BOOK
Practical Surgical Neuropathology: A Diagnostic Approach E-Book
(2010)
Additional Information
Book Details
Abstract
Practical Surgical Neuropathy—a volume in the new Pattern Recognition series— offers you a practical guide to solving the problems you encounter in the surgical reporting room. Drs. Arie Perry and Daniel J. Brat present diagnoses according to a pattern-based organization that guides you from a histological pattern, through the appropriate work-up, around the pitfalls, and to the best diagnosis. Lavish illustrations capture key neuropathological patterns for a full range of common and rare conditions, and a "visual index" at the beginning of the book directs you to the exact location of in-depth diagnostic guidance. No other single source delivers the practical, hands-on information you need to solve even the toughest diagnostic challenges in neuropathology.
- Provides all the information essential for completing a sign-out report: clinical findings, pathologic findings, diagnosis, treatment, and prognosis.
- Illustrates key pathologic and clinical aspects of disease entities through over 1430 superb, high-quality full-color images that help you evaluate and interpret biopsy samples.
- Presents a team of internationally recognized experts for authoritative and up-to-date information from leading diagnosticians in neuropathology.
- Features a user-friendly design with patterns color-coded to specific entities in the table of context and text and key points summarized in tables, charts, and graphs so you can quickly and easily find what you are looking for.
- Directs you to the chapter and specific page number of the in-depth diagnostic guidance you need through a unique, pattern-based visual index at the beginning of the book.
- Details key diagnostic features associated with rare and esoteric conditions in a visual encyclopedia with distinctive findings and artifacts for unusual patterns at the end of the book.
Table of Contents
| Section Title | Page | Action | Price |
|---|---|---|---|
| Front Cover | Cover | ||
| Practical Surgical Neuropathology: A Diagnostic Approach | iii | ||
| Copyright Page | iv | ||
| Contributors | v | ||
| Series Preface | vii | ||
| Preface | ix | ||
| Acknowledgments | xi | ||
| Contents | xiii | ||
| Practical Surgical Neuropathology Major Patterns | xv | ||
| Chapter 1: Neuropathology Patterns and Introduction | 1 | ||
| Central Nervous System Tumor Classification Schemes and Additional “Neuropathology Patterns” | 1 | ||
| Electron Microscopy | 1 | ||
| Immunohistochemistry | 11 | ||
| Molecular Diagnostics | 13 | ||
| References | 14 | ||
| Chapter 2: Normal Brain Histopathology | 15 | ||
| Cell Types | 15 | ||
| Tissue Organization | 22 | ||
| Suggested Readings | 33 | ||
| Chapter 3: Intraoperative Consultation and Optimal Processing | 35 | ||
| Types of Neurosurgical Specimens | 35 | ||
| Intraoperative Cytologic Preparations as a Complement to Frozen Tissue Sections | 36 | ||
| Fixation and Staining Options for Intraoperative Cytologic Preparations | 36 | ||
| Frozen Sectioning of Central Nervous System Tissue | 36 | ||
| Artifacts | 37 | ||
| Iatrogenically Introduced Hemostatic \nand Embolic Agents | 42 | ||
| The Bottom Line: What Does the SurgeonNeed to Know? | 42 | ||
| Suggested Readings | 45 | ||
| References | 45 | ||
| Chapter 4: Neuroradiology: The Surrogate of Gross Neuropathology | 47 | ||
