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Critical Care Nursing - E-Book

Critical Care Nursing - E-Book

Linda D. Urden | Kathleen M. Stacy | Mary E. Lough

(2014)

Additional Information

Book Details

Abstract

Praised for its comprehensive coverage and clear organization, Critical Care Nursing: Diagnosis and Management, 7th Edition is the go-to critical care nursing text for both practicing nurses and nursing students preparing for clinicals. Nine sections highlight the alterations seen in critical care and make it easy to understand the unique challenges of critical care nursing. An abundance of learning tools such as Patient Safety Alerts, Evidence-Based Practice boxes, NIC interventions, case studies, Pharmacologic Management boxes, and more give you a better understanding of clinical practice and help you reference vital information quickly and easily.

  • Consistent organization within each body-system unit allows you to use this book as a one-stop resource for your critical care nursing education, as well as a reference for the relevant assessment techniques, lab values, and patient management principles needed by practicing nurses.
  • Evidence-Based Practice boxes reinforce practice guidelines for both collaborative and nursing care.
  • Case studies in each chapter help you internalize and apply chapter content to clinical situations.
  • Pharmacologic Management tables offer quick summaries of the drugs most often used in critical care.
  • Patient Safety Alerts provide key information for special safety issues to keep safety in the forefront of your mind.
  • Nursing Management Plans of Care appendix provides detailed, clinically-relevant care plans tied to 35 different NANDA nursing diagnoses.
  • Highlighted QSEN content makes it easy to identify QSEN competencies as they relate to critical care nursing.
  • Internet Resources box provides a list of key websites from leading organizations in critical care.
  • Combined chapter on shock, sepsis and multiple organ dysfunction syndrome makes understanding similar physiologic processes easier.
  • Chapter summaries provide quick study guides by organizing key information in the chapter.
  • New! 6-second, standard ECG strips help you learn to identify wave forms and accurately reflect what you’ll use in practice.
  • New equipment information and photos accurately depicts what you’ll encounter in a modern critical care unit.

Table of Contents

Section Title Page Action Price
Front Cover cover
Inside Front Cover ifc1
Half title page i
Evolve page ii
Critical Care Nursing, 7/e iii
Copyright Page iv
Dedication v
About the Authors vii
Linda D. Urden, DNSc, RN, CNS, NE-BC, FAAN vii
Kathleen M. Stacy, PhD, RN, CNS, CCRN, PCCN, CCNS vii
Mary E. Lough, PhD, RN, CNS, CCRN, CNRN, CCNS vii
Contributors ix
Reviewers xii
Preface xiii
Organization xiii
Nursing Diagnosis and Management xiii
New to This Edition xiv
Special Features xiv
Evolve Resources for Critical Care Nursing xiv
Student Resources xiv
Instructor Resources xiv
Acknowledgments xvii
Table Of Contents xix
Unit 1 Foundations of Critical Care Nursing 1
1 Critical Care Nursing Practice 1
Overview 1
History of Critical Care 1
Critical Care Nursing 1
Contemporary Critical Care 2
Critical Care Nursing Roles 2
Expanded-Role Nursing Positions 2
Advanced Practice Nurses 2
Critical Care Professional Accountability 3
Critical Care Nursing Standards 3
Evidence-Based Nursing Practice 3
Holistic Critical Care Nursing 4
Caring 4
Individualized Care 4
Cultural Care 4
Complementary and Alternative Therapies 7
Spirituality and Prayer 7
Guided Imagery 7
Massage 7
Animal-Assisted Therapy 7
Nursing’s Unique Role in Health Care 7
Critical Care Nursing Practice 7
The Nursing Process 8
Nursing Diagnosis 8
Nursing Interventions 8
Outcomes Evaluation 8
Technology in Critical Care 8
Interprofessional Collaborative Practice 9
Interdisciplinary Care Management Models and Tools 10
Care Management 10
Case Management 10
Care Management Tools 10
Algorithm 10
Practice Guideline 10
Protocol 11
Order Set 11
Managing and Tracking Variances 11
Quality, Safety, and Regulatory Issues in Critical Care 11
Quality and Safety Issues 11
Quality and Safety Regulations 12
Quality and Safety Resources 12
Privacy and Confidentiality 13
Healthy Work Environment 13
Summary 14
References 14
2 Ethical Issues 17
Differences between Morals and Ethics 17
Moral Distress 17
Moral Courage 20
Ethical Principles 20
Autonomy 20
Beneficence 20
Nonmaleficence 21
Veracity 21
Fidelity 21
Justice 21
Scarce Resources in Critical Care 22
Technologies and Treatments 22
Health Care Personnel 23
Withholding and Withdrawing Treatment 23
Medical Futility 23
Ethics as a Foundation for Nursing Practice 23
Nursing Code of Ethics 24
Ethical Decision Making in Critical Care 24
The Nurse’s Role 24
What Is an Ethical Dilemma? 25
Steps in Ethical Decision Making 25
Step One 26
Step Two 26
Step Three 26
Step Four 26
Step Five 26
Step Six 27
Step Seven 27
Step Eight 27
Strategies for Promotion of Ethical Decision Making 27
Institutional Ethics Committees 27
Inservice and Education Programs 27
Nursing Ethics Committees 27
Ethics Rounds and Conferences 27
Summary 28
References 29
3 Legal Issues 30
Overview 30
Administrative Law: Professional Regulation 30
Functions of Boards of Nursing 31
Scope of Practice 31
Standards of Practice 31
Tort Law: Negligence and Professional Malpractice, Intentional Torts 32
Ordinary Negligence 32
Professional Malpractice 32
Duty 36
Breach 36
Harm Caused by the Breach 37
Damages 37
Professional Malpractice and the Nursing Process 37
Assessment Failure: Failure to Assess and Analyze the Level of Care Needed by the Patient. 38
Assessment Failure: Failure to Ascertain a Patient’s Wishes with Regard to Self-Determination. 38
Planning Failure: Failure to Appropriately Diagnose. 38
Implementation Failure: Failure to Timely Communicate Patient Findings. 38
Implementation Failure: Failure to Take Appropriate Action. 39
Implementation Failure: Failure to Document. 39
Implementation Failure: Failure to Preserve Patient Privacy. 39
Evaluation Failure: Failure to Act as a Patient Advocate. 40
Wrongful Death 40
Assault and Battery 41
Special Clinical Circumstances and Professional Malpractice 41
Respiratory Management 41
Blood Transfusions 42
Infection Control 43
Constitutional Law: Patient Decision Making 43
Patients Without Decision-Making Capacity 44
Never and Not Yet Competent Patients 44
Previously Competent Patients 44
Advance Directives 44
Futile Treatment and Orders Not to Resuscitate 45
Legal Issues Looking Forward 45
Summary 46
References 47
4 Genetics and Genomics in Critical Care 48
Genetics and Genomics 48
Genetic and Genomic Structure and Function 49
Chromosomes 49
DNA and the Double Helix 49
DNA Base Pairs 50
DNA Replication 50
DNA Alphabet 51
Transcription 51
Translation 52
Genetic Variation, Mutation and Polymorphism 53
Variation 53
Mutation 53
Single-Nucleotide Polymorphisms 53
Alleles 54
Genetic Inheritance 54
Genetic Disorders 54
Chromosome Disorders 55
Single-Gene Disorders 55
Complex Gene and Multifactorial Disorders 55
Mitochondrial Disorders 55
Genotype and Phenotype 56
Genetic History and Family Pedigree 56
Homozygous versus Heterozygous 56
Modes of Inheritance 56
Autosomal Dominant Inheritance 56
Autosomal Recessive Inheritance 56
Sex-Linked Inheritance 56
Hemophilia A and Hemophilia B. 56
Complex Gene-Gene and Gene-Environment Disorders 57
Obesity and the FTO Gene 58
How Information about Genetics is Obtained 58
Genetic Epidemiology 58
Family-Based Genetic Studies 58
Twin Studies 58
Genetic Association Studies 58
Case-Control Studies 59
Candidate Gene Studies 59
Genome-Wide Association Studies 59
Genome Mapping Projects 59
The Human Genome Project 59
ENCODE Project 59
HapMap Project 59
1000 Genomes Project 59
Personal Genome Project 60
The Human Microbiome Project 60
Genetic Diversity 60
Copy Number Variation 60
Individual Genome Sequences 60
Genetics in Critical Care 60
Cancer Genetics 61
Somatic Mutations 61
The Cancer Genome Atlas 61
Cardiovascular Genetics 61
Long QT Syndrome 61
Cardiomyopathy 62
Hypertrophic Cardiomyopathy. 62
Dilated Cardiomyopathy. 62
Restrictive Cardiomyopathy. 62
Pharmacogenetics 62
Cytochrome P450 Family and Medication Metabolism 62
Warfarin 62
Malignant Hyperthermia 62
Genetics, Genomics, and Nursing 62
Ethical and Legal Issues in Genetics and Genomics 63
Direct-to-Consumer Tests 63
The Genetic Information Nondiscrimination Act 63
Human Genetics Key Terms 65
Summary 66
References 66
5 Patient and Family Education 69
Challenges of Patient and Family Education 69
Education 70
Definition 70
Benefits 70
The Education Process 70
Step 1: Assessment 70
Learner Identification 71
Family 71
Age-Specific Considerations 71
Adult Learners 71
Factors Affecting the Learning Process 72
Readiness, Willingness, Ability 72
Physiologic Factors 72
Health Literacy 72
Sociocultural Factors 74
Financial Factors 74
Psychologic Factors 74
Coping 74
Adaptation 74
Environmental Factors 75
Step 2: Education Plan Development 75
Determining What to Teach 76
Writing Goals or Outcomes 76
Developing Interventions 76
Standardized Education Plans 78
Step 3: Implementation 78
Setting up the Environment 78
Teaching Strategies 79
Discussion 79
Demonstration and Practice 79
Audiovisual Media 79
Written Materials 80
Computer-Assisted Instruction 81
Internet Sites 81
Communication 81
Special Considerations 82
The Older Adult 82
Cognitive Effects of Aging. 82
Physical Effects of Aging. 82
Psychologic Effects of Aging. 82
Sedated and Unconscious Patients 82
The Noncompliant Patient 82
Step 4: Evaluation 83
How to Evaluate 83
Step 5: Documentation 83
What Should Be Documented? 83
Factors that Affect the Teaching-Learning Process 84
Informational Needs of Families in Critical Care 84
Preparation of the Patient and Family for Transfer from Critical Care 84
Summary 85
References 86
6 Psychosocial and Spiritual Alterations and Management 88
Stress and Psychoneuroimmunology 88
Stress Response 89
Psychoneuroimmunology 89
Post-Traumatic Stress Reactions 90
Anxiety 91
Anxiety and Pain 91
Alterations in Self-Concept 91
Body Image 92
Self-Esteem 92
Identity Disturbance 92
Risk for Compromised Human Dignity 92
