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Basics of Anesthesia E-Book

Basics of Anesthesia E-Book

Ronald D. Miller | Manuel Pardo

(2011)

Additional Information

Book Details

Abstract

With the most authoritative and complete overview of anesthesia theory and practice, the latest edition of Basic Anesthesia, edited by noted anesthesiologist Ronald D. Miller, MD and Manuel C. Pardo, Jr., MD, continues to serve as an excellent primer on the scope and practice of anesthesiology. Widely acknowledged as the foremost introductory text, the new edition—now presented in full color throughout—has been thoroughly updated to reflect new and rapidly changing areas in anesthesia practice including new chapters on awareness under anesthesia, quality and patient safety, orthopedics, and expanded coverage of new ultrasound techniques in regional anesthesiology with detailed illustrated guidance.

  • Obtain a clear overview of everything you need to know about the fundamentals of anesthesia, including basic science and emerging clinical topics.
  • Efficiently retain and synthesize information more easily thanks to a concise, at-a-glance format with numerous illustrations and tables throughout the book that condense complex concepts, and ‘Questions of the Day’ to assist you in understanding key material presented in each chapter.
  • Discover the newest in anesthesiology with rigorously updated chapters and the addition of appropriate new chapters on important emerging topics such as awareness under anesthesia; quality and patient safety; orthopedics; and expanded coverage of new ultrasound techniques in regional anesthesiology.
  • Learn from one of the very best. World-renowned anesthesiologist Dr. Ronald D. Miller, along with new co-editor Dr. Manuel Pardo, presents definitive coverage on new and rapidly changing areas in anesthesia practice.
  • Grasp vital concepts easily thanks to concise, easy-to-read, masterfully edited chapters and a user-friendly format—now presented in full color throughout.
  • Gain a detailed visual understanding on how to perform ultrasound techniques in regional anesthesiology (Peripheral Nerve Blocks) using illustrations and high-quality images.

