BOOK
The Harriet Lane Handbook of Pediatric Antimicrobial Therapy E-Book
Julia McMillan | Carlton K. Lee | George K. Siberry | Karen Carroll
(2012)
Additional Information
Book Details
Abstract
From the experts at Johns Hopkins University who bring you the bestselling Harriet Lane Handbook, the Harriet Lane Handbook of Pediatric Antimicrobial Therapy delivers quick, dependable answers to help you effectively treat a broad spectrum of pediatric infectious diseases. This highly regarded medical reference book is your pocket-sized source for all of the evidence-based recommendations you need to provide the best possible care to your young patients.
- Consult this title on your favorite e-reader , conduct rapid searches, and adjust font sizes for optimal readability.
- Get all of the information you need to prescribe the correct drug and the appropriate dose through a detailed drug formulary, expanded from the popular Harriet Lane Handbook.
- Better manage persistent, hard-to-fight pediatric infections with a section on adverse effects and drug resistance.
- Make the best clinical decisions with up-to-date practice guidelines from the AAP, CDC, and other authoritative pediatric and infectious disease sources.
- Stay on top of the most effective treatments with leading-edge coverage of antiretroviral drugs for HIV and hepatitis; antimicrobial pharmacokinetic/pharmacodynamics (PK/PD) information; the latest Vancomycin therapeutic drug-monitoring recommendations; antimicrobial desensitization; pediatric developmental effects of antimicrobials approved in adults but not children; and much more.
- Depend on the professional wisdom of an expert author team, combined with the front-line input of current pediatric infectious disease fellows.
Table of Contents
| Section Title | Page | Action | Price |
|---|---|---|---|
| Front cover | cover | ||
| IFC | ifc2 | ||
| The Harriet Lane Handbook of Pediatric Antimicrobial Therapy | i | ||
| Copyright page | iv | ||
| Dedication | v | ||
| Contributors | vii | ||
| Preface | ix | ||
| Table of Contents | xi | ||
| Notes and Abbreviations Used in Tables | xiii | ||
| Table 1-1 | xiii | ||
| Table 1-2 | xiii | ||
| Table 1-3 | xiv | ||
| Table 1-4 | xiv | ||
| Table 1-6 | xv | ||
| Table 2-1 | xv | ||
| Table 3-1 | xvi | ||
| Table 3-3 | xvi | ||
| Table 3-4 | xvi | ||
| Table 3-7 | xvii | ||
| Table 3-8 | xvii | ||
| Table 3-9 | xvii | ||
| Table 4-1 | xvii | ||
| Table 6-1 | xvii | ||
| Table 6-2 | xviii | ||
| Table 6-3 | xviii | ||
| Table 6-4 | xviii | ||
| Table 6-5 | xviii | ||
| Table 8-1 | xviii | ||
| Table 9-1 | xix | ||
| Table 9-2 | xix | ||
| Table 9-3 | xix | ||
| Table 9-4 | xix | ||
| Table 9-5 | xix | ||
| Table 9-6 | xix | ||
| Table 9-7 | xix | ||
| Table 9-10 | xix | ||
| Table 9-11 | xix | ||
| Table 9-12 | xx | ||
| Table 9-14 | xx | ||
| Table 9-17 | xx | ||
| Table 9-18 | xx | ||
| Table 9-19 | xx | ||
| Second half title page | xxi | ||
| 1 Infectious Agents and Drugs of Choice | 1 | ||
| I. Recommended Treatment for Bacterial Infections | 2 | ||
| II. Recommended Treatment for Mycobacterial Infections | 44 | ||
| III. Recommended Treatment for Viral Infections | 51 | ||
| IV. Recommended Treatment for Fungal Infections | 56 | ||
| V. Recommended Treatment for Parasitic and Protozoal Infections | 79 | ||
| Acknowledgments | 122 | ||
| 2 Recommended Empiric Antimicrobial Therapy for Selected Clinical Syndromes | 123 | ||
