BOOK
Cancer of the Skin E-Book
Darrell S. Rigel | Robert Friedman | June K. Robinson | Merrick I. Ross | Clay J Cockerell | Henry Lim | Eggert Stockfleth | John M Kirkwood
(2011)
Additional Information
Book Details
Abstract
Cancer of the Skin, edited by Drs. Rigel, Robinson, Ross, Friedman, Cockerell, Lim, Stockfleth, and Kirkwood, is your complete, multimedia guide to early diagnosis and effective medical and surgical treatment of melanoma and other skin cancers. Thoroughly updated with 11 new chapters, this broad-based, comprehensive reference provides you with the latest information on clinical genetics and genomics of skin cancer, targeted therapy for melanoma, the Vitamin D debate concerning the risks and benefits of sun exposure, and other timely topics. A new, multi-disciplinary team of contributors and editors comprised of leading experts in this field offers truly diverse perspectives and worldwide best practices.
- Broaden your understanding of all aspects of skin cancer—from the underlying biology to clinical manifestations of the disease to diagnosis, and medical and surgical treatment—with this easy-to-use, comprehensive, multimedia reference.
- See conditions as they appear in practice with guidance from detailed full-color images and step-by-step procedural videos.
- Stay current with the latest advancements and therapies! 11 new chapters cover clinical genetics and genomics of skin cancer, targeted therapy for melanoma, the Vitamin D debate concerning the risks and benefits of sun exposure, and other essential topics.
- Get truly diverse perspectives and worldwide best practices from a new, multi-disciplinary team of contributors and editors comprised of the world’s leading experts
Access the complete text online—including image bank and video library—at www.expertconsult.com
Table of Contents
| Section Title | Page | Action | Price |
|---|---|---|---|
| Front Cover | Cover | ||
| Cancer of the skin | iii | ||
| Copyright | iv | ||
| Contents | v | ||
| Foreword | viii | ||
| Preface | ix | ||
| List of Contributors | x | ||
| Dedication & Acknowledgements | xv | ||
| Chapter 1 : The Biology of Skin Cancer Invasion and Metastasis | 1 | ||
| Introduction | 1 | ||
| Mechanisms Of Cancer Growth And Metastasis | 1 | ||
| Cancer Stem Cells And Proliferation | 8 | ||
| Future Outlook | 8 | ||
| References | 9 | ||
| Chapter 2 : Genetics of Skin Cancer | 12 | ||
| Introduction | 12 | ||
| Basal Cell Carcinoma | 12 | ||
| Squamous Cell Carcinoma | 15 | ||
| Cutaneous Malignant Melanoma | 16 | ||
| Future Outlook | 20 | ||
| References | 20 | ||
| Chapter 3 : The Biology of the Melanocyte | 23 | ||
| Introduction | 23 | ||
| History | 23 | ||
| Structure And Function\nOf The Melanocyte | 23 | ||
| Structure And Function Of The Melanosome | 26 | ||
| Melanin Biosynthesis And Its Regulation | 29 | ||
| Future Outlook | 38 | ||
| References | 38 | ||
| Chapter 4 : Skin Cancer: Burden of Disease | 40 | ||
| Introduction | 40 | ||
| Melanoma | 40 | ||
| Non-Melanoma Skin Cancer | 42 | ||
| Future Trends | 43 | ||
| References | 43 | ||
| Chapter 5 : Epidemiology of Skin Cancer | 44 | ||
| Introduction | 44 | ||
| History | 44 | ||
| Descriptive Epidemiology | 44 | ||
| Analytic Epidemiology | 52 | ||
| Interventional Epidemiology | 52 | ||
| Future Outlook | 53 | ||
| References | 53 | ||
| Chapter 6 : Etiological Factors in Skin Cancers: Environmental and Biological | 56 | ||
