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Nelson Essentials of Pediatrics E-Book

Nelson Essentials of Pediatrics E-Book

Karen Marcdante | Robert M. Kliegman

(2014)

Additional Information

Abstract

The resource of choice for pediatric residencies, clerkships, and exams, Nelson Essentials of Pediatrics continues to provide a focused overview of the core knowledge in pediatrics. Succinct, targeted coverage of normal childhood growth and development, as well as the diagnosis, management, and prevention of common pediatric diseases and disorders, make this an ideal medical reference book for students, pediatric residents, nurse practitioners, and physician assistants.

  • Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability.
  • Get an effective overview of pediatrics with help from concise text, a full-color design, high-yield tables, and numerous images.
  • Take advantage of a wealth of images that capture the clinical manifestations and findings associated with Kawasaki disease, lupus, lymphoma, stroke, and many other disorders seen in children.
  • Efficiently review essential, concise pediatric content with this popular extension of the Nelson Textbook of Pediatrics (ISBN: 978-1-4377-0755-7).
  • Focus on the core knowledge needed for your pediatric clerkship or rotation with coverage that follows the COMSEP curriculum guidelines.
  • Easily visualize complex aspects with a full-color layout and images, as well as numerous tables throughout the text.

Table of Contents

Section Title Page Action Price
Front Cover Cover
IFC IFC
Nelson Essentials of Pediatrics v
Copyright vi
Dedication vii
Contributors ix
Preface xiii
Acknowledgments xv
Contents xvii
Section 1 - The Profession of\rPediatrics 1
Chapter 1 - POPULATION AND CULTURE: THE CARE OF CHILDREN IN SOCIETY 1
CURRENT CHALLENGES 1
LANDSCAPE OF HEALTH CARE FOR CHILDREN IN THE UNITED STATES 1
OTHER HEALTH ISSUES THAT AFFECT CHILDREN IN THE UNITED STATES 2
HEALTH DISPARITIES IN HEALTH CARE FOR CHILDREN 3
CHANGING MORBIDITY: THE SOCIAL/EMOTIONAL ASPECTS OF PEDIATRIC PRACTICE 3
CULTURE 3
Chapter 2 - PROFESSIONALISM 4
CONCEPT OF PROFESSIONALISM 4
PROFESSIONALISM FOR PEDIATRICIANS 4
Chapter 3 - ETHICS AND LEGAL ISSUES 5
ETHICS IN HEALTH CARE 5
ETHICAL PRINCIPLES RELATED TO INFANTS, CHILDREN, AND ADOLESCENTS 5
LEGAL ISSUES 5
ETHICAL ISSUES IN PRACTICE 6
Chapter 4 - PALLIATIVE CARE AND END-OF-LIFE ISSUES 7
PALLIATIVE AND END-OF-LIFE CARE 7
BEREAVEMENT 8
COGNITIVE ISSUES IN CHILDREN AND ADOLESCENTS: UNDERSTANDING DEATH AND DYING 8
CULTURAL, RELIGIOUS, AND SPIRITUAL CONCERNS ABOUT PALLIATIVE CARE AND END-OF-LIFE DECISIONS 9
ETHICAL ISSUES IN END-OF-LIFE DECISION MAKING 9
Suggested Reading 9
Section 2 - Growth and Development 10
THE HEALTH MAINTENANCE VISIT 10
Chapter 5 - NORMAL GROWTH 10
Chapter 6 - DISORDERS OF GROWTH 12
Chapter 7 - NORMAL DEVELOPMENT 13
PHYSICAL DEVELOPMENT 13
NEWBORN PERIOD 13
LATER INFANCY 13
SCHOOL AGE/PREADOLESCENT 13
ADOLESCENCE 13
DEVELOPMENTAL MILESTONES 13
PSYCHOSOCIAL ASSESSMENT 14
MODIFYING PSYCHOSOCIAL BEHAVIORS 15
TEMPERAMENT 15
Chapter 8 - DISORDERS OF DEVELOPMENT 15
DEVELOPMENTAL SURVEILLANCE AND SCREENING 15
OTHER ISSUES IN ASSESSING DEVELOPMENT AND BEHAVIOR 19
Chapter 9 - EVALUATION OF THE WELL CHILD 20
EVALUATING DEVELOPMENTAL AND BEHAVIORAL ISSUES 20
SCREENING TESTS 21
IMMUNIZATIONS 22
DENTAL CARE 23
NUTRITIONAL ASSESSMENT 23
ANTICIPATORY GUIDANCE 23
Chapter 10 - EVALUATION OF THE CHILD WITH SPECIAL NEEDS 26
MULTIFACETED TEAM ASSESSMENT OF COMPLEX PROBLEMS 26
MANAGEMENT OF DEVELOPMENTAL PROBLEMS 29
SELECTED CLINICAL PROBLEMS: THE SPECIAL NEEDS CHILD 31
Suggested Reading 36
Section 3 - Behavioral Disorders 37
Chapter 11 - CRYING AND COLIC 37
NORMAL DEVELOPMENT 37
COLIC 37
Chapter 12 - TEMPER TANTRUMS 39
ETIOLOGY 39
EPIDEMIOLOGY 39
CLINICAL MANIFESTATIONS 39
DIFFERENTIAL DIAGNOSIS 40
TREATMENT 40
PREVENTION 40
Chapter 13 - ATTENTION-DEFICIT/HYPERACTIVITY DISORDER 41
ETIOLOGY 41
EPIDEMIOLOGY 41
CLINICAL MANIFESTATIONS 41
DIFFERENTIAL DIAGNOSIS 41
TREATMENT 41
COMPLICATIONS 42
PREVENTION 42
Chapter 14 - CONTROL OF ELIMINATION 43
NORMAL DEVELOPMENT OF ELIMINATION 43
ENURESIS 43
FUNCTIONAL CONSTIPATION AND SOILING 44
Chapter 15 - NORMAL SLEEP AND PEDIATRIC SLEEP DISORDERS 47
SLEEP DISORDERS 48
Suggested Reading 50
Section 4 - Psychiatric Disorders 51
Chapter 16 - SOMATOFORM DISORDERS, FACTITIOUS DISORDERS, AND MALINGERING 51
FACTITIOUS DISORDERS AND MALINGERING 54
Chapter 17 - ANXIETY AND PHOBIAS 55
ANXIETY DISORDERS 55
