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Esophageal Function Testing, An Issue of Gastrointestinal Endoscopy Clinics, E-Book

Esophageal Function Testing, An Issue of Gastrointestinal Endoscopy Clinics, E-Book

John Pandolfino

(2014)

Additional Information

Abstract

This issue devoted to Esophageal Function Testing highlights these tests that are complimentary to endoscopy and should be considered after endoscopy is performed. In fact, a prerequisite for performing many of these studies is a negative endoscopy and thus, the endoscopist should be well-informed regarding the indication and utility of these tests. Additionally, some of these newer technologies require endoscopy to be performed during the study as the placement or positioning of the measurement tool will require endoscopic landmarks or direct placement. There have been major advances in most of these older techniques, and new novel measurement paradigms have been created that allow for a more visual and accurate depiction of physiologic and anatomic data. These technologies have evolved to be more akin to an imaging technique and thus, the visual display and data acquisition is much more intuitive and easier to teach to trainees. This review would be of the utmost importance to readers of GI Endoscospy Clinics.

Table of Contents

Section Title Page Action Price
Front Cover Cover
Esophageal FunctionTesting i
Copyrights ii
Contributors iii
Contents v
Gastrointestinal Endoscopy Clinics Of North America ix
New and Improved Methods for Esophageal Function Testing xi
Esophageal Function Testing xiii
Esophageal Motor Function 527
Key points 527
Introduction 527
Indications and contraindications 528
The procedure 530
Equipment Preparation 530
Patient Preparation 530
Patient Positioning 530
Catheter Insertion 531
Catheter Positioning 531
Technique 533
Landmark Phase 533
Adequate Swallows 533
Provocative Maneuvers 535
Complications and management 535
Postoperative care 536
Reporting, follow-up, and clinical implications 536
Metrics Used in Clinical HRM Interpretation 536
Reporting Manometry Study Findings 537
Follow-Up 538
Clinical Implications 538
Outcomes 539
Reproducibility 539
Comprehension and Retention 539
Current controversies 539
Artifacts 539
Equipment-related artifacts 539
Vascular and respiratory artifacts 540
Future considerations 540
High-Resolution Impedance Manometry 540
Three-Dimensional Manometry 540
Summary 541
References 541
The Chicago Classification of Motility Disorders 545
Key points 545
Introduction 546
Metrics and swallow pattern characterization 546
Esophagogastric Junction Morphology and Deglutitive Relaxation 546
Deglutitive Peristaltic Vigor and Pattern 548
Intrabolus Pressure Pattern 552
Disorders with EGJ outflow obstruction 552
Major motility disorders 554
Aperistalsis 554
Distal Esophageal Spasm 554
Jackhammer Esophagus 554
Minor motility disorders 556
Peristaltic Abnormalities as Defined in the 2012 Chicago Classification 556
Limitations of the 2012 Chicago Classification 557
Minor Motility Disorders Proposed for Chicago Classification v3.0 557
Ineffective Esophageal Motility 557
Fragmented Peristalsis 558
Normal Esophageal Motility 558
What is in the future? 558
Acknowledgments 558
References 559
The Role of Barium Esophagography in an Endoscopy World 563
Key points 563
Introduction 563
Terminology 563
Video Swallow Study 564
Esophagram 564
Performance of the examination 564
Theoretic advantages of radiography compared with endoscopy 564
The use of barium esophagography in specific esophageal disorders 566
Oropharyngeal Dysfunction 566
Zenker Diverticulum 567
Gastroesophageal Reflux Disease 567
Schatzki Ring 569
Postfundoplication Syndromes 570
Achalasia 572
Stricturing diseases 574
EoE 574
Lichen Planus 575
Caustic Injury 575
Esophageal Perforation 576
Esophageal Disorders Owing to Vascular Compression 576
Miscellaneous Disorders 577
Use of barium to describe esophageal physiology 579
Summary 579
References 579
Ambulatory Esophageal pH Monitoring 581
Key points 581