| Introduction | 56 | ||
| History | 56 | ||
| Risk Factors(Table 6.1) | 56 | ||
| Future Outlook | 64 | ||
| References | 64 | ||
| Chapter 7 : The Importance of Primary and Secondary Prevention Programs for Skin Cancer | 66 | ||
| Introduction | 66 | ||
| History | 66 | ||
| Targeting Prevention Efforts | 66 | ||
| Primary Prevention Of Skin Cancer: Protection From Ultraviolet Radiation | 67 | ||
| Secondary Prevention Of Skin Cancer: Early Detection | 69 | ||
| Future Outlook | 71 | ||
| Acknowledgement | 71 | ||
| References | 71 | ||
| Chapter 8 : Chemoprevention of Skin Cancers | 73 | ||
| Introduction | 73 | ||
| History Of Chemoprevention | 73 | ||
| Principles And Rationale For Chemoprevention Of Non-Melanoma Skin Cancers | 73 | ||
| Principles And Rationale For Melanoma Chemoprevention | 75 | ||
| Future Outlook | 78 | ||
| References | 78 | ||
| Chapter 9 : Current Concepts in Photoprotection | 80 | ||
| Introduction | 80 | ||
| History | 80 | ||
| Sunscreens | 80 | ||
| Adjunctive Photoprotection | 85 | ||
| Future Outlook | 87 | ||
| References | 87 | ||
| Chapter 10 : Actinic Keratoses and Other Precursors of Keratinocytic Cutaneous Malignancies | 89 | ||
| Introduction | 89 | ||
| Actinic Keratosis (Solar Keratosis) | 89 | ||
| Other Lesions Associated With Keratinocytic Malignancies | 94 | ||
| Cutaneous Squamous Cell Carcinoma In Situ And Its Variants | 96 | ||
| Future Outlook | 97 | ||
| References | 97 | ||
| Chapter 11 : Basal cell carcinoma | 99 | ||
| Introduction | 99 | ||
| History | 99 | ||
| Epidemiology | 99 | ||
| Pathogenesis | 99 | ||
| Biological Behavior | 101 | ||
| Clinical Presentation Of Bcc | 101 | ||
| Histology | 104 | ||
| Immunohistochemical Features | 113 | ||
| Treatment | 113 | ||
| Future Outlook | 120 | ||
| References | 120 | ||
| Chapter 12 : Squamous Cell Carcinoma | 124 | ||
| Introduction And History | 124 | ||
| Epidemiology | 124 | ||
| Pathogenesis | 125 | ||
| Clinical Features | 126 | ||
| Patient Evaluation, Diagnosis, And Differential Diagnosis | 130 | ||
| Pathology | 131 | ||
| Treatment | 135 | ||
| Prevention | 137 | ||
| Future Outlook | 138 | ||
| References | 138 | ||
| Chapter 13 : Adnexal Carcinomas of the Skin | 140 | ||
| Introduction | 140 | ||
| Epidemiology | 140 | ||
| Carcinomas Of The Eccrine And Apocrine Glands | 140 | ||
| Carcinomas Of The Hair Follicle | 146 | ||
| Carcinomas Of The Sebaceous Glands | 148 | ||
| Future Outlook | 148 | ||
| References | 149 | ||
| Chapter 14 : Paget’s Disease | 150 | ||
| Introduction | 150 | ||
| Mammary Paget’S Disease | 150 | ||
| Extramammary Paget’S Disease | 152 | ||
| Future Outlook | 156 | ||
| Acknowledgement | 156 | ||
| References | 156 | ||
| Chapter 15 : Sarcomas of the Skin | 157 | ||
| Introduction | 157 | ||
| History | 157 | ||
| Epidemiology | 157 | ||
| Pathogenesis And Etiology | 158 | ||
| General Principles Of Natural History And Diagnosis | 158 | ||
| Clinicopathologic Features Of Specific Types Of Cutaneous Sarcomas | 160 | ||
| Other Sarcomas In The Skin | 165 | ||
| Surveillance | 165 | ||
| Future Outlook | 167 | ||
| Acknowledgement | 167 | ||
| References | 167 | ||
| Chapter 16 : Kaposi’s Sarcoma | 168 | ||
| Introduction | 168 | ||
| History | 168 | ||
| Pathogenesis | 168 | ||
| Clinical Findings | 168 | ||
| Clinical Variants | 169 | ||
| Differential Diagnosis | 172 | ||
