| References | 1124 | ||
| Index | 1127 |