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Crash Course: Neurology - E-Book

Crash Course: Neurology - E-Book

Mahinda Yogarajah | Daniel Horton-Szar | Katia Cikurel | Naheed Khan

(2013)

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Book Details

Abstract

The new series of Crash Course continues to provide readers with complete coverage of the MBBS curriculum in an easy-to-read, user-friendly manner. Building on the success of previous editions, the new Crash Courses retain the popular and unique features that so characterised the earlier volumes and are fully updated throughout.

  • More than 200 tables and illustrations present clinical, diagnostic and practical information in an easy-to-follow manner
  • Friendly and accessible approach to the subject makes learning especially easy
  • Written by junior doctors for students - authors who understand exam pressures
  • Contains ‘Hints and Tips’ boxes, and other useful aide-mémoires
  • Succinct coverage of the subject enables ‘sharp focus’ and efficient use of time during exam preparation
  • Contains a fully updated self-assessment section - ideal for honing exam skills and self-testing
  • Self-assessment section fully updated to reflect current exam requirements
  • Contains ‘common exam pitfalls’ as advised by faculty
  • Crash Courses also available electronically!
  • Online self-assessment bank also available - content edited by Dan Horton-Szar!

Now celebrating over 10 years of success - Crash Course has been specially devised to help you get through your exams with ease.

Completely revised throughout, the new edition of Crash Course is perfectly tailored to meet your needs by providing everything you need to know in one place. Clearly presented in a tried and trusted, easy-to-use, format, each book in the series gives complete coverage of the subject in a no-nonsense, user-friendly fashion.

Commencing with 'Learning Objectives', each chapter guides you succinctly through the topic, giving full coverage of the curriculum whilst avoiding unnecessary and often confusing detail. Each chapter is also supported by a full artwork programme, and features the ever popular 'Hints and Tips' boxes as well as other useful aide-mémoires. All volumes contain an up-to-date self-assessment section which allows you to test your knowledge and hone your exam skills.

Authored by students or junior doctors - working under close faculty supervision - each volume has been prepared by someone who has recently been in the exam situation and so relates closely to your needs. So whether you need to get out of a fix or aim for distinction Crash Course is for you!!