| 3 Drug Dosing in Special Circumstances | 166 | ||
| I. General Pediatric Drug Dosing | 166 | ||
| II. Developmental Dosing Considerations (Developmental Pharmacology) (Table 3-1) | 168 | ||
| III. Drug Dosing in Renal Insufficiency | 170 | ||
| IV. Drug Dosing in Hepatic Insufficiency | 189 | ||
| V. Drug Dosing in Obesity | 203 | ||
| VI. Antimicrobial Tissue Distribution by Key Organ Systems (Table 3-9) | 212 | ||
| References | 240 | ||
| 4 Mechanisms of Action and Routes of Administration of Antimicrobial Agents | 243 | ||
| 5 Mechanisms of Drug Resistance | 252 | ||
| I. Common Mechanisms of Microbial Resistance | 253 | ||
| II. Discordance between in Vitro Susceptibility and in Vivo Efficacy | 255 | ||
| 6 Therapeutic Drug Monitoring | 257 | ||
| I. General Principles | 257 | ||
| II. Antimicrobials that Require Therapeutic Drug Monitoring | 260 | ||
| III. Special Topics in Antimicrobial Therapeutic Drug Monitoring | 264 | ||
| IV. Pharmacokinetic Monitoring in Therapeutic Drug Monitoring | 266 | ||
| V. Pharmacokinetics/Pharmacodynamics (PK / PD) Antimicrobial Relationships | 270 | ||
| VI. Drug Interactions | 272 | ||
| References | 311 | ||
| 7 Adverse Drug Reactions | 313 | ||
| I. Blood | 314 | ||
| II. Cardiovascular | 315 | ||
| III. Central Nervous System | 316 | ||
| IV. Skin | 320 | ||
| V. Gastrointestinal | 322 | ||
| VI. Endocrine/Metabolic | 326 | ||
| VII. Renal/Genitourinary | 327 | ||
| VIII. Respiratory | 328 | ||
| IX. Hepatic | 329 | ||
| X. Ocular | 330 | ||
| XI. Musculoskeletal | 330 | ||
| XII. Hypersensitivity | 331 | ||
| XIII. Other | 331 | ||
| References | 332 | ||
| 8 Recommended Antimicrobial Prophylaxis for Selected Infectious Agents and Conditions | 333 | ||
| References | 348 | ||
| 9 Antimicrobial Desensitization Protocols | 349 | ||
| I. Penicillin | 349 | ||
| II. Amoxicillin | 351 | ||
| III. Cephalosporins | 352 | ||
| IV. Trimethoprim/Sulfamethoxazole Oral | 353 | ||
| V. Fluoroquinolone | 354 | ||
| VI. Vancomycin | 355 | ||
| VII. Aminoglycosides | 357 | ||
| VIII. Clindamycin | 359 | ||
| IX. Linezolid | 359 | ||
| X. Darunavir | 359 | ||
| References | 361 | ||
| 10 Formulary | 362 | ||
| I. Note to Reader | 362 | ||
| II. Sample Entry | 364 | ||
| III. Explanation of Breast-Feeding Categories | 365 | ||
| IV. Explanation of Pregnancy Categories | 365 | ||
| V. Drug Index | 366 | ||
| Abacavir Sulfate | 375 | ||
| Acyclovir | 376 | ||
| Adefovir Dipivoxil | 377 | ||
| Albendazole | 378 | ||
| Amantadine Hydrochloride | 379 | ||
| Aminosalicylic Acid | 380 | ||
| Amikacin Sulfate | 380 | ||
| Amoxicillin | 381 | ||
| Amoxicillin with Clavulanic Acid | 382 | ||
| Amphotericin B (Conventional) | 383 | ||
| Amphotericin B Cholesteryl Sulfate | 384 | ||
| Amphotericin B Lipid Complex | 385 | ||
| Amphotericin B, Liposomal | 385 | ||
| Ampicillin | 386 | ||
| Ampicillin with Sulbactam | 387 | ||
| Amprenavir | 388 | ||
| Anidulafungin | 389 | ||
| Artemether with Lumefantrine | 390 | ||
| Artesunate | 391 | ||
| Antitoxin, Diphtheria | 391 | ||
| Atazanavir | 391 | ||
| Atovaquone ± Proguanil | 393 | ||
| Azithromycin | 395 | ||
| Aztreonam | 397 | ||
| Bacitracin ± Polymyxin B | 398 | ||
| Benzyl Alcohol | 399 | ||
| Besifloxacin | 399 | ||
| Boceprevir | 400 | ||
| Botulinum Immune Globulin Intravenous, Human | 401 | ||
| Butenafine | 401 | ||
| Capreomycin | 402 | ||
| Caspofungin | 402 | ||