Chapter 18 - DEPRESSION AND BIPOLAR DISORDERS 59
DEPRESSION 59
BIPOLAR DISORDERS 60
Chapter 19 - OBSESSIVE-COMPULSIVE DISORDER 62
Chapter 20 - PERVASIVE DEVELOPMENTAL DISORDERS AND PSYCHOSES 63
AUTISM 63
SCHIZOPHRENIA 64
Suggested Reading 66
Section 5 - Psychosocial Issues 67
Chapter 21 - FAILURE TO THRIVE 67
ETIOLOGY 67
DIAGNOSIS AND CLINICAL MANIFESTATIONS 67
TREATMENT 69
COMPLICATIONS 69
Chapter 22 - CHILD ABUSE AND NEGLECT 70
PHYSICAL ABUSE 70
SEXUAL ABUSE 73
MANAGEMENT 73
Chapter 23 - HOMOSEXUALITY AND GENDER IDENTITY 75
DEVELOPMENT OF SEXUAL IDENTITY 75
GENDER IDENTITY DISORDER 75
Chapter 24 - FAMILY STRUCTURE AND FUNCTION 76
FAMILY FUNCTIONS 76
HOMOSEXUALITY 76
FAMILY STRUCTURE 77
FAMILY DYSFUNCTION 79
Chapter 25 - VIOLENCE 79
INTIMATE PARTNER VIOLENCE AND CHILDREN 79
YOUTH VIOLENCE 80
Chapter 26 - DIVORCE, SEPARATION, AND BEREAVEMENT 82
DIVORCE 82
DATING VIOLENCE AND DATE RAPE 82
SEPARATIONS FROM PARENTS 84
DEATH OF A PARENT OR FAMILY MEMBER AND BEREAVEMENT 84
Suggested Readings 85
Section 6 - Pediatric Nutrition and\rNutritional Disorders 86
Chapter 27 - DIET OF THE NORMAL INFANT 86
BREASTFEEDING 86
FORMULA FEEDING 88
COMPLEMENTARY FOODS 89
Chapter 28 - DIET OF THE NORMAL CHILD AND ADOLESCENT 89
NUTRITION ISSUES FOR TODDLERS AND OLDER CHILDREN 89
MILK 89
JUICES 89
GENERAL RECOMMENDATIONS 89
Chapter 29 - OBESITY 90
EPIDEMIOLOGY 90
IRON INTAKE 90
NUTRITION ISSUES FOR ADOLESCENTS 90
CLINICAL MANIFESTATIONS 91
ASSESSMENT 91
PREVENTION 92
TREATMENT 92
Chapter 30 - PEDIATRIC UNDERNUTRITION 93
FAILURE TO THRIVE 94
MARASMUS 94
KWASHIORKOR 94
MIXED MARASMUS-KWASHIORKOR 95
TREATMENT OF MALNUTRITION 95
Chapter 31 - VITAMIN AND MINERAL DEFICIENCIES 96
WATER-SOLUBLE VITAMINS 96
COMPLICATIONS OF MALNUTRITION 96
FAT-SOLUBLE VITAMINS 101
MINERALS 103
Suggested Readings 105
Section 7 -Fluids and Electrolytes 106
Chapter 32 - MAINTENANCE FLUID THERAPY 106
BODY COMPOSITION 106
REGULATION OF INTRAVASCULAR VOLUME AND OSMOLALITY 106
MAINTENANCE FLUIDS 107
Chapter 33 - DEHYDRATION AND REPLACEMENT THERAPY 107
REPLACEMENT THERAPY 107
DEHYDRATION 108
Chapter 34 - PARENTERAL NUTRITION 111
INDICATIONS 111
Chapter 35 - SODIUM DISORDERS 112
ACCESS FOR PARENTERAL NUTRITION 112
COMPOSITION OF PARENTERAL NUTRITION 112
COMPLICATIONS 112
HYPONATREMIA 113
HYPERNATREMIA 114
Chapter 36 - POTASSIUM DISORDERS 116
HYPOKALEMIA 116
HYPERKALEMIA 117
Chapter 37 - ACID-BASE DISORDERS 119
CLINICAL ASSESSMENT OF ACID-BASE DISORDERS 119
METABOLIC ACIDOSIS 120
METABOLIC ALKALOSIS 121
RESPIRATORY ACID-BASE DISTURBANCES 122
Suggested Reading 123
Section 8 - The Acutely Ill or\rInjured Child 124
Chapter 38 - ASSESSMENT AND RESUSCITATION 124
INITIAL ASSESSMENT 124
HISTORY 124
PHYSICAL EXAMINATION 124
COMMON MANIFESTATIONS 124
INITIAL DIAGNOSTIC EVALUATION 124
RESUSCITATION 125
CARDIOPULMONARY ARREST 126
Chapter 39 - RESPIRATORY FAILURE 128
ETIOLOGY 128
EPIDEMIOLOGY 128
CLINICAL MANIFESTATIONS 128
LABORATORY AND IMAGING STUDIES 128
DIFFERENTIAL DIAGNOSIS 128
TREATMENT 129
COMPLICATIONS 129
PROGNOSIS 129
PREVENTION 129
Chapter 40 - SHOCK 129
ETIOLOGY AND EPIDEMIOLOGY 129
HYPOVOLEMIC SHOCK 129
DISTRIBUTIVE SHOCK 130
CARDIOGENIC SHOCK 130
OBSTRUCTIVE SHOCK 130
DISSOCIATIVE SHOCK 130
CLINICAL MANIFESTATIONS 130
LABORATORY AND IMAGING STUDIES 131
DIFFERENTIAL DIAGNOSIS 131
TREATMENT 131
COMPLICATIONS 132
PROGNOSIS 132
Chapter 41 - INJURY PREVENTION 133
EPIDEMIOLOGY AND ETIOLOGY 133
EDUCATION FOR PREVENTING INJURIES 133
PREVENTION 133
Chapter 42 - MAJOR TRAUMA 133
ASSESSMENT AND RESUSCITATION 133
ETIOLOGY AND EPIDEMIOLOGY 134
LABORATORY AND IMAGING STUDIES 134
CLINICAL MANIFESTATIONS AND TREATMENT 134
COMPLICATIONS 135
Chapter 43 - DROWNING 136
ETIOLOGY 136
EPIDEMIOLOGY 136
CLINICAL MANIFESTATIONS 136
LABORATORY AND IMAGING STUDIES 136
TREATMENT 136
Section 9 - Human Genetics\rand Dysmorphology 146
Chapter 47 - PATTERNS OF INHERITANCE 146
TYPES OF GENETIC DISORDERS 146
INTRODUCTION TO GENETICS AND GENOMICS 146
OTHER TYPES OF GENETIC DISORDERS 151
TERATOGENIC AGENTS 153
Chapter 48 - GENETIC ASSESSMENT 154
PRECONCEPTION AND PRENATAL COUNSELING 154
GENERAL APPROACH TO PATIENTS 155
Chapter 49 - CHROMOSOMAL DISORDERS 156
ABNORMALITIES IN NUMBER (ANEUPLOIDY) 157
SYNDROMES INVOLVING CHROMOSOMAL DELETIONS 159
SYNDROMES INVOLVING CHROMOSOME DUPLICATION 160
Chapter 50 - THE APPROACH TO THE DYSMORPHIC CHILD 160
DEFINITIONS 160
HISTORY AND PHYSICAL EXAMINATION 161
LABORATORY EVALUATION 163
DIAGNOSIS 163
Suggested Reading 163
Section 10 - Metabolic Disorders 164