Table of Contents

Section Title Page Action Price
Front Cover Cover
Crash Course: Neurology iii
Copyright iv
Series editor foreword v
Preface vii
Acknowledgements ix
Dedication xi
Contents xiii
PART I: HISTORY, EXAMINATION AND COMMON INVESTIGATIONS 1
Chapter 1: Taking a history 3
STRUCTURE OF THE HISTORY 3
The presenting complaint 3
History of the presenting complaint 3
Past medical history 4
Drug history 4
Review of systems 4
Family history 4
Social history 4
Summary 5
Chapter 2: The neurological examination 7
MENTAL STATE AND HIGHER CEREBRAL FUNCTIONS 7
Consciousness 7
Appearance and behaviour 7
Affect 7
Cognitive function 7
Mini-mental State Examination 7
SPEECH 8
Phonation: dysphonia 8
Assessment 8
Articulation: dysarthria 9
PART II: THE PATIENT PRESENTS WITH... 31
Chapter 4: Disorders of higher cerebral function 33
FRONTAL LOBE 33
Normal functions 33
Blood supply 33
Symptoms from lesions of the frontal lobe 33
PARIETAL LOBE 35
Function 35
Blood supply 35
Symptoms from lesions of the parietal lobe 35
Syndromes of the dominant parietal lobe 35
Syndromes of the non-dominant parietal lobe 36
TEMPORAL LOBE 36
Function 36
Blood supply 36
Symptoms from lesions of the temporal lobe 36
DYSPHASIA 37
OCCIPITAL LOBE 37
Function 37
Blood supply 37
Symptoms from lesions of the occipital lobe 38
Chapter 5: Disturbances of consciousness 39
TRANSIENT LOSS OF CONSCIOUSNESS 39
Syncope 39
1. Vasovagal syncope 39
2. Situational syncope – micturition and cough syncope 40
3. Postural hypotension 40
4. Syncope due to primary cardiac dysfunction 40
5. Carotid sinus disease 41
Seizures 41
Hypoglycaemia 41
Narcolepsy/cataplexy 41
Hyperventilation 41
Vertebrobasilar ischaemia 41
Non-epileptic attacks 42
Investigating transient loss of consciousness 42
DRIVING AND EPISODES OF DISTURBANCES OF CONSCIOUSNESS 42
COMA 42
Differential diagnosis of coma 42
Non-convulsive status epilepticus 42
Akinetic mutism 42
Locked-in syndrome 43
Persistent vegetative state 43
Catatonia 43
Causes of persistent disturbance of consciousness 43
Clinical approach to the comatose patient 44
Examination of the comatose patient 45
Signs of head injury 45
Neck stiffness 45
Respiratory pattern 45
Pupil responses 45
Resting position of the eyes 45
Ocular movements 45
Fundoscopic abnormalities 46
Corneal reflexes 46
Limb posture and movement 46
Investigations in the comatose patient 46
Prognosis of coma 47
BRAINSTEM DEATH 47
Chapter 6: Headache 49
Recurrent episodic headache 49
Chronic daily headache 49
New daily persistent headache 49
Subacute-onset and progressive headache 50
Acute-onset headache 51
HISTORY 51
EXAMINATION 52
Chapter 7: Disorders of smell and taste 53
DIFFERENTIAL DIAGNOSIS 53
Anosmia and hyposmia 53
Ageusia and dysgeusia 53
Hyperosmia 54
Olfactory hallucinations 54
Examination 54
INVESTIGATIONS 55
Chapter 8: Visual impairment 57
THE ANATOMICAL PATH OF LIGHT STIMULATION 57
1. Retina to optic nerve 57
2. Optic nerve to optic chiasm 57
3. Optic chiasm to lateral geniculate nucleus 57
4. Lateral geniculate nucleus to occipital cortex 58
BLOOD SUPPLY TO THE VISUAL PATHWAY 58
Visual field defects 58
CLINICAL FEATURES TO AID LOCALIZATION OF A LESION 59
Retinal lesion 59
Optic nerve lesion (see 1, Fig. 8.1) 59
Optic chiasm lesion (see 2, Fig. 8.1) 60
Optic radiation and optic tract lesions (see 3, 4, 5, Fig. 8.1) 60
Occipital cortex lesions (see 6, Fig. 8.1) 60
