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Current Concepts in Pulmonary Pathology, An Issue of Surgical Pathology Clinics - E-Book

Current Concepts in Pulmonary Pathology, An Issue of Surgical Pathology Clinics - E-Book

Sanja Dacic

(2010)

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Book Details

Abstract

Pathology of lung cancers is presented, along with targeted therapies current in 2010. Additionally, asbestosis, mesothelioma, and malignant lymphomas are presented with reference to their features, differential diagnoses, and prognosis. Topics include: Bronchioloalveolar carcinoma and minimally invasive adenocarcinoma; Neuroendocrine tumors; Lung carcinoma staging problems; Targeted therapies in lung cancer; Benign and malignant mesothelial proliferations; Asbestos related lung disease; Primary Lymphoproliferative diseases of the lung; Vasculitis; and Small airway disease.

Table of Contents

Section Title Page Action Price
Front Cover Cover
Contributors iii
Contents v
Surgical Pathology Clinics viii
Pulmonary Pathology Integral to Clinical Decision Making ix
CHAPTER 1. BRONCHIOLOALVEOLAR CARCINOMA AND MINIMALLY INVASIVE ADENOCARCINOMA 1
OVERVIEW 1
NONMUCINOUS BRONCHIOLOALVEOLAR CARCINOMA 1
MUCINOUS BRONCHIOLOALVEOLAR CARCINOMA 21
MINIMALLY INVASIVE ADENOCARCINOMA 23
SUMMARY 24
CHAPTER 2. PULMONARY NEUROENDOCRINE TUMORS 27
OVERVIEW 27
CARCINOID TUMORS: TYPICAL AND ATYPICAL 28
SMALL CELL CARCINOMA 39
LCNEC 47
PITFALLS IN SMALL BIOPSY DIAGNOSIS 50
PITFALLS IN FROZEN SECTION DIAGNOSIS 54
SUMMARY 57
CHAPTER 3. LUNG CARCINOMA STAGING PROBLEMS 61
GROSS FEATURES 61
MICROSCOPIC FEATURES 62
DIFFERENTIAL DIAGNOSIS 63
DIAGNOSIS 68
PROGNOSIS 68
CHAPTER 4. TARGETED THERAPIES IN LUNG CANCER 71
OVERVIEW 71
MOLECULAR ALTERATIONS AND TARGETED THERAPIES IN LUNG CANCER 72
OTHER TARGETED MOLECULAR THERAPIES 78
SUMMARY 79
CHAPTER 5. BENIGN AND MALIGNANT MESOTHELIAL PROLIFERATION 83
GROSS FEATURES 83
MICROSCOPIC FEATURES 85
DIFFERENTIAL DIAGNOSIS 94
DIAGNOSIS 101
PROGNOSIS 104
CHAPTER 6. ASBESTOS-RELATED LUNG DISEASE 109
MINERALOGY OF ASBESTOS 109
ASBESTOS-RELATED NONNEOPLASTIC DISEASE 110
ASBESTOS-RELATED NEOPLASTIC DISEASE 121
SUMMARY 125
CHAPTER 7. A PRACTICAL APPROACH TO THE EVALUATION OF LYMPHOID AND PLASMA CELL INFILTRATES IN THE LUNG 129
IDENTIFYING AND EVALUATING LYMPHOID FOLLICLES 130
IDENTIFYING AND EVALUATING PLASMACYTIC DIFFERENTIATION 133
EVALUATION OF AN INFILTRATE COMPOSED PREDOMINANTLY OF SMALL LYMPHOID CELLS 139
EVALUATION OF AN INFILTRATE COMPOSED PREDOMINANTLY OF LARGER LYMPHOID CELLS 148
SUMMARY 153
CHAPTER 8. VASCULITIS 155
OVERVIEW 155
WEGENER GRANULOMATOSIS 156
CS SYNDROME (ALLERGIC ANGIITIS AND GRANULOMATOSIS) 160
NECROTIZING SARCOID GRANULOMATOSIS 163
MICROSCOPIC POLYANGIITIS AND OTHER DIFFUSE ALVEOLAR HEMORRHAGE SYNDROMES 163
CHAPTER 9. SMALL AIRWAYS DISEASE 171
PERIBRONCHIOLAR METAPLASIA 172
ACUTE BRONCHIOLITIS 174
ACUTE AND CHRONIC BRONCHIOLITIS 174
CHRONIC BRONCHIOLITIS 175
FOLLICULAR BRONCHIOLITIS 176
CONSTRICTIVE BRONCHIOLITIS 177
ORGANIZING PNEUMONIA WITH INTRALUMINAL POLYPS 178
SMOKING-RELATED BRONCHIOLAR DISEASES 180
DIFFUSE PANBRONCHIOLITIS 182
AIRWAY-CENTERED INTERSTITIAL FIBROSIS/ PERIBRONCHIOLAR METAPLASIA AND FIBROSIS/IDIOPATHIC BRONCHIOLOCENTRIC INTERSTITIAL PNEUMONIA 183
CHAPTER 10. HYPERSENSITIVITY PNEUMONITIS: ESSENTIAL RADIOLOGIC AND PATHOLOGIC FINDINGS 187
OVERVIEW 187
GROSS FEATURES 188
MICROSCOPIC FEATURES 191
DIFFERENTIAL DIAGNOSIS 194
AN APPROACH TO BIOPSY DIAGNOSIS 196
PATHOGENESIS, PROGNOSIS, AND TREATMENT 197
Erratum 200
ERRATUM: FIGURE 4A 200
INDEX 201