| Basic Noninvasive Diagnostic Imaging Techniques | 47 | ||
| Advanced Noninvasive Diagnostic Imaging Techniques | 51 | ||
| Basic Invasive Diagnostic Imaging Techniques | 52 | ||
| Advanced Invasive Therapeutic Techniques | 53 | ||
| Imaging Patterns in Neuroradiology | 53 | ||
| Advanced Strategies of Lesion Analysis | 59 | ||
| Conclusion | 61 | ||
| Selected Readings | 62 | ||
| References | 62 | ||
| Chapter 5: Astrocytic and Oligodendroglial Tumors | 63 | ||
| Introduction and Brief Historical Overview | 63 | ||
| Diffuse Astrocytomas | 63 | ||
| Pilocytic Astrocytoma | 82 | ||
| Subependymal Giant-Cell Astrocytoma | 88 | ||
| Pleomorphic Xanthoastrocytoma | 91 | ||
| Oligodendroglioma | 93 | ||
| Oligoastrocytoma | 99 | ||
| Suggested Readings | 101 | ||
| References | 101 | ||
| Chapter 6: Ependymomas and Choroid Plexus Tumors | 103 | ||
| Definitions and Synonyms | 103 | ||
| Brief Historical Overview | 103 | ||
| Ependymal Tumors | 103 | ||
| Choroid Plexus Tumors | 113 | ||
| Suggested Readings | 120 | ||
| References | 120 | ||
| Chapter 7: Neuronal and Glioneuronal Neoplasms | 125 | ||
| Gangliogliomas and Gangliocytomas (“Ganglion Cell Tumors”) | 125 | ||
| Desmoplastic Infantile Astrocytoma \nand Ganglioglioma | 130 | ||
| Dysplastic Gangliocytoma of the Cerebellum (Lhermitte-Duclos Disease) | 133 | ||
| Central Neurocytoma and Other Neurocytic Neoplasms | 135 | ||
| Cerebellar Liponeurocytoma | 139 | ||
| Dysembryoplastic Neuroepithelial Tumor | 140 | ||
| Papillary Glioneuronal Tumor | 143 | ||
| Rosette-Forming Glioneuronal Tumor \nof the Fourth Ventricle | 144 | ||
| Hypothalamic Hamartoma | 146 | ||
| Suggested Readings | 148 | ||
| References | 148 | ||
| Chapter 8: Pineal Parenchymal Tumors | 151 | ||
| Introduction, Definitions, and Synonyms | 151 | ||
| Brief Historical Overview | 151 | ||
| Incidence and Demographics | 152 | ||
| Localization and Clinical Manifestations | 152 | ||
| Radiologic Features and Gross Pathology | 152 | ||
| Histopathology | 152 | ||
| Histologic Variants and Grading | 156 | ||
| Principles of Diagnosis and Grading on \nSmall or Artifact-Ridden Samples | 157 | ||
| Differential Diagnosis | 157 | ||
| Ancillary Diagnostic Studies | 160 | ||
| Treatment and Prognosis | 161 | ||
| Suggested Readings | 162 | ||
| References | 162 | ||
| Chapter 9: Embryonal (Primitive) Neoplasms of the Central Nervous System | 165 | ||
| Definition and Synonyms | 165 | ||
| Brief Historical Overview | 165 | ||
| Medulloblastoma (Cerebellar Primitive Neuroectodermal Tumor) | 166 | ||
| Central Nervous System Supratentorial Primitive Neuroectodermal Tumors and Related Embryonal Neoplasms | 175 | ||
| Atypical Teratoid Rhabdoid Tumor | 179 | ||
| Suggested Readings | 183 | ||
| References | 183 | ||
| Chapter 10: Meningiomas | 185 | ||
| Introduction and Proposed Etiologies | 185 | ||
| Definition and Analogies with Meningothelial Cells | 185 | ||
| Brief Historical Overview of Nomenclature and Histogenetic Notions | 186 | ||
| Incidence and Demographics | 186 | ||
| Localization and Clinical Manifestations | 186 | ||
| Multiple Meningiomas | 188 | ||
| Radiologic Features and Gross Pathology | 189 | ||
| Histopathology | 191 | ||
| Histologic Variants and Grading | 192 | ||
| Meningiomas That Are Mostly Benign (WHO Grade I) | 193 | ||
| WHO Grade II Meningiomas | 198 | ||
| WHO Grade III (Malignant) Meningiomas | 203 | ||
