BOOK
Randomized Clinical Trials in Surgical Oncology, An Issue of Surgical Oncology Clinics -- E-Book
Adam C. Yopp | Ronald P. DeMatteo
(2009)
Additional Information
Book Details
Abstract
This issue of the Surgical Oncology Clinics will review the important clinical trials from the past eight years in following topics: breast cancer, soft tissue sarcoma, rectal and anal carcinoma, pancreatic adenocarcinoma, hepatocellular carcinoma, gastric cancer, esophageal cancer, colon cancer, advanced and metastatic colorectal carcinoma, gastrointestinal stromal tumors, and melanoma.
Table of Contents
| Section Title | Page | Action | Price |
|---|---|---|---|
| Front Cover | Cover | ||
| Contents | vii | ||
| Foreword | xiii | ||
| Preface | xv | ||
| Commentary: Randomized Controlled Trials | xix | ||
| Chapter 1. Randomized Clinical Trials in Soft Tissue Sarcoma | 1 | ||
| SURGERY | 1 | ||
| RADIATION THERAPY | 2 | ||
| CHEMOTHERAPY | 2 | ||
| SUMMARY | 3 | ||
| FUTURE DIRECTIONS | 3 | ||
| LEVEL I EVIDENCE: RANDOMIZED CLINICAL TRIALS | 3 | ||
| DISCLOSURE | 10 | ||
| REFERENCES | 10 | ||
| Chapter 2. Randomized Clinical Trials in Melanoma | 13 | ||
| PRIMARY MELANOMA | 13 | ||
| REGIONAL METASTATIC DISEASE | 14 | ||
| ADJUVANT TREATMENT OF HIGH-RISK MELANOMA | 15 | ||
| TREATMENT OF METASTATIC MELANOMA | 16 | ||
| LEVEL IA EVIDENCE IN MELANOMA | 17 | ||
| DISCLOSURE | 28 | ||
| REFERENCES | 28 | ||
| Chapter 3. Randomized Clinical Trials in Breast Cancer | 33 | ||
| LEVEL IA EVIDENCE: PROSPECTIVE RANDOMIZED TRIALS ADDRESSING ADJUVANT RADIATION OF THE BREAST | 40 | ||
| LEVEL IA EVIDENCE: META-ANALYSIS ANALYZING USE OF POLYCHEMOTHERAPY IN OPERABLE BREAST CANCER | 44 | ||
| LEVEL IA EVIDENCE: PROSPECTIVE RANDOMIZED TRIALS ADDRESSING THE ROLE OF ENDOCRINE THERAPY IN BREAST CANCER PREVENTION AND TREATMENT | 49 | ||
| DISCLOSURE | 55 | ||
| REFERENCES | 55 | ||
| Chapter 4. Randomized Clinical Trials in Esophageal Carcinoma | 59 | ||
| CURATIVEINTENT: SURGERY VERSUS CHEMORADIOTHERAPY | 60 | ||
| CURATIVEINTENT: SURGERYALONEVERSUSNEOADJUVANT THERAPY | 60 | ||
| CURATIVEINTENT: SURGERYALONEVERSUSADJUVANT THERAPY | 62 | ||
| CURATIVEINTENT: DEFINITIVECHEMORADIOTHERAPY VERSUSTRIMODALITY THERAPY | 63 | ||
| CURATIVEINTENT: SURGICALTECHNIQUE | 64 | ||
| CURATIVEINTENT: RADIOTHERAPY TECHNIQUE | 65 | ||
| STAGING | 66 | ||
| PALLIATIVEINTENT: ADJUVANTCHEMOTHERAPY | 66 | ||
| DISCLOSURE | 75 | ||
| REFERENCES | 75 | ||
| Chapter 5. Randomized Clinical Trials in Gastric Cancer | 81 | ||
| SURGERY | 81 | ||
| CHEMOTHERAPY WITH AND WITHOUT RADIATION THERAPY | 84 | ||