Chapter 51 - METABOLIC ASSESSMENT 164
SIGNS AND SYMPTOMS 164
TYPES OF CLINICAL PRESENTATION OF INBORN ERRORS 165
CLINICAL ASSESSMENT AND LABORATORY TESTING 169
GENETIC ASPECTS OF INBORN ERRORS 169
IDENTIFICATION OF INBORN ERRORS BY NEONATAL SCREENING 170
OVERVIEW OF TREATMENT 171
Chapter 52 - CARBOHYDRATE DISORDERS 172
GLYCOGEN STORAGE DISEASES 172
GALACTOSEMIA 173
Chapter 53 - AMINO ACID DISORDERS 174
DISORDERS OF AMINO ACID METABOLISM 174
PHENYLKETONURIA 174
TYROSINEMIAS 175
HOMOCYSTINURIA 175
MAPLE SYRUP URINE DISEASE 176
DISORDERS OF AMMONIA DISPOSAL 176
DISORDERS OF AMINO ACID TRANSPORT THAT AFFECT SPECIFIC TRANSPORT MECHANISMS IN THE KIDNEY AND INTESTINE 177
Chapter 54 - ORGANIC ACID DISORDERS 177
DISORDERS OF ORGANIC ACID METABOLISM 177
PROPIONIC ACIDEMIA AND METHYLMALONIC ACIDEMIA 177
ISOVALERIC ACIDEMIA 178
GLUTARIC ACIDEMIA I 178
BIOTINIDASE DEFICIENCY AND HOLOCARBOXYLASE DEFICIENCY 178
Chapter 55 - FAT METABOLIC DISORDERS 179
DISORDERS OF FATTY ACID OXIDATION 179
GLUTARIC ACIDURIA TYPE II 179
Chapter 56 - LYSOSOMAL AND PEROXISOMAL DISORDERS 180
PEROXISOMAL DISORDERS 180
CARNITINE DEFICIENCY 180
LYSOSOMAL STORAGE DISORDERS 183
DIAGNOSTIC TESTING 183
TREATMENT STRATEGIES 183
Chapter 57 - MITOCHONDRIAL DISORDERS 183
MITOCHONDRIAL FUNCTION 183
SIGNS AND SYMPTOMS OF GENETIC DISORDERS OF MITOCHONDRIAL FUNCTION 184
BIOCHEMICAL ABNORMALITIES IN MITOCHONDRIAL FUNCTION 184
GENETICS OF MITOCHONDRIAL DISORDERS 185
TREATMENT OF MITOCHONDRIAL DISORDERS 185
Suggested Reading 185
Section 11 - Fetal and Neonatal\rMedicine 186
Chapter 58 - ASSESSMENT OF THE MOTHER, FETUS, AND NEWBORN 186
ASSESSMENT OF THE MOTHER 186
FETUS AND NEWBORN 187
ASSESSMENT OF THE FETUS 188
ASSESSMENT OF THE NEWBORN 189
NEUROLOGIC ASSESSMENT 200
MISCELLANEOUS DISORDERS 204
Chapter 59 - MATERNAL DISEASES AFFECTING THE NEWBORN 204
ANTIPHOSPHOLIPID SYNDROME 205
IDIOPATHIC THROMBOCYTOPENIA 205
SYSTEMIC LUPUS ERYTHEMATOSUS 205
NEONATAL HYPERTHYROIDISM 206
DIABETES MELLITUS 206
OTHER CONDITIONS 206
Chapter 60 - DISEASES OF THE FETUS 208
INTRAUTERINE GROWTH RESTRICTION AND SMALL FOR GESTATIONAL AGE 208
HYDROPS FETALIS 209
Chapter 61 - RESPIRATORY DISEASES OF THE NEWBORN 209
RESPIRATORY DISTRESS SYNDROME (HYALINE MEMBRANE DISEASE) 210
COMPLICATIONS OF RESPIRATORY DISTRESS SYNDROME 212
TRANSIENT TACHYPNEA OF THE NEWBORN 214
MECONIUM ASPIRATION SYNDROME 214
PRIMARY PULMONARY HYPERTENSION OF THE NEWBORN 215
APNEA OF PREMATURITY 215
Chapter 62 - ANEMIA AND HYPERBILIRUBINEMIA 216
ANEMIA 216
HYPERBILIRUBINEMIA 219
COAGULATION DISORDERS 222
Chapter 63 - NECROTIZING ENTEROCOLITIS 223
Chapter 64 - HYPOXIC-ISCHEMIC ENCEPHALOPATHY, INTRACRANIAL HEMORRHAGE, AND SEIZURES 224
NEONATAL SEIZURES 224
INTRACRANIAL HEMORRHAGE 226
HYPOXIC-ISCHEMIC ENCEPHALOPATHY 226
Chapter 65 - SEPSIS AND MENINGITIS 227
Chapter 66 - CONGENITAL INFECTIONS 229
TOXOPLASMOSIS 229
RUBELLA 229
CYTOMEGALOVIRUS 231
HERPES SIMPLEX VIRUS 231
CONGENITAL SYPHILIS 232
HUMAN IMMUNODEFICIENCY VIRUS 232
HEPATITIS B 232
NEISSERIA GONORRHOEAE 232
CHLAMYDIA 233
MYCOBACTERIUM TUBERCULOSIS 233
Suggested Reading 233
Section 12 - Adolescent Medicine 234
Chapter 67 - OVERVIEW AND ASSESSMENT OF ADOLESCENTS 234
INTERVIEWING ADOLESCENTS 234
PHYSICAL GROWTH AND DEVELOPMENT OF ADOLESCENTS 237
PSYCHOLOGICAL GROWTH AND DEVELOPMENT OF ADOLESCENTS 240
Chapter 68 - WELL-ADOLESCENT CARE 240
EARLY ADOLESCENCE (AGES 10 TO 14 YEARS) 240
MIDDLE ADOLESCENCE (AGES 15 TO 17 YEARS) 240
LATE ADOLESCENCE (AGES 18 TO 21 YEARS) 240
PELVIC EXAMINATION 240
NORMAL VARIANTS OF PUBERTY 241
Chapter 69 - ADOLESCENT GYNECOLOGY 242
MENSTRUAL DISORDERS 242
PREGNANCY 244
CONTRACEPTION 245
RAPE 247
Chapter 70 - EATING DISORDERS 248
ANOREXIA NERVOSA 248
BULIMIA NERVOSA 248
Chapter 71 - SUBSTANCE ABUSE 250
ACUTE OVERDOSE 250
ACUTE AND CHRONIC EFFECTS 251
TREATMENT 251
Suggested Reading 251
Section 13 - Immunology 252
Chapter 72 - ASSESSMENT 252
HISTORY 253
PHYSICAL EXAMINATION 254
DIFFERENTIAL DIAGNOSIS 254
DIAGNOSTIC EVALUATION 255
Chapter 73 - LYMPHOCYTE DISORDERS 256
ETIOLOGY AND CLINICAL MANIFESTATIONS 256
TREATMENT 262
PREVENTION AND NEWBORN SCREENING 263
Chapter 74 - NEUTROPHIL DISORDERS 263
ETIOLOGY AND CLINICAL MANIFESTATIONS 263
Chapter 75 - COMPLEMENT SYSTEM 266
LABORATORY DIAGNOSIS 266
TREATMENT 266
PROGNOSIS AND PREVENTION 266
ETIOLOGY 267
LABORATORY STUDIES 268
TREATMENT 269
Chapter 76 - HEMATOPOIETIC STEM CELL TRANSPLANTATION 269
COMPLICATIONS 270
Suggested Reading 270
Section 14 - Allergy 271
Chapter 77 - ASSESSMENT 271
HISTORY 272