Table of Contents

Section Title Page Action Price
Front Cover Cover
Basics of Anesthesia iii
Copyright iv
Contributors v
Preface ix
Contents xi
Section I: Introduction 1
Chapter 1: History of Anesthesia 3
Inhaled Anesthetics 3
Local Anesthetics 6
Neuraxial Block 6
Methods For Delivery Of General Anesthesia 6
Difficult Airway 7
Neuromuscular Blocking Drugs 7
Improved Inhaled And Intravenous Anesthetics 8
Ablation Of The Stress Response 8
Recent Developments 8
Modern Anesthesiology Practice 9
Questions Of The Day 9
References 10
Chapter 2: Scope of Anesthesia Practice 11
Definition Of Anesthesiology As A Speciality 11
Evolution Of Anesthesia As A Multidisciplinary Medical Specialty 12
Perioperative Patient Care 13
Training And Certification In Anesthesiology 13
Other Anesthetic Providers 14
Quality Of Care And Safety In Anesthesia 15
Organizations With Emphasis On Anesthesia Quality And Safety 15
Professional Liability 16
Risks Of Anesthesia 17
Hazards Of Working In The Operating Room 18
Summary And Future Outlook 18
Questions Of The Day 18
Acknowledgment 18
References 18
Chapter 3: Approach to Learning Anesthesia 20
Competencies 20
Structured Approach To Anesthesia Care\t 20
Questions Of The Day 24
References 25
Chapter 4: Medical Informatics 26
Purpose Of Medical Informatics 26
Computers In Medicine 27
Electronic Medical Record 29
Evidence-Based Medicine 29
Decision Support 31
Conclusion 32
Questions Of The Day 32
References 32
Section II: Pharmacology and Physiology 33
Chapter 5: Basic Pharmacologic Principles 35
Pharmacokinetics 35
Pharmacodynamics 44
Questions of the Day 47
Acknowledgment 47
References 48
Chapter 6: Clinical Cardiac and Pulmonary Physiology 50
Hemodynamics 50
Cardiac Reflexes 53
Coronary Blood Flow 54
Pulmonary Circulation 54
Pulmonary Gas Exchange 56
Pulmonary Mechanics 61
Control Of Breathing 62
Integration Of The Heart And Lungs 64
Questions of the Day 65
References 65
Chapter 7: Autonomic Nervous System 66
Anatomy Of The Autonomic Nervous System 66
Adrenergic Pharmacology 70
Selective α-Adrenergic Receptor Agonists 73
β2-Adrenergic Receptor Agonists 74
α-Adrenergic Receptor Antagonists 74
β-Adrenergic Antagonists 74
Cholinergic Pharmacology 75
Questions of the Day 76
Acknowledgment 76
References 77
Chapter 8: Inhaled Anesthetics 78
History 78
The First Inhaled Anesthetics 78
Inhaled Anesthetics Between 1920 And 1940 79
Fluorine Chemistry And Modern Inhaled Anesthetics 80
Mechanism Of Action 81
Physical Properties 82
Relative Potency Of Inhaled Anesthetics 83
Pharmacokinetics Of Inhaled Anesthetics 84
Effects On Organ Systems 90
Questions of the Day 96
Acknowledgment 97
References 97
Chapter 9: Intravenous Anesthetics 99
Propofol 99
Fospropofol 102
Barbiturates 103
Benzodiazepines 106
Ketamine 109
Etomidate 111
Dexmedetomidine 112
Questions of the Day 113
References 113
Chapter 10: Opioids 115
Basic Pharmacology 115
Clinical Pharmacology 118
Clinical Application 126
Emerging Developments 127
Questions of the Day 127
Acknowledgment 127
References 127
Chapter 11: Local Anesthetics 130
History 130
Mechanisms Of Action And Factors Affecting Block 131
Pharmacokinetics 136
Adverse Effects 136
Specific Local Anesthetics 138
Future Local Anesthetics 141
Questions of the Day 141
References 141
Chapter 12: Neuromuscular Blocking Drugs 143
Clinical Uses 144
Neuromuscular Junction 144
Structure-Activity Relationships 146
Depolarizing Neuromuscular Blocking Drugs 148
Nondepolarizing Neuromuscular Blocking Drugs 151
Long-Acting Nondepolarizing Neuromuscular Blocking Drugs 152
Intermediate-Acting Nondepolarizing Neuromuscular Blocking Drugs 153
Short-Acting Nondepolarizing Neuromuscular Blocking Drugs 154
Monitoring The Effects Of Nondepolarizing Neuromuscular Blocking Drugs 154
Antagonism Of Nondepolarizing Neuromuscular Blocking Drugs 158
Adverse Outcomes From Inadequate Antagonism Of Neuromuscular Blockade 158
Summary 160
Questions of the Day 160
References 160
Section III: Preoperative Preparation And Intraoperative Management 163
Chapter 13: Preoperative Evaluation and Medication 165
Overview 165
Consultations 176
Testing 176
Medications 178
Fasting 184
Formulation Of Anesthestic Plan, Assessment Of Risk, And Informed Consent 185