Spiritual Challenges in Critical Care 93
Spiritual Distress 93
Hope and Hopelessness 93
Loss of Control and Powerlessness 93
Coping with Stress and Illness 94
Use of Psychologic Defense Mechanisms 94
Regression 94
Denial 95
Holistic Psychosocial-Spiritual Care 95
Communicate with Compassion and Care 95
Trust 96
Practice Dignity-Enhancing Care 96
Support Patient Coping 97
Helping Patients Maintain Control 97
Support Patient Preferred Complementary Therapies 97
Creating Healing Environments 97
Visiting Policies 97
Physical Environment 97
Provide Family-Centered Care 97
Engage Spiritual Resources 98
Patients with Mental Health Co-Morbidities 99
Alcohol Withdrawal in Critical Care Settings 99
Caring for Patients After Attempted Suicide 99
Nurse Self-Care 99
Summary 100
References 101
7 Sleep Alterations and Management 104
Normal Human Sleep 104
Sleep Physiology 104
Sleep Stages 105
Non-Rapid Eye Movement Sleep 105
Rapid Eye Movement Sleep 105
Sleep Cycles 105
Chronobiology 105
Circadian System 106
Homeostatic Mechanism 106
Circadian and Homeostatic Interaction 106
Pharmacology 106
Sleep Pattern Disturbance 107
Description 107
Etiology and Pathophysiology 107
Assessment and Diagnosis 108
Medical Management 108
Nursing Management 108
Sleep Apnea Syndrome 108
Description 108
Obstructive Sleep Apnea 109
Etiology and Pathophysiology 109
Assessment and Diagnosis 110
Medical Management 110
Nursing Management 111
Central Sleep Apnea 111
Etiology and Pathophysiology 111
Assessment and Diagnosis 112
Medical Management 112
Nursing Management 112
Summary 113
Normal Human Sleep 113
Pharmacology 113
Sleep Pattern Disturbance 113
Sleep Apnea Syndrome 113
References 113
8 Nutrition Alterations and Management 115
Nutrient Metabolism 115
Energy-Yielding Nutrients 115
Carbohydrates 115
Proteins 116
Lipids (Fats) 116
Assessing Nutritional Status 117
Anthropometric Measurements 117
Biochemical Data 119
Clinical or Physical Manifestations 119
Diet and Health History 119
Evaluating Nutrition Assessment Findings 120
Determining Nutritional Needs 120
Implications of Undernutrition for the Sick or Stressed Patient 121
Energy Deficiency 121
Protein-Calorie Malnutrition 121
Metabolic Response to Starvation and Stress 121
Nutrition Support 122
Nursing Management of Nutrition Support 122
Oral Supplementation 122
Enteral Nutrition 122
Enteral Feeding Access. 124
Location and Type of Feeding Tube. 124
Assessment and Prevention of Feeding Tube Complications. 124
Feeding Tube Occlusion. 125
Aspiration. 125
Gastrointestinal Complications. 127
Formula Delivery. 127
Adequacy of Enteral Nutrition. 127
Tubing and Catheter Misconnections. 127
Total Parenteral Nutrition 128
Types of Parenteral Nutrition. 128
Nursing Management of Potential Complications. 128
Lipid Emulsion. 130
Monitoring and Evaluation of Nutrition Support 130
Nutrition and Cardiovascular Alterations 130
Nutrition Assessment in Cardiovascular Alterations 130
Nutrition Intervention and Education in Cardiovascular Alterations 130
Myocardial Infarction 130
Short-Term Interventions. 130
Long-Term Changes 131
Heart Failure 131
Cardiac Cachexia 131
Nutrition and Pulmonary Alterations 132
Nutrition Assessment in Pulmonary Alterations 132
Nutrition Intervention and Education in Pulmonary Alterations 132
Prevent or Correct Undernutrition and Underweight 132
Avoid Overfeeding 132
Prevent Fluid Volume Excess 132
Nutrition and Neurologic Alterations 133
Nutrition Assessment in Neurologic Alterations 133
Nutrition Intervention and Education in Neurologic Alterations 133
Prevention or Correction of Nutritional Deficits 133
Oral Feedings. 133
Tube Feedings or Total Parenteral Nutrition. 133
Prevention of Overweight and Obesity. 134
Nutrition and Renal Alterations 134
Nutrition Assessment in Renal Alterations 134
Nutrition Intervention and Education in Renal Alterations 134
Protein 134
Fluid 135
Energy (Calories) 135
Other Nutrients 135
Nutrition and Gastrointestinal Alterations 135
Nutrition Assessment in Gastrointestinal Alterations 135
Nutrition Intervention and Education in Gastrointestinal Alterations 136
Hepatic Failure 136
Monitoring Fluid and Electrolyte Status. 136
Provision of a Nutritious Diet and Evaluation of Response to Dietary Protein. 136
Pancreatitis 137
Prevention of Further Damage to the Pancreas and Preventing Nutritional Deficits. 137
Nutrition and Endocrine Alterations 137
Nutrition Assessment in Endocrine Alterations 137
Nutrition Intervention in Endocrine Alterations 137
Nutrition Support and Blood Glucose Control 137
Severe Vomiting or Diarrhea in the Patient with Type 1 Diabetes Mellitus 138
Nutrition Education in Diabetes 138
Summary 139
Nutrient Metabolism 139
Assessing Nutritional Status 139
Implications of Undernutrition for the Sick or Stressed Patient 139
Nursing Management of Nutrition Support 139
Nutrition and Cardiovascular Alterations 139
Nutrition and Pulmonary Alterations 139
Nutrition and Neurologic Alterations 139
Nutrition and Renal Alterations 139
Nutrition and Gastrointestinal Alterations 139
Nutrition and Endocrine Alterations 139
References 140
9 Pain and Pain Management 143
Importance of Pain Assessment 143
Definition and Description of Pain 143
Components of Pain 144
Types of Pain 144
Acute Pain 144
Chronic Pain 144
Nociceptive Pain 144
Neuropathic Pain 144
Physiology of Pain 144
Nociception 144
Transduction 144
Transmission 144
Perception 145
Modulation 146
Biologic Stress Response 147
Short-Term Direct Response 148
Midterm Indirect Response 148
Long-Term Indirect Response 148
Framework for Pain Assessment and Definition 148
Pain Assessment 149
Pain Assessment: The Subjective Component 149
P: Provocative and Palliative or Aggravating Factors 149
Q: Quality 149
R: Region or Location, Radiation 150
S: Severity and Other Symptoms 150
T: Timing 150
U: Understanding 150
Pain Assessment: The Observable or Objective Component 150
Behavioral Pain Scale 151
Critical-Care Pain Observation Tool 151
Use of Cut-Off Scores 151
Limitations Related to the Use of Behavioral Pain Scales 151
Physiologic Indicators 151
Cerebral Monitoring and Pain Assessment 153
Electroencephalogram 153
Bispectral Index 153
Pain as a Vital Sign 154
Patient Barriers to Pain Assessment and Management 154
Communication 154
Altered Level of Consciousness and Unconsciousness 154
Older Adult Patients 154
Neonates and Infants 154
Cultural Influences. 154
Lack of Knowledge 155
Health Professional Barriers to Pain Assessment and Management 155
Addiction and Tolerance 155
Respiratory Depression 155
Organizational Barriers to Pain Assessment and Management 155
Pain Management 155
Pharmacologic Control of Pain 156
Opioid Analgesics 156
Morphine. 156
Fentanyl. 158
Hydromorphone. 159
Meperidine. 159
Codeine. 159
Methadone. 159
More Potent Opioids: Remifentanil and Sufentanil. 159
Preventing and Treating Respiratory Depression 159
Monitoring. 159
Opioid Reversal. 159
New Sedative with Analgesic Properties: Dexmedetomidine 160
Nonopioid Analgesics 160
Acetaminophen. 160
Nonsteroidal Antiinflammatory Drugs. 160
Adjuvants. 161
Ketamine. 161
Lidocaine. 161
Delivery Methods 161
Patient-Controlled Analgesia 161
Intraspinal Pain Control 161
Intrathecal Analgesia 162
Epidural Analgesia 162
Equianalgesia 163
Nonpharmacologic Methods of Pain Management 163
Physical Techniques 165
Cold Application 165
Massage 165
Cognitive-Behavioral Techniques 165
Relaxation 165
Guided Imagery 165
Music Therapy 166
Summary 166
References 166
10 Sedation, Agitation, Delirium: Assessment and Management 170
Sedation 170
Sedation and Agitation Assessment Scales 170
Pain Assessment Scales 170
Complications of Sedation 170
Pharmacologic Management of Sedation 170
Targeted Sedation 172
Neuromuscular Blockade 172
Peripheral Muscle Monitoring. 172
Brain Function Monitoring. 172
Benzodiazepines 172
Sedative-Hypnotic Agents 174
Central Alpha Agonists 175
Daily Sedation Interruption 175
Agitation 175
Delirium 176
Pharmacologic Management of Delirium 176
Nonpharmacologic Interventions to Prevent Delirium 176
Alcohol Withdrawal Syndrome and Delirium Tremens 179
Collaborative Management 179
Summary 180
References 180
11 End-of-Life Issues 182
End-of-Life Experience in Critical Care 183
Advance Directives 183
Physician Orders for Life Sustaining Treatment 184
Advance Care Planning 184
Ethical and Legal Issues 184
Comfort Care 185
Cardiopulmonary Resuscitation 185
Impact of Do Not Resuscitate Orders 185
Prognostication and Prognostic Tools 186
Communication and Decision Making 186
Patient Communication 187
Family Communication 187
Cultural and Spiritual Influences on Communication 187
Hospice Information 187
Withdrawal or Withholding of Treatment 188
Proactive Approach 188
Disagreement and Distress for Caregivers 188
Barriers to Dying 188
Steps Toward Comfort Care 188
Palliative Care 188
Pain Management 189
Symptom Management 189
Dyspnea 189
Nausea and Vomiting 189
Fever and Infection 189
Edema 189
Anxiety 189
Delirium 190
Metabolic Derangement 190
Providing Comfort 190
Near-Death Awareness 190
Family Meetings 190
Withdrawal of Mechanical Ventilation 190
Opioids and Sedatives 191
Ventilator Settings 191
Professional Issues 191
Health Care Settings 191
Emotional Support for the Nurse 191
Organ Donation 192
Legal Issues 192
Brain Death 192
Family Care 192
Communication Needs 192
Waiting for Good News 192
Family Meetings 193
Family Presence During Cardiopulmonary Resuscitation 193
Visiting Hours 193
After Death 194
Collaborative Care 194
Summary 195
References 195
Unit 2 Cardiovascular Alterations 200
12 Cardiovascular Anatomy and Physiology 200
Anatomy 200
Macroscopic Structure 200
Structures of the Heart 200
Size and Weight of the Heart 200
Layers of the Heart 200
Pericardium. 200
Epicardial Fat. 201
Epicardium. 201
Myocardium. 201
Endocardium. 201
Cardiac Chambers 202
Cardiac Valves 202
Atrioventricular Valves. 202
Semilunar Valves. 203
Conduction System 203
Sinoatrial Node. 203
Atrioventricular Node. 203
Bundle of His, Bundle Branches, and Purkinje Fibers. 204
Coronary Blood Supply 204
Coronary Veins. 206
Physiologic Cardiac Shunts. 206
Major Cardiac Vessels 206
Aorta 206
Pulmonary Artery 206
Pulmonary Veins 206
Systemic Circulation 206
Arterial System. 206
Blood Flow and Blood Pressure. 207
Microcirculation. 208