PHYSICAL EXAMINATION 272
COMMON MANIFESTATIONS 272
INITIAL DIAGNOSTIC EVALUATION 272
DIAGNOSTIC IMAGING 273
Chapter 78 - ASTHMA 273
ETIOLOGY 273
EPIDEMIOLOGY 273
CLINICAL MANIFESTATIONS 273
LABORATORY AND IMAGING STUDIES 274
DIFFERENTIAL DIAGNOSIS 274
TREATMENT 274
COMPLICATIONS 278
PROGNOSIS 278
PREVENTION 279
Chapter 79 - ALLERGIC RHINITIS 282
ETIOLOGY 282
EPIDEMIOLOGY 282
CLINICAL MANIFESTATIONS 282
LABORATORY AND IMAGING STUDIES 283
DIFFERENTIAL DIAGNOSIS 283
TREATMENT 284
COMPLICATIONS 285
PROGNOSIS AND PREVENTION 285
Chapter 80 - ATOPIC DERMATITIS 285
ETIOLOGY 285
EPIDEMIOLOGY 285
CLINICAL MANIFESTATIONS 285
LABORATORY AND IMAGING STUDIES 286
DIFFERENTIAL DIAGNOSIS 286
TREATMENT 287
COMPLICATIONS 287
PROGNOSIS 287
PREVENTION 287
Chapter 81 - URTICARIA, ANGIOEDEMA, AND ANAPHYLAXIS 288
ETIOLOGY 288
EPIDEMIOLOGY 289
CLINICAL MANIFESTATIONS 289
LABORATORY AND IMAGING STUDIES 290
DIFFERENTIAL DIAGNOSIS 290
TREATMENT 291
PREVENTION 291
Chapter 82 - SERUM SICKNESS 292
ETIOLOGY 292
EPIDEMIOLOGY 292
CLINICAL MANIFESTATIONS 292
LABORATORY AND IMAGING STUDIES 292
TREATMENT AND PREVENTION 293
Chapter 83 - INSECT ALLERGIES 293
ETIOLOGY 293
EPIDEMIOLOGY 293
CLINICAL MANIFESTATIONS 293
LABORATORY AND IMAGING STUDIES 293
DIFFERENTIAL DIAGNOSIS 293
Chapter 84 - ADVERSE REACTIONS TO FOODS 294
ETIOLOGY AND EPIDEMIOLOGY 294
CLINICAL MANIFESTATIONS 294
LABORATORY AND IMAGING STUDIES 294
DIAGNOSIS 294
TREATMENT 294
COMPLICATIONS 294
PROGNOSIS 294
PREVENTION 294
TREATMENT 296
COMPLICATIONS 296
PROGNOSIS AND PREVENTION 296
Chapter 85 - ADVERSE REACTIONS TO DRUGS 296
ETIOLOGY 296
EPIDEMIOLOGY 296
CLINICAL MANIFESTATIONS 297
LABORATORY AND IMAGING STUDIES 297
DIFFERENTIAL DIAGNOSIS 297
TREATMENT 297
COMPLICATIONS 298
PROGNOSIS 298
PREVENTION 298
Suggested Reading 298
Section 15 - Rheumatic Diseases\rof Childhood 299
Chapter 86 - ASSESSMENT 299
HISTORY 299
PHYSICAL EXAMINATION 299
COMMON MANIFESTATIONS 299
INITIAL DIAGNOSTIC EVALUATION 301
LABORATORY TESTING 301
DIAGNOSTIC IMAGING 301
Chapter 87 - HENOCH-SCHÖNLEIN PURPURA 301
ETIOLOGY 301
EPIDEMIOLOGY 301
CLINICAL MANIFESTATIONS 302
LABORATORY AND IMAGING STUDIES 302
DIFFERENTIAL DIAGNOSIS 302
TREATMENT 302
COMPLICATIONS 302
Chapter 88 - KAWASAKI DISEASE 303
ETIOLOGY 303
EPIDEMIOLOGY 303
CLINICAL MANIFESTATIONS 303
PROGNOSIS 303
LABORATORY AND IMAGING STUDIES 304
DIFFERENTIAL DIAGNOSIS 304
TREATMENT 304
COMPLICATIONS 305
PROGNOSIS 305
Chapter 89 - JUVENILE IDIOPATHIC ARTHRITIS 305
ETIOLOGY 305
EPIDEMIOLOGY 305
CLINICAL PRESENTATION 305
LABORATORY AND IMAGING STUDIES 307
DIFFERENTIAL DIAGNOSIS 307
TREATMENT 308
COMPLICATIONS 308
PROGNOSIS 308
Chapter 90 - SYSTEMIC LUPUS ERYTHEMATOSUS 309
ETIOLOGY 309
EPIDEMIOLOGY 309
CLINICAL MANIFESTATIONS 309
LABORATORY AND IMAGING STUDIES 309
DIFFERENTIAL DIAGNOSIS 311
TREATMENT 311
COMPLICATIONS 311
PROGNOSIS 311
Chapter 91 - JUVENILE DERMATOMYOSITIS 311
ETIOLOGY 311
EPIDEMIOLOGY 311
CLINICAL MANIFESTATIONS 311
Chapter 92 - MUSCULOSKELETAL PAIN SYNDROMES 312
GROWING PAINS 312
LABORATORY AND IMAGING STUDIES 312
DIFFERENTIAL DIAGNOSIS 312
TREATMENT 312
COMPLICATIONS 312
PROGNOSIS 312
BENIGN HYPERMOBILITY 313
MYOFASCIAL PAIN SYNDROMES AND FIBROMYALGIA 313
Suggested Reading 314
Section 16 - Infectious Diseases 315
Chapter 93 - ASSESSMENT 315
INITIAL DIAGNOSTIC EVALUATION 315
DIFFERENTIAL DIAGNOSIS 315
SCREENING TESTS 315
DIAGNOSTIC IMAGING 317
Chapter 94 - IMMUNIZATION AND PROPHYLAXIS 317
IMMUNIZATION 317
PROPHYLAXIS 318
Chapter 95 - ANTI-INFECTIVE THERAPY 323
Chapter 96 - FEVER WITHOUT A FOCUS 324
FEVER IN INFANTS YOUNGER THAN 3 MONTHS OF AGE 325
FEVER IN CHILDREN 3 MONTHS TO 3 YEARS OF AGE 325
FEVER OF UNKNOWN ORIGIN 326
Chapter 97 - INFECTIONS CHARACTERIZED BY FEVER AND RASH 329
MEASLES (RUBEOLA) 329
RUBELLA (GERMAN OR 3-DAY MEASLES) 331
ROSEOLA INFANTUM (EXANTHEM SUBITUM) 332
ERYTHEMA INFECTIOSUM (FIFTH DISEASE) 333
VARICELLA-ZOSTER VIRUS INFECTION (CHICKENPOX AND ZOSTER) 333
Chapter 98 - CUTANEOUS INFECTIONS 335
SUPERFICIAL BACTERIAL INFECTIONS 335
SUPERFICIAL FUNGAL INFECTIONS 336
SUPERFICIAL VIRAL INFECTIONS 336
Chapter 99 - LYMPHADENOPATHY 338
ETIOLOGY 338
EPIDEMIOLOGY 340
CLINICAL MANIFESTATIONS 340
LABORATORY AND IMAGING STUDIES 340
DIFFERENTIAL DIAGNOSIS 341
TREATMENT 341
COMPLICATIONS AND PROGNOSIS 341
Chapter 100 - MENINGITIS 342
ETIOLOGY 342
EPIDEMIOLOGY 342
CLINICAL MANIFESTATIONS 342
PREVENTION 342
LABORATORY AND IMAGING STUDIES 343
DIFFERENTIAL DIAGNOSIS 343
TREATMENT 343
COMPLICATIONS AND PROGNOSIS 344
PREVENTION 344
