BOOK
Cellular and Molecular Immunology E-Book
Abul K. Abbas | Andrew H. H. Lichtman | Shiv Pillai
(2014)
Additional Information
Book Details
Abstract
Popular for its highly visual, straightforward approach, Cellular and Molecular Immunology delivers an accessible yet thorough understanding of this active and fast-changing field. Drs. Abul K. Abbas, Andrew H. Lichtman, and Shiv Pillai present key updates in this new edition to cover the latest developments in antigen receptors and signal transduction in immune cells, mucosal and skin immunity, cytokines, leukocyte-endothelial interaction, and more. With additional online features, this is an ideal resource for medical, graduate and undergraduate students of immunology who need a clear, introductory text for immunology courses.
- Consult this title on your favorite e-reader , conduct rapid searches, and adjust font sizes for optimal readability.
- Develop a thorough, clinically relevant understanding of immunology through a clear overview of immunology with a distinct focus on the management of human disease.
- Visualize immunologic processes more effectively. Meticulously developed and updated illustrations, 3-dimensional art, and all-new animations provide a detailed, visual description of the key immunologic and molecular processes.
- Grasp the details of experimental observations that form the basis for the science of immunology at the molecular, cellular, and whole-organism levels and draw the appropriate conclusions.
- Find information more quickly and easily through an organized chapter structure and a more logical flow of material.
- Glean all essential, up-to-date, need-to-know information about immunology and molecular biology through extensive updates that cover cytokines, innate immunity, leukocyte-endothelial interactions, signaling, costimulation, and more.
- Benefit from numerous new figures and tables that facilitate easier retention of the material; quick summaries of each chapter; and nearly 400 illustrations that clarify key concepts.
Table of Contents
| Section Title | Page | Action | Price |
|---|---|---|---|
| Front Cover | Cover | ||
| IFC | IFC | ||
| Cellular and Molecular Immunology | i | ||
| Copyright | ii | ||
| DEDICATION | iii | ||
| PREFACE | v | ||
| CONTENTS | vii | ||
| CHAPTER 1 - Properties and Overview of Immune Responses | 1 | ||
| INNATE AND ADAPTIVE IMMUNITY | 2 | ||
| TYPES OF ADAPTIVE IMMUNE RESPONSES | 3 | ||
| CARDINAL FEATURES OF ADAPTIVE IMMUNE RESPONSES | 5 | ||
| CELLULAR COMPONENTS OF THE ADAPTIVE IMMUNE SYSTEM | 7 | ||
| OVERVIEW OF IMMUNE RESPONSES TO MICROBES | 9 | ||
| SELECTED READINGS | 12 | ||
| CHAPTER 2 - Cells and Tissues of the Immune System | 13 | ||