| Cefaclor | 403 | ||
| Cefadroxil | 403 | ||
| Cefazolin | 404 | ||
| Cefdinir | 405 | ||
| Cefditoren Pivoxil | 405 | ||
| Cefepime | 406 | ||
| Cefixime | 406 | ||
| Cefotaxime | 407 | ||
| Cefotetan | 408 | ||
| Cefoxitin | 408 | ||
| Cefpodoxime Proxetil | 409 | ||
| Cefprozil | 410 | ||
| Ceftaroline Fosamil | 410 | ||
| Ceftazidime | 411 | ||
| Ceftibuten | 412 | ||
| Ceftriaxone | 412 | ||
| Cefuroxime (IV, IM)/Cefuroxime Axetil (PO) | 413 | ||
| Cephalexin | 414 | ||
| Chloramphenicol | 415 | ||
| Chlorhexidine Gluconate | 416 | ||
| Chloroquine Phosphate | 416 | ||
| Ciclopirox/Ciclopirox Olamine | 417 | ||
| Cidofovir | 418 | ||
| Ciprofloxacin | 419 | ||
| Clarithromycin | 421 | ||
| Clindamycin | 422 | ||
| Clofazimine | 423 | ||
| Clotrimazole | 424 | ||
| Colistimethate Sodium | 425 | ||
| Colistin | 425 | ||
| Co-Trimoxazole | 426 | ||
| Cycloserine | 426 | ||
| Cytomegalovirus Immune Globulin | 426 | ||
| Dapsone | 427 | ||
| Daptomycin | 428 | ||
| Darunavir | 428 | ||
| Delavirdine | 430 | ||
| Demeclocycline | 431 | ||
| Dicloxacillin Sodium | 431 | ||
| Didanosine | 432 | ||
| Diethylcarbamazine | 433 | ||
| Diiodohydroxyquin | 434 | ||
| Diphtheria Antitoxin (Equine) | 434 | ||
| Docosanol | 435 | ||
| Doripenem | 436 | ||
| Doxycycline | 436 | ||
| Econazole Nitrate | 437 | ||
| Efavirenz | 438 | ||
| Emtricitabine | 439 | ||
| Enfuvirtide | 440 | ||
| Entecavir | 440 | ||
| Ertapenem | 441 | ||
| Erythromycin Ethylsuccinate and Acetylsulfisoxazole | 442 | ||
| Erythromycin Preparations | 442 | ||
| Ethambutol Hcl | 444 | ||
| Ethionamide | 444 | ||
| Etravirine | 445 | ||
| Famciclovir | 446 | ||
| Fidaxomicin | 446 | ||
| Fluconazole | 447 | ||
| Flucytosine | 448 | ||
| Fosamprenavir | 449 | ||
| Foscarnet | 450 | ||
| Fosfomycin Tromethamine | 451 | ||
| Ganciclovir | 452 | ||
| Gatifloxacin | 453 | ||
| Gemifloxacin | 454 | ||
| Gentamicin | 454 | ||
| Gentian Violet | 456 | ||
| Griseofulvin | 456 | ||
| Hepatitis B Immune Globulin | 457 | ||
| Hexachlorophene | 458 | ||
| Hydrogen Peroxide | 458 | ||
| Hydroxychloroquine | 459 | ||
| Imipenem-Cilastatin | 459 | ||
| Imiquimod | 460 | ||
| Immune Globulin | 461 | ||
| Immune Globulin, Botulinum | 463 | ||
| Immune Globulin, Cytomegalovirus | 463 | ||
| Intravenous (Human) Immune Globulin, Hepatitis B | 463 | ||
| Immune Globulin, Rabies | 463 | ||
| Immune Globulin, Tetanus | 463 | ||
| Immune Globulin, Varicella Zoster | 463 | ||
| Indinavir | 463 | ||
| Iodoquinol | 464 | ||
| Isoniazid | 465 | ||
| Itraconazole | 466 | ||
| Ivermectin | 467 | ||
| Kanamycin | 468 | ||
| Ketoconazole | 469 | ||
| Kunecatechins | 470 | ||
| Lamivudine | 470 | ||
| Levofloxacin | 472 | ||
| Lindane | 473 | ||
| Linezolid | 474 | ||
| Lopinavir with Ritonavir | 475 | ||
| Malarone | 476 | ||
| Malathion | 476 | ||
| Maraviroc | 477 | ||
| Mebendazole | 478 | ||
| Mefloquine HCl | 478 | ||
| Melarsoprol | 479 | ||
| Meropenem | 480 | ||
| Methenamine Preparations | 481 | ||
| Metronidazole | 482 | ||
| Micafungin Sodium | 483 | ||
| Miconazole | 484 | ||
| Minocycline | 485 | ||
| Moxifloxacin | 486 | ||
| Mupirocin | 487 | ||
| Nafcillin | 488 | ||
| Naftifine | 489 | ||
| Natamycin | 489 | ||
| Nelfinavir | 489 | ||
| Neomycin Sulfate | 491 | ||
| NEOMYCIN/HYDROCORTISONE Otic Preparations | 492 | ||
| Neomycin/POLYMYXIN B/± BACITRACIN | 492 | ||
| Nevirapine | 493 | ||
| Nifurtimox | 495 | ||
| Nitazoxanide | 495 | ||