Chapter 101 - ENCEPHALITIS 344
ETIOLOGY 344
EPIDEMIOLOGY 345
CLINICAL MANIFESTATIONS 345
DIFFERENTIAL DIAGNOSIS 345
LABORATORY AND IMAGING STUDIES 345
TREATMENT 346
COMPLICATIONS AND PROGNOSIS 346
PREVENTION 346
Chapter 102 - THE COMMON COLD 346
ETIOLOGY 346
EPIDEMIOLOGY 346
CLINICAL MANIFESTATIONS 346
LABORATORY AND IMAGING STUDIES 347
DIFFERENTIAL DIAGNOSIS 347
TREATMENT 347
COMPLICATIONS AND PROGNOSIS 347
PREVENTION 347
Chapter 103 - PHARYNGITIS 347
ETIOLOGY 347
EPIDEMIOLOGY 347
CLINICAL MANIFESTATIONS 347
LABORATORY EVALUATION 348
DIFFERENTIAL DIAGNOSIS 348
TREATMENT 349
COMPLICATIONS AND PROGNOSIS 349
PREVENTION 349
Chapter 104 - SINUSITIS 350
ETIOLOGY 350
EPIDEMIOLOGY 350
CLINICAL MANIFESTATIONS 350
LABORATORY AND IMAGING STUDIES 350
DIFFERENTIAL DIAGNOSIS 350
TREATMENT 350
COMPLICATIONS AND PROGNOSIS 350
PREVENTION 351
Chapter 105 - OTITIS MEDIA 351
ETIOLOGY 351
EPIDEMIOLOGY 351
CLINICAL MANIFESTATIONS 351
LABORATORY AND IMAGING STUDIES 351
DIFFERENTIAL DIAGNOSIS 352
TREATMENT 352
COMPLICATIONS AND PROGNOSIS 352
PREVENTION 352
Chapter 106 - OTITIS EXTERNA 353
ETIOLOGY 353
EPIDEMIOLOGY 353
CLINICAL MANIFESTATIONS 353
LABORATORY AND IMAGING STUDIES 353
DIFFERENTIAL DIAGNOSIS 353
TREATMENT 353
COMPLICATIONS AND PROGNOSIS 353
Chapter 107 - CROUP (LARYNGOTRACHEOBRONCHITIS) 354
ETIOLOGY AND EPIDEMIOLOGY 354
CLINICAL MANIFESTATIONS 354
LABORATORY AND IMAGING STUDIES 354
DIFFERENTIAL DIAGNOSIS 354
TREATMENT 354
PREVENTION 354
COMPLICATIONS AND PROGNOSIS 356
PREVENTION 356
Chapter 108 - PERTUSSIS 356
ETIOLOGY 356
EPIDEMIOLOGY 356
CLINICAL MANIFESTATIONS 356
LABORATORY AND IMAGING STUDIES 356
DIFFERENTIAL DIAGNOSIS 357
TREATMENT 357
COMPLICATIONS AND PROGNOSIS 357
PREVENTION 357
Chapter 109 - BRONCHIOLITIS 357
ETIOLOGY 357
EPIDEMIOLOGY 357
CLINICAL MANIFESTATIONS 357
Chapter 110 - PNEUMONIA 358
ETIOLOGY 358
LABORATORY AND IMAGING STUDIES 358
DIFFERENTIAL DIAGNOSIS 358
TREATMENT 358
COMPLICATIONS AND PROGNOSIS 358
PREVENTION 358
EPIDEMIOLOGY 359
CLINICAL MANIFESTATIONS 359
LABORATORY AND IMAGING STUDIES 361
DIFFERENTIAL DIAGNOSIS 362
TREATMENT 362
COMPLICATIONS AND PROGNOSIS 363
PREVENTION 363
Chapter 111 - INFECTIVE ENDOCARDITIS 364
ETIOLOGY 364
EPIDEMIOLOGY 364
CLINICAL MANIFESTATIONS 364
LABORATORY STUDIES AND IMAGING 364
DIFFERENTIAL DIAGNOSIS 365
TREATMENT 365
COMPLICATIONS AND PROGNOSIS 365
PREVENTION 366
Chapter 112 - ACUTE GASTROENTERITIS 366
ETIOLOGY AND EPIDEMIOLOGY 366
CLINICAL MANIFESTATIONS 367
LABORATORY AND IMAGING STUDIES 368
DIFFERENTIAL DIAGNOSIS 368
TREATMENT 368
COMPLICATIONS AND PROGNOSIS 369
PREVENTION 369
Chapter 113 - VIRAL HEPATITIS 369
ETIOLOGY 369
EPIDEMIOLOGY 369
CLINICAL MANIFESTATIONS 370
LABORATORY AND IMAGING STUDIES 370
DIFFERENTIAL DIAGNOSIS 371
TREATMENT 371
Chapter 114 - URINARY TRACT INFECTION 372
ETIOLOGY 372
COMPLICATIONS AND PROGNOSIS 372
PREVENTION 372
EPIDEMIOLOGY 373
CLINICAL MANIFESTATIONS 373
LABORATORY AND IMAGING STUDIES 373
DIFFERENTIAL DIAGNOSIS 373
TREATMENT 373
Chapter 115 - VULVOVAGINITIS 374
ETIOLOGY 374
EPIDEMIOLOGY 374
CLINICAL MANIFESTATIONS 374
LABORATORY AND IMAGING STUDIES 374
DIFFERENTIAL DIAGNOSIS 374
TREATMENT 374
COMPLICATIONS AND PROGNOSIS 374
PREVENTION 374
COMPLICATIONS AND PROGNOSIS 375
PREVENTION 375
Chapter 116 - SEXUALLY TRANSMITTED INFECTIONS 376
PELVIC INFLAMMATORY DISEASE 379
GONORRHEA (NEISSERIA GONORRHOEAE) 379
CHLAMYDIA (CHLAMYDIA TRACHOMATIS) 379
SYPHILIS (TREPONEMA PALLIDUM) 380
HERPES SIMPLEX VIRUS (HSV) INFECTION 380
TRICHOMONIASIS (TRICHOMONAS VAGINALIS) 381
GENITAL WARTS (HUMAN PAPILLOMAVIRUSES) 381
PUBIC LICE (PHTHIRUS PUBIS) 381
Chapter 117 - OSTEOMYELITIS 381
ETIOLOGY 381
EPIDEMIOLOGY 382
CLINICAL MANIFESTATIONS 382
LABORATORY AND IMAGING STUDIES 382
DIFFERENTIAL DIAGNOSIS 383
TREATMENT 383
Chapter 118 - INFECTIOUS ARTHRITIS 384
ETIOLOGY 384
EPIDEMIOLOGY 384
CLINICAL MANIFESTATIONS 384
COMPLICATIONS AND PROGNOSIS 384
PREVENTION 384
LABORATORY AND IMAGING STUDIES 385
DIFFERENTIAL DIAGNOSIS 385
TREATMENT 386
COMPLICATIONS AND PROGNOSIS 386
PREVENTION 386
Chapter 119 - OCULAR INFECTIONS 386
ETIOLOGY 386
EPIDEMIOLOGY 387
CLINICAL MANIFESTATIONS 387
LABORATORY AND IMAGING STUDIES 387
DIFFERENTIAL DIAGNOSIS 387
TREATMENT 389
COMPLICATIONS AND PROGNOSIS 389
PREVENTION 389
Chapter 120 - INFECTION IN THE IMMUNOCOMPROMISED PERSON 390
ETIOLOGY 390
EPIDEMIOLOGY 391
CLINICAL MANIFESTATIONS 391
LABORATORY TESTS AND IMAGING 391
DIFFERENTIAL DIAGNOSIS 391
TREATMENT 391
PREVENTION 394
Chapter 121 - INFECTIONS ASSOCIATED WITH MEDICAL DEVICES 394