| CELLS OF THE IMMUNE SYSTEM | 13 | ||
| ANATOMY AND FUNCTIONS OF LYMPHOID TISSUES | 24 | ||
| SELECTED READINGS | 33 | ||
| CHAPTER 3 - Leukocyte Circulation and Migration into Tissues | 35 | ||
| OVERVIEW OF LEUKOCYTE MIGRATION | 35 | ||
| ADHESION MOLECULES ON LEUKOCYTES AND ENDOTHELIAL CELLS INVOLVED IN LEUKOCYTE RECRUITMENT | 37 | ||
| CHEMOKINES AND CHEMOKINE RECEPTORS | 39 | ||
| LEUKOCYTE-ENDOTHELIAL INTERACTIONS AND LEUKOCYTE RECRUITMENT INTO TISSUES | 41 | ||
| MIGRATION OF NEUTROPHILS AND MONOCYTES TO SITES OF INFECTION OR TISSUE INJURY | 42 | ||
| MIGRATION AND RECIRCULATION OF T LYMPHOCYTES | 43 | ||
| MIGRATION OF B LYMPHOCYTES | 48 | ||
| SELECTED READINGS | 50 | ||
| CHAPTER4 - Innate Immunity | 51 | ||
| OVERVIEW OF INNATE IMMUNITY | 51 | ||
| RECOGNITION OF MICROBES AND DAMAGED SELF BY THE INNATE IMMUNE SYSTEM | 52 | ||
| CELL-ASSOCIATED PATTERN RECOGNITION RECEPTORS AND SENSORS OF INNATE IMMUNITY | 54 | ||
| CELLULAR COMPONENTS OF THE INNATE IMMUNE SYSTEM | 63 | ||
| SOLUBLE RECOGNITION AND EFFECTOR MOLECULES OF INNATE IMMUNITY | 69 | ||
| THE INFLAMMATORY RESPONSE | 72 | ||
| THE ANTIVIRAL RESPONSE | 80 | ||
| STIMULATION OF ADAPTIVE IMMUNITY | 81 | ||
| MECHANISMS THAT LIMIT INNATE IMMUNE RESPONSES | 83 | ||
| SUGGESTED READINGS | 85 | ||
| CHAPTER 5 - Antibodies and Antigens | 87 | ||
| ANTIBODY STRUCTURE | 88 | ||
| SYNTHESIS, ASSEMBLY, AND EXPRESSION OF IG MOLECULES | 97 | ||
| ANTIBODY BINDING OF ANTIGENS | 99 | ||
| STRUCTURE-FUNCTION RELATIONSHIPS IN ANTIBODY MOLECULES | 102 | ||
| SUGGESTED READINGS | 105 | ||
| CHAPTER 6 - Major Histocompatibility Complex Molecules and Antigen Presentation to T Lymphocytes | 107 | ||
| PROPERTIES OF ANTIGENS RECOGNIZED BY T LYMPHOCYTES | 108 | ||
| ANTIGEN CAPTURE AND THE FUNCTIONS OF ANTIGEN-PRESENTING CELLS | 108 | ||
| THE MAJOR HISTOCOMPATIBILITY COMPLEX (MHC) | 114 | ||
| PROCESSING OF PROTEIN ANTIGENS | 124 | ||
| PRESENTATION OF NON-PROTEIN ANTIGENS TO SUBSETS OF T CELLS | 133 | ||
| SUGGESTED READINGS | 135 | ||
| CHAPTER 7 - Immune Receptors and Signal Transduction | 137 | ||
| OVERVIEW OF SIGNAL TRANSDUCTION | 138 | ||
| THE IMMUNE RECEPTOR FAMILY | 141 | ||
| THE T CELL RECEPTOR COMPLEX AND T CELL SIGNALING | 143 | ||
| THE B LYMPHOCYTE ANTIGEN RECEPTOR COMPLEX | 156 | ||
| THE ATTENUATION OF IMMUNE RECEPTOR SIGNALING | 160 | ||
| CYTOKINE RECEPTORS AND SIGNALING | 161 | ||
| SUGGESTED READINGS | 168 | ||
| CHAPTER 8 - Lymphocyte Development and Antigen Receptor Gene Rearrangement | 171 | ||
| OVERVIEW OF LYMPHOCYTE DEVELOPMENT | 171 | ||
| REARRANGEMENT OF ANTIGEN RECEPTOR GENES IN B AND T LYMPHOCYTES | 176 | ||
| B LYMPHOCYTE DEVELOPMENT | 184 | ||