Conclusion 185
Questions of the Day 186
Acknowledgment 186
References 186
Appendix A: Basic Standards For Preanesthesia Care 189
Chapter 14: Choice of Anesthetic Technique 190
Anesthetic Technique 190
Preparation for Anesthesia 195
Pharmacoeconomics 196
Questions of the Day 196
Acknowledgment 196
References 196
Chapter 15: Anesthesia Delivery Systems 198
Anesthesia Workstation 198
Vaporizers 202
Anesthetic Breathing Systems 204
Anesthesia Machine Ventilators 209
Pollution Of The Atmosphere With Anesthetic Gases 211
Elimination Of Carbon Dioxide 212
Checking Anesthesia Machine And Circle System Function 214
Questions of the Day 216
Acknowledgment 216
References 217
Chapter 16: Airway Management 219
Anatomy And Physiology Of The Upper Airway 220
Airway Assessment 220
Airway Management Techniques 227
Flexible Fiberoptic Laryngoscopy 234
Rigid Fiberoptic Laryngoscopes/Videolaryngoscopes 235
Retrograde Tracheal Intubation 237
Blind Nasotracheal Intubation 237
Supraglottic Airway Devices 237
Transtracheal Techniques 241
Tracheal Extubation 241
Airway Management In Infants And Children 243
Questions of the Day 250
References 250
Chapter 17: Spinal and Epidural Anesthesia 252
Comparison Of Spinal And Epidural Anesthesia 253
Anatomy 253
Preoperative Preparation 262
Spinal Anesthesia 263
Epidural Anesthesia 273
Combined Spinal-Epidural Anesthesia 280
Combined Epidural-General Anesthesia 281
Questions of the Day 281
References 282
Chapter 18: Peripheral Nerve Blocks 284
Preparation For Nerve Blocks 284
Specific Block Techniques 285
Peripheral Nerve Catheters 287
Cervical Plexus Block 287
Brachial Plexus Anatomy 287
Distal Nerve Blocks Of The Upper Extremity-Forearm Block 292
Blocks Of The Lower Extremity 293
Intravenous Regional Anesthesia 297
Questions of the Day 298
Acknowledgment 298
References 299
Chapter 19: Patient Positioning and Associated Risks 300
Cardiovascular Concerns 300
Pulmonary Concerns 301
Specific Positions 302
Peripheral Nerve Injury 310
Perioperative Eye Injury And Visual Loss 314
Evaluation And Treatment Of Perioperative Neuropathies 315
Anesthesia Outside The Operating Room 315
Conclusion 316
Questions of the Day 316
References 316
Chapter 20: Anesthetic Monitoring 319
Electrocardiography 320
Arterial Blood Pressure Cuff Monitoring 321
Central Venous Pressure Monitoring 324
Pulmonary Artery Catheter Measurements 324
Echocardiography 325
Pulse Oximetry 327
Evoked Potentials 327
Capnography 328
Brain Electrical Activity Monitoring 329
Temperature Monitoring 330
Inhaled Anesthetic Monitoring 330
Questions of the Day 331
References 331
Appendix B: Standards For Basic Anesthetic Monitoring 332
Standard I 332
Standard II 332
Oxygenation 332
Ventilation 333
Circulation 333
Body Temperature 333
Chapter 21: Acid-Base Balance and Blood Gas Analysis 334
Definitions 334
Regulation Of The Hydrogen Ion Concentration 335
Measurement Of Arterial Blood Gases 337
Differential Diagnosis Of Acid-Base Disturbances 339
Other Information Provided By Blood Gases And pH 343
Questions of the Day 347
Acknowledgment 347
References 347
Chapter 22: Hemostasis 348
Coagulation 349
Common Laboratory Tests Of Hemostasis 351
Disorders Associated With Altered Hemostasis During Surgery 352
Disorders Favoring Thrombosis 356
Anticoagulants, Thrombolytics, And Antiplatelet Drugs 357
An Approach To Patients Who Are Anticoagulated 359
An Approach To Patients Receiving Antiplatelet Therapy 360
Neuraxial Interventions In Patients Being Treated With Anticoagulant Drugs 361
An Intraoperative Approach To Uncontrolled Bleeding 361
Questions of the Day 363
Acknowledgment 363
References 363
Chapter 23: Fluid Management 364
Overview Of Fluid And Electrolyte Physiology 364
Perioperative Fluid Balance 365
Fluid Replacement Solutions 365
Perioperative Fluid Strategies 368
Questions of the Day 371
Acknowledgment 371
References 371
Chapter 24: Blood Therapy 372
Blood Therapy Procedures 372
Decision To Transfuse 373
Blood Components 374
Complications Of Blood Therapy 376
Autologous Blood Transfusions 378
Conclusions And Future Directions 379
Questions of the Day 379
References 379
Section IV: Special Anesthetic Considerations 381
Chapter 25: Cardiovascular Disease 383