Venous System 209
Microscopic Structure 210
Cardiac Fibers 210
Cardiac Cells 210
Physiology 213
Electrical Activity 213
Transmembrane Potentials 213
Resting Membrane Potential 213
Phases of the Action Potential 213
Phase 0. 213
Phase 1 and Phase 2. 213
Phase 3. 214
Phase 4. 214
Fiber Conduction and Excitability. 214
Pacemaker Cell versus Non-pacemaker Cell Action Potentials. 215
Mechanical Activity 215
Excitation–Contraction Coupling 215
Cardiac Cycle 215
Atrial Systole 215
Isovolumic Contraction 216
Ventricular Systole 216
Isovolumic Relaxation 217
Ventricular Diastole 217
Interplay of the Heart and Vessels: Cardiac Output 217
Preload 217
Afterload 218
Contractility 218
Regulation of the Heartbeat 218
Nervous Control 218
Intrinsic Regulation 219
Baroreceptors. 219
Chemoreceptors. 219
Right Atrial Receptors. 219
Natriuretic Peptides. 219
Renin–Angiotensin–Aldosterone System. 219
Respiratory Influences. 220
Control of Peripheral Circulation 220
Intrinsic Control 220
Extrinsic Control 220
Summary 221
References 221
13 Cardiovascular Clinical Assessment 222
History 222
Physical Examination 224
Inspection 224
Face 224
Thorax 224
Abdomen 224
Nail Beds and Cyanosis 224
Lower Extremities 224
Posture 225
Weight 225
Mentation 225
Jugular Veins 225
Abdominojugular Reflux 225
Thoracic Reference Points 226
Apical Impulse 227
Palpation 227
Arterial Pulses 227
Carotid Pulses 227
Brachial, Ulnar, and Radial Pulses 227
Femoral Pulses 228
Popliteal Pulses 228
Dorsalis Pedis and Posterior Tibial Pulses 228
Descending Aorta Pulse 228
Capillary Refill 229
Edema 229
Auscultation 229
Blood Pressure Measurement 229
Noninvasive Blood Pressure Monitoring. 229
Orthostatic Hypotension. 229
Blood Pressure Cuff Size. 229
Korotkoff Sounds. 230
Auscultatory Gap. 230
Automated Blood Pressure Devices. 230
Pulse Pressure. 230
Pulsus Paradoxus. 230
Pulsus Alternans. 231
Vascular Bruits. 231
Normal Heart Sounds 231
First and Second Heart Sounds. 231
Physiologic Splitting of S1 and S2. 231
Pathologic Splitting of S1 and S2. 231
Abnormal Heart Sounds 231
Third and Fourth Heart Sounds. 231
Heart Murmurs 233
Mitral Stenosis. 234
Mitral Regurgitation. 234
Aortic Stenosis. 234
Aortic Insufficiency. 234
Innocent Murmurs 234
Murmurs Associated with Myocardial Infarction 234
Papillary Muscle Rupture. 235
Ventricular Septal Rupture. 235
Cardiac Rubs 235
Pericardial Friction Rub. 235
Summary 236
References 236
14 Cardiovascular Diagnostic Procedures 237
Cardiovascular Assessment and Monitoring 237
Bedside Hemodynamic Monitoring 237
Equipment 237
Heparin. 237
Calibration of Equipment. 238
Zeroing the Transducer. 238
Phlebostatic Axis. 239
Leveling the Transducer. 239
Patient Position 240
Head of Bed Backrest Position. 240
Lateral Position. 240
Intra-arterial Blood Pressure Monitoring 240
Indications 240
Catheters 240
Insertion and Allen Test. 240
Nursing Management 240
Infection. 240
Perfusion Pressure. 242
Pulse Pressure. 242
Cuff Blood Pressure. 242
Arterial Pressure Waveform Interpretation 242
Decreased Arterial Perfusion. 242
Pulse Deficit. 243
Pulsus Paradoxus. 244
Pulsus Alternans. 244
Damped Waveform. 244
Underdamped Waveform. 246
Fast-Flush Square Waveform Test. 246
Alarms. 247
Central Venous Pressure Monitoring 247
Indications 247
Central Venous Catheters 248
Insertion. 248
Internal Jugular Vein. 248
Subclavian Vein. 248
Femoral Vein. 249
Central Venous Catheter Complications 249
Air Embolus. 249
Thrombus Formation. 249
Infection. 249
Nursing Management 250
Central Venous Pressure—Volume Assessment. 250
Passive Leg Raise. 250
Water Versus Mercury Central Venous Pressure. 250
Removal. 251
Patient Position. 251
Central Venous Pressure Waveform Interpretation. 251
Cannon Waves. 251
Specialized Central Venous Catheters 252
Pulmonary Artery Pressure Monitoring 252
Indications 253
Cardiac Output Determinants 253
Oxygen Supply and Demand 253
Preload. 253
Measurement of Preload. 255
Frank-Starling Law of the Heart. 255
Ejection Fraction. 256
Cardiac Dysfunction. 256
Pulmonary Artery Diastolic Pressure and Pulmonary Artery Occlusion Pressure Relationship. 256
Pulmonary Hypertension. 256
Heart Failure. 256
Mitral Stenosis. 256
Mitral Regurgitation. 257
Afterload. 258
Systemic Vascular Resistance. 258
Systemic Vascular Resistance and Afterload Reduction. 258
Pulmonary Vascular Resistance. 258
Contractility. 258
Optimizing Contractility. 258
Pulmonary Artery Catheters 258
Right Atrial Lumen. 259
Pulmonary Artery Lumen. 260
Balloon Lumen. 260
Thermistor Lumen. 260
Additional Features. 260
Insertion 260
Pulmonary Artery Waveform Interpretation 260
Right Atrial Waveform. 260
Right Ventricular Waveform. 261
Pulmonary Artery Waveform. 261
Pulmonary Artery Occlusion Waveform (Wedge). 261
Medical Management 261
Nursing Management 261
Patient Position. 261
Respiratory Variation. 261
Positive End-Expiratory Pressure. 261
Avoiding Complications. 262
Pulmonary Artery Catheter Removal. 263
Cardiac Output Measurement 263
Thermodilution Cardiac Output Bolus Method. 263
Cardiac Output Curve. 263
Injectate Temperature. 264
Patient Position and Cardiac Output. 264
Clinical Conditions That Alter Cardiac Output. 264
Continuous Invasive Cardiac Output Measurement. 264
Calculated Hemodynamic Profiles. 264
Noninvasive and Minimally Invasive Measurement of Cardiac Output 264
Thoracic Electrical Bioimpedance. 264
Arterial Waveform - Pulse Contour Cardiac Output Methods. 264
Lithium Dilution Cardiac Output. 264
Pulse Index Contour Cardiac Output. 265
Pulse Contour Cardiac Output Method. 266
Esophageal Doppler Cardiac Output. 266
Partial Carbon Dioxide Rebreathing Cardiac Output. 268
Continuous Monitoring of Venous Oxygen Saturation 268
Indications 268
Catheters 269
Svo2 Catheter. 269
Scvo2 Catheter. 269
Svo2 or Scvo2 Calibration. 269
Nursing Management 269
Normal Svo2 Values. 269
Normal Scvo2 Values. 269
Svo2 or Scvo2 and Arterial Oxygen Saturation. 270
Svo2 or Scvo2 and Cardiac Output. 270
Svo2 or Scvo2 and Hemoglobin. 271
Svo2 or Scvo2 and Oxygen Consumption. 271
Normal Svo2 or Scvo2. 273
Low Svo2 or Scvo2. 273
High Svo2. 274
Electrocardiography 274
Basic Principles of Electrocardiography 274
Phase 0. 274
Phases 1 and 2. 274
Phase 3. 275
Phase 4. 275
Electrocardiographic Leads. 275
12-Lead Electrocardiogram. 275
Standard Limb Leads. 275
Augmented Vector Leads. 276
Precordial Leads. 277
Right Ventricular Precordial Leads. 277
Posterior Wall Leads. 277
Baseline Distortion. 277
Electrocardiographic Analysis 277
Specialized Electrocardiographic Paper. 277
Calibration. 277
Waveforms. 278
P Wave. 278
QRS Complex. 278
T Wave. 278
Intervals Between Waveforms. 278
PR Interval. 278
QT Interval. 279
Ventricular Axis. 281
Calculating the Ventricular Axis. 281
Cardiac Monitor Lead Analysis 281
Lead II. 282
Lead V1. 283
MCL1. 283
Electrocardiographic Lead Selection for Optimal Bedside Monitoring 284
Continuous Dysrhythmia Monitoring. 284
Continuous ST Segment Monitoring. 284
Atrial Hypertrophy 285
Ventricular Hypertrophy 285
Ischemia and Infarction 286
Electrocardiographic Changes Indicating Ischemia and Infarction. 286
Non–Q-wave Infarction. 287
Infarct Location by 12-Lead Electrocardiogram. 287
lnfarct Electrocardiographic Progression. 287
Intraventricular Conduction Defects 287
Right and Left Bundle Branch Blocks. 288
Right Bundle Branch Block. 288
Left Bundle Branch Block. 288
Hemiblocks. 289
Bifascicular Block. 289
Dysrhythmia Interpretation 289
Heart Rate Determination. 289
Rhythm Determination. 290
P-Wave Evaluation. 290
PR-Interval Evaluation. 290
QRS Complex Evaluation. 290
QT Evaluation. 291
Sinus Rhythms 291
Normal Sinus Rhythm. 291
Sinus Bradycardia. 291
Sinus Tachycardia. 291
Sinus Dysrhythmia. 292
Atrial Dysrhythmias 292
Premature Atrial Contractions. 292
Supraventricular Tachycardia. 293
Supraventricular Tachycardia with Aberrant Conduction. 294
Paroxysmal Supraventricular Tachycardia. 294
Multifocal Atrial Tachycardia. 295
Atrial Flutter. 295
Pathogenesis of Atrial Flutter. 295
Atrial and Ventricular Rates in Atrial Flutter. 296
Atrial Flutter Management. 296
Atrial Fibrillation. 296
Pathogenesis of Atrial Fibrillation. 297
Types of Atrial Fibrillation. 298
Atrial Fibrillation Risk Factors. 299
Atrial Fibrillation Management. 299
Rhythm Control. 299
Rate Control. 300
Stroke Risk Assessment and Antithrombotic Therapy in Atrial Fibrillation 300
CHADS2. 300
CHA2DS2-VASc. 300
Nonpharmacologic Procedures to Treat Atrial Fibrillation. 300
Junctional Dysrhythmias 301
Premature Junctional Contraction. 301
Junctional Escape Rhythm. 301
Junctional Tachycardia and Accelerated Junctional Rhythm. 302
Ventricular Dysrhythmias 302
Premature Ventricular Contractions. 302
Compensatory Pause. 302
Describing Ventricular Ectopy. 303
Premature Ventricular Contraction Timing. 303
Causes of Premature Ventricular Contractions. 303
Premature Ventricular Contraction Management. 304
Idioventricular Rhythms. 304
Ventricular Tachycardia. 305
Ventricular Fibrillation. 306
Differential Diagnosis of a Wide QRS-Complex Tachycardia. 306
Significance of Ventricular Tachycardia and Supraventricular Tachycardia. 306
Clinical Differentiation of Ventricular Tachycardia from Supraventricular Tachycardia. 307
Nursing Management. 308
First-Degree Atrioventricular Block. 309
Second-Degree Atrioventricular Block. 309
Mobitz Type I. 309
Mobitz Type II. 310
2 : 1 Conduction. 310
Third-Degree Atrioventricular Block. 310
Management of Atrioventricular Block. 311
Laboratory Assessment 311
Electrolytes 311
Potassium 311
Hyperkalemia. 311
Hypokalemia. 312
Calcium 312
Hypercalcemia. 312
Hypocalcemia. 313
Magnesium 313
Hypermagnesemia. 313
Hypomagnesemia. 314
Cardiac Biomarker Studies 315
Cardiac Biomarkers in Acute Coronary Syndrome 315
Creatine Kinase-MB. 315
Troponin T and Troponin I. 315
Cardiac Biomarkers and Reperfusion. 316
Natriuretic Peptide Biomarkers in Heart Failure 316
Hematologic Studies 316
Red Blood Cells 316
Hemoglobin 317
Hematocrit 317
White Blood Cells 317
Platelets 317
Blood Coagulation Studies 317
Prothrombin Time. 317
International Normalized Ratio. 317
Activated Partial Thromboplastin Time. 317
Anti-Factor Xa Test of Heparin Activity. 317
Activated Coagulation Time. 317
Serum Lipid Studies 317
Total Cholesterol 318
Low-Density Lipoproteins 318
Very-Low-Density Lipoproteins and Triglycerides 318