| Nitrofurantoin | 496 | ||
| Norfloxacin | 496 | ||
| Nystatin | 497 | ||
| Ofloxacin | 498 | ||
| Oseltamivir Phosphate | 499 | ||
| Oxacillin | 500 | ||
| Oxiconazole | 501 | ||
| Palivizumab | 502 | ||
| Para-Aminosalicylic Acid | 502 | ||
| Paromomycin Sulfate | 503 | ||
| Penciclovir | 503 | ||
| Penicillin G Preparations—Aqueous Potassium and Sodium | 504 | ||
| Penicillin G Preparations—Benzathine | 505 | ||
| Penicillin G Preparations—Penicillin G Benzathine and Penicillin G Procaine | 506 | ||
| Penicillin G Preparations—Procaine | 506 | ||
| Penicillin V Potassium | 507 | ||
| Pentamidine Isethionate | 508 | ||
| Pentostam | 509 | ||
| Permethrin | 509 | ||
| Phenazopyridine HCl | 509 | ||
| Piperacillin | 510 | ||
| Piperacillin/Tazobactam | 511 | ||
| Podofilox | 512 | ||
| Podophyllin/Podophyllum Resin | 512 | ||
| Polymyxin B Sulfate and Bacitracin | 513 | ||
| Polymyxin B Sulfate and Trimethoprim Sulfate | 513 | ||
| Polymyxin B Sulfate, Neomycin Sulfate, and Hydrocortisone | 513 | ||
| Polytrim Ophthalmic Solution | 514 | ||
| Posaconazole | 514 | ||
| Potassium Iodide | 515 | ||
| Praziquantel | 516 | ||
| Primaquine Phosphate | 517 | ||
| Pyrantel Pamoate | 517 | ||
| Pyrazinamide | 518 | ||
| Pyrethrins with Piperonyl Butoxide | 519 | ||
| Pyrimethamine | 519 | ||
| Quinidine Gluconate | 520 | ||
| Quinine Sulfate | 521 | ||
| Quinupristin with Dalfopristin | 522 | ||
| Rabies Immune Globulin (Human) | 523 | ||
| Raltegravir | 523 | ||
| Retapamulin | 524 | ||
| Ribavirin | 524 | ||
| Rifabutin | 526 | ||
| Rifampin | 527 | ||
| Rifapentine | 529 | ||
| Rifaximin | 530 | ||
| Rilpivirine | 530 | ||
| Rimantadine | 531 | ||
| Ritonavir | 532 | ||
| Saquinavir Mesylate | 533 | ||
| Selenium Sulfide | 534 | ||
| Sertaconazole Nitrate | 535 | ||
| Silver Sulfadiazine | 535 | ||
| Spectinomycin | 536 | ||
| Spinosad | 536 | ||
| Stavudine | 537 | ||
| Stibogluconate | 537 | ||
| Streptomycin Sulfate | 538 | ||
| Sulconazole | 539 | ||
| Sulfacetamide Sodium, Ophthalmic | 539 | ||
| Sulfadiazine | 540 | ||
| Sulfamethoxazole and Trimethoprim | 541 | ||
| Sulfanilamide | 542 | ||
| Suramin | 542 | ||
| Telaprevir | 543 | ||
| Telavancin | 544 | ||
| Telbivudine | 545 | ||
| Telithromycin | 545 | ||
| Tenofovir Disoproxil Fumarate | 546 | ||
| Terbinafine | 548 | ||
| Terconazole | 549 | ||
| Tetanus Immune Globulin | 550 | ||
| Tetracycline HCl | 550 | ||
| Thalidomide | 551 | ||
| Ticarcillin with Clavulanate | 552 | ||
| Tigecycline | 553 | ||
| Tinidazole | 554 | ||
| Tioconazole | 554 | ||
| Tipranavir | 555 | ||
| Tobramycin | 556 | ||
| Tolnaftate | 558 | ||
| Trifluridine | 559 | ||
| Trimethoprim | 559 | ||
| Trimethoprim and Sulfamethoxazole | 560 | ||
| Trimetrexate Glucuronate | 560 | ||
| Undecylenic Acid | 561 | ||
| Valacyclovir | 562 | ||
| Valganciclovir | 563 | ||
| Vancomycin | 564 | ||
| Varicella Zoster Immune Globulin (Human) | 566 | ||
| Voriconazole | 567 | ||
| Zanamivir | 568 | ||
| Zidovudine | 569 | ||
| Index | 571 | ||
| A | 571 | ||
| B | 575 | ||
| C | 576 | ||
| D | 581 | ||
| E | 583 | ||
| F | 586 | ||
| G | 587 | ||
| H | 588 | ||
| I | 589 | ||
| J | 591 | ||
| K | 591 | ||
| L | 592 | ||
| M | 593 | ||
| N | 596 | ||
| O | 597 | ||
| P | 598 | ||
| Q | 602 | ||
| R | 603 | ||
| S | 605 | ||
| T | 608 | ||
| U | 612 | ||
| V | 612 | ||
| W | 613 | ||
| X | 613 | ||
| Y | 613 | ||
| Z | 613 | ||
| IBC | ibc1 |