| T LYMPHOCYTE DEVELOPMENT | 190 | ||
| SUGGESTED READINGS | 198 | ||
| CHAPTER 9 - Activation of T Lymphocytes | 199 | ||
| OVERVIEW OF T LYMPHOCYTE ACTIVATION | 199 | ||
| SIGNALS FOR T LYMPHOCYTE ACTIVATION | 201 | ||
| FUNCTIONAL RESPONSES OF T LYMPHOCYTES | 206 | ||
| DECLINE OF T CELL RESPONSES | 211 | ||
| SELECTED READINGS | 212 | ||
| CHAPTER 10 - Differentiation and Functions of CD4+ Effector T Cells | 213 | ||
| OVERVIEW OF CELL-MEDIATED IMMUNITY | 213 | ||
| SUBSETS OF CD4+ EFFECTOR T CELLS | 216 | ||
| THE TH1 SUBSET | 218 | ||
| THE TH2 SUBSET | 222 | ||
| THE TH17 SUBSET | 225 | ||
| FUNCTIONS OF OTHER T CELL SUBSETS | 228 | ||
| SELECTED READINGS | 229 | ||
| CHAPTER 11 - Differentiation and Functions of CD8+ Effector T Cells | 231 | ||
| DIFFERENTIATION OF CD8+ T CELLS INTO CYTOTOXIC T LYMPHOCYTES | 231 | ||
| EFFECTOR FUNCTIONS OF CD8+ CYTOTOXIC T LYMPHOCYTES | 234 | ||
| ROLES OF CD8+ CTLS IN HOST DEFENSE | 238 | ||
| SELECTED READINGS | 238 | ||
| CHAPTER 12 - B Cell Activation and Antibody Production | 239 | ||
| OVERVIEW OF HUMORAL IMMUNE RESPONSES | 239 | ||
| ANTIGEN RECOGNITION AND ANTIGEN-INDUCED B CELL ACTIVATION | 241 | ||
| HELPER T CELL–DEPENDENT ANTIBODY RESPONSES TO PROTEIN ANTIGENS | 245 | ||
| ANTIBODY RESPONSES TO T-INDEPENDENT ANTIGENS | 259 | ||
| ANTIBODY FEEDBACK: REGULATION OF HUMORAL IMMUNE RESPONSES BY FC RECEPTORS | 260 | ||
| SELECTED READINGS | 262 | ||
| CHAPTER 13 - Effector Mechanisms of Humoral Immunity | 265 | ||
| OVERVIEW OF HUMORAL IMMUNITY | 265 | ||
| NEUTRALIZATION OF MICROBES AND MICROBIAL TOXINS | 267 | ||
| ANTIBODY-MEDIATED OPSONIZATION AND PHAGOCYTOSIS | 267 | ||
| THE COMPLEMENT SYSTEM | 272 | ||
| NEONATAL IMMUNITY | 287 | ||
| SELECTED READINGS | 288 | ||
| CHAPTER 14 - Specialized Immunity at Epithelial Barriers and in Immune Privileged Tissues | 289 | ||
| GENERAL FEATURES OF IMMUNITY AT EPITHELIAL BARRIERS | 289 | ||
| IMMUNITY IN THE GASTROINTESTINAL SYSTEM | 291 | ||
| IMMUNITY IN OTHER MUCOSAL TISSUES | 304 | ||
| THE CUTANEOUS IMMUNE SYSTEM | 305 | ||
| IMMUNE PRIVILEGED TISSUES | 309 | ||
| SELECTED READINGS | 312 | ||
| CHAPTER 15 - Immunologic Tolerance and Autoimmunity | 315 | ||
| OVERVIEW OF IMMUNOLOGIC TOLERANCE | 315 | ||
| T LYMPHOCYTE TOLERANCE | 317 | ||
| B LYMPHOCYTE TOLERANCE | 327 | ||
| TOLERANCE INDUCED BY FOREIGN PROTEIN ANTIGENS | 329 | ||
| MECHANISMS OF AUTOIMMUNITY | 329 | ||
| SELECTED READINGS | 336 | ||
| CHAPTER 16 - Immunity to Microbes | 339 | ||
| OVERVIEW OF IMMUNE RESPONSES TO MICROBES | 339 | ||
| IMMUNITY TO EXTRACELLULAR BACTERIA | 340 | ||
| IMMUNITY TO INTRACELLULAR BACTERIA | 344 | ||
| IMMUNITY TO FUNGI | 347 | ||
| IMMUNITY TO VIRUSES | 348 | ||