DIFFERENTIAL DIAGNOSIS OF VISUAL LOSS 60
Monocular or binocular visual impairment 61
Acute transient visual impairment 61
Amaurosis fugax 61
Migraine with aura 61
Papilloedema 61
Acute persistent visual impairment 61
Optic neuritis 62
Retinal or optic nerve ischaemia 62
Arterial thromboembolism of the middle or posterior cerebral artery 62
OPTIC ATROPHY 62
Chapter 9: Disorders of the pupils and eye movements 63
PUPILLARY REFLEXES 63
Pupillary light reflex pathway – parasympathetic pathways 63
Pupillary light reflex pathway – sympathetic pathways 63
The accommodation reflex 64
DIFFERENTIAL DIAGNOSIS OF PUPIL DISORDERS 64
Anisocoria 64
Physiological anisocoria 65
Small constricted (miotic) pupil 65
Old age 65
Medications 65
Horner syndrome 65
Argyll Robertson pupils 65
Large dilated (mydriatic) pupil 66
Disorders of the iris and iatrogenic mydriasis 66
Third nerve lesions 66
Holmes–Adie pupil 66
Relative afferent pupillary defect 66
DISORDERS OF EYE MOVEMENTS 66
Conjugate gaze 66
Binocular diplopia 68
Dysfunction of the extraocular muscles 68
Dysfunction at the neuromuscular junction 68
Dysfunction of the ocular cranial nerves 69
Lesions of the third (oculomotor) nucleus and nerve (see Figs 9.6 and 9.7) 69
Lesions of the fourth (trochlear) nucleus and nerve (see Figs 9.8 and 9.9) 69
Lesions of the sixth (abducens) nucleus and nerve (see Figs 9.10 and 9.11) 70
Lesions of the brainstem and the internuclear pathways 70
Supranuclear lesions 71
Horizontal gaze palsy 71
One-and-a-half syndrome 71
Vertical gaze palsy 71
Nystagmus 72
Pendular nystagmus due to visual impairment 72
Congenital nystagmus 72
Jerky nystagmus 72
Physiological nystagmus 72
‘Nystagmoid jerks’ 72
Optokinetic nystagmus 73
Pathological nystagmus 73
Central nystagmus 73
Peripheral nystagmus 73
Chapter 10: Facial sensory loss and weakness 75
THE TRIGEMINAL NERVE 75
DIFFERENTIAL DIAGNOSIS OF FACIAL SENSORY LOSS 75
Supranuclear lesions 76
Brainstem lesions 76
Cerebellopontine angle lesions 77
Cavernous sinus lesions 77
Lesions of the trigeminal root, ganglion and peripheral branches of the nerve 77
FACIAL NERVE 78
Facial nerve anatomy 78
Upper and lower motor neuron facial weakness 78
Differential diagnosis of facial weakness 79
Chapter 11: Deafness, tinnitus, dizziness and vertigo 81
DEAFNESS AND TINNITUS 81
THE AUDITORY SYSTEM 81
DIFFERENTIAL DIAGNOSIS OF DEAFNESS 81
Rinne's test 81
Weber's test 82
Conductive deafness 82
Sensorineural deafness 83
Disorders of the cochlear apparatus 83
Disorders of the cochlear nerve 83
Disorders of the brainstem 83
Disorders of the supranuclear connections 83
Investigations for deafness 83
DIFFERENTIAL DIAGNOSIS OF TINNITUS 83
THE VESTIBULAR SYSTEM 84
DIFFERENTIAL DIAGNOSIS OF DIZZINESS AND VERTIGO 84
Clinical features of labyrinthine failure 84
Examples of labyrinthine failure 84
Ménière's disease 84
Benign paroxysmal positional vertigo 84
Other causes 85
Vestibular nerve lesions 85
Vestibular neuronitis 85
Cerebellopontine angle lesions 86
Brainstem lesions 86
Cerebellar lesions 86
Other types of dizziness 86
INVESTIGATIONS FOR VERTIGO 86
Hallpike manoeuvre 86
Caloric test 86
Chapter 12: Dysarthria, dysphonia and dysphagia 89
DEFINITIONS 89
DYSARTHRIA 89
Upper motor neuron lesions 89
Lower motor neuron lesions 90
Basal ganglia lesions 90
Parkinson's disease 90
Chorea 90
Athetosis 91
Cerebellar lesions 91
Myopathies and disorders of the neuromuscular junction 91