VASCULAR DEVICE INFECTIONS 394
VENTILATOR-ASSOCIATED PNEUMONIA 395
URINARY CATHETERS 395
PERITONEAL DIALYSIS–ASSOCIATED INFECTIONS 396
CENTRAL NERVOUS SYSTEM SHUNTS 396
Chapter 122 - ZOONOSES 396
LYME DISEASE (BORRELIA BURGDORFERI) 396
ROCKY MOUNTAIN SPOTTED FEVER (RICKETTSIA RICKETTSII) 401
EHRLICHIOSIS (EHRLICHIA CHAFFEENSIS) AND ANAPLASMOSIS (ANAPLASMA PHAGOCYTOPHILUM) 401
Chapter 123 - PARASITIC DISEASES 402
PROTOZOAL DISEASES 402
HELMINTHIASES 404
Chapter 124 - TUBERCULOSIS 407
ETIOLOGY 407
EPIDEMIOLOGY 408
CLINICAL MANIFESTATIONS 408
LABORATORY AND IMAGING STUDIES 409
DIFFERENTIAL DIAGNOSIS 410
TREATMENT 410
COMPLICATIONS AND PROGNOSIS 411
PREVENTION 411
Chapter 125 - HIV AND AIDS 412
ETIOLOGY 412
EPIDEMIOLOGY 412
CLINICAL MANIFESTATIONS 412
LABORATORY AND IMAGING STUDIES 413
DIFFERENTIAL DIAGNOSIS 413
TREATMENT 413
COMPLICATIONS 415
PROGNOSIS 415
PREVENTION 416
Suggested Reading 416
Section 17 - The Digestive System 417
Chapter 126 - ASSESSMENT 417
HISTORY 417
PHYSICAL EXAMINATION 417
SCREENING TESTS 417
DIAGNOSTIC IMAGING 417
COMMON MANIFESTATIONS OF GASTROINTESTINAL DISORDERS 417
Chapter 127 - ORAL CAVITY 429
EFFECTS OF SYSTEMIC DISEASE ON THE ORAL CAVITY 429
DECIDUOUS AND PRIMARY TEETH 429
DENTAL CARIES 429
Chapter 128 - ESOPHAGUS AND STOMACH 430
GASTROESOPHAGEAL REFLUX 430
CLEFT LIP AND PALATE 430
THRUSH 430
EOSINOPHILIC ESOPHAGITIS (EOE) 431
ESOPHAGEAL ATRESIA AND TRACHEOESOPHAGEAL FISTULA 433
ESOPHAGEAL FOREIGN BODIES 434
CAUSTIC INJURIES AND PILL ULCERS 434
PYLORIC STENOSIS 435
PEPTIC DISEASE 436
CYCLIC VOMITING SYNDROME 437
Chapter 129 - INTESTINAL TRACT 437
MIDGUT MALROTATION 437
INTESTINAL ATRESIA 438
OTHER CONGENITAL DISORDERS 439
INFLAMMATORY BOWEL DISEASE (IBD) 440
CELIAC DISEASE 442
MILK AND SOY PROTEIN INTOLERANCE (ALLERGIC COLITIS) 442
INTUSSUSCEPTION 442
APPENDICITIS 443
Chapter 130 - LIVER DISEASE 444
CHOLESTASIS 444
VIRAL HEPATITIS 447
FULMINANT LIVER FAILURE 447
CHRONIC LIVER DISEASE 448
SELECTED CHRONIC HEPATIC DISORDERS 449
Chapter 131 - PANCREATIC DISEASE 450
PANCREATIC INSUFFICIENCY 450
ACUTE PANCREATITIS 451
CHRONIC PANCREATITIS 452
Chapter 132 - PERITONITIS 453
Suggested Reading 454
Section 18 - The Respiratory System 455
Chapter 133 - RESPIRATORY SYSTEM ASSESSMENT 455
ANATOMY OF THE RESPIRATORY SYSTEM 455
PULMONARY PHYSIOLOGY 455
HISTORY 457
PHYSICAL EXAMINATION 457
DIAGNOSTIC MEASURES 458
THERAPEUTIC MEASURES 460
Chapter 134 - CONTROL OF BREATHING 461
CONTROL OF VENTILATION 461
DISORDERS OF CONTROL OF BREATHING 461
Chapter 135 - UPPER AIRWAY OBSTRUCTION 464
ETIOLOGY 464
CLINICAL MANIFESTATIONS 464
DIAGNOSTIC STUDIES 464
DIFFERENTIAL DIAGNOSIS 467
Chapter 136 - LOWER AIRWAY, PARENCHYMAL, AND PULMONARY VASCULAR DISEASES 469
ETIOLOGY 469
CLINICAL MANIFESTATIONS 469
DIAGNOSTIC STUDIES 469
DIFFERENTIAL DIAGNOSIS 470
Chapter 137 - CYSTIC FIBROSIS 475
ETIOLOGY AND EPIDEMIOLOGY 475
CLINICAL MANIFESTATIONS 475
DIAGNOSTIC STUDIES 476
TREATMENT 477
Chapter 138 - CHEST WALL AND PLEURA 478
SCOLIOSIS 478
PECTUS EXCAVATUM AND CARINATUM 478
PNEUMOTHORAX 478
PNEUMOMEDIASTINUM 479
PLEURAL EFFUSION 479
Suggested Reading 480
Section 19 - The Cardiovascular System 481
Chapter 139 - CARDIOVASCULAR SYSTEM ASSESSMENT 481
HISTORY 481
PHYSICAL EXAMINATION 481
LABORATORY AND IMAGING TESTS 484
Chapter 140 - SYNCOPE 486
ETIOLOGY 486
CLINICAL MANIFESTATIONS 486
DIAGNOSTIC STUDIES 487
Chapter 141 - CHEST PAIN 487
ETIOLOGY 487
Chapter 142 - DYSRHYTHMIAS 488
ETIOLOGY AND DIFFERENTIAL DIAGNOSIS 488
CLINICAL MANIFESTATIONS 488
DIAGNOSTIC STUDIES 488
TREATMENT 490
Chapter 143 - ACYANOTIC CONGENITAL HEART DISEASE 491
ETIOLOGY AND EPIDEMIOLOGY 491
VENTRICULAR SEPTAL DEFECT 491
ATRIAL SEPTAL DEFECT 492
PATENT DUCTUS ARTERIOSUS 492
ENDOCARDIAL CUSHION DEFECT 493
PULMONARY STENOSIS 493
AORTIC STENOSIS 494
COARCTATION OF THE AORTA 494
Chapter 144 - CYANOTIC CONGENITAL HEART DISEASE 495
TETRALOGY OF FALLOT 495
TRANSPOSITION OF THE GREAT ARTERIES 496
TRICUSPID ATRESIA 497
TRUNCUS ARTERIOSUS 497
TOTAL ANOMALOUS PULMONARY VENOUS RETURN 498
HYPOPLASTIC LEFT HEART SYNDROME 498
COMPLICATIONS OF CONGENITAL HEART DISEASE 499
Chapter 145 - HEART FAILURE 499
ETIOLOGY AND EPIDEMIOLOGY 499
Section 20 - Hematology 506
Chapter 149 - HEMATOLOGY ASSESSMENT: AVAILABLE @ STUDENTCONSULT.COM 506
HISTORY 506
PHYSICAL EXAMINATION AND COMMON MANIFESTATIONS 506
INITIAL DIAGNOSTIC EVALUATION 506
DEVELOPMENTAL HEMATOLOGY 506
Chapter 150 - ANEMIA 509
ETIOLOGY 509
CLINICAL MANIFESTATIONS 510
LABORATORY STUDIES 511
DIFFERENTIAL DIAGNOSIS 513
