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Renal Physiology E-Book

Renal Physiology E-Book

Bruce M. Koeppen | Bruce A. Stanton

(2012)

Additional Information

Abstract

Renal Physiology helps you to quickly and easily grasp the fundamentals of renal physiology and learn how to apply them in a clinical context. Thoroughly updated, this medical reference book in the Mosby Physiology Monograph Series provides a basic understanding of normal kidney function at the cellular and molecular level. Attractively illustrated with clear 2-color diagrams, it also facilitates study with learning objectives, "In the Clinic" and "At the Molecular Level" boxes, chapter summaries, and clinical cases with review questions and explained answers.

  • Stay current with clear, accurate coverage of the physiology of normal renal function focusing on the needs of the student. 
  • Bridge the gap between normal function and disease with pathophysiology content throughout the book. 
  • Understand complex concepts by examining more than more than 250 clear, 2-color diagrams.
  • Perform quick searches ... add your own notes and bookmarks ... and more!
  • Put theory into practice with "In the Clinic" or "At the Molecular Level " boxes in each chapter that explain the practical applications of fundamental knowledge.
  • Deepen your understanding of fundamental and advanced information with an expanded collection of review questions reviewed and reorganized by chapter.
  • Master the material more easily with learning objectives, overview boxes, key words and concepts, and chapter summaries.
  • Apply what you've learned to real-life clinical situations with clinical cases in question-answer format at the end of each chapter.
Gain a quick and easy understanding of the physiology of kidney and renal function

Table of Contents

Section Title Page Action Price
Front Cover Cover
Renal Physiology iii
Copyright iv
Dedication v
Preface vii
Acknowledgments ix
Contents xi
CHAPTER 1 - PHYSIOLOGY OF BODY FLUIDS 1
PHYSICOCHEMICAL PROPERTIES OF ELECTROLYTE SOLUTIONS 1
VOLUMES OF BODY FLUID COMPARTMENTS 4
COMPOSITION OF BODY FLUID COMPARTMENTS 6
FLUID EXCHANGE BETWEEN BODY FLUID COMPARTMENTS 7
SUMMARY 12
CHAPTER 2 - STRUCTURE AND FUNCTION OF THE KIDNEYS 15
STRUCTURE OF THE KIDNEYS 15
SUMMARY 25
CHAPTER 3 - GLOMERULAR FILTRATION AND RENAL BLOOD FLOW 27
RENAL CLEARANCE 27
GLOMERULAR FILTRATION 31
RENAL BLOOD FLOW 33
REGULATION OF RENAL BLOOD FLOW AND GLOMERULAR FILTRATION RATE 36
SUMMARY 42
CHAPTER 4 - RENAL TRANSPORT MECHANISMS: NACL AND WATER REABSORPTION ALONG THE NEPHRON 45
GENERAL PRINCIPLES OF MEMBRANE TRANSPORT 46
GENERAL PRINCIPLES OF TRANSEPITHELIAL SOLUTE AND WATER TRANSPORT 49
NACL, SOLUTE, AND WATER REABSORPTION ALONG THE NEPHRON 50
REGULATION OF NACL AND WATER REABSORPTION 62
SUMMARY 70
CHAPTER 5 - REGULATION OF BODY FLUID OSMOLALITY: REGULATION OF WATER BALANCE 73
ARGININE VASOPRESSIN 75
THIRST 82
RENAL MECHANISMS FOR DILUTION AND CONCENTRATION OF THE URINE 82
ASSESSMENT OF RENAL DILUTING AND CONCENTRATING ABILITY 89
SUMMARY 91
CHAPTER 6 - REGULATION OF EXTRACELLULAR FLUID VOLUME AND NACL BALANCE 93
CONCEPT OF EFFECTIVE CIRCULATING VOLUME 95
VOLUME-SENSING SYSTEMS 96
CONTROL OF RENAL NACL EXCRETION DURING EUVOLEMIA 103
CONTROL OF NA+ EXCRETION WITH VOLUME EXPANSION 105
CONTROL OF NA+ EXCRETION WITH VOLUME CONTRACTION 107
EDEMA 109
SUMMARY 112
CHAPTER 7 - REGULATION OF POTASSIUM BALANCE 115
OVERVIEW OF K+ HOMEOSTASIS 115
REGULATION OF PLASMA [K+] 117
ALTERATIONS OF PLASMA [K+] 119
K+ EXCRETION BY THE KIDNEYS 120
CELLULAR MECHANISMS OF K+ TRANSPORT BY PRINCIPAL CELLS AND INTERCALATED CELLS IN THE DISTAL TUBULE AND COLLECTING DUCT 122
REGULATION OF K+ SECRETION BY THE DISTAL TUBULE AND COLLECTING DUCT 123
FACTORS THAT PERTURB K+ EXCRETION 125
SUMMARY 130
CHAPTER 8 - REGULATION OF ACID-BASE BALANCE 131
HCO−3 BUFFER SYSTEM 132
OVERVIEW OF ACID-BASE BALANCE 132
RENAL NET ACID EXCRETION 134
HCO−3 REABSORPTION ALONG THE NEPHRON 135
REGULATION OF H+ SECRETION 138
FORMATION OF NEW HCO−3 139
RESPONSE TO ACID-BASE DISORDERS 143
SIMPLE ACID-BASE DISORDERS 146
ANALYSIS OF ACID-BASE DISORDERS 148
SUMMARY 150
CHAPTER 9 - REGULATION OF CALCIUM AND PHOSPHATE HOMEOSTASIS 153
CALCIUM 154
PHOSPHATE 160
INTEGRATIVE REVIEW OF PARATHYROID HORMONE AND CALCITRIOL ON CA++ AND PI HOMEOSTASIS 164
SUMMARY 165
CHAPTER 10 - PHYSIOLOGY OF DIURETIC ACTION 167
GENERAL PRINCIPLES OF DIURETIC ACTION 168
DIURETIC BRAKING PHENOMENON 169
MECHANISMS OF ACTION OF DIURETICS 171
EFFECT OF DIURETICS ON THE EXCRETION OF WATER AND SOLUTES 173
SUMMARY 176
ADDITIONAL READING 179
APPENDIX A - INTEGRATIVE CASE STUDIES 181
CASE 1 181
CASE 2 181
CASE 3 182
CASE 4 182
CASE 5 183
CASE 6 183
CASE 7 183
CASE 8 183
CASE 9 184
CASE 10 184
APPENDIX B - NORMAL LABORATORY VALUES 185
APPENDIX C - NEPHRON FUNCTION 187
APPENDIX D - ANSWERS TO SELF-STUDY PROBLEMS 191
CHAPTER 1 191
CHAPTER 2 193
CHAPTER 3 194
CHAPTER 4 195
CHAPTER 5 197
CHAPTER 6 198
CHAPTER 7 199
CHAPTER 8 200
CHAPTER 9 201
CHAPTER 10 201
APPENDIX E - ANSWERS TO INTEGRATIVE CASE STUDIES 205
CASE 1 205
CASE 2 206
CASE 3 207
CASE 4 208
CASE 5 209
CASE 6 210
CASE 7 210
CASE 8 210
CASE 9 211
CASE 10 211
APPENDIX F - REVIEW EXAMINATION 213
CHAPTER 2 213
CHAPTER 3 214
CHAPTER 4 215
CHAPTER 5 216
CHAPTER 6 217
CHAPTER 7 219
CHAPTER 8 220
CHAPTER 9 222
CHAPTER 10 222
INDEX 227