Coronary Artery Disease 384
Valvular Heart Disease 393
Disturbances Of Cardiac Conduction And Rhythm 397
Artificial Cardiac Pacemakers 399
Essential Hypertension 400
Congestive Heart Failure 402
Hypertrophic Cardiomyopathy 403
Pulmonary Hypertension And Cor Pulmonale 404
Cardiac Tamponade 404
Aneurysms Of The Aorta 405
Cardiopulmonary Bypass 406
Questions of the Day 415
References 415
Chapter 26: Congenital Heart Disease 418
Fundamental Pathophysiology In Congenital Heart Disease 418
Perioperative Management 421
Postoperative Care 429
Questions of the Day 429
Acknowledgment 429
References 429
Chapter 27: Chronic Pulmonary Disease 430
Asthma 431
Chronic Obstructive Pulmonary Disease 433
Pulmonary Hypertension 434
Obstructive Sleep Apnea 435
Anesthesia For Lung Resection 436
Gas Exchange During One-Lung Ventilation 442
Conclusion Of Surgery 446
Postoperative Pulmonary Complications 446
Mediastinoscopy 446
Questions of the Day 446
Acknowledgment 446
References 446
Chapter 28: Renal, Liver, and Biliary Tract Disease 448
Renal Disease 448
Liver Disease 455
Diseases Of The Biliary Tract 460
Questions of the Day 461
Acknowledgment 461
References 461
Chapter 29: Nutritional and Gastrointestinal Disease 463
Nutritional Disorders 463
Gastrointestinal Disease 465
Endocrine Disorders 467
Questions of the Day 473
Acknowledgment 473
References 473
Chapter 30: Central Nervous System Disease 476
Neuroanatomy 476
Neurophysiology 477
Intracranial Pressure 478
Neuroprotection 479
Neurophysiologic Monitoring 480
Anesthesia For Neurosurgery 480
Common Clinical Cases 483
Questions of the Day 485
Acknowledgment 485
References 485
Chapter 31: Ophthalmology and Otolaryngology 486
Ophthalmology 486
Otolaryngology 492
Questions of the Day 497
References 497
Chapter 32: Anesthesia for Orthopedic Surgery 499
Rheumatologic Disorders 499
Spine Surgery 503
Surgery In The Sitting Position 507
Fractured Hip 508
Total Joint Replacement 509
Questions of the Day 511
References 512
Chapter 33: Obstetrics 514
Physiologic Changes In Pregnant Women 515
Physiology Of The Uteroplacental Circulation 519
Stages Of Labor 520
Anatomy Of Labor Pain 520
Methods Of Labor Analgesia 521
Neuraxial Techniques 523
Contraindications To Neuraxial Anesthesia 526
Complications Of Regional Anesthesia 526
Other Nerve Blocks For Labor 527
Inhaled Analgesia For Vaginal Delivery 527
Anesthesia For Cesarean Delivery 528
Abnormal Presentations And Multiple Births 531
Hypertensive Disorders Of Pregnancy 532
Hemorrhage In Pregnant Women 534
Amniotic Fluid Embolism 536
Anesthesia For Nonobstetric Surgery During Pregnancy 536
Diagnosis And Management Of Fetal Distress 538
Evaluation Of The Neonate And Neonatal Resuscitation 539
Questions of the Day 543
References 543
Chapter 34: Pediatrics 546
Developmental Physiology 547
Pharmacologic Differences 550
Fluids And Electrolytes 552
Transfusion Therapy 553
Pediatric Airway 554
Anesthetic Considerations 555
Medical And Surgical Diseases Affecting The Neonate 559
Special Anesthetic Considerations 565
Questions of the Day 566
Acknowledgments 566
References 566
Chapter 35: Elderly Patients 568
Why Geriatric Anesthesiology Is Important 568
Morbidity And Mortality Rates 569
Medications To Avoid In The Geriatric Population 569
Age-Related Physiologic Changes 570
Perioperative Care In The Elderly 572
Postoperative Care 576
Reduction Of Perioperative Risk 577
Summary 577
Questions of the Day 577
Acknowledgments 578
References 578
Chapter 36: Organ Transplantation 580
Considerations For Organ Transplantation 580
Kidney Transplantation 581
Liver Transplantation 582
Heart Transplantation 585
Lung Transplantation 586
Pancreas Transplantation 586
Conclusions 587
Questions of the Day 587
Acknowledgments 587
References 587
Chapter 37: Outpatient Anesthesia 588
Patient Goals And Expectations 589
Four Key Focus Points For Success In Outpatient Anesthesia 589
Clinical Issues 590
Techniques Of Anesthesia For Outpatient Surgery 591
Some Topics Of Importance In Outpatient Anesthesia 593
Postoperative Issues 598
Unique Roles Of The Anesthesiologist And Medical Director 598
Conclusion 599
Questions of the Day 599
Acknowledgments 599
References 600
Appendix C: Guidelines For Case And Patient Selection 606