Introduction 581
Esophageal pH monitoring: what, why, and when 582
Test selection 584
Test interpretation 586
Current controversies 590
pH Electrode Placement Location 590
Discrepancy Between the Two Systems 591
The Influence of Diet on Test Accuracy 591
On or Off PPI Therapy 592
Summary and future directions 592
References 592
Evaluating Esophageal Bolus Transit by Impedance Monitoring 595
Key points 595
Introduction 595
Validation of impedance measurements to assess esophageal bolus transit 596
Conventional impedance manometry 598
High-resolution impedance manometry 600
Summary 604
References 604
Measuring Mechanical Properties of the Esophageal Wall Using Impedance Planimetry 607
Key points 607
Introduction 607
Earlier methods to measure distensibility 608
Principle of impedance planimetry 609
Functional luminal imaging and EGJ disease 610
Healthy Volunteers 610
GERD 610
Functional measurement 611
Intraoperative measurement 611
Achalasia 612
Intraoperative measurement 612
Functional measurement 613
Therapeutic use of impedance planimetry 613
Functional luminal imaging and esophageal body disease 614
Eosinophilic Esophagitis 614
Systemic Sclerosis 616
Functional luminal imaging and the upper esophageal sphincter 616
Summary 617
References 617
Evaluation of Esophageal Sensation 619
Key points 619
Introduction 619
Neurophysiology of the esophagus 620
Gastrointestinal sensitivity and gastroesophageal reflux disease 621
Esophageal sensitivity testing 621
Esophageal Manometry and 24-Hour Esophageal pH/Impedance 621
Provocative Esophageal Perfusion Testing 622
Noncardiac Chest Pain Provocative Testing 623
Provocative Barostat Balloon Testing 623
Impedance Planimetry 625
Multimodal Esophageal Assessment 626
Esophageal Evoked Potentials 626
Brain Imaging 627
Immunologically Mediated Sensory Pathways 628
Implications for Esophageal Sensory Testing in Understanding the Pathophysiology of Esophageal Disease and in Drug Development 629
Current Clinical Assessment Recommendations 629
References 630
Utilization of Esophageal Function Testing for the Diagnosis of the Rumination Syndrome and Belching Disorders 633
Key points 633
Introduction 633
The rumination syndrome 634
Pathophysiology 634
Clinical Evaluation and Diagnostic Approach 634
Treatment 635
Belching disorders 637
Pathophysiology 637
Clinical Evaluation and Diagnostic Approach 637
Treatment 639
Summary 640
References 640
Uses of Esophageal Function Testing 643
Key points 643
Introduction 643
Dysphagia associated with esophageal motility disorders defined in the Chicago Classification 644
Achalasia 644
Persistent Dysphagia After Treatment in Achalasia 645
EGJ Outflow Obstruction 646
Distal Esophageal Spasm 646
Hypercontractile Esophagus 647
Esophageal Hypomotility 648
Investigation of dysphagia resulting from other causes 649
Dysphagia with Normal Esophageal Peristalsis on Wet Swallows 649
Dysphagia Following Antireflux Surgery 650
Functional Dysphagia 651
Diagnostic flowchart 652
References 652
Diagnostic Work-Up of GERD 655
Key points 655
Introduction 655
Diagnosing GERD by symptoms and response to acid suppression 656
Esophagram and esophageal manometry 658
Endoscopic evaluation and role of esophageal biopsies 658
Reflux monitoring 658
Catheter-Based and Wireless pH Monitoring 659
Impedance-pH Monitoring 659
Beyond Reflux Burden: Symptom Association Studies During Reflux Monitoring 660
Work up of patients with PPI-refractory symptoms 661
Summary 663
References 663
Esophageal Function Testing 667
Key points 667
Introduction 667
Ultrasound imaging of esophagus 668
Static US imaging 669
Muscle Hypertrophy in Esophageal Motor Disorders and Its Significance 669
Dynamic US imaging 671
Patterns of Longitudinal Muscle Contraction in Health and Their Significance to Normal Esophageal Function 671
Patterns of longitudinal muscle contraction in the diseased states 673
Luminal distension measurement by US imaging and impedance recordings 677
Laser Doppler flowmetry to measure esophageal wall blood perfusion 681
Summary 681
References 682
Index 687