Oropharyngeal lesions 91
DYSPHAGIA 91
Sites of lesions causing dysphagia 91
DYSPHONIA 91
Chapter 13: Cerebellar dysfunction 93
CLINICAL FEATURES OF CEREBELLAR DYSFUNCTION 93
Incoordination of movement 93
Ataxic gait 93
Ataxic dysarthric speech 93
Abnormal eye movements 93
Titubation 94
Altered posture 94
Hypotonia 94
LOCALIZATION OF A CEREBELLAR LESION 95
Cerebellar hemisphere 95
Cerebellar vermis 95
Chapter 14: Movement disorders 97
THE ANATOMICAL BASIS AND CLASSIFICATION OF MOVEMENT DISORDERS 97
THE HYPERKINETIC MOVEMENT DISORDERS: TREMOR AND DYSTONIA 97
Tremor 97
Resting tremor 97
Postural tremor 99
1. Physiological tremor 99
2. Essential tremor 99
3. Neuropathic tremor 99
4. Dystonic tremor 99
Kinetic tremor 99
1. Cerebellar tremor (intention tremor) 99
2. Red nuclear ‘rubral’ tremor 99
Mixed tremors 99
DYSTONIA 99
1. Primary dystonia 100
2. Dystonia-plus syndromes – dopa-responsive dystonia 100
3. Secondary dystonia 100
4. Paroxysmal dystonia 101
THE HYPERKINETIC MOVEMENT DISORDERS: CHOREA, TICS AND MYOCLONUS 101
Chorea 101
Huntington's disease (Huntington's chorea) 101
Ballism 101
Tics 101
Myoclonus 102
1. Myoclonic epilepsy 102
2. Progressive myoclonic epilepsy 102
3. Symptomatic myoclonus 102
Chapter 15: Limb weakness 103
NEUROANATOMY 103
The upper motor neuron pathway 103
The lower motor neuron pathway 103
The neuromuscular junction and muscle pathway 103
TERMINOLOGY 104
UPPER MOTOR NEURON WEAKNESS 104
Increased tone (spasticity) 105
‘Pyramidal-pattern’ weakness 105
Absence of muscle wasting and fasciculations 105
Brisk tendon reflexes and extensor plantar responses 105
UPPER MOTOR NEURON SYNDROMES 105
Hemiparesis – unilateral arm and leg weakness 105
Tetraparesis – weakness in all four limbs 105
Paraparesis – weakness in both legs 106
Monoparesis – weakness of a single limb 107
LOWER MOTOR NEURON WEAKNESS 107
Decreased tone 108
Focal pattern of weakness and wasting 108
Fasciculations 108
Pain and sensory disturbance 108
Reduced tendon reflexes and flexor plantar responses 108
LOWER MOTOR NEURON SYNDROMES 108
Anterior horn cell disease 109
Radiculopathy and plexopathy 109
Brachial plexopathy 109
Lumbosacral plexopathy 110
Neuropathy 110
DISORDERS OF THE NEUROMUSCULAR JUNCTION 110
MYOPATHY 110
Chapter 16: Limb sensory symptoms 113
DORSAL (POSTERIOR) COLUMN PATHWAY 113
SPINOTHALAMIC PATHWAY 113
TROPHIC SKIN CHANGES AND ULCERS 113
SENSORY SYNDROMES 114
Lesions of peripheral nerves 114
Mononeuropathy 114
Multiple mononeuropathy 115
Polyneuropathy 115
Lesions of the spinal nerve roots, dorsal roots and ganglia 115
Lesions of the spinal cord 115
Transection of the cord 116
Lesion of the posterior spinal cord 116
Lesion of the anterior cord 116
Hemisection of the cord (Brown–Séquard syndrome) 116
Central cord lesion 117
Lesions of the brainstem 117
Lesions of the thalamus 118
Lesions of the parietal lobe 118
Chapter 17: Disorders of gait 119
PRACTICAL APPROACH TO THE ASSESSMENT OF GAIT 119
DIFFERENTIAL DIAGNOSIS OF DISORDERS OF GAIT 120
Gait of cerebellar ataxia 120
Hemiparetic gait 120
Spastic gait 120
Parkinsonian gait 120
Gait of sensory ataxia 120
Steppage gait 120
Myopathic gait 121
Apraxic gait 121
Antalgic gait 121
Functional gait 121
PART III: DISEASES AND DISORDERS 123
Chapter 18: Dementia 125
DEFINITION 125
DIFFERENTIAL DIAGNOSES 125
EPIDEMIOLOGY 125
GENERAL CLINICAL FEATURES 125
HISTORY 126
EXAMINATION 126
INVESTIGATIONS 126