| Evaluation | 172 | ||
| Treatment | 174 | ||
| Future Outlook | 176 | ||
| Acknowledgement | 177 | ||
| References | 177 | ||
| Chapter 17 : Merkel Cell Carcinoma | 179 | ||
| Introduction | 179 | ||
| History | 179 | ||
| Epidemiology | 179 | ||
| Pathogenesis And Etiology | 179 | ||
| Clinical Features | 180 | ||
| Patient Evaluation, Diagnosis, And Differential Diagnosis | 180 | ||
| Pathology | 182 | ||
| Treatment | 183 | ||
| Future Outlook | 184 | ||
| References | 185 | ||
| Chapter 18 : Malignant Neoplasms: Vascular Differentiation | 186 | ||
| Introduction | 186 | ||
| History | 186 | ||
| Epidemiology | 186 | ||
| Pathogenesis And Etiology | 186 | ||
| Low-Grade Angiosarcomas | 187 | ||
| Intermediate Grade Angiosarcomas (Epithelioid Hemangioendothelioma) | 189 | ||
| High-Grade Angiosarcomas | 191 | ||
| Glomangiosarcomas | 192 | ||
| Future Outlook | 193 | ||
| References | 193 | ||
| Chapter 19 : Cutaneous Neoplastic Disorders Related to HPV and HIV Infection | 196 | ||
| Introduction | 196 | ||
| Neoplastic Disorders In Hpv-Infected Patients | 196 | ||
| Vaccination For Hpv | 203 | ||
| Neoplastic Disorders In Hiv-Infected Patients | 203 | ||
| Future Outlook | 205 | ||
| References | 205 | ||
| Chapter 20 : Pseudolymphomas of the Skin | 207 | ||
| Introduction | 207 | ||
| History And Classification | 207 | ||
| Epidemiology | 207 | ||
| Patient Evaluation, Diagnosis And Differential Diagnosis | 207 | ||
| Specific Clinicopathologic Entities | 207 | ||
| Lymphomatoid drug reactions | 210 | ||
| Future Outlook | 216 | ||
| References | 216 | ||
| Chapter 21 : Cutaneous T-cell Lymphoma: Mycosis Fungoidesand Sézary Syndrome | 217 | ||
| Introduction | 217 | ||
| History | 217 | ||
| Epidemiology | 217 | ||
| Pathogenesis And Etiology | 217 | ||
| Clinical Features | 218 | ||
| Diagnosis, Staging And Pathology | 220 | ||
| Prognosis | 225 | ||
| Treatment | 226 | ||
| Future Outlook | 229 | ||
| References | 229 | ||
| Chapter 22 : Dysplastic Nevi | 231 | ||
| Introduction | 231 | ||
| History | 231 | ||
| Epidemiology | 232 | ||
| Etiology And Pathogenesis: Genes, Environment, And Biology | 232 | ||
| Clinical Features | 234 | ||
| Histology | 238 | ||
| Management | 240 | ||
| Conclusions | 243 | ||
| Future Outlook | 243 | ||
| References | 243 | ||
| Chapter 23 : Congenital Melanocytic Nevi | 246 | ||
| Introduction | 246 | ||
| Epidemiology | 246 | ||
| Pathogenesis And Etiology | 246 | ||
| Clinical Features | 247 | ||
| Pathology | 254 | ||
| Patient Evaluation, Diagnosis And Differential Diagnosis | 254 | ||
| Potential Complications | 254 | ||
| Management | 256 | ||
| Future Outlook | 259 | ||
| References | 259 | ||
| Chapter 24 : The Many Faces of Melanoma | 262 | ||
| References | 271 | ||
| Chapter 25 : The Importance of Early Detection of Melanoma,Physician and Self-Examination | 272 | ||
| Introduction | 272 | ||
| History Of Melanoma Diagnosis | 272 | ||
| Clinical Considerations | 273 | ||
| Patient Evaluation, Diagnosis And Differential Diagnosis | 275 | ||
| Mass Screenings | 280 | ||
| Future Outlook | 280 | ||
| References | 280 | ||
| Chapter 26 : Prognostic Factors and Staging in Melanoma | 282 | ||
| Introduction | 282 | ||
| Ajcc Melanoma Staging System – Overview | 282 | ||
| Prognostic Factors In Primary Melanoma (Stages I And Ii) | 283 | ||
| Regional Disease | 288 | ||
| Distant Metastases | 291 | ||