High-Density Lipoproteins 318
Triglycerides 318
Diagnostic Procedures 318
Cardiac Catheterization and Coronary Arteriography 318
Left-Heart Cardiac Catheterization 318
Right-Heart Cardiac Catheterization 318
Procedure 318
Prevention of Contrast-Induced Nephropathy. 319
Nursing Management 319
Femoral Artery Site Care. 319
Peripheral Pulses. 319
Rehydration. 319
Angina. 319
Dysrhythmias. 319
Patient Education 319
Electrophysiology Study 320
Indications 320
Atrial Measurements. 320
Ventricular Measurements. 320
Implantable Cardioverter Defibrillators. 320
Chest Radiography 321
Basic Principles and Technique 321
Tissue Densities. 321
Standard Views. 321
Portable Chest Radiography. 321
Nursing Interventions to Produce an Optimal Chest Radiograph. 321
Indications 321
Chest Radiograph Analysis: Lines and Tubes 322
Central Venous Catheter. 322
Pulmonary Artery Catheter. 322
Endotracheal Tube. 322
Enteric Tube. 322
Chest Tube. 322
Intra-aortic Balloon Catheter. 322
Pacemaker or Implantable Defibrillator. 322
Chest Radiograph Analysis: Cardiac and Pulmonary Factors 322
Cardiac Heart Size. 322
Pulmonary Edema. 323
Pneumonia. 323
Pneumothorax. 323
Digital Radiography 323
Ambulatory Electrocardiographic Tests 323
Continuous Electrocardiographic Recording Systems 323
Electrocardiographic Monitoring Leads. 323
Unit 3 Pulmonary Alterations 467
17 Pulmonary Anatomy and Physiology 467
Thorax 467
Thoracic Cage 467
Lungs 467
Lobes and Segments 467
Mediastinum 467
Pleura 469
Intrapleural Pressure 469
Muscles of Ventilation 470
Inhalation 470
Exhalation 471
Accessory Muscles 471
Conducting Airways 471
Upper Airways 471
Epiglottis 472
Trachea 472
Bronchial Tree 472
Bronchi 473
Bronchioles 473
Defense System 473
Respiratory Airways 474
Respiratory Bronchioles 474
Alveoli 474
Type I Alveolar Epithelial Cells 474
Collateral Air Passages. 474
Type II Alveolar Epithelial Cells 474
Surfactant. 474
Defense System 474
Pulmonary Blood and Lymph Supply 475
Pulmonary Circulation 475
Pulmonary Artery Pressures 475
Alveolar-Capillary Membrane 476
Membrane Layers 476
Bronchial Circulation 476
Physiologic Shunting 476
Lymphatic Circulation 477
Ventilation 477
Work of Breathing 477
Pulmonary Volumes and Capacities 477
Physiologic Dead Space 477
Regulation of Ventilation 478
Controller 478
Brainstem. 478
Cerebral Cortex. 479
Effectors 479
Sensors 479
Central Chemoreceptors. 480
Peripheral Chemoreceptors. 480
Other Receptors. 480
Respiration 480
Diffusion 480
Ventilation/Perfusion Relationships 481
Distribution of Ventilation 481
Distribution of Perfusion 482
Ventilation/Perfusion Mismatch 482
Hypoxic Vasoconstriction 483
Gas Transport 483
Oxygen Content 484
Oxygen Content Formula 484
Oxyhemoglobin Dissociation Curve 484
Shifts in the Oxyhemoglobin Dissociation Curve. 484
Shift to the Right. 484
Shift to the Left. 485
Abnormalities of Hemoglobin 485
Carbon Dioxide Content 486
Summary 486
Anatomy 486
Physiology 486
References 486
18 Pulmonary Clinical Assessment 488
History 488
Physical Examination 488
Inspection 488
Tongue and Sublingual Area 490
Chest Wall Configuration 490
Respiratory Effort 490
Additional Assessment Areas 491
Palpation 491
Position of the Trachea 491
Thoracic Expansion 492
Tactile Fremitus 492
Percussion 492
Underlying Lung Structure 492
Diaphragmatic Excursion 493
Auscultation 493
Normal Breath Sounds 493
Abnormal Breath Sounds 493
Voice Sounds 495
Assessment Findings of Common Disorders 495
Summary 500
History 500
Clinical Assessment 500
References 501
19 Pulmonary Diagnostic Procedures 502
Laboratory Studies 502
Arterial Blood Gases 502
Steps for Interpretation of Blood Gas Levels 502
Step 1. 502
Step 2. 502
Step 3. 503
Step 4. 503
Step 5. 503
Oxygen Saturation 503
Oxygen Content 504
Base Excess and Base Deficit 505
Classic Shunt Equation and Oxygen Tension Indices 505
Pao2/FiO2 Ratio 505
Pao2/Pao2 Ratio 505
Alveolar-Arterial Gradient 505
Dead Space Equation 506
Sputum Studies 506
Diagnostic Procedures 506
Bronchoscopy 506
Thoracentesis 507
Bedside Pulmonary Function Tests 508
Ventilation/Perfusion Scanning 508
Chest Radiography 509
Bones 509
Mediastinum 509
Diaphragm 509
Pleural Space 510
Lung Tissue 510
Tubes, Wires, and Lines 510
Nursing Management 510
Bedside Monitoring 511
Capnography 511
Pulse Oximetry 511
Physiologic Limitations 512
Technical Limitations 512
Summary 512
Laboratory Studies 512
Diagnostic Procedures 512
Bedside Monitoring 512
References 513
20 Pulmonary Disorders 514
Acute Lung Failure 514
Description 514
Etiology 514
Pathophysiology 514
Alveolar Hypoventilation 514
Ventilation/Perfusion Mismatching 516
Intrapulmonary Shunting 516
Assessment and Diagnosis 516
Medical Management 516
Oxygenation 516
Ventilation 517
Pharmacology 517
Acidosis 517
Nutrition Support 518
Complications 518
Nursing Management 518
Optimizing Oxygenation and Ventilation 518
Positioning. 518
Preventing Desaturation. 518
Promoting Secretion Clearance. 518
Educating the Patient and Family 519
Acute Respiratory Distress Syndrome 519
Description 519
Etiology 519
Pathophysiology 519
Exudative Phase 521
Fibroproliferative Phase 522
Resolution Phase 522
Assessment and Diagnosis 522
Medical Management 523
Ventilation 523
Low Tidal Volume. 523
Permissive Hypercapnia. 523
Pressure Control Ventilation. 523
Inverse Ratio Ventilation. 523
High-Frequency Oscillatory Ventilation. 523
Oxygen Therapy 523
Positive End-Expiratory Pressure. 523
Extracorporeal and Intracorporeal Gas Exchange. 524
Tissue Perfusion 524
Nursing Management 524
Optimizing Oxygenation and Ventilation 524
Prone Positioning. 524
Pneumonia 524
Description 524
Etiology 525
Severe Community-Acquired Pneumonia 525
Hospital-Acquired Pneumonia 525
Health Care-Associated Pneumonia 525
Pathophysiology 525
Assessment and Diagnosis 527
Medical Management 527
Antibiotic Therapy 527
Independent Lung Ventilation 527
Nursing Management 527
Optimizing Oxygenation and Ventilation 527
Preventing the Spread of Infection 527
Aspiration Pneumonitis 528
Description 528
Etiology 528
Pathophysiology 528
Acid Liquid 528
Acid Food Particles 529
Nonacid Liquid 529
Nonacid Food Particles 529
Assessment and Diagnosis 529
Medical Management 529
Nursing Management 530
Optimizing Oxygenation and Ventilation 530
Preventing Aspiration 530
Pulmonary Embolism 530
Description 530
Etiology 531
Pathophysiology 531
Increased Dead Space 531
Bronchoconstriction 531
Compensatory Shunting 531
Hemodynamic Consequences 531
Assessment and Diagnosis 531
Medical Management 532
Prevention of Recurrence 533
Clot Dissolution 533
Reversal of Pulmonary Hypertension 533
Nursing Management 534
Optimizing Oxygenation and Ventilation 534
Monitoring for Bleeding 534
Educating the Patient and Family 534
Status Asthmaticus 535
Description 535
Etiology 535
Pathophysiology 535
Pulmonary Effects 535
Cardiovascular Effects 535
Assessment and Diagnosis 535
Medical Management 536
Bronchodilators 536
Systemic Corticosteroids 536
Oxygen Therapy 536
Intubation and Mechanical Ventilation 536
Nursing Management 536
Optimizing Oxygenation and Ventilation 536
Educating the Patient and Family 536
Air Leak Disorders 537
Description 537
Etiology 537
Pathophysiology 538
Pneumothorax 538
Barotrauma 538
Assessment and Diagnosis 538
Medical Management 538
Tension Pneumothorax 539
Tension Pneumopericardium 539
Nursing Management 539
Optimizing Oxygenation and Ventilation 539
Maintaining the Chest Tube System 539
Long-Term Mechanical Ventilator Dependence 540
Description 540
Etiology and Pathophysiology 540
Medical and Nursing Management 541
Preweaning Stage 541
Weaning Preparedness. 541
Weaning Readiness. 541
Weaning Approach. 541
Weaning Method. 544
Weaning Process Stage 544
Weaning Initiation. 544
Weaning Progress. 544
Weaning Intolerance. 544
Facilitative Therapies. 544
Weaning Outcome Stage 544
Weaning Completed. 544
Incomplete Weaning. 545
Summary 546
Acute Lung Failure 546
Acute Respiratory Distress Syndrome 546
Pneumonia 546
Aspiration Pneumonitis 546
Pulmonary Embolism 546
Status Asthmaticus 546
Air Leak Disorders 546
Long-Term Mechanical Ventilation Dependence 546
References 547
21 Pulmonary Therapeutic Management 549
Oxygen Therapy 549
Principles of Therapy 549
Methods of Delivery 549
Low-Flow Systems 549
Reservoir Systems 549
High-Flow Systems 551
Complications of Oxygen Therapy 551
Oxygen Toxicity 551
Carbon Dioxide Retention 552
Absorption Atelectasis 552
Nursing Management 552
Artificial Airways 552
Pharyngeal Airways 552
Oropharyngeal Airway 552
Nasopharyngeal Airway 553
Endotracheal Tubes 553
Rapid Sequence Intubation 553
Step 1—Preparation. 553
Step 2—Preoxygenation. 554
Step 3—Pretreatment. 554
Step 4—Paralysis with Induction. 554
Step 5—Protection and Positioning. 554
Step 6—Placement of the Endotracheal Tube. 554
Step 7—Post Intubation Management. 554
Complications 554
Tracheostomy Tubes 555
Tracheostomy Procedure 555
Complications 555
Nursing Management 557
Humidification 559
Cuff Management 559
Cuff Inflation Techniques. 559
Cuff Pressure Monitoring. 560
Foam Cuff Tracheostomy Tubes. 560
Subglottic Secretion Removal. 560
Suctioning 560
Complications. 560
Suctioning Protocol. 561
Closed Tracheal Suction System. 561
Communication 561
Passy-Muir Valve. 562
Oral Hygiene 562
Extubation and Decannulation 563
Invasive Mechanical Ventilation 563
Indications 563
Use of Mechanical Ventilators 563
Types of Ventilators 563
Ventilator Mechanics 563
Trigger. 563
Limit. 563
Cycle. 563
Baseline. 564
Modes of Ventilation 564
Ventilator Settings 564
Complications 566
Ventilator-Induced Lung Injury 566
Cardiovascular Compromise 566
Gastrointestinal Disturbances 566
Patient-Ventilator Dyssynchrony 566
Ventilator-Associated Pneumonia 566
Semirecumbency. 566
Sedation Vacation. 567
Other Measures to Reduce the Incidence of Ventilator-Associated Pneumonia. 567
Weaning 568
Readiness to Wean 568
Weaning Methods 568
T-Piece Trials. 568
Synchronized Intermittent Mandatory Ventilation Trials. 568
Pressure Support Ventilation Trials. 568
Nursing Management 568
Patient Assessment 569
Symptom Management 569
ABCDE Bundle 571
Ventilator Assessment 571
Patient Safety 571
Noninvasive Ventilation 571
Nursing Management 572
Positioning Therapy 573
Prone Positioning 573
Rotation Therapy 575
Thoracic Surgery 575
Preoperative Care 575
