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Update in Sexually Transmitted Infections, an Issue of Infectious Disease Clinics, E-Book

Update in Sexually Transmitted Infections, an Issue of Infectious Disease Clinics, E-Book

Jeanne Marrazzo

(2013)

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Book Details

Abstract

This issue of the Infectious Disease Clinics is devoted to the treatment and prevention of the most common STDs – including syphilis, gonorrhea, herpes, and HPV. The articles will discuss the current research in the field such as antimicrobial resistance in treating gonorrhea and the development/trials of a genital herpes vaccine.

Table of Contents

Section Title Page Action Price
Front Cover Cover
Update in SexuallyTransmitted Infections\r i
Copyright\r ii
Contributors iii
Contents v
Infectious Disease Clinics\rOf North America\r viii
Preface\r ix
Syphilis in the Modern Era 705
Key points 705
Etiology and pathogenesis 705
Epidemiology 706
Historical perspective 707
Clinical features 708
Early Syphilis 708
Primary syphilis 708
Secondary syphilis 708
Early latent syphilis 709
Late Syphilis 711
Tertiary syphilis 711
Late neurologic complications of syphilis 711
Cardiovascular syphilis 713
Gummatous (or late benign) syphilis 713
Congenital syphilis 713
Diagnosis 713
Primary Syphilis 714
Secondary Syphilis 714
Tertiary Syphilis 715
CSF Analysis: Indications and Interpretation 715
Congenital Syphilis 715
Treatment 716
Follow-up 716
Pregnancy and congenital syphilis 718
Public health response: management of sex partners 718
References 719
Control of Neisseria gonorrhoeae in the Era of Evolving Antimicrobial Resistance 723
Key points 723
Introduction 723
Epidemiology 724
Antimicrobial Surveillance 724
Evolution of antimicrobial resistance in Neisseria gonorrhoeae 725
Contemporary Cephalosporin Resistance 725
Cephalosporin Treatment Failures 726
Molecular Mechanisms of Resistance 728
Screening and diagnosis 728
Screening Recommendations 728
Diagnostic Technology 729
Specimen Collection 730
Treatment 730
Current Treatment Guidelines 730
Potential Future Treatment Options 731
Test-of-Cure and Rescreening 732
Partner Treatment 732
A Gonorrhea Vaccine? 732
Summary 733
References 733
Screening and Management of Genital Chlamydial Infections 739
Key points 739
Introduction 739
Clinical manifestations in women 740
Cervicitis 740
Urethritis 740
Pelvic inflammatory disease 740
Clinical manifestations in men 741
Urethritis 741
Epididymitis 741
Prostatitis 742
Proctitis/Proctocolitis 742
LGV 743
Pharyngeal Infection 743
Diagnosis 743
NAAT 743
Screening 744
Epidemiology 744
Young women 745
Race/Ethnicity 745
Sexual minority populations 745
WSW 746
MSM 747
LGV 747
Treatment 748
Follow-up 750
Summary 750
References 751
Trichomoniasis 755
Key points 755
Introduction 755
Epidemiology 755
Pathophysiology 756
Diagnosis 757
Clinical management 758
Adverse outcomes 759
Special considerations 760
HIV 760
Pregnancy and Breastfeeding 760
Children 761
Prevention 761
Controversies 761
Summary 761
References 761
HPV and HPV-Associated Diseases 765
Key points 765
Background 765
Magnitude of infection/disease burden 766
Epidemiology of HPV: transmission and natural history 766
Natural history of HPV-associated diseases 767
Clinical features 768
Screening and diagnostic approaches 768
Clinical management and treatment 770
Prevention and control 771
References 775
Mycoplasma genitalium 779
Key points 779
Introduction 779
M genitalium: the bacterium 780
M genitalium: epidemiology 780
Human immunodeficiency virus infection and M genitalium 783
Treatment 783
Future challenges 784
References 785
Pelvic Inflammatory Disease 793
Key points 793
Epidemiology 793
Etiology 794
Pathogenesis 794
Clinical evaluation and differential diagnosis 795
Sensitivity and specificity of CDC diagnostic criteria 796
Laboratory testing 797
Imaging studies 797
Inpatient versus outpatient management 798
CDC recommendations for antimicrobial therapy 798
Alternative antimicrobial regimens 799
Anaerobes: to cover or not? 800
Additional treatment considerations 801
Tubo-ovarian abscess 801
Special populations: HIV-infected women 802
Special populations: postmenopausal women 802
Special populations: intrauterine devices 802
Sequelae 802
Prevention 803
Summary 803
References 804
Sexual Transmission of Viral Hepatitis 811
Key points 811
Introduction 811
Methods 812
Hepatitis A 812
Prevention of Hepatitis A 813
Hepatitis B 815
Prevention of Hepatitis B 817
Hepatitis C 820
Sexual Transmission of HCV Among Heterosexual Partnerships 820
Sexual Transmission of HCV Among MSM 820
Prevention of Hepatitis C 824
Summary 824
References 824
Index 837