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Advanced Lung Cancer: Radical Surgical Therapy, An Issue of Thoracic Surgery Clinics, E-Book

Advanced Lung Cancer: Radical Surgical Therapy, An Issue of Thoracic Surgery Clinics, E-Book

Raja Flores

(2014)

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Book Details

Abstract

This issue of Thoracic Surgery Clinics is devoted to "Advanced Lung Cancer: Radical Surgical Therapy" and is edited by Dr. Raja M. Flores.  Articles in this outstanding issue include: Surgical Resection of Lung Cancer in the Elderly; Extended Chest Wall Resection and Reconstruction in the Setting of Lung Cancer; The Management of Non–Small Cell Lung Cancer with Oligometastases; Lung Resection in Patients with Marginal Pulmonary Function; Surgery for Small Cell Lung Cancer; Bronchial and Arterial Sleeve Resection after Induction Therapy for Lung Cancer; Advanced Lung Cancer: Aggressive Surgical Therapy Vertebral Body Involvement; Pulmonary Resection after Pneumonectomy; Superior Vena Caval Resection in Lung Cancer; Surgical Resection of Non-Small Cell Lung Cancer with N2 Disease; Lung Transplantation for Multifocal Lung Adenocarcinoma; Extended Resections of Non-Small Cell Lung Cancers Invading the Aorta, Pulmonary Artery, Left Atrium or Esophagus: Can They Be Justified?; VATS Lobectomy after Induction Therapy; Extrapleural Pneumonectomy for Pleural Disease; Carinal Resection, and more!