Surgical Considerations 575
Complications and Medical Management 578
Acute Lung Failure 578
Bronchopleural Fistula 578
Hemorrhage 578
Cardiovascular Disturbances 578
Postoperative Nursing Management 578
Optimizing Oxygenation and Ventilation 578
Preventing Atelectasis 578
Patient Positioning and Early Ambulation. 578
Deep Breathing and Incentive Spirometry. 579
Pain Management. 579
Maintaining the Chest Tube System 579
Assisting Patient to Return to Adequate Activity Level 579
Pharmacology 579
Bronchodilators and Adjuncts 579
Neuromuscular Blocking Agents 579
Peripheral Nerve Stimulator 581
Summary 582
Oxygen Therapy 582
Artificial Airways 582
Invasive Mechanical Ventilation 583
Noninvasive Mechanical Ventilation 583
Positioning Therapy 583
Thoracic Surgery 583
Pharmacology 583
References 584
Unit 4 Neurologic Alterations 587
22 Neurologic Anatomy and Physiology 587
Divisions of the Nervous System 587
Anatomic Divisions 587
Physiologic Divisions 587
Microstructure of the Nervous System 587
Neuroglia 588
Neurons 588
Central Nervous System 590
Cranial Protective Mechanisms 590
Bony Structures 590
Meninges 591
Dura Mater. 591
Arachnoid Mater. 591
Pia Mater. 593
Ventricular System 593
Cerebrospinal Fluid 593
Blood–Brain Barrier 593
Cerebrum 595
Frontal Lobe 595
Parietal Lobe 595
Temporal Lobe 597
Occipital Lobe 597
Limbic Lobe 597
Internal Capsule 598
Basal Ganglia 598
Diencephalon 598
Thalamus 598
Hypothalamus 598
Cerebellum 598
Brainstem 600
Midbrain 600
Pons 600
Medulla Oblongata 600
Reticular Formation 600
Arterial Circulation 600
Anterior Circulation 600
Posterior Circulation 609
Circle of Willis 609
Venous Circulation 610
Spinal Cord 610
Spinal Protective Mechanisms 610
Bony Structures 612
Intervertebral Disk 612
Meninges 612
Spinal Nerves 613
Cross-Section of the Spinal Cord 615
Vascular Supply 615
Summary 618
Anatomy 618
Physiology 618
References 618
23 Neurologic Clinical Assessment and Diagnostic Procedures 620
Clinical Assessment 620
History 620
Physical Examination 620
Level of Consciousness 620
Evaluation of Arousal 621
Appraisal of Awareness 621
Glasgow Coma Scale 621
Motor Function 622
Evaluation of Muscle Size and Tone 622
Estimation of Muscle Strength 622
Abnormal Motor Responses 623
Evaluation of Reflexes 623
Pupillary Function 624
Estimation of Pupil Size and Shape 625
Evaluation of Pupillary Reaction to Light 625
Assessment of Eye Movement 626
Respiratory Function 626
Observation of Respiratory Pattern 626
Evaluation of Airway Status 627
Vital Signs 627
Evaluation of Blood Pressure 627
Observation of Heart Rate and Rhythm 628
Cushing Reflex. 628
Rapid Neurologic Assessment 628
The Conscious Patient 628
The Unconscious Patient 628
Neurologic Changes Associated with Intracranial Hypertension 628
Diagnostic Procedures 628
Radiologic Procedures 629
Skull and Spine Films 629
Computed Tomography 630
Magnetic Resonance Imaging 631
Cerebral Angiography 632
Conventional Angiography. 632
Digital Subtraction Angiography. 633
Magnetic Resonance Angiography. 633
Computed Tomography Angiography. 633
Myelography 633
Cerebral Blood Flow and Metabolism Imaging 634
Perfusion Computed Tomography 634
Xenon Computed Tomography 634
Perfusion Magnetic Resonance Imaging 634
Carotid Ultrasonography 634
Emission Tomography Studies 635
Positive Emission Tomography. 635
Single-Photon Emission Computed Tomography. 635
Electrophysiology Studies 635
Electroencephalography 635
Evoked Potentials 636
Laboratory Studies 636
Cerebrospinal Fluid Analysis 636
Multimodal Bedside Monitoring 636
Intracranial Pressure Monitoring 636
Types of Catheters 636
Monitoring Sites 637
Intraventricular Space. 638
Subarachnoid Space. 638
Epidural Space. 638
Subdural Space. 640
Intraparenchymal Site. 640
Intracranial Pressure Waves 640
Normal Intracranial Pressure Waveform. 640
A-Waves. 640
B-Waves. 640
C-Waves. 640
Pupillometry 641
Cerebral Perfusion Pressure Monitoring 641
Cerebral Blood Flow Monitoring 641
Transcranial Doppler Studies 641
Transcranial Color-Coded Duplex Sonography. 641
Thermal Diffusion Flowmetry 641
Laser Doppler Flowmetry 642
Cerebral Oxygenation and Metabolic Monitoring 642
Jugular Venous Oxygen Saturation 642
Near Infrared Spectroscopy 642
Brain Tissue Oxygen Pressure 642
Cerebral Microdialysis 642
Continuous Electroencephalography Monitoring 643
Summary 643
Clinical Assessment 643
Diagnostic Procedures 643
Laboratory Studies 643
Multimodal Monitoring 643
References 643
24 Neurologic Disorders and Therapeutic Management 646
Coma 646
Description 646
Etiology 646
Pathophysiology 646
Assessment and Diagnosis 647
Medical Management 648
Nursing Management 648
Eye Care 648
Stroke 649
Ischemic Stroke 649
Description 649
Etiology 649
Pathophysiology 649
Assessment and Diagnosis 649
Medical Management 651
Subarachnoid Hemorrhage 652
Description 652
Etiology 653
Pathophysiology 654
Cerebral Aneurysm. 654
Arteriovenous Malformation. 654
Assessment and Diagnosis 654
Medical Management 655
Rebleeding. 655
Surgical Clipping of Aneurysms. 655
Surgical Excision of Arteriovenous Malformations. 656
Embolization. 656
Cerebral Vasospasm. 656
Hypertensive, Hypervolemic, Hemodilution Therapy. 656
Nimodipine. 657
Cerebral Angioplasty. 657
Hyponatremia. 658
Hydrocephalus. 658
Intracerebral Hemorrhage 658
Description 658
Etiology 658
Pathophysiology 658
Assessment and Diagnosis 658
Medical Management 658
Nursing Management 659
Monitoring for Changes in Neurologic and Hemodynamic Status 659
Maintaining Surveillance for Complications 659
Bleeding and Vasospasm. 659
Increased Intracranial Pressure. 660
Damage to the Nondominant Hemisphere. 660
Agnosia. 660
Visual Field Defects. 660
Apraxia. 660
Damage to the Dominant Hemisphere. 660
Receptive Aphasia. 661
Expressive Aphasia. 661
Global Aphasia. 661
Impaired Swallowing. 661
Educating the Patient and Family 661
Guillain-BARRé Syndrome 662
Description 662
Etiology 662
Pathophysiology 662
Assessment and Diagnosis 662
Medical Management 663
Nursing Management 663
Maintaining Surveillance for Complications 663
Initiating Rehabilitation 663
Facilitating Nutritional Support 663
Providing Comfort and Emotional Support 663
Educating the Patient and Family 664
Craniotomy 664
Types of Surgery 664
Preoperative Care 664
Surgical Considerations 665
Transcranial Approach 665
Trans-sphenoidal Approach 665
Postoperative Medical Management 666
Intracranial Hypertension 666
Surgical Hemorrhage 666
Fluid Imbalance 667
Cerebrospinal Fluid Leak 667
Deep Vein Thrombosis 667
Postoperative Nursing Management 667
Preserving Adequate Cerebral Perfusion 667
Positioning. 667
Fluid Management. 668
Avoidance of Vomiting and Fever. 668
Promoting Arterial Oxygenation 668
Providing Comfort and Emotional Support 668
Maintaining Surveillance for Complications 668
Infection. 668
Corneal Abrasions. 668
Injury. 668
Initiating Early Rehabilitation 668
Educating the Patient and Family 668
Intracranial Hypertension 668
Pathophysiology 668
Volume-Pressure Curve 669
Cerebral Blood Flow and Autoregulation 669
Assessment and Diagnosis 670
Medical and Nursing Management 670
Positioning and Other Nursing Activities 670
Hyperventilation 672
Temperature Control 672
Blood Pressure Control 672
Seizure Control 673
Cerebrospinal Fluid Drainage 673
Hyperosmolar Therapy 674
Control of Metabolic Demand 674
Barbiturate Therapy. 675
Herniation Syndromes 675
Supratentorial Herniation 675
Uncal Herniation. 675
Central Herniation. 675
Cingulate Herniation. 676
Transcalvarial Herniation. 676
Infratentorial Herniation 676
Upward Transtentorial Herniation. 676
Downward Cerebellar Herniation. 676
Pharmacologic Agents 676
Summary 678
Coma 678
Stroke 678
Ischemic Stroke 678
Subarachnoid Hemorrhage 678
Intracerebral Hemorrhage 678
Guillain-Barré Syndrome 678
Craniotomy 678
Intracranial Hypertension 678
References 678
Unit V Kidney Alterations 681
25 Kidney Anatomy and Physiology 681
Macroscopic Anatomy 681
Vascular Anatomy 681
Microscopic Structure and Function 682
Glomerulus 683
The Bowman Capsule 683
Proximal Tubule 683
Loop of Henle 683
Distal Tubule 683
Collecting Duct 684
Nervous System Innervation 684
Urine Formation 684
Glomerular Filtration 684
Tubular Resorption 685
Passive Transport 685
Active Transport 685
Tubular Secretion 685
Functions of the Kidneys 685
Elimination of Metabolic Wastes 685
Urea 686
Creatinine 686
Blood Pressure Regulation 686
Erythrocyte Production 686
Vitamin D Activation 686
Prostaglandin Synthesis 687
Acid–Base Balance 687
Fluid Balance 687
Fluid Compartments 687
Electrolytes 688
Fluid Physiology 688
Tonicity 688
Hydrostatic Pressure 688
Osmotic Pressure 688
Diffusion, Osmosis, and Active Transport 688
Movement of Water 688
Factors Controlling Fluid Balance 689
Antidiuretic Hormone and Aquaporins 689
Aldosterone 689
Atrial Natriuretic Peptide 689
Electrolyte Balance 689
Potassium 689
Sodium 690
Calcium 690
Phosphorus 691
Magnesium 691
Chloride 691
Bicarbonate 691
Effects of Aging 692
Summary 692
Anatomy 692
Physiology 692
References 692
26 Kidney Clinical Assessment and Diagnostic Procedures 694
History 694
Physical Examination 694
Inspection 695
Bleeding 695
Volume 695
Edema 696
Auscultation 696
Heart 696
Blood Pressure 697
Lungs 697
Palpation 697
Percussion 697
Kidneys 697
Abdomen 697
Additional Assessments 698
Weight Monitoring 698
Intake and Output Monitoring 698
Hemodynamic Monitoring 698
Other Observations 699
Laboratory Assessment 699
Serum Components 700
Blood Urea Nitrogen 700
Creatinine 700
BUN to Creatinine Ratio. 700
Creatinine Clearance 700
Cystatin C 701
Osmolality 701
Anion Gap 701
Hemoglobin and Hematocrit 701
Albumin 702
Urinalysis 702
Urine Appearance 702
Urine pH 702
Urine Specific Gravity 702
Urine Osmolality 702
Urine Protein 702
Urine Glucose 703
Urine Ketones 703
Urine Electrolytes 703
Urine Sodium. 704
Urine Sediment 704
Hematuria 704
Urine Toxicology Screen 704
Imaging Studies 704
Kidney Biopsy 704
Summary 705
Clinical Assessment 705
Laboratory Studies 705
Diagnostic Procedures 705
References 705
27 Kidney Disorders and Therapeutic Management 707
Acute Kidney Injury 707
Critical Illness and Acute Kidney Injury 707
Definitions of Acute Kidney Injury 707
RIFLE Criteria 708
Acute Kidney Injury Network Criteria 708
Types of Acute Kidney Injury 709
Prerenal Acute Kidney Injury 709