| Future Outlook | 292 | ||
| References | 293 | ||
| Chapter 27 : Pathology of Melanoma: Interpretation and New Concepts | 295 | ||
| Introduction | 295 | ||
| Histologic Diagnosis Of Melanoma | 295 | ||
| Future Outlook | 315 | ||
| References | 315 | ||
| Chapter 28 : Management of the Patient with Melanoma | 318 | ||
| Introduction | 318 | ||
| Management | 318 | ||
| Future Outlook | 325 | ||
| References | 325 | ||
| Chapter 29 : Pregnancy and Melanoma | 327 | ||
| Introduction | 327 | ||
| History | 327 | ||
| Epidemiology | 327 | ||
| Pathogenesis And Etiology | 327 | ||
| Clinical Features And Prognosis | 328 | ||
| Patient Evaluation And Diagnosis | 330 | ||
| Pathology | 331 | ||
| Treatment | 331 | ||
| Future Outlook | 331 | ||
| References | 332 | ||
| Chapter 30 : Genetic Testing for Melanoma | 334 | ||
| Introduction | 334 | ||
| Gene Identification | 334 | ||
| Genetic Testing In Clinical Practice | 335 | ||
| Future Outlook | 339 | ||
| References | 340 | ||
| Chapter 31 : Spitz Nevus | 341 | ||
| History | 341 | ||
| Clinical Features | 341 | ||
| Pathology | 341 | ||
| Differentiation From Melanoma | 346 | ||
| Management Considerations | 348 | ||
| Future Outlook | 348 | ||
| References | 348 | ||
| Chapter 32 : Cutaneous Carcinogenesis Related to Dermatologic Therapy | 349 | ||
| Introduction | 349 | ||
| Potential Mechanisms Of Drug-Related Carcinogenesis | 349 | ||
| Therapies Associated With Increased Skin Cancer Risk | 349 | ||
| Future Outlook | 354 | ||
| References | 354 | ||
| Chapter 33 : Genetic Disorders Predisposing to Skin Malignancy | 357 | ||
| Basal Cell Nevus Syndrome | 357 | ||
| Inherited Epidermolysis Bullosa | 359 | ||
| Xeroderma Pigmentosum | 360 | ||
| Muir–Torre Syndrome | 361 | ||
| Epidermodysplasia Verruciformis | 362 | ||
| Other Genetic Conditions Associated With Skin Cancers | 363 | ||
| Future Outlook | 364 | ||
| References | 364 | ||
| Chapter 34 : Dermatologic Manifestations of Internal Malignancy | 367 | ||
| Introduction | 367 | ||
| History | 367 | ||
| Inherited Syndromes Associated With Internal Malignancy | 367 | ||
| Skin Changes Resulting from Hormone-Secreting Tumors | 367 | ||
| Proliferative and Inflammatory Dermatoses Associated with Internal Maligancy (Table 34.2) | 371 | ||
| Future Outlook | 377 | ||
| References | 378 | ||
| Chapter 35 : Dermatologic Manifestations of Systemic Oncologic Therapy of Cutaneous Malignancies | 379 | ||
| History | 379 | ||
| Cutaneous Manifestations Of Skin Cancer Systemic Therapy | 379 | ||
| Chemotherapeutic Agents that Lead to dermatologic Manifestations | 380 | ||
| Radiation Dermatitis | 383 | ||
| Future Outlook | 383 | ||
| References | 384 | ||
| Chapter 36 : The Dermoscopic Patterns of Melanoma and Non-Melanoma Skin Cancer | 386 | ||
| Introduction | 386 | ||
| Dermoscopic Equipment | 386 | ||
| Basal Cell Carcinoma | 387 | ||
| Squamous Cell Carcinoma | 388 | ||
| Melanoma | 389 | ||
| Future Outlook | 399 | ||
| References | 399 | ||
| Chapter 37 : Computer-Aided Diagnosis for Cutaneous Melanoma | 400 | ||
| Introduction | 400 | ||
| Computer-Enhanced Total Body Digital Imaging (TBDI) | 400 | ||
| Dermoscopy | 400 | ||
| Multispectral Imaging (Multispectral Digital Dermoscopy And Computer-Based Analysis) | 401 | ||
| Confocal Scanning Laser Microscopy (CLSM) (Reflectance Confocal Microscopy [RCM]) | 404 | ||