Chapter 151 - HEMOSTATIC DISORDERS 523
NORMAL HEMOSTASIS 523
DEVELOPMENTAL HEMOSTASIS 523
HEMOSTATIC DISORDERS 523
Chapter 152 - BLOOD COMPONENT THERAPY 532
Suggested Reading 533
Section 21 - Oncology 534
Chapter 153 - ONCOLOGY ASSESSMENT 534
HISTORY 534
PHYSICAL EXAMINATION 534
COMMON MANIFESTATIONS 534
DIFFERENTIAL DIAGNOSIS 535
INITIAL DIAGNOSTIC EVALUATION 535
Chapter 154 - PRINCIPLES OF ­CANCER TREATMENT 538
ONCOLOGIC EMERGENCIES 538
SURGERY 538
CHEMOTHERAPY 539
RADIATION THERAPY 541
OTHER THERAPIES 541
ADVERSE EFFECTS 541
Chapter 155 - LEUKEMIA 542
ETIOLOGY 542
EPIDEMIOLOGY 542
CLINICAL MANIFESTATIONS 542
LABORATORY AND IMAGING STUDIES 543
DIFFERENTIAL DIAGNOSIS 543
TREATMENT 543
COMPLICATIONS 544
PROGNOSIS 544
Chapter 156 - LYMPHOMA 544
ETIOLOGY 544
EPIDEMIOLOGY 545
CLINICAL MANIFESTATIONS 545
LABORATORY/IMAGING STUDIES 545
DIFFERENTIAL DIAGNOSIS 545
TREATMENT 545
COMPLICATIONS 546
PROGNOSIS 546
Chapter 157 - CENTRAL NERVOUS SYSTEM TUMORS 546
ETIOLOGY 546
EPIDEMIOLOGY 546
CLINICAL MANIFESTATIONS 546
LABORATORY/IMAGING STUDIES 547
DIFFERENTIAL DIAGNOSIS 547
TREATMENT 547
COMPLICATIONS 547
PROGNOSIS 547
Chapter 158 - NEUROBLASTOMA 548
ETIOLOGY 548
EPIDEMIOLOGY 548
CLINICAL MANIFESTATIONS 548
LABORATORY/IMAGING STUDIES 548
DIFFERENTIAL DIAGNOSIS 548
TREATMENT 549
COMPLICATIONS 549
PROGNOSIS 549
Chapter 159 - WILMS TUMOR 550
ETIOLOGY 550
EPIDEMIOLOGY 550
CLINICAL MANIFESTATIONS 550
LABORATORY/IMAGING STUDIES 550
DIFFERENTIAL DIAGNOSIS 550
TREATMENT 550
COMPLICATIONS 550
PROGNOSIS 550
Chapter 160 - SARCOMAS 551
ETIOLOGY 551
EPIDEMIOLOGY 551
CLINICAL MANIFESTATIONS 551
LABORATORY/IMAGING STUDIES 551
DIFFERENTIAL DIAGNOSIS 552
TREATMENT 552
COMPLICATIONS 552
PROGNOSIS 552
Suggested Reading 552
Section 22 - Nephrology and Urology 553
Chapter 161 - NEPHROLOGY AND UROLOGY ASSESSMENT 553
HISTORY 553
PHYSICAL EXAMINATION 553
RENAL PHYSIOLOGY 553
COMMON MANIFESTATIONS 554
DIAGNOSTIC STUDIES 555
Chapter 162 - NEPHROTIC SYNDROME AND PROTEINURIA 556
ETIOLOGY AND EPIDEMIOLOGY 556
IMAGING STUDIES 556
CLINICAL MANIFESTATIONS 557
DIAGNOSTIC STUDIES 557
DIFFERENTIAL DIAGNOSIS 557
TREATMENT 557
COMPLICATIONS 557
PROGNOSIS 558
Chapter 163 - GLOMERULONEPHRITIS AND HEMATURIA 558
ETIOLOGY AND EPIDEMIOLOGY 558
CLINICAL MANIFESTATIONS 558
DIAGNOSTIC STUDIES 559
THERAPY 559
PROGNOSIS AND PREVENTION 560
Chapter 164 - HEMOLYTIC UREMIC SYNDROME 560
ETIOLOGY AND EPIDEMIOLOGY 560
CLINICAL MANIFESTATIONS 560
DIAGNOSTIC STUDIES 560
TREATMENT AND PROGNOSIS 560
Chapter 165 - ACUTE AND CHRONIC RENAL FAILURE 561
ACUTE KIDNEY INJURY 561
CHRONIC KIDNEY DISEASE 562
Chapter 166 - HYPERTENSION 563
DEFINITION 563
ETIOLOGY 563
CLINICAL MANIFESTATIONS 563
Chapter 167 - VESICOURETERAL REFLUX 564
ETIOLOGY AND EPIDEMIOLOGY 564
DIAGNOSTIC STUDIES 564
TREATMENT 564
PROGNOSIS 564
CLINICAL MANIFESTATIONS 565
DIAGNOSTIC STUDIES 565
TREATMENT 565
Chapter 168 - CONGENITAL AND DEVELOPMENTAL ABNORMALITIES OF THE URINARY TRACT 565
ETIOLOGY AND EPIDEMIOLOGY 565
CLINICAL MANIFESTATIONS 566
DIAGNOSTIC IMAGING 566
Chapter 169 - OTHER URINARY TRACT AND GENITAL DISORDERS 567
URINARY TRACT STONES 567
VOIDING DYSFUNCTION 567
TREATMENT 567
ANOMALIES OF THE PENIS 568
DISORDERS AND ABNORMALITIES OF THE SCROTUM AND ITS CONTENTS 568
ACKNOWLEDGMENT 569
Suggested Reading 569
Section 23 - Endocrinology 570
Chapter 170 - ENDOCRINOLOGY ASSESSMENT 570
HYPOTHALAMIC-PITUITARY AXIS 570
DISORDERS OF THE HYPOTHALAMIC-PITUITARY AXIS 571
Chapter 171 - DIABETES MELLITUS 572
DEFINITION 572
INSULIN-DEPENDENT (TYPE 1) DIABETES MELLITUS 573
DIABETIC KETOACIDOSIS 573
NON-INSULIN−DEPENDENT (TYPE 2) DIABETES MELLITUS 578
MATURITY-ONSET DIABETES OF YOUTH (MODY) 579
Chapter 172 - HYPOGLYCEMIA 579
DEFINITION 579
CLINICAL MANIFESTATIONS 579
PATHOPHYSIOLOGY 580
ENERGY STORES 582
IDIOPATHIC KETOTIC HYPOGLYCEMIA 582
DISRUPTED METABOLIC RESPONSE PATHWAYS 582
OTHER METABOLIC DISORDERS 582
MEDICATIONS AND INTOXICATION 582
Chapter 173 - SHORT STATURE 583
GROWTH 583
DIAGNOSIS 583
EMERGENCY MANAGEMENT 583
ABNORMALITIES OF GROWTH 584
Chapter 174 - DISORDERS OF PUBERTY 589
PHYSIOLOGY 589
DELAYED PUBERTY 589
SEXUAL PRECOCITY 592
Chapter 175 - THYROID DISEASE 596
THYROID PHYSIOLOGY AND DEVELOPMENT 596
VARIATIONS IN PUBERTAL DEVELOPMENT 596
THYROID DISORDERS 598
NODULES/TUMORS OF THE THYROID 601
Chapter 176 - DISORDERS OF PARATHYROID BONE AND MINERAL ENDOCRINOLOGY 602
PARATHYROID HORMONE AND VITAMIN D 602
HYPOCALCEMIA 602
RICKETS 603
Chapter 177 - DISORDERS OF SEXUAL DEVELOPMENT 604
NORMAL SEXUAL DEVELOPMENT 604