Appendix D: An Allocation Of Medications To Anesthesia Controlled Devices, Emergency Boxes, And Anesthesia Carts 607
Appendix E: An Outcomes Management Program 608
Appendix F: Some Policies And Procedures 612
Chapter 38: Procedures Performed Outside the Operating Room 617
Characteristics of Remote Locations 618
Radiation Safety 619
Allergic Reactions 619
Noninvasive X-Ray Procedures 620
Computed Tomography 620
Magnetic Resonance Imaging 621
Invasive X-Ray Procedures 622
Radiation Therapy 623
Electroconvulsive Therapy 624
Cardiac Catheterization-Angiography, Intervention, Electrophysiology 626
Cardioversion 626
Extracorporeal Shock Wave Lithotripsy 627
Dental Surgery 628
Questions Of The Day 628
References 628
Section V: Recovery Period 629
Chapter 39: Postanesthesia Recovery 631
Admission To The Postanesthesia Care Unit 632
Early Postoperative Physiologic Disorders 632
Upper Airway Obstruction 632
Hypoxemia In The Pacu 635
Pulmonary Edema In The Pacu 637
Oxygen Supplementation 637
Hemodynamic Instability 638
Delirium 641
Renal Dysfunction 642
Body Temperature And Shivering 643
Postoperative Nausea And Vomiting 643
Delayed Awakening 644
Discharge Criteria 644
Questions Of The Day 646
References 646
Appendix G: Standards For Post Anesthesia Care Committee Of Origin: Standards And Practice Parameters 648
Standard I 648
Standard II 648
Standard III 648
Standard IV 648
Standard V 649
Chapter 40: Perioperative Pain Management 650
Common Terminology 651
Neurophysiology Of Pain 652
Analgesic Delivery Systems 654
Systemic Therapy 655
Neuraxial Analgesia 657
Intra-Articular Administration 659
Intrapleural Regional Analgesia 659
Paravertebral Blocks 659
Peripheral Nerve Block 659
Regional Analgesia 659
Transversus Abdominis Plane Block 660
Questions of the Day 660
Acknowledgments 660
References 660
Section VI: Consultant Anesthetic Practice 663
Chapter 41: Critical Care Medicine 665
Mechanical Ventilation 666
Noninvasive Positive-Pressure Ventilation 668
Acute Respiratory Distress Syndrome 669
Sedation And Analgesia In The Intensive Care Unit 669
Shock 673
Acute Renal Failure 676
Delirium 677
Nutritional Support 677
Rapid Response Teams 678
Intensive Insulin Therapy 678
End-Of-Life Issues 678
Questions of the Day 679
Acknowledgments 679
References 679
Chapter 42: Trauma, Bioterrorism, and Natural Disasters 681
Basic Principles Of Trauma Care 681
Acute Management Of Trauma Patients 682
Emergency Surgery For Trauma 685
Mass Casualty Disasters 687
Nuclear Exposure 690
Chemical And Biologic Terrorism 690
Bioterrorism Agents 691
Chemical Terrorism Agents 695
Infectious Disease Disasters 696
Questions of the Day 696
Acknowledgments 697
References 697
Chapter 43: Chronic Pain Management 698
Classification Of Chronic Pain 698
Multidisciplinary Pain Management 699
Common Pain Syndromes 699
Pharmacologic Management Of Chronic Pain 703
Interventional Pain Therapies 705
Summary 713
Questions of the Day 713
Acknowledgments 713
References 713
Chapter 44: Cardiopulmonary Resuscitation 715
Basic Life Support 715
Adult Advanced Cardiovascular Life Support: Algorithms 718
Adult Advanced Cardiovascular Life Support: Drug Therapy 723
Pediatric Advanced Life Support 724
Postresuscitation Care 725
Special Perioperative Considerations 727
Questions Of The Day 728
References 728
Chapter 45: Operating Room Management 729
Anesthesiology Staffing 730
Operating Room Efficiency 731
Questions of the Day 735
Acknowledgments 736
References 736
Chapter 46: Awareness Under Anesthesia 737
Incidence 737
Etiology And Risk Factors For Intraoperative Awareness 738
Psychological Sequelae 739
Prevention Of Awareness 739
The Asa's Practice Advisory On Intraoperative Awareness And Brain Function Monitors 741
Medicolegal Sequelae Of Awareness 742
Summary 743
Questions of the Day 744
References 744
Chapter 47: Quality of Care and Patient Safety 746
Anesthesiology And Patient Safety 747
Patient Safety, Medical Error, Adverse And Sentinel Events 748
The Joint Commission National Patient Safety Initiative 749
Surgical Care Improvement Project 751
Never Events 752
Operating Room Efficiency 753
Patient And Staff Satisfaction 753
Questions of the Day 753
References 753
Index 755