| Electrical Impedance Spectroscopy (EIS) | 404 | ||
| Cellular Electrical Resistance (Bio-Impedance) | 404 | ||
| Ultrasound Imaging | 404 | ||
| Magnetic Resonance Imaging (Mri) | 404 | ||
| Optical Coherence Tomography | 405 | ||
| Future Outlook | 405 | ||
| References | 405 | ||
| Chapter 38 : Confocal Microscopy in Skin Cancer | 407 | ||
| Introduction | 407 | ||
| History | 407 | ||
| Principles Of Reflectance Confocal Microscopy | 407 | ||
| Normal Skin | 409 | ||
| Non-Melanoma Skin Cancers | 409 | ||
| Melanocytic Neoplasms | 415 | ||
| RCM In Margin Mapping And Monitoring Of Treatment Of Skin Cancer | 421 | ||
| Future Outlook | 428 | ||
| References | 428 | ||
| Chapter 39 : Clinical Genomics for Melanoma Detection | 429 | ||
| Introduction | 429 | ||
| Current Melanoma Detection | 429 | ||
| Epidermal Genetic Information Retrieval (EGIR) | 429 | ||
| Egir Genomic Characterization Of Melanoma, Nevi, And Normal Skin | 430 | ||
| Genomic Detection Of Melanoma | 431 | ||
| Further Development | 431 | ||
| Future Outlook | 432 | ||
| Acknowledgements | 433 | ||
| References | 433 | ||
| Chapter 40 : Biopsy Techniques | 434 | ||
| Introduction | 434 | ||
| Decision-Making Process | 434 | ||
| Biopsy Techniques – Illustrated | 436 | ||
| Diagnosis Of Melanoma | 439 | ||
| Diagnosis Of Non-Melanoma Skin Cancer | 441 | ||
| Post-Biopsy Care | 441 | ||
| Summary | 441 | ||
| Future Outlook | 441 | ||
| References | 441 | ||
| Chapter 41 : Curettage and Electrodesiccation | 443 | ||
| Introduction | 443 | ||
| History | 443 | ||
| Description Of Procedure/Therapy | 443 | ||
| Indications And Contraindications | 448 | ||
| Future Outlook | 449 | ||
| References | 449 | ||
| Chapter 42 : Cryosurgery | 450 | ||
| Introduction | 450 | ||
| History | 450 | ||
| Basic Principles | 450 | ||
| Equipment | 451 | ||
| Techniques | 452 | ||
| Considerations And Applications | 454 | ||
| Indications And Contraindications | 458 | ||
| Postoperative Care And Expected Side Effects | 458 | ||
| Complications (Table 42.5) | 459 | ||
| Future Outlook | 461 | ||
| References | 461 | ||
| Chapter 43 : Topical Treatment of Skin Cancer | 462 | ||
| Introduction | 462 | ||
| DNA Analog Antimetabolites | 462 | ||
| 5-fluorouracil | 462 | ||
| Topical Imidazoquinolones | 466 | ||
| Cyclooxygenase (COX) Enzyme Inhibitors | 468 | ||
| Photodynamic Therapy | 469 | ||
| Retinoids | 470 | ||
| Bexarotene | 470 | ||
| Colchicine | 471 | ||
| Nitrogen Mustard | 471 | ||
| Emerging Therapies | 471 | ||
| Head-To-Head Trials Of Topical Chemotherapy | 473 | ||
| Combination Therapy | 473 | ||
| Future Outlook | 473 | ||
| References | 474 | ||
| Chapter 44 : Immune Response Modulators in the Treatment of Skin Cancer | 477 | ||
| Introduction | 477 | ||
| Interferons | 477 | ||
| Imiquimod | 482 | ||
| Resiquimod | 491 | ||
| Interleukin-2 (Il-2) | 492 | ||
| Other Therapies Which Include Immunomodulative Components | 492 | ||
| Future Outlook | 493 | ||
| References | 493 | ||
| Chapter 45 Photodynamic Therapy in Skin Cancer | 497 | ||
| Introduction | 497 | ||
| History | 497 | ||
| Overview | 498 | ||
| Topical PDT Therapy | 500 | ||
| Indications | 502 | ||
| Adverse Effects | 505 | ||
| Future Outlook | 505 | ||
| References | 506 | ||
| Chapter 46 : Surgical Excision for Non-Melanoma Skin Cancer | 508 | ||
| Introduction | 508 | ||
| Perioperative Management | 508 | ||
| Planning An Excision | 509 | ||