Blood tests 126
Imaging of the brain 127
Lumbar puncture 127
Neuropsychometry 127
Electroencephalography 127
Genetic testing 127
Brain biopsy 127
MANAGEMENT 127
PRIMARY NEURODEGENERATIVE DEMENTIAS 128
Alzheimer's disease 128
Pathology 128
Clinical features 128
Diagnosis 128
Drug treatment 128
Prognosis 128
Dementia with Lewy bodies 128
Frontotemporal lobar dementia 129
Vascular dementia 129
Diagnosis 129
Treatment 130
VASCULITIS 130
DEMENTIA AS A PART OF OTHER DEGENERATIVE DISEASES 130
PSEUDODEMENTIA 130
Chapter 19: Epilepsy 131
DEFINITIONS 131
CLASSIFICATION OF SEIZURES 131
EPIDEMIOLOGY 131
AETIOLOGY 131
Family history 131
Antenatal and perinatal factors 132
Trauma and surgery 132
Metabolic causes 132
Toxic causes 132
Infectious and inflammatory causes 132
Vascular causes 132
Intracranial tumours 132
Hypoxia 132
Degenerative diseases 132
Photosensitivity 132
Sleep deprivation 133
CLINICAL FEATURES 133
Partial seizures 133
Simple partial seizures 133
Complex partial seizures 133
Secondarily generalized seizures 134
Generalized seizures 134
Generalized tonic–clonic seizures 134
Absence seizures 134
Myoclonic seizures 134
Atonic and tonic seizures 134
HISTORY AND INVESTIGATIONS TO AID DIAGNOSIS 134
DIFFERENTIAL DIAGNOSES 135
DRUG TREATMENT 135
When to start drug treatment 135
What drugs to choose 135
Pharmacokinetics of antiepileptic drugs 136
Adverse effects of antiepileptic drugs 136
Acute toxicity 136
Idiosyncratic toxicity 136
Chronic toxicity 136
Teratogenicity and pregnancy 136
Withdrawal of antiepileptic drugs 136
STATUS EPILEPTICUS 137
Drug treatment 137
NEUROSURGICAL TREATMENT OF EPILEPSY 137
MORTALITY OF EPILEPSY 137
DRIVING AND EPILEPSY 138
Chapter 20: Headache and craniofacial pains 139
TENSION-TYPE HEADACHE 139
MIGRAINE 139
Migraine with aura or ‘classical migraine’ 140
Common migraine 140
Basilar migraine 140
Hemiplegic migraine 140
Management 140
During an attack 140
Prophylaxis 140
CLUSTER HEADACHE 140
Treatment 141
OTHER NEUROLOGICAL CAUSES OF HEADACHE AND CRANIOFACIAL PAIN 141
Headache of raised intracranial pressure 141
Low pressure headache 141
NON-NEUROLOGICAL CAUSES OF HEADACHE AND CRANIOFACIAL PAIN 142
Giant-cell arteritis (temporal arteritis) 142
Diagnosis 142
Treatment 143
Local causes 143
Chapter 21: Parkinson's disease and other extrapyramidal disorders 145
AKINETIC–RIGID SYNDROMES 145
Parkinson's disease 145
Pathology 145
Aetiology 145
Clinical features 146
Tremor 146
Rigidity 146
Bradykinesia, hypokinesia and akinesia 146
Postural changes 147
Non-motor, cognitive and psychiatric features 147
Natural history 147
Investigations 147
Treatment 147
Levodopa (L-dopa) 147
Dopamine agonists 148
Anticholinergic drugs 148
Monoamine oxidase B inhibitors 148
COMT (catechol-O-methyltransferase) inhibitors 148
Management of hallucinations, psychosis and confusion 148
Surgery 148
Differential diagnosis of Parkinson’s disease 148
The atypical parkinsonian disorders 149
Progressive supranuclear palsy 149
Multisystem atrophy 149
Corticobasal degeneration 149
Other parkinsonian syndromes 150
SELF-ASSESSMENT 255
Single best answer questions (SBAs) 257
Extended-matching questions (EMQs) 267
SBA answers 273
EMQ answers 283
Objective structured clinical examination (OSCE) stations 285
1. This 33 year old lady has developed clumsiness and has difficulty walking. Please conduct a physical examination of he... 285
Glossary 289
Index 293