Intrarenal Acute Kidney Injury 709
Postrenal Acute Kidney Injury 709
Azotemia 709
Assessment and Diagnosis 709
Laboratory Assessment 709
Acidosis 709
Blood Urea Nitrogen 710
Serum Creatinine 710
Creatinine Clearance 710
Fractional Excretion of Sodium 710
At-Risk Disease States and Acute Kidney Injury 710
Underlying Chronic Kidney Disease 710
Older Age and Acute Kidney Injury 711
Heart Failure and Acute Kidney Injury 713
Respiratory Failure and Acute Kidney Injury 713
Sepsis and Acute Kidney Injury 713
Trauma and Acute Kidney Injury 713
Trauma Admissions 713
Rhabdomyolysis 713
Contrast-Induced Nephrotoxic Injury and Acute Kidney Injury 714
Radiopaque Contrast 714
Promote Hydration and Avoid Dehydration 714
Medications 714
Catheter-Associated Urinary Tract Infection 714
Hemodynamic Monitoring and Fluid Balance 714
Hemodynamic Monitoring 714
Daily Weight 714
Physical Assessment 715
Electrolyte Balance 715
Potassium 715
Sodium 716
Calcium and Phosphorus 716
Calcium Replacement 716
Dietary–Phosphorus-Binding Medications 716
Medical Management 716
Treatment Goals 716
Prevention 716
Fluid Resuscitation 716
Crystalloids and Colloids. 717
Crystalloids. 717
Colloids. 717
Fluid Restriction. 718
Fluid Removal. 718
Pharmacologic Management 718
Diuretics 718
Loop Diuretics. 718
Thiazide Diuretics. 718
Osmotic Diuretics. 718
Carbonic Anhydrase Inhibitor Diuretics. 718
Potassium Sparing Diuretics. 719
Vaptans. 719
Dopamine 719
Acetylcysteine 720
Dietary-Phosphorus Binders 720
Nutrition 720
Nursing Management 720
Risk Factors for Acute Kidney Injury 720
Infectious Complications 721
Fluid Balance 721
Electrolyte Imbalance 721
Preventing Anemia 721
Erythropoiesis-Stimulating Medications. 721
Patient Education 721
Renal Replacement Therapy: Dialysis 722
Hemodialysis 722
Hemodialyzer 722
Ultrafiltration 722
Anticoagulation 723
Vascular Access 723
Temporary Vascular Access. 723
Permanent Vascular Access. 723
Arteriovenous Fistula. 723
Arteriovenous Grafts. 724
Tunneled Catheters. 724
Medical Management 724
Nursing Management 724
Continuous Renal Replacement Therapy 725
Continuous Renal Replacement Therapy Terminology 726
Diffusion. 726
Convection. 726
Absorption. 726
Ultrafiltrate Volume. 726
Replacement Fluid. 726
Anticoagulation. 727
Modes of Continuous Renal Replacement 727
Slow Continuous Ultrafiltration. 727
Continuous Venovenous Hemofiltration. 727
Continuous Venovenous Hemodialysis 727
Continuous Venovenous Hemodiafiltration. 727
Complications 728
Medical Management 729
Nursing Management 730
Peritoneal Dialysis 730
Catheter Placement 731
Infection 731
Medical Management 732
Nursing Management 732
Summary 734
Acute Kidney Injury 734
Catheter-Associated Urinary Tract Infection 734
Diuretics and Renal Replacement Therapies 734
References 734
Unit VI Gastrointestinal Alterations 737
28 Gastrointestinal Anatomy and Physiology 737
Mouth 737
Ingestion and Mastication 737
Salivation 737
Esophagus 737
Swallowing 738
Stomach 738
Gastric Secretion 740
Gastric Motility 740
Small Intestine 740
Intestinal Secretion 741
Intestinal Motility 741
Digestion and Absorption 742
Large Intestine 742
Colonic Motility 743
Resorption 743
Accessory Organs 743
Liver 745
Nutrient Metabolism 745
Hematologic Function 747
Detoxification and Storage 747
Unit VII Endocrine Alterations 788
31 Endocrine Anatomy and Physiology 788
Pancreas 788
Anatomy 788
Pancreas Blood Supply 788
Exocrine Cells 788
Endocrine Cells 788
Physiology 789
Insulin 790
Blood Glucose 790
Carbohydrate Anabolism. 791
Fat Anabolism. 791
Protein Conservation. 791
Glucagon 791
Somatostatin 791
Pancreatic Polypeptide 791
Glucose Transporters 791
GLUT1 and GLUT3. 792
GLUT2. 792
GLUT4. 792
GLUT5. 792
Incretins 792
Glucose-Dependent Insulinotropic Polypeptide. 792
Glucagon-Like-Peptide 1. 792
Pituitary Gland and Hypothalamus 793
Anatomy 793
Anterior Pituitary 793
Posterior Pituitary 794
Physiology 794
Antidiuretic Hormone 794
Thyroid Gland 795
Anatomy 795
Physiology 795
Pituitary Gland and Thyroid-Stimulating Hormone 795
Iodine and Iodide 795
Thyroglobulin 795
Triiodothyronine and Thyroxine 796
Calcitonin 796
Hypothalamic–Pituitary–Thyroid Axis Feedback Loop 796
Adrenal Gland 797
Anatomy 797
Adrenal Cortex 797
Adrenal Medulla 797
Adrenal Blood Supply 798
Physiology 798
Hormones of the Adrenal Cortex 798
Hormones of the Adrenal Medulla 798
Hypothalamic–Pituitary–Adrenal Axis 798
Summary 798
Pancreas 798
Pituitary 798
Thyroid 799
Adrenal 799
References 799
32 Endocrine Clinical Assessment and Diagnostic Procedures 800
History 800
Pancreas 800
Physical Assessment 800
Hyperglycemia 800
Laboratory Studies 800
Blood Glucose 801
Urine Glucose 801
Glycated Hemoglobin 802
Blood Ketones 802
Urine Ketones 802
Pituitary Gland 802
Physical Assessment 802
Hydration Status 802
Vital Signs 803
Weight Changes and Intake and Output 803
Laboratory Assessment 803
Serum Antidiuretic Hormone 803
Serum and Urine Osmolality 803
Antidiuretic Hormone Test 803
Diagnostic Procedures 803
Radiographic Examination 803
Computed Tomography 803
Magnetic Resonance Imaging 804
Thyroid Gland 804
Clinical Assessment 804
History 804
Physical Examination 804
Laboratory Studies 804
Thyroid Stimulating Hormone 805
Thyroid Tests in the Critically Ill 805
Medications and Thyroid Testing 805
Diagnostic Procedures 805
Adrenal Gland 805
Primary Adrenal Disorders 805
Clinical Assessment 806
History 806
Physical Examination 806
Adrenal Cortex 806
Primary Cushing Syndrome. 806
Secondary Cushing Syndrome. 806
Primary Aldosteronism 806
Addison Disease 806
Critical Illness-Related Corticosteroid Insufficiency 807
Adrenal Medulla 807
Pheochromocytoma. 807
Laboratory Studies 807
Adrenal Insufficiency and Critical Illness 807
Diagnostic Procedures 807
Summary 808
Pancreas 808
Pituitary 808
Thyroid 808
Adrenal 808
References 808
33 Endocrine Disorders and Therapeutic Management 809
Neuroendocrinology of Stress and Critical Illness 809
Acute Neuroendocrine Response to Critical Illness 809
Hypothalamic-Pituitary-Adrenal Axis in Critical Illness 809
Serum Cortisol Level 811
Cosyntropin Stimulation Test 811
Corticosteroid Replacement 811
Liver and Pancreas in Critical Illness 811
Hyperglycemia in Critical Illness 811
Clinical Practice Guidelines Related to Blood Glucose Management in Critically Ill Patients 811
Insulin Management in the Critically Ill 811
Frequent Blood Glucose Monitoring 812
Continuous Insulin Infusion 812
Transition from Continuous to Intermittent Insulin Coverage 812
Corrective Insulin Coverage 814
Hypoglycemia Management 814
Nursing Management 815
Monitor Hyperglycemic Side Effects of Vasopressor Therapy 815
Administer Prescribed Corticosteroids 815
Monitor Blood Glucose, Insulin Effectiveness, Avoid Hypoglycemia 815
Provide Nutrition 815
Patient Education 815
Collaborative Management 815
Diabetes Mellitus 815
Diagnosis of Diabetes 815
Types of Diabetes 816
Glycated Hemoglobin 816
Type 1 Diabetes 816
Management of Type 1 Diabetes 816
Type 2 Diabetes 816
Lifestyle Management for Type 2 Diabetes 817
Pharmacologic Management of Type 2 Diabetes 817
Diabetic Ketoacidosis 819
Epidemiology and Etiology 819
Pathophysiology 819
Insulin Deficiency 819
Hyperglycemia 820
Fluid Volume Deficit 820
Ketoacidosis 820
Acid–Base Balance 820
Gluconeogenesis 820
Assessment and Diagnosis 822
Clinical Manifestations 822
Laboratory Studies 822
Medical Management 822
Reversing Dehydration 822
Replacing Insulin 822
Reversing Ketoacidosis 822
Replenishing Electrolytes 823
Nursing Management 824
Administering Fluids, Insulin, and Electrolytes 824
Monitoring Response to Therapy 824
Surveillance for Complications 824
Fluid Volume Overload. 824
Hypoglycemia. 825
Hypokalemia and Hyperkalemia. 825
Hyponatremia. 826
Risk for Cerebral Edema. 826
Risk for Infection. 826
Patient Education 826
Collaborative Management 826
Hyperglycemic Hyperosmolar State 826
Epidemiology and Etiology 826
Differences Between Hyperglycemic Hyperosmolar State and Diabetic Ketoacidosis 827
Pathophysiology 827
Assessment and Diagnosis 829
Clinical Manifestations 829
Laboratory Studies 829
Medical Management 829
Rapid Rehydration 829
Insulin Administration 829
Insulin Resistance. 830
Electrolyte Replacement 830
Nursing Management 830
Administering Fluids, Insulin, and Electrolytes 830
Monitoring Response to Therapy 830
Surveillance for Complications 830
Patient Education 830
Collaborative Management 831
Diabetes Insipidus 831
Etiology 831
Central Diabetes Insipidus 832
Nephrogenic Diabetes Insipidus 832
Primary Polydipsia 832
Pathophysiology 832
Assessment and Diagnosis 832
Clinical Manifestations 832
Laboratory Studies 832
Serum Sodium. 834
Serum Osmolality Test. 834
Urine Osmolality. 834
Measurement of Antidiuretic Hormone. 834
Medical Management 834
Volume Restoration 834
Medications 834
Medications Used for Central Diabetes Insipidus. 834
Medications Used for Nephrogenic Diabetes Insipidus. 834
Nursing Management 834
Administration of Fluids and Medications 834
Evaluation of Response to Therapy 835
Surveillance for Complications 835
Patient Education 836
Collaborative Management 836
Syndrome of Inappropriate Secretion of Antidiuretic Hormone 836
Etiology 836
Pathophysiology 836
Assessment and Diagnosis 836
Clinical Manifestations 836
Laboratory Values 836
Medical Management 837
Fluid Restriction 837
Sodium Replacement 837
Medications 837
Vasopressin Receptor Antagonists. 839
Nursing Management 839
Restriction of Fluids 839
Patient Education 839
Collaborative Management 839
Thyroid Storm 839
Description 839
Etiology 840
Pathophysiology 840
Assessment and Diagnosis 840
Medical Management 840
Prevent Cardiovascular Collapse 840
Reduce Hyperthermia 841
Reverse Dehydration 841
Pharmacologic Management 841
Medications That Block the Catecholamine Effect 841
Medications That Block Thyroid Synthesis 841
Medications That Block Release of Thyroid Hormone 842
Nursing Management 842
Medication Administration 842
Normalize Body Temperature 842
Rehydration and Correction of Metabolic Derangements 843
Patient Education 843
Collaborative Management 843
Myxedema Coma 843
Description 843
Etiology 843
Pathophysiology 843
Skin 843
Cardiopulmonary System 844
Pulmonary System 844
Kidneys and Fluid and Electrolyte Balance 844
Nutrition and Elimination 844
Thermoregulation 844