| IMMUNITY TO PARASITES | 352 | ||
| STRATEGIES FOR VACCINE DEVELOPMENT | 354 | ||
| SELECTED READINGS | 357 | ||
| CHAPTER 17 - Transplantation Immunology | 359 | ||
| GENERAL PRINCIPLES OF TRANSPLANTATION IMMUNOLOGY | 359 | ||
| ADAPTIVE IMMUNE RESPONSES TO ALLOGRAFTS | 360 | ||
| PATTERNS AND MECHANISMS OF ALLOGRAFT REJECTION | 368 | ||
| PREVENTION AND TREATMENT OF ALLOGRAFT REJECTION | 371 | ||
| XENOGENEIC TRANSPLANTATION | 376 | ||
| BLOOD TRANSFUSION AND THE ABO AND RH BLOOD GROUP ANTIGENS | 377 | ||
| HEMATOPOIETIC STEM CELL TRANSPLANTATION | 379 | ||
| SELECTED READINGS | 381 | ||
| CHAPTER 18 - Immunity to Tumors | 383 | ||
| OVERVIEW OF TUMOR IMMUNITY | 383 | ||
| TUMOR ANTIGENS | 385 | ||
| IMMUNE RESPONSES TO TUMORS | 388 | ||
| EVASION OF IMMUNE RESPONSES BY TUMORS | 389 | ||
| IMMUNOTHERAPY FOR TUMORS | 391 | ||
| THE ROLE OF INNATE AND ADAPTIVE IMMUNITY IN PROMOTING TUMOR GROWTH | 396 | ||
| SELECTED READINGS | 397 | ||
| CHAPTER 19 - Hypersensitivity Disorders | 399 | ||
| CAUSES OF HYPERSENSITIVITY DISEASES | 399 | ||
| MECHANISMS AND CLASSIFICATION OF HYPERSENSITIVITY REACTIONS | 400 | ||
| DISEASES CAUSED BY ANTIBODIES | 401 | ||
| DISEASES CAUSED BY T LYMPHOCYTES | 405 | ||
| THERAPEUTIC APPROACHES FOR IMMUNOLOGIC DISEASES | 409 | ||
| SELECTED IMMUNOLOGIC DISEASES: PATHOGENESIS AND THERAPEUTIC STRATEGIES | 411 | ||
| SELECTED READINGS | 415 | ||
| CHAPTER 20 - Allergy | 417 | ||
| OVERVIEW OF IGE-DEPENDENT ALLERGIC REACTIONS | 417 | ||
| PRODUCTION OF IGE | 419 | ||
| ROLE OF TH2 CELLS, MAST CELLS, BASOPHILS, AND EOSINOPHILS IN ALLERGIC REACTIONS | 420 | ||
| IGE- AND MAST CELL–DEPENDENT REACTIONS | 428 | ||
| GENETIC SUSCEPTIBILITY TO ALLERGIC DISEASE | 430 | ||
| ALLERGIC DISEASES IN HUMANS: PATHOGENESIS AND THERAPY | 431 | ||
| THE PROTECTIVE ROLES OF IGE- AND MAST CELL–MEDIATED IMMUNE REACTIONS | 434 | ||
| SELECTED READINGS | 435 | ||
| CHAPTER 21 - Congenital and Acquired Immunodeficiencies | 437 | ||
| OVERVIEW OF IMMUNODEFICIENCY DISEASES | 437 | ||
| CONGENITAL (PRIMARY) IMMUNODEFICIENCIES | 438 | ||
| ACQUIRED (SECONDARY) IMMUNODEFICIENCIES | 450 | ||
| HUMAN IMMUNODEFICIENCY VIRUS AND THE ACQUIRED IMMUNODEFICIENCY SYNDROME | 451 | ||
| SELECTED READINGS | 462 | ||
| APPENDI XI - GLOSSARY | 465 | ||
| APPENDIX II - CYTOKINES | 493 | ||
| APPENDIX III - PRINCIPAL FEATURES OF SELECTED CD MOLECULES | 497 | ||
| APPENDIX IV - LABORATORY TECHNIQUES COMMONLY USED IN IMMUNOLOGY | 503 | ||
| LABORATORY METHODS USING ANTIBODIES | 503 | ||
| TRANSGENIC MICE AND GENE TARGETING | 510 | ||
| METHODS FOR STUDYING T LYMPHOCYTE RESPONSES | 513 | ||
| METHODS FOR STUDYING B LYMPHOCYTE RESPONSES | 515 | ||
| Index | 517 | ||
| IBC | IBC |