| Other Meningioma Patterns Not Included in the WHO | 205 | ||
| Metastasis of and to Meningiomas | 205 | ||
| Differential Diagnosis | 210 | ||
| Ancillary Diagnostic Studies | 212 | ||
| Genetics | 214 | ||
| Treatment and Prognosis | 215 | ||
| Suggested Readings | 216 | ||
| References | 216 | ||
| Chapter 11: Mesenchymal Tumors of the Central Nervous System | 219 | ||
| Brief Historical Overview | 219 | ||
| Incidence and Demographics | 219 | ||
| Lipoma and Liposarcoma | 220 | ||
| Fibroblastic–Myofibroblastic Tumors | 220 | ||
| Smooth Muscle Tumors | 225 | ||
| Skeletal Muscle Tumors | 226 | ||
| Vascular Tumors | 227 | ||
| Bone Tumors | 228 | ||
| Chondromatous Tumors | 230 | ||
| Chordoma | 231 | ||
| Undifferentiated Sarcoma | 232 | ||
| Miscellaneous Tumors and Tumor-like Lesions | 233 | ||
| Suggested Readings | 234 | ||
| References | 234 | ||
| Chapter 12: Peripheral Nerve Sheath Tumors | 235 | ||
| Traumatic Neuroma | 235 | ||
| Schwannoma | 240 | ||
| Neurofibroma | 251 | ||
| Perineurioma | 260 | ||
| Granular Cell Tumor | 267 | ||
| Miscellaneous Benign Neurogenic Tumors | 268 | ||
| Primary Malignant Tumors of Nerve | 272 | ||
| Malignant Granular Cell Tumor | 279 | ||
| Primitive Neuroectodermal Tumor of the Nerve | 281 | ||
| Suggested Readings | 282 | ||
| References | 282 | ||
| Chapter 13: Epithelial, Neuroendocrine, and Metastatic Lesions | 287 | ||
| Metastatic Epithelial and Epithelioid Neoplasms | 287 | ||
| Paraganglioma | 296 | ||
| Papillary Tumor of the Pineal Region | 299 | ||
| Cysts of the Central Nervous System | 303 | ||
| Suggested Readings | 312 | ||
| References | 312 | ||
| Chapter 14: Lymphomas and Histiocytic Tumors | 315 | ||
| Definition and Synonyms | 315 | ||
| Histiocytic Disorders | 326 | ||
| Suggested Readings | 331 | ||
| References | 331 | ||
| Chapter 15: Germ Cell Tumors | 333 | ||
| Definition and Synonyms | 333 | ||
| Brief Historical Overview | 333 | ||
| Incidence and Demographics | 334 | ||
| Clinical Manifestations and Localization | 334 | ||
| Radiologic Features and Gross Pathology | 335 | ||
| Histopathology | 336 | ||
| Histologic Variants | 336 | ||
| Ancillary Diagnostic Studies | 343 | ||
| Differential Diagnosis | 346 | ||
| Genetics | 348 | ||
| Treatment and Prognosis | 348 | ||
| Suggested Readings | 350 | ||
| References | 350 | ||
| Chapter 16: Melanocytic Neoplasms of the Central Nervous System | 353 | ||
| Definitions and Synonyms | 353 | ||
| Brief Historical Overview | 353 | ||
| Melanocytoma and Melanoma | 353 | ||
| Neurocutaneous Melanosis/Melanomatosis | 357 | ||
| Suggested Readings | 358 | ||
| References | 359 | ||
| Chapter 17: Other Glial Neoplasms | 361 | ||
| Angiocentric Glioma | 361 | ||
| Astroblastoma | 363 | ||
| Chordoid Glioma | 364 | ||
| Suggested Readings | 369 | ||
| References | 369 | ||
| Chapter 18: Pathology of the Pituitaryand Sellar Region | 371 | ||
| The Sellar Region and Normal Pituitary | 371 | ||
| Anterior Pituitary Tumors | 372 | ||
| Invasion and Malignancy in Anterior \nPituitary Tumors | 397 | ||
| Pituitary Hyperplasia | 400 | ||
| Other Primary Pituitary Tumors | 401 | ||
| Miscellaneous Sellar Region Tumors | 402 | ||
| Sellar Region Cysts | 408 | ||
| Inflammatory Lesions | 409 | ||
| Infectious Lesions | 411 | ||
| Acknowledgment | 412 | ||
| References | 412 | ||
| Chapter 19: Therapy-Associated Neuropathology | 417 | ||