| METASTATIC DISEASE | 86 | ||
| LEVEL 1A EVIDENCE: PROSPECTIVE RANDOMIZED CLINICAL TRIALS IN GASTRIC CANCER | 87 | ||
| DISCLOSURE | 98 | ||
| REFERENCES | 98 | ||
| Chapter 6. Randomized Clinical Trials in Gastrointestinal Stromal Tumors | 101 | ||
| SURGERY AND RADIATION | 101 | ||
| CHEMOTHERAPY AND METASTATIC DISEASE | 102 | ||
| ONGOING TRIALS | 103 | ||
| LEVEL IA EVIDENCE: RANDOMIZED CLINICAL TRIALS IN GIST | 103 | ||
| DISCLOSURE | 111 | ||
| REFERENCES | 111 | ||
| Chapter 7. Randomized Clinical Trials in Pancreatic Adenocarcinoma | 115 | ||
| RANDOMIZED CONTROLLED TRIALS IN PANCREAS CANCER BETWEEN1977 AND 2000 | 115 | ||
| SURGERY | 116 | ||
| CHEMOTHERAPY | 117 | ||
| MOLECULAR THERAPY | 127 | ||
| GASTROENTEROLOGY | 129 | ||
| NUTRITION | 129 | ||
| RADIATION THERAPY | 129 | ||
| IMMUNOTHERAPY | 132 | ||
| PALLIATIVE THERAPY | 132 | ||
| OTHERS | 132 | ||
| LEVEL IA EVIDENCE: RANDOMIZED CLINICALTRIALSIN PANCREAS CANCER | 132 | ||
| DISCLOSURE | 142 | ||
| REFERENCES | 142 | ||
| Chapter 8. Randomized Clinical Trials in Hepatocellular Carcinoma | 151 | ||
| LOCOREGIONAL THERAPY: SURGERY AND ABLATION | 151 | ||
| ADJUVANT OR PALLIATIVE THERAPY | 153 | ||
| SURGERY | 155 | ||
| ADJUVANT OR PALLIATIVE THERAPY | 157 | ||
| DISCLOSURE | 160 | ||
| REFERENCES | 160 | ||
| Chapter 9. An Update on Randomized Clinical Trials in Advanced and Metastatic Colorectal Carcinoma | 163 | ||
| TRIALS USING DIFFERENT TYPES OF CHEMOTHERAPY | 163 | ||
| TRIALS ON NEOADJUVANT AND ADJUVANT CHEMOTHERAPY FOR RESECTABLE LIVER METASTASES | 164 | ||
| TRIALS FOR HAI REGIONAL CHEMOTHERAPY | 165 | ||
| TRIALS ON MOLECULAR MARKERS OF CHEMOTHERAPY EFFICACY | 165 | ||
| TRIALS ON THE DURATION, DOSING, AND SEQUENCING OF CHEMOTHERAPY | 166 | ||
| LEVEL IA EVIDENCE RANDOMIZED CLINICAL TRIALS | 166 | ||
| DISCLOSURE | 179 | ||
| REFERENCES | 179 | ||
| Chapter 10. Randomized Clinical Trials in Colon Cancer | 183 | ||
| SURGERY | 183 | ||
| ADJUVANT THERAPY | 186 | ||
| SURGICAL TRIALS | 188 | ||
| DISCLOSURE | 200 | ||
| REFERENCES | 200 | ||
| Chapter 11. Randomized Clinical Trials in Rectal and Anal Cancers | 205 | ||
| SURGERY | 205 | ||
| RADIATION | 208 | ||
| CHEMOTHERAPY | 209 | ||
| SUMMARY | 211 | ||
| RANDOMIZED CLINICAL TRIALS IN THE TREATMENT OF EPIDERMOID CANCERS OF THE ANAL CANAL | 212 | ||
| LEVEL 1A EVIDENCE: PROSPECTIVE RANDOMIZED CLINICAL TRIALS IN RECTAL CANCER | 212 | ||
| LEVEL 1A EVIDENCE: PROSPECTIVE RANDOMIZED CLINICAL TRIALS IN ANAL CANCER | 216 | ||
| DISCLOSURE | 218 | ||
| REFERENCES | 218 | ||
| Index | 225 |