Anemia 844
Assessment and Diagnosis 844
Clinical Presentation 845
Laboratory Studies 845
Medical Management 845
Pharmacologic Management 845
Nursing Management 845
Pulmonary Care 845
Cardiac Concerns 845
Thermoregulation 845
Thyroid Replacement Therapy 845
Skin Care 846
Elimination 846
Patient Education 846
Collaborative Management 846
Summary 847
Stress of Critical Illness 847
Pancreas: DKA and HHS 847
Pituitary: DI and SIADH 847
Thyroid: Thyroid Storm and Myxedema Coma 847
References 847
Unit VIII Multisystem Alterations 849
34 Trauma 849
Mechanisms of Injury 849
Blunt Trauma 849
Penetrating Trauma 850
Phases of Trauma Care 850
Prehospital Resuscitation 851
Emergency Department Resuscitation 851
Primary Survey 851
Airway. 851
Breathing. 852
Circulation. 852
Disability. 852
Exposure. 853
Resuscitation Phase 853
Damage Control Resuscitation. 853
Massive Transfusion Protocols. 853
Secondary Survey 853
Definitive Care and Operative Phase 854
Critical Care Phase 854
Specific Trauma Injuries 855
Traumatic Brain Injuries 855
Mechanism of Injury 855
Pathophysiology 855
Primary Injury. 855
Secondary Injury. 855
Tissue Ischemia. 855
Hypotension. 855
Hypercapnia. 855
Brain Edema. 855
Classification of Brain Injuries 855
Skull Fracture. 855
Concussion. 856
Contusion. 856
Cerebral Hematomas. 856
Epidural Hematoma. 856
Subdural Hematoma. 857
Acute Subdural Hematoma. 857
Subacute Subdural Hematoma. 857
Chronic Subdural Hematoma. 857
Intracerebral Hematoma. 857
Missile Injuries. 857
Diffuse Axonal Injury. 858
Neurologic Assessment of Traumatic Brain Injury 858
Degree of Injury 858
Mild Brain Injury. 858
Moderate Brain Injury. 858
Severe Brain Injury. 858
Nursing Assessment of the Patient with Traumatic Brain Injury. 859
Diagnostic Procedures. 859
Medical Management 859
Surgical Management. 859
Nonsurgical Management. 859
Nursing Management 859
Spinal Cord Injuries 860
Mechanism of Injury 860
Hyperflexion. 860
Hyperextension. 860
Rotation. 860
Axial Loading. 860
Penetrating Injuries. 860
Pathophysiology 860
Functional Injury of the Spinal Cord 861
Complete Injury. 861
Tetraplegia. 861
Paraplegia. 862
Incomplete Injury. 862
Brown-Séquard Syndrome. 862
Central Cord Syndrome. 862
Anterior Cord Syndrome. 862
Posterior Cord Syndrome. 862
Spinal Shock. 862
Neurogenic Shock. 862
Autonomic Dysreflexia. 862
Assessment 862
Airway. 863
Breathing. 863
Circulation. 863
Neurologic Assessment for Spinal Cord Injury. 863
Diagnostic Procedures. 863
Screening for Spinal Cord Injury. 863
Medical Management 866
Pharmacologic Management. 866
Surgical Management. 866
Laminectomy. 866
Spinal Fusion. 866
Rodding. 866
Nonsurgical Management. 866
Cervical Injury. 866
Thoracolumbar Injury. 867
Nursing Management 867
Cardiovascular Complications. 867
Pulmonary Complications. 868
Musculoskeletal Complications. 868
Integumentary Complications. 868
Elimination Complications. 868
Maximizing Psychosocial Adaptation. 869
Maxillofacial Injuries 869
Mechanism of Injury 869
Maxillofacial Skeletal Injuries. 869
Assessment and Diagnostic Procedures 869
Medical Management 870
Nursing Management 870
Thoracic Injuries 870
Mechanism of Injury 870
Blunt Thoracic Trauma. 870
Penetrating Thoracic Injuries. 870
Specific Thoracic Traumatic Injuries 870
Chest Wall Injuries 870
Rib Fractures. 870
Flail Chest. 871
Ruptured Diaphragm. 871
Pulmonary Injuries 872
Pulmonary Contusion. 872
Tension Pneumothorax. 872
Open Pneumothorax. 872
Hemothorax. 873
Cardiac and Vascular Injuries 873
Penetrating Cardiac Injuries. 873
Cardiac Tamponade. 873
Blunt Cardiac Injuries. 874
Blunt Cardiac Injury. 874
Aortic Injury. 874
Abdominal Injuries 875
Mechanism of Injury 875
Blunt Trauma. 875
Penetrating Trauma. 875
Assessment 875
Physical Assessment. 875
Diagnostic Procedures. 875
Diagnostic Peritoneal Lavage. 875
Bedside Ultrasound. 876
Combined Abdominal Organ Injuries 876
Abdominal Compartment Syndrome. 877
Specific Organ Injuries 877
Liver Injuries. 877
Spleen Injuries. 878
Hollow Viscus Injuries. 878
Genitourinary Injuries 878
Mechanism of Injury 878
Assessment 878
Specific Genitourinary Injuries 878
Kidney Trauma. 878
Bladder Trauma. 879
Nursing Management 879
Pelvic Fractures 879
Mechanism of Injury 879
Assessment 879
Classification of Pelvic Fractures 879
Lateral Compression Pelvic Injury. 879
Anteroposterior Compression Pelvic Injury. 879
Vertical Shear. 880
Open Fractures. 880
Medical Management 880
Nursing Management 880
Complications of Trauma 880
Hypermetabolism 880
Infection 881
Sepsis 881
Pulmonary Complications 881
Respiratory Failure 881
Fat Embolism Syndrome 881
Pain 881
Kidney Complications 881
Acute Kidney Injury 881
Rhabdomyolysis and Myoglobinuria 882
Vascular Complications 882
Compartment Syndrome 882
Venous Thromboembolism 882
Missed Injury 882
Multiple Organ Dysfunction Syndrome 883
Special Considerations 883
Meeting the Needs of Family Members and Significant Others 883
Trauma in the Older Patient 883
Summary 885
Phases of Trauma Care 885
Specific Trauma Injuries 885
References 885
35 Shock, Sepsis, and Multiple Organ Dysfunction Syndrome 887
Shock Syndrome 887
Description 887
Etiology 887
Pathophysiology 887
Assessment and Diagnosis 889
Medical Management 890
Nursing Management 891
Hypovolemic Shock 891
Description 891
Etiology 891
Pathophysiology 891
Assessment and Diagnosis 891
Medical Management 893
Nursing Management 893
Cardiogenic Shock 894
Description 894
Etiology 894
Pathophysiology 894
Assessment and Diagnosis 894
Medical Management 896
Nursing Management 896
Anaphylactic Shock 897
Description 897
Etiology 897
Pathophysiology 897
Assessment and Diagnosis 897
Medical Management 899
Nursing Management 900
Neurogenic Shock 900
Description 900
Etiology 902
Pathophysiology 902
Assessment and Diagnosis 902
Medical Management 902
Nursing Management 902
Severe Sepsis and Septic Shock 902
Description 902
Etiology 903
Pathophysiology 903
Assessment and Diagnosis 905
Medical Management 906
Nursing Management 908
Multiple Organ Dysfunction Syndrome 908
Description 908
Etiology 912
Pathophysiology 912
Inflammatory Cells 914
Neutrophils. 914
Monocytes and Macrophages. 914
Mast Cells. 914
Lymphocytes. 914
Endothelial Cells. 914
Biochemical Mediators 915
Reactive Oxygen Species. 915
Tumor Necrosis Factor-alpha. 915
Interleukins. 915
Platelet-Activating Factor. 915
Arachidonic Acid Metabolites. 915
Proteases. 915
Assessment and Diagnosis 916
Gastrointestinal Dysfunction 916
Hepatobiliary Dysfunction 917
Pulmonary Dysfunction 917
Kidney Dysfunction 918
Cardiovascular and Hematologic System Dysfunction 918
Medical Management 918
Identification and Treatment of Infection 918
Maintenance of Tissue Oxygenation 919
Nutritional and Metabolic Support 919
Nursing Management 919
Summary 921
Shock 921
Hypovolemic Shock 921
Cardiogenic Shock 921
Anaphylactic Shock 921
Neurogenic Shock 921
Septic Shock 921
Systemic Inflammatory Response 922
Multiple Organ Dysfunction Syndrome 922
References 922
36 Burns 926
Anatomy and Functions of the Skin 926
Pathophysiology and Etiology of Burn Injury 927
Zones of Injury 927
Classification of Burn Injury 928
Size of Injury 928
Depth of Burn Injury 928
Types of Injury 931
Thermal Burns 931
Electrical Burns 931
Chemical Burns 931
Radiation Burns 931
Location of Injury 931
Patient Age and History 931
Child Abuse 931
Initial Emergency Burn Management 932
Airway Management 932
Respiratory Management 932
Circulatory Management 932
Pathophysiology of Burn Shock 933
Kidney Management 934
Gastrointestinal System Management 934
Extremity Pulse Assessment 934
Laboratory Assessment 934
Wound Care 934
Burn Center Referral 935
Special Management Considerations 935
Inhalation Injury 935
Carbon Monoxide Poisoning 935
Upper Airway Injury 935
Lower Airway Injury 936
Nonthermal Burns 936
Chemical Burns 936
Electrical Burns 936
Burn Nursing Diagnoses and Management 937
Resuscitation Phase 937
Oxygenation Alterations 937
Impaired Gas Exchange. 937
Ineffective Airway Clearance. 937
Fluid Resuscitation 938
Deficient Fluid Volume. 938
Risk for Infection 938
Tissue Perfusion 939
Ineffective Kidney Tissue Perfusion 939
Ineffective Cerebral Tissue Perfusion 939
Ineffective Peripheral Tissue Perfusion 939
Ineffective Gastrointestinal Tissue Perfusion 940
Invasive Monitoring. 940
Hypothermia. 940
Laboratory Assessment. 940
Acute Care Phase 940
Inflammatory Phase 941
Proliferative Phase 941
Maturation Phase 941
Impaired Tissue Integrity 941
Factors Affecting Healing of the Burn Wound 941
Wound Cleansing 941
Wound Care 941
Topical Antibiotic Therapy 942
Wound Débridement 943
Mechanical Débridement. 943
Enzymatic Débridement. 943
Surgical Débridement. 943
Skin Substitutes 943
Definitive Burn Wound Closure 943
Autograft 944
Biosynthetic Skin Substitutes 945
Synthetic Skin 945
Imbalanced Nutrition: Less Than Body Requirements 945
Pain Management 946
Rehabilitation Phase 946
Impaired Physical Mobility 947
Scar Management 947
Itching 948
Multidisciplinary Care 948
Outpatient Burn Care 948
Support of the Burn Patient 948
Stressors of Burn Nursing 949
Summary 949
References 950
37 Organ Donation and Transplantation 951
Organ Donation 951
Role of the Critical Care Nurse in Organ Donation 951
Organ Procurement Organization as Part of the Health Care Team 952
National Donation and Transplantation Laws 953
The Uniform Anatomical Gift Act 953
Uniform Determination of Death Act 953
National Organ Transplant Act (NOTA) (1984) 953
Omnibus Budget Reconciliation Act 953
Medical Examiner State Laws 953
Overview of the Donation Process 953
Types of Referrals 954
Donation After Brain Death 954
Donation After Cardiac Death 954
Donor Evaluation 954
Brain Death 955
Confirmatory Tests 955
Cerebral Motor Responses. 955
Brainstem Reflexes. 955
Pupillary Reflexes. 955
Oculocephalic Reflex. 956
Oculovestibular Reflex. 956
Corneal and Jaw Reflexes. 956
Gag and Cough Reflexes. 956
Apnea Testing. 956
Donation After Cardiac Death 956
Controlled Donation After Cardiac Death 956
Uncontrolled Donation After Cardiac Death 956
Authorization for Donation 957
Donor Management 957
Organ Allocation 958
Role of the Medical Examiner/Coroner in Organ and Tissue Donation 958
Organ Recovery 958
Tissue Donation 958
Organ Donation Summary 959
Immunology of Transplant Rejection 959
Immune Mechanism 959