| Radiation Necrosis and Other Forms \nof Radiation Injury | 417 | ||
| Therapy-Induced Leukoencephalopathies and Vasculopathies | 421 | ||
| Therapy-Induced Secondary Neoplasms | 424 | ||
| Suggested Readings | 425 | ||
| References | 425 | ||
| Chapter 20: Familial Tumor Syndromes | 427 | ||
| Neurofibromatosis Type 1 | 427 | ||
| Neurofibromatosis Type 2 | 432 | ||
| Schwannomatosis | 435 | ||
| Tuberous Sclerosis Complex | 436 | ||
| Von Hippel-Lindau Disease | 439 | ||
| Turcot Syndrome | 443 | ||
| Nevoid Basal Cell Carcinoma Syndrome (Gorlin Syndrome) | 444 | ||
| Cowden Disease | 445 | ||
| Li-Fraumeni Syndrome | 447 | ||
| Carney Complex | 448 | ||
| Rhabdoid Predisposition Syndrome | 450 | ||
| Other Syndromes | 451 | ||
| Suggested Readings | 452 | ||
| References | 452 | ||
| Chapter 21: Infections and Inflammatory Disorders | 455 | ||
| Meningitis | 456 | ||
| Encephalitis | 468 | ||
| Focal Discrete Central Nervous System Infection | 477 | ||
| Inflammatory Conditions of the Nervous System Mimicking Infections | 481 | ||
| Central Nervous System Manifestations of Rheumatoid Arthritis | 481 | ||
| Central Nervous System Manifestations of Wegener Granulomatosis | 483 | ||
| Acknowledgment | 483 | ||
| Suggested Readings | 484 | ||
| References | 484 | ||
| Chapter 22: White Matter and Myelin Disorders | 485 | ||
| Multiple Sclerosis | 485 | ||
| Neuromyelitis Optica | 494 | ||
| Acute Disseminated Encephalomyelitis | 495 | ||
| Acute Hemorrhagic Leukoencephalitis | 496 | ||
| Progressive Multifocal Leukoencephalopathy | 497 | ||
| Subacute Sclerosing Panencephalitis | 498 | ||
| HIV Leukoencepahlopathy and Vacuolar Myelopathy | 500 | ||
| Binswanger Encephalopathy | 502 | ||
| Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy | 503 | ||
| Fat Embolism | 504 | ||
| Leukodystrophies | 506 | ||
| Osmotic Demyelination Syndrome (Central Pontine and Extrapontine Myelinolysis) | 510 | ||
| Suggested Readings | 512 | ||
| References | 512 | ||
| Chapter 23: Pathology of Epilepsy | 515 | ||
| Malformations of Cortical Development (Cortical Dysplasia) | 515 | ||
| Hippocampal Sclerosis | 520 | ||
| Infarct Including Porencephalic Cyst | 522 | ||
| Rasmussen Encephalitis | 523 | ||
| Suggested Readings | 525 | ||
| References | 525 | ||
| Chapter 24: Vascular and Ischemic Disorders | 527 | ||
| Ischemic Cerebral Infarct | 528 | ||
| Hypertensive Cerebrovascular Disease | 532 | ||
| Cerebral Amyloid Angiopathy | 535 | ||
| Vasculitis Involving the Nervous System | 537 | ||
| Giant-Cell Arteritis | 537 | ||
| Primary Angiitis of the Central Nervous System | 538 | ||
| Polyarteritis Nodosa | 539 | ||
| Cerebral Aneurysms | 539 | ||
| Fusiform and Infective (“Mycotic”) Aneurysms | 541 | ||
| Vascular Malformations | 542 | ||
| Cerebral Autosomal Dominant Arteriopathy \nwith Subcortical Infarcts and Leukoencephalopathy | 546 | ||
| Moyamoya Syndrome | 547 | ||
| Suggested Readings | 549 | ||
| References | 549 | ||
| Chapter 25: Biopsy Pathology of Neurodegenerative Disorders in Adults | 551 | ||
| Alzheimer Disease | 553 | ||
| Dementia with Lewy Bodies and Idiopathic Parkinson Disease | 558 | ||
| Frontotemporal Lobar Degeneration \nand Pick Disease | 564 | ||
| Human Prion Diseases (Transmissible Spongiform Encephalopathies) Including Creutzfeldt-Jakob Disease | 566 | ||
| Suggested Readings | 570 | ||
| References | 571 | ||
| Index | 573 |