| Clinical, Surgical, And Histologic Margins | 510 | ||
| Incomplete Excision And Tumor Recurrence | 513 | ||
| Future Outlook | 513 | ||
| References | 513 | ||
| Chapter 47 : Mohs Surgery | 515 | ||
| Introduction | 515 | ||
| Description Of Procedure | 515 | ||
| General Indications and Contraindications | 517 | ||
| MMS for Skin Cancer Treatment | 518 | ||
| Therapuetic Controversies | 523 | ||
| Safety | 523 | ||
| Future Outlook | 524 | ||
| References | 524 | ||
| Chapter 48 : Treatment of Disseminated Non-Melanoma Skin Cancers | 526 | ||
| Introduction | 526 | ||
| Disseminated Basal Cell Carcinoma | 526 | ||
| Disseminated Squamous Cell Carcinoma | 526 | ||
| Disseminated Merkel Cell Carcinoma | 529 | ||
| Adnexal Carcinomas | 530 | ||
| Future Outlook | 530 | ||
| References | 531 | ||
| Chapter 49 : Surgical Excision of Melanoma | 532 | ||
| Introduction | 532 | ||
| History | 532 | ||
| Excision Margin Trials | 532 | ||
| Current Recommendations | 536 | ||
| Special Excisional Considerations | 537 | ||
| Excision Of Histologic Variants | 538 | ||
| Techniques For Wound Closure Of Resected Melanomas | 539 | ||
| Mohs Surgery In Melanoma | 541 | ||
| Future Outlook | 542 | ||
| References | 542 | ||
| Chapter 50 : Regional Lymph Node Surgery in Melanoma Patients | 544 | ||
| Introduction | 544 | ||
| Approach To Clinically Negative Nodal Basins | 544 | ||
| Sentinel Lymph Node Biopsy (Sln) | 544 | ||
| Regional Lymphadenectomy: Indications, Technique And Extent, And Morbidity | 552 | ||
| Future Outlook | 557 | ||
| References | 557 | ||
| Chapter 51 : Reconstructive Surgery for Skin Cancer | 559 | ||
| Introduction | 559 | ||
| Planning Reconstructive Surgery For Skin Cancer | 559 | ||
| Selection Of Reconstructive Techniques | 560 | ||
| Reconstruction Of The Head And Neck | 561 | ||
| Reconstruction Of The Trunk | 568 | ||
| Reconstruction Of The Pelvis/Perineum Area | 570 | ||
| Reconstruction Of The Upper And Lower Extremities | 572 | ||
| Future Outlook | 575 | ||
| References | 575 | ||
| Chapter 52 : Radiation Therapy in the Treatment of Skin Cancers | 576 | ||
| Introduction | 576 | ||
| Principles Of Radiation Therapy | 576 | ||
| Treatment Of Basal And Squamous Cell Carcinomas | 578 | ||
| Treatment Of Malignant Melanoma | 582 | ||
| Treatment Of Kaposi Sarcoma | 583 | ||
| Treatment Of Cutaneous Lymphomas | 585 | ||
| Treatment Of Merkel Cell Carcinoma | 586 | ||
| Future Outlook | 586 | ||
| References | 587 | ||
| Chapter 53 : Adjuvant Therapy for Cutaneous Melanoma | 589 | ||
| Introduction | 589 | ||
| Prior Approaches | 590 | ||
| Present Concepts | 590 | ||
| Indications And Contraindications For IFN | 600 | ||
| Next Phases Of Development Of Adjuvant Therapies | 602 | ||
| Future Outlook | 603 | ||
| References | 603 | ||
| Chapter 54 : Vaccine Therapy for Melanoma | 606 | ||
| Introduction | 606 | ||
| Requirements For An Effective Anti-Melanoma Vaccine | 606 | ||
| Types Of Vaccines | 606 | ||
| The Use Of Immunostimulatory Adjuvants | 608 | ||
| Patient Selection For Vaccine Therapy | 608 | ||
| Clinical Trials | 609 | ||
| Could Vaccines Actually Be Harmful? | 610 | ||
| Current Vaccine Therapy Trials | 610 | ||
| Future Outlook | 611 | ||
| References | 611 | ||
| Chapter 55 : Targeted Therapy for Melanoma | 613 | ||
| Introduction | 613 | ||
| Targets In Metastatic Melanoma | 613 | ||