Cells of the Immune System 959
Humoral Immunity 959
Cell-Mediated Immunity 959
Cytotoxic T Cells. 959
Helper T Cells. 960
Suppressor T Cells. 960
Other Immune System Defenses 960
Natural Killer Cells. 960
Phagocytes. 960
Complement. 960
Graft Rejection 960
Hyperacute Rejection 961
Acute Rejection 961
Chronic Rejection 961
Immunosuppressive Therapy 961
Corticosteroids 961
Cyclosporine 963
Tacrolimus 964
Azathioprine 964
Mycophenolate Mofetil 964
Sirolimus 964
Everolimus 965
Induction Therapy 965
Antilymphocyte Preparations 965
Antithymocyte Preparations 965
Interleukin-2 Receptor Antagonists 965
Alemtuzumab (Campath 1H) 966
Heart Transplantation 966
Indications and Selection 966
Heart Transplantation Surgical Procedure 967
Biatrial Technique 967
Bicaval Technique 968
Postoperative Medical and Nursing Management 968
Signs and Symptoms of Rejection 968
Rejection Surveillance 969
Infection Surveillance 969
Patient Education 969
Long-Term Considerations 970
Heart–Lung Transplantation 971
Indications and Selection 971
Heart–Lung Transplant Surgical Procedure 971
Postoperative Management 972
Ventilation 972
Fluids 972
Pleural Drainage 973
Ischemia-Reperfusion Injury 973
Rejection Surveillance 973
Infection 974
Immunosuppression 974
Patient Education 974
Long-Term Considerations 974
Bronchiolitis Obliterans Syndrome 974
Co-morbidities 974
Single-Lung and Double-Lung Transplantation 975
Single-Lung Transplantation Indications 975
Single-Lung Transplant Surgical Procedure 975
Double-Lung Transplantation Surgical Procedure 975
Lung Volume Reduction Surgery 976
Living Donor Lung Transplantation 976
Postoperative Management 976
Patient Education 976
Long-Term Considerations 976
Liver Transplantation 976
Indications and Selection 976
Recipient Evaluation 977
Model for End-Stage Liver Disease Formula. 978
Pediatric End-Stage Liver Disease Formula. 978
Pretransplantation Phase 979
Determining Donor Suitability 979
Living Donor Liver Transplantation 980
Living Liver Donor Complications. 980
Donor Advocate. 980
Liver Transplantation Surgical Procedure 980
Recipient Hepatectomy 980
Vascular Anastomoses with a Donor Liver 980
Biliary Anastomosis 980
Postoperative Medical and Nursing Management 981
Hemodynamics 981
Electrolytes 982
Pulmonary Management 982
Coagulopathy Risk 982
Neurologic Status 982
Pain Management 982
Glucose Control 983
Kidney Function 983
Infection Risk 983
Bile Drains 983
Nutrition 983
Liver Function Tests 983
Liver Graft Nonfunction 983
Rejection Surveillance 983
Transfer Out of Critical Care 984
Patient Education 984
Long-Term Follow-Up 984
The Future 985
Kidney Transplantation 985
Indications and Selection 985
Deceased Kidney Donation 986
Living Kidney Donation 986
Living Kidney Paired Donation. 986
Kidney Transplantation Surgical Procedure 986
Living Donor Kidney Transplantation 986
Deceased Donor Kidney Transplantation Surgery 986
Recipient Surgery 987
Postoperative Medical Management and Nursing Care 987
Fluid Status 987
Electrolytes 988
Postoperative Complications 988
Immunosuppression 988
Infection Risk 988
Kidney Graft Nonfunction 988
Preparation for Discharge Home 988
Long-Term Considerations 988
Pancreas Transplantation 989
Indications and Selection 989
Pancreas Transplantation Surgical Procedure 989
Arterial and Venous Revascularization 989
Exocrine Drainage 990
Enteric Exocrine Drainage. 990
Bladder Exocrine Drainage. 990
Postoperative Medical Management and Nursing Care 990
Long-Term Considerations 991
Islet Cell Transplantation 991
Summary 991
Organ Donation 991
Heart Transplantation 992
Lung Transplantation 992
Liver Transplantation 992
Kidney Transplantation 992
Pancreas Transplantation 992
References 992
38 Hematologic Disorders and Oncologic Emergencies 997
Overview of Coagulation and Fibrinolysis 997
Coagulation Mechanism 997
Clot Formation 997
Regulatory Mechanisms 997
Fibrinolysis 998
Disseminated Intravascular Coagulation 998
Description 998
Etiology 998
Pathophysiology 998
Assessment and Diagnosis 998
Clinical Manifestations 999
Laboratory Findings 1000
Medical Management 1001
Nursing Management 1002
Supporting Patient’s Vital Functions 1002
Initiating Bleeding Precautions 1002
Providing Comfort and Emotional Support 1003
Thrombocytopenia 1003
Description 1003
Etiology 1003
Pathophysiology 1003
Assessment and Diagnosis 1004
Clinical Manifestations 1004
Laboratory Findings 1004
Medical Management 1004
Nursing Management 1004
Heparin-Induced Thrombocytopenia 1005
Description 1005
Etiology 1005
Pathophysiology 1005
Assessment and Diagnosis 1006
Clinical Manifestations 1006
Laboratory Findings 1006
Medical Management 1006
Direct Thrombin Inhibitors 1006
Nursing Management 1006
Decreasing the Incidence of Heparin Exposure 1006
Maintaining Surveillance for Complications 1007
Educating the Patient and Family 1007
Sickle Cell Anemia 1007
Description 1007
Etiology 1008
Pathophysiology 1008
Assessment and Diagnosis 1008
Clinical Manifestations 1008
Laboratory Studies 1008
Medical Management 1008
Prevent Infection 1009
Pain Management 1009
Transfusion Therapy 1010
Administration of Hydroxyurea 1010
Nursing Management 1010
Supporting Patient’s Vital Functions 1010
Maintaining Surveillance for Complications 1010
Educating the Patient and Family 1010
Tumor Lysis Syndrome 1011
Description 1011
Etiology 1011
Pathophysiology 1011
Hyperuricemia 1012
Hyperkalemia 1012
Hyperphosphatemia and Hypocalcemia 1012
Assessment and Diagnosis 1012
Clinical Manifestations 1012
Laboratory Findings 1012
Other Diagnostic Tests 1013
Medical Management 1013
Adequate Hydration 1013
Metabolic Imbalances 1013
Life-Threatening Complications 1013
Nursing Management 1013
Monitoring Fluid and Electrolytes 1013
Maintaining Surveillance for Complications 1013
Educating the Patient and Family 1013
Anemia of Critical Illness 1014
Etiology 1014
Blood Conservation Strategies 1014
Minimizing Blood Loss 1014
Managing Oxygen Delivery and Consumption 1014
Stimulating Production of Red Blood Cells 1014
Encouraging Safer Transfusions and Alternative Agents 1014
Summary 1015
Coagulation and Fibrinolysis 1015
Disseminated Intravascular Coagulation 1015
Idiopathic Thrombocytopenia Purpura 1015
Heparin-Induced Thrombocytopenia 1015
Sickle Cell Anemia 1015
Tumor Lysis Syndrome 1015
Hospital-Acquired Anemia 1015
References 1016
Unit IX Special Populations 1017
39 The Obstetric Patient 1017
Risks to Fetal Development 1018
Perinatal Infection 1018
Group B Streptococcal Infection 1018
Cytomegalovirus Infection 1018
Toxoplasmosis 1019
Rubella 1019
Herpes Simplex Virus 1019
Prematurity 1020
Physiologic Alterations in Pregnancy 1020
Physiologic Changes during Labor and Delivery 1021
Cardiac Disorders in Pregnancy 1022
Congenital Cardiac Disorders 1022
Atrial Septal Defect 1022
Ventricular Septal Defect 1022
Patent Ductus Arteriosus 1022
Tetralogy of Fallot 1023
Coarctation of the Aorta 1023
Eisenmenger Syndrome 1023
Acquired Cardiac Disorders 1023
Mitral Stenosis 1023
Aortic Stenosis 1023
Marfan Syndrome 1024
Peripartum Cardiomyopathy 1024
Ischemic Cardiac Disease 1024
Acute Myocardial Infarction 1024
Prior Myocardial Infarction 1024
Cardiac Arrest in Pregnancy 1024
Basic Cardiac Life Support. 1025
Advanced Cardiac Life Support. 1025
Hypertensive Disease 1025
Classification of Hypertension 1026
Preeclampsia and Eclampsia 1026
Hemolysis, Elevated Liver Enzymes, and Low Platelet Syndrome 1027
Disseminated Intravascular Coagulation 1027
Abruptio Placentae 1028
Dead Fetus Syndrome 1028
Septic Abortion 1028
Shock 1028
Pulmonary Dysfunction 1028
Asthma 1029
Cystic Fibrosis 1030
Pneumonia 1030
Acute Respiratory Distress Syndrome 1030
Management of Respiratory Failure 1030
Pulmonary Embolism 1031
Amniotic Fluid Embolism 1032
Trauma 1033
Types of Injuries 1033
Cardiovascular Injuries 1033
Pulmonary Injuries 1033
Neurologic Injuries 1035
Abdominal and Pelvic Injuries 1036
Reproductive System Injuries 1036
Fetal Injuries 1036
Postpartum Hemorrhage 1036
Risk Factors and Causes 1036
Prevention 1037
Summary 1037
References 1038
40 The Pediatric Patient 1041
Respiratory System 1041
Anatomy and Physiology 1041
Upper Airway 1041
Lower Airway 1042
Chest Mechanics 1042
Assessment and Oxygen Devices 1042
Airway Positioning 1043
Supplemental Oxygen Devices 1044
Endotracheal Intubation 1045
Procedure 1045
Securing Endotracheal and Nasotracheal Tubes 1045
Mechanical Ventilation 1047
Extubation Complications 1047
Tracheostomies 1048
Bronchiolitis 1049
Appendix A Nursing Management Plans of Care 1119
Appendix B Physiologic Formulas for Critical Care 1163
Hemodynamic Formulas 1163
Mean (Systemic) Arterial Pressure (MAP) 1163
Systemic Vascular Resistance (SVR) 1163
Systemic Vascular Resistance Index (SVRI) 1163
Pulmonary Vascular Resistance (PVR) 1163
Pulmonary Vascular Resistance Index (PVRI) 1163
Left Cardiac Work Index (LCWI) 1163
Left Ventricular Stroke Work Index (LVSWI) 1163
Right Cardiac Work Index (RCWI) 1163
Right Ventricular Stroke Work Index (RVSWI) 1163
Corrected QT Interval (QTc) 1163
Body Surface Area (BSA) 1163
Pulmonary Formulas 1164
Shunt Equation (Qs/Qt) 1164
Pulmonary Capillary Oxygen Content (Cco2) 1164
Arterial Oxygen Content (CO2) 1164
Venous Oxygen Content (Cvo2) 1164
Alveolar Pressure of Oxygen (Pao2) 1164
Arterial/Inspired Oxygen Ratio 1165
Arterial/Alveolar Oxygen Ratio 1165
Alveolar-Arterial Gradient 1165
Dead Space Equation (Vd/Vt) 1165
Static Compliance (CST) 1165
Dynamic Compliance (CDY) 1165
Neurologic Formulas 1165
Cerebral Perfusion Pressure (CPP) 1165
Arteriojugular Oxygen Difference (Ajdo2) 1165
Endocrine Formulas 1165
Serum Osmolality 1165
Fluid Volume Deficit in Liters 1165
Kidney Formulas 1165
Anion Gap 1165
Clearance 1165
Nutritional Formulas 1166
Resting Metabolic Rate (RMR) 1166
PSU 2003b (Penn State Equation) 1166
PSU 2010 (Modified Penn State Equation) 1166
Mifflin-St. Jeor Equation 1166
Caloric and Protein Needs4 1166
Estimating Caloric Needs 1166
Estimating Protein Needs 1166
Example of a Calculation of Calorie and Protein Needs 1166
Energy Needs 1166
Protein Needs 1166
References 1166
Index 1167
A 1167
B 1171
C 1173
D 1177
E 1179
F 1181
G 1182
H 1184
I 1186
J 1188
K 1188
L 1189
M 1190
N 1192
O 1193
P 1194
Q 1199
R 1200
S 1200
T 1203
U 1205
V 1206
W 1207
X 1207
Z 1207
Inside Back Cover ibc1