Table of Contents

Section Title Page Action Price
Front Cover Cover
Advanced Lung Cancer:Radical Surgical Therapy i
Copyright\r ii
Contributors iii
Contents vii
Thoracic Surgery Clinics\r xi
Preface\r\r xiii
Erratum xv
Lung Resection in Patients with Marginal Pulmonary Function 361
Key points 361
Introduction 361
Historical context 361
Current guidelines 362
Worst-case forced expiratory volume in the first second of expiration 362
Specific considerations 362
Minimally invasive surgery 362
Anatomic considerations 366
Sublobar resections 366
Discussion 367
Summary 369
References 369
Surgical Resection of Lung Cancer in the Elderly 371
Key points 371
Introduction: nature of the problem 371
Therapeutic options and/or surgical techniques 372
Clinical outcomes and the preoperative assessment 373
Physiologic Changes of Age 373
Preoperative Evaluation 373
Cardiac Risk Assessment 374
Pulmonary Risk Assessment 374
Cognitive Assessment 376
Geriatric Assessments 376
Complications and Concerns 377
Practical Recommendations 378
Summary 379
References 379
Extended Chest Wall Resection and Reconstruction in the Setting of Lung Cancer 383
Key points 383
Introduction 383
Preoperative Diagnosis and Staging 383
Neoadjuvant Therapy 384
Preoperative Planning 384
Resection and surgical technique 384
Surgical Technique 384
Positioning and Incision 384
Chest Wall Resection 385
En Bloc Resection 385
Reconstruction 385
General Considerations 385
Mesh Repair 385
Methyl Methacrylate 386
Riblike Method 386
Titanium Ribs 386
Biologics 386
Titanium Mesh 387
Soft Tissue Coverage 387
Clinical outcomes 388
Survival (Lung Cancer) 388
Functional 388
Complications and Concerns 388
Summary 389
References 389
The Management of Non–Small Cell Lung Cancer With Oligometastases 391
Key points 391
Introduction 391
Background 391
Extent of the problem: percentage of patients with non–small cell lung cancer with oligometastatic disease 392
The present 393
Lung metastases 393
Cerebral metastases 394
Adrenal metastases 394
Completed clinical trials 395
Future directions 395
Summary 396
References 396
Surgery for Small Cell Lung Cancer 399
Key points 399
Staging of SCLC 400
Patterns of failure in treated SCLC 401
Evidence supporting surgery for SCLC 401
Prospective Randomized Trials 401
Prospective Nonrandomized Trials 402
Institutional Retrospective Reviews 403
National Cancer Database Reviews 403
Indications for surgery 405
T1-2N0 Disease 405
Solitary Pulmonary Nodules (SPN) 406
Combined Histology Tumors 406
Salvage Surgery for Initial Treatment Failure or Relapse 406
New Tumors in Survivors of SCLC 406
Current guidelines and conclusions 407
References 408
Bronchial and Arterial Sleeve Resection After Induction Therapy for Lung Cancer 411
Key points 411
Introduction 411
Indications and preoperative evaluation 412
Operative technique 413
Dissection Phase 413
Resection and reconstruction phase 414
Bronchial resection and reconstruction 414
PA resection and reconstruction 415
Partial Resection and Patch Reconstruction 415
Sleeve Resection and Reconstruction by End-to-end Anastomosis 415
Sleeve Resection and Reconstruction by a Prosthetic Conduit 416
Complications and perioperative management 416
Short-term and long-term results 417
Comparison Between Bronchovascular Reconstructions and PN After Induction Therapy 419
Impact on Postoperative Quality of Life 420
Acknowledgments 420
References 420
Advanced Lung Cancer 423
Key points 423
Introduction 423
NOMS decision framework for spine metastases 424
NOMS assessment for NSCLC 424
NSCLC without ESCC 424
NSCLC with high-grade ESCC 424
Mechanical instability 425
Systemic disease and medical comorbidities 426
Imaging spine tumors 426
Surgical approaches 427
Separation surgery 427
Superior sulcus tumors with involvement of the spine 428
Major Complications 429
Instrumentation failure 429
Wound dehiscence or infection 429
Summary 430
References 430
Pulmonary Resection After Pneumonectomy 433
Key points 433
Introduction 433
Selection of patients for resection 434
Functional Status Evaluation and Cardiopulmonary Reserve 434
Non–Small Cell Lung Caner Extension Assessment 435
Surgical technique 435
Anesthetic Management 435
Surgical Procedure 436
Clinical outcomes 438
Alternatives to surgical management 438
Summary 438
References 439
Superior Vena Caval Resection in Lung Cancer 441
Key points 441
Introduction 441
Background 441
Preoperative evaluation 441
Therapeutic options and/or surgical techniques 441
Complications and concerns 445
Clinical outcomes 446
Summary 446
References 446
Surgical Resection of Non–Small Cell Lung Cancer with N2 Disease 449
Key points 449
Introduction 449
Extent of N2 disease 449
Induction chemotherapy 451
Induction chemoradiotherapy 452
Morbidity and mortality after induction therapy 453
Mediastinal restaging 453
T4N2 disease 454
Summary 454
References 454
Extended Resections of Non-small Cell Lung Cancers Invading the Aorta, Pulmonary Artery, Left Atrium, or Esophagus 457
Key points 457
Introduction 457
Historical background 457
More recent experience 458
Extended resections 460
Aorta 460
Pulmonary Artery 460
Left Atrium 461
Esophagus 462
Preoperative workup 462
Neoadjuvant therapy 462
Summary 463
References 463
Video-Assisted Thoracoscopic (VATS) Lobectomy After Induction Therapy 465
Key points 465
Introduction 465
Outcomes 465
Patient selection 467
Technique 468
References 470
Extrapleural Pneumonectomy for Pleural Malignancies 471
Key points 471
Introduction 471
History 471
Pleural dissemination of malignancy 472
Thymoma 472
Sarcoma 472
Pleural dissemination of nonsmall cell lung cancer 472
Nonsmall Cell Lung Cancer Staging 472
Mediastinal Nodal Disease 472
Care of the extrapleural pneumonectomy patient 473
Preoperative Assessment 473
Perioperative Considerations 474
Postoperative Care 474
Summary 474
References 475
Carinal Resection 477
Key points 477
Introduction 477
Indications 477
Operative management 478
Anesthesia 478
Surgical Incisions 479
Intraoperative Dissection 479
Resections 479
Carinal resection with right pneumonectomy/right upper lobectomy 479
Carinal resection with left pneumonectomy 479
Carinal resection without pulmonary resection 480
Lesion confined to the carina: neocarina 480
Carinal lesion with involvement of the distal trachea 480
Reconstruction Technique 482
General principles 482
Specific aspects 482
The end to side anastomosis 482
Isolated neocarina, tracheal transplant 482
Release Maneuvers 483
Clinical outcomes 483
Complications and concerns 483
Acute Respiratory Distress Syndrome 483
Anastomotic complications 483
Summary 484
Supplementary data 484
References 484
Lung Transplantation for Multifocal Lung Adenocarcinoma (Multifocal Lung Carcinoma) 485
Key points 485
Introduction 485
Patient selection 486
Bronchioloalveolar Carcinoma and Current Classification 486
Lung transplantation 487
Patient Outcomes 487
Summary 489
References 490
Index 493