| Targeting The Melanoma Tumor Microenvironment | 617 | ||
| Combining Approaches | 619 | ||
| Future Outlook | 619 | ||
| References | 622 | ||
| Chapter 56 : Imaging Work-up of the Patient with Melanoma | 623 | ||
| Introduction | 623 | ||
| Imaging At Diagnosis | 623 | ||
| Ultrasound | 623 | ||
| Imaging For Surveillance Of Advanced Disease | 625 | ||
| Management Summary | 627 | ||
| Future Outlook | 627 | ||
| References | 627 | ||
| Chapter 57 : Treatment of Disseminated Melanoma | 629 | ||
| Introduction | 629 | ||
| Epidemiology | 629 | ||
| Staging Of Metastatic Disease | 629 | ||
| Medical Therapy For Advanced Melanoma | 629 | ||
| Surgery For Advanced Melanoma | 632 | ||
| Brain Metastases | 632 | ||
| Conclusions | 632 | ||
| Future Outlook | 632 | ||
| References | 633 | ||
| Chapter 58 : Management of Skin Cancer in the Immunocompromised Patient | 634 | ||
| Introduction | 634 | ||
| Solid Organ Transplant Recipients | 634 | ||
| Human Immunodeficiency Virus/Acquired Immunodeficiency Disease | 641 | ||
| Future Outlook | 642 | ||
| References | 642 | ||
| Chapter 59 : Indoor Tanning | 644 | ||
| Introduction | 644 | ||
| History Of Intentional Tanning | 644 | ||
| Mechanisms Of Indoor Tanning | 645 | ||
| Effects Of Indoor Tanning | 646 | ||
| Indoor Tanning And Skin Cancer | 647 | ||
| Tanning And Vitamin D | 648 | ||
| Future Outlook | 648 | ||
| References | 649 | ||
| Chapter 60 : Vitamin D and UV: Risks and Benefits | 650 | ||
| History | 650 | ||
| Sources And Metabolism Of Vitamin D | 650 | ||
| Vitamin D In Health And Disease | 650 | ||
| Optimal Vitamin D Levels | 654 | ||
| Populations At Risk Of Low Vitamin D Status | 654 | ||
| Sun Exposure And Vitamin D Levels | 654 | ||
| Current Vitamin D Recommendations | 655 | ||
| Future Outlook | 655 | ||
| References | 655 | ||
| Chapter 61 : Photography in Skin Cancer Treatment | 657 | ||
| Introduction | 657 | ||
| Image Capture Overview | 657 | ||
| Total Body Photography (TBP) | 658 | ||
| Close-Up Photography | 659 | ||
| Image Capture And Management Software | 660 | ||
| Outside Services | 661 | ||
| Reimbursement For Services | 661 | ||
| Future Outlook | 661 | ||
| References | 661 | ||
| Chapter 62 : Psychological Responses and Coping Strategies in SkinCancer Patients | 662 | ||
| Introduction | 662 | ||
| Psychological Challenges Associated With Early-Stage Skin Cancers | 662 | ||
| Prevalence Of Psychological Distress In Patients With Skin Cancer | 662 | ||
| Psychological Distress In Individuals With A Strong Family History Of Skin Cancer | 664 | ||
| Vulnerability Factors: Demographic, Clinical, And Psychosocial Correlates Of Distress | 664 | ||
| Coping Skills And Strategies | 664 | ||
| Psychological Support For Patients With Skin Cancer | 665 | ||
| Cost-Effectiveness Of Psychosocial Interventions | 665 | ||
| Communication Skills And Strategies | 665 | ||
| Current Care And Future Directions | 666 | ||
| Future Outlook | 666 | ||
| References | 667 | ||
| Chapter 63 : Medical and Legal Aspects of Skin Cancer Patients | 668 | ||
| Introduction | 668 | ||
| Medical Malpractice | 668 | ||
| Consent/Refusal For Treatment | 670 | ||
| Medical Records | 670 | ||
| Adverse Events And Complications In Skin Cancer Treatment | 670 | ||
| Special Medicolegal Issues In Skin Cancer Treatment (Dermatopathology) | 672 | ||
| Future Outlook | 674 | ||
| References | 674 | ||
| Index | 676 |