ABNORMAL SEXUAL DEVELOPMENT 605
APPROACH TO THE INFANT WITH GENITAL AMBIGUITY 606
Chapter 178 - ADRENAL GLAND DYSFUNCTION 607
PHYSIOLOGY 607
ADRENAL INSUFFICIENCY 608
21-HYDROXYLASE DEFICIENCY 609
OTHER ENZYME DEFECTS 611
ADDISON DISEASE 611
CUSHING SYNDROME 611
Suggested Reading 611
Section 24 - Neurology 612
Chapter 179 - NEUROLOGY ASSESSMENT 612
HISTORY 612
PHYSICAL EXAMINATION 612
NEUROLOGIC EXAMINATION OF A NEONATE 612
NEUROLOGIC EXAMINATION OF A CHILD 613
CRANIAL NERVE EVALUATION 613
MOTOR EXAMINATION 614
SENSORY EXAMINATION 615
SPECIAL DIAGNOSTIC PROCEDURES 615
Chapter 180 - HEADACHE AND MIGRAINE 616
ETIOLOGY AND EPIDEMIOLOGY 616
CLINICAL MANIFESTATIONS 617
DIAGNOSTIC STUDIES 617
Chapter 181 - SEIZURES ­(PAROXYSMAL DISORDERS) 618
ETIOLOGY AND EPIDEMIOLOGY 618
FOCAL SEIZURES 618
TREATMENT 618
GENERALIZED SEIZURES 619
EPILEPSY SYNDROMES 621
STATUS EPILEPTICUS 621
LABORATORY AND DIAGNOSTIC EVALUATION 622
LONG-TERM THERAPY 622
Chapter 182 - WEAKNESS AND HYPOTONIA 623
ETIOLOGY 623
CLINICAL MANIFESTATIONS 623
DISEASE OF THE UPPER MOTOR NEURON 624
DISEASES OF THE SPINAL CORD 624
DISEASES OF THE LOWER MOTOR NEURON 624
STROKE IN CHILDHOOD 630
Chapter 183 - ATAXIA AND MOVEMENT ­DISORDERS 631
ATAXIA 631
MOVEMENT DISORDERS 633
Chapter 184 - ALTERED MENTAL ­STATUS 634
DISORDERS OF CONSCIOUSNESS 634
TRAUMATIC BRAIN INJURY 637
INCREASED INTRACRANIAL PRESSURE 640
Chapter 185 - NEURODEGENERATIVE DISORDERS 642
HEREDITARY AND METABOLIC DEGENERATIVE DISEASES 642
ACQUIRED ILLNESSES MIMICKING DEGENERATIVE DISEASES 645
Chapter 186 - NEUROCUTANEOUS DISORDERS 645
NEUROFIBROMATOSIS TYPE 1 645
TUBEROUS SCLEROSIS COMPLEX 646
STURGE-WEBER SYNDROME 646
Chapter 187 - CONGENITAL MALFORMATIONS OF THE CENTRAL ­NERVOUS SYSTEM 647
CONGENITAL ANOMALIES OF THE SPINAL CORD 647
CONGENITAL MALFORMATIONS OF THE BRAIN 647
ACKNOWLEDGMENT 649
Suggested Reading 649
Section 25 - Dermatology 650
Chapter 188 - ASSESSMENT 650
HISTORY 650
PHYSICAL EXAMINATION 650
COMMON MANIFESTATIONS 650
INITIAL DIAGNOSTIC EVALUATION AND TESTS 651
Chapter 189 - ACNE 652
ETIOLOGY 652
EPIDEMIOLOGY 652
CLINICAL MANIFESTATIONS 652
TREATMENT 652
COMPLICATIONS 652
PROGNOSIS 652
PREVENTION 653
Chapter 190 - ATOPIC DERMATITIS 653
ETIOLOGY 653
EPIDEMIOLOGY 653
CLINICAL MANIFESTATIONS 653
LABORATORY AND IMAGING STUDIES 654
DIFFERENTIAL DIAGNOSIS 654
TREATMENT 654
COMPLICATIONS 655
Chapter 191 - CONTACT DERMATITIS 656
ETIOLOGY AND EPIDEMIOLOGY 656
CLINICAL MANIFESTATIONS 656
LABORATORY AND IMAGING STUDIES 656
PROGNOSIS 656
PREVENTION 656
DIFFERENTIAL DIAGNOSIS 657
TREATMENT 657
COMPLICATIONS 657
PREVENTION 657
Chapter 192 - SEBORRHEIC DERMATITIS 657
ETIOLOGY 657
CLINICAL MANIFESTATIONS 657
LABORATORY AND IMAGING STUDIES 658
DIFFERENTIAL DIAGNOSIS 658
TREATMENT 658
PROGNOSIS 658
PREVENTION 658
OTHER PAPULOSQUAMOUS DERMATOSES 658
Chapter 193 - PIGMENTED LESIONS 659
DERMAL MELANOSIS 659
CAFÉ AU LAIT MACULES 659
CONGENITAL MELANOCYTIC NEVI 660
CONGENITAL GIANT MELANOCYTIC NEVI 660
ACQUIRED NEVI 661
Chapter 194 - VASCULAR ANOMALIES 661
VASCULAR TUMORS 661
Chapter 195 - ERYTHEMA MULTIFORME, STEVENS-JOHNSON SYNDROME, AND TOXIC EPIDERMAL NECROLYSIS 662
VASCULAR MALFORMATIONS 662
ERYTHEMA MULTIFORME 663
STEVENS-JOHNSON SYNDROME AND TOXIC EPIDERMAL NECROLYSIS 664
Chapter 196 - CUTANEOUS INFESTATIONS 664
SCABIES 664
PEDICULOSES 665
Suggested Reading 666
Section 26 - Orthopedics 667
Chapter 197 - ORTHOPEDICS ASSESSMENT 667
GROWTH AND DEVELOPMENT 667
DEVELOPMENTAL MILESTONES 668
Chapter 198 - FRACTURES 670
PEDIATRIC FRACTURE PATTERNS 670
MANAGEMENT OF PEDIATRIC FRACTURES 671
SPECIAL CONCERNS 671
Chapter 199 - HIP 672
DEVELOPMENTAL DYSPLASIA OF THE HIP 672
TRANSIENT MONOARTICULAR SYNOVITIS 674
LEGG-CALVE-PERTHES DISEASE 674
SLIPPED CAPITAL FEMORAL EPIPHYSIS 675
Chapter 200 - LOWER EXTREMITY AND KNEE 676
TORSIONAL VARIATIONS 676
ANGULAR VARIATIONS 677
LEG-LENGTH DISCREPANCY 678
KNEE 679
Chapter 201 - FOOT 681
CLUB FOOT (TALIPES EQUINOVARUS) 681
METATARSUS ADDUCTUS 682
CALCANEOVALGUS FOOT 682
HYPERMOBILE PES PLANUS (FLEXIBLE FLATFOOT) 682
TARSAL COALITION 682
CAVUS FOOT 683
IDIOPATHIC AVASCULAR NECROSIS 683
SEVER DISEASE (CALCANEAL APOPHYSITIS) 683
TOE DEFORMITIES 683
Chapter 202 - SPINE 684
SPINAL DEFORMITIES 684
SCOLIOSIS 685
KYPHOSIS 688
TORTICOLLIS 688
BACK PAIN IN CHILDREN 689
SPONDYLOLYSIS AND SPONDYLOLISTHESIS 689
DISKITIS 690
Chapter 203 - UPPER EXTREMITY 691
SHOULDER 691
ELBOW 692
WRIST AND HAND 693
Chapter 204 - BENIGN BONE TUMORS AND CYSTIC LESIONS 693
Suggested Reading 694
Index 695
IBC IBC