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Book Details
Abstract
The Handbook of Liver Disease, 3rd Edition, by Drs. Lawrence S. Friedman and Emmet B. Keeffe, gives you quick reference to the most recent diagnostic and treatment options for patients with liver disorders. International authorities share the latest clinical findings and procedures to help you expertly manage illnesses like hepatitis B and C and hepatocellular carcinoma, as well as apply new practices like genetic testing, noninvasive imaging techniques, and so much more. Quickly access updated information on all aspects of liver disease including new drugs, therapy trials, and post-transplant conditions with this full-color, templated edition–in print and online at www.expertconsult.com.
- Expedite diagnostic and therapeutic decision making with a highly templated outline format that uses full-color illustrations, tables, algorithms and figures, key point boxes, and alert symbols to present information at a glance.
- Apply some of the latest treatments for liver disease including the role of pretreatment IL28B testing for patients with hepatitis B and C; radiofrequency ablation and sorafenib in cases of hepatocellular carcinoma; the use of the drug rifaximin to treat hepatic encephalopathy; and much more.
Make optimal use of genetic testing to assess your patients’ risk of metabolic liver disease and to personalize treatment regimens for chronic hepatitis C.
- Offer your liver transplantation patients the best prognosis and follow-up with the latest information on outcomes and the management of complications.
Use blood test panels and noninvasive imaging techniques to evaluate the degree of liver fibrosis.
- Make informed treatment decisions with the latest clinical trial results for portal hypertension, autoimmune liver diseases, acute liver failure, and hepatic infections.
- Search the complete text online, download all the images, and test your knowledge with 200 board-style review questions at www.expertconsult.com.
Table of Contents
| Section Title | Page | Action | Price |
|---|---|---|---|
| Front Cover | Cover | ||
| Handbook of Liver Disease | iii | ||
| Copyright | iv | ||
| Contributors | v | ||
| Foreword | xi | ||
| Dedication | xiv | ||
| Preface To The Third Edition | xv | ||
| Acknowledgments | xvi | ||
| Special Tribute | xvi | ||
| Contents | xvii | ||
| Chapter 1 - Assessment of liver function and diagnostic studies | 1 | ||
| Key Points | 1 | ||
| Routine Liver Biochemical Tests | 1 | ||
| Assessment of Hepatic Metabolic Capacity | 9 | ||
| Other Tests of Liver Function | 11 | ||
| Liver Biopsy | 12 | ||
| Hepatic Imaging | 14 | ||
| Chapter 2 - Acute liver failure | 20 | ||
| Key Points | 20 | ||
| Definitions | 20 | ||
| Epidemiology | 21 | ||
| Causes | 22 | ||
| Pathophysiology | 22 | ||
| Clinical Features | 23 | ||
| Complications | 28 | ||
| Treatment | 29 | ||
| Chapter 3 - Acute viral hepatitis | 34 | ||
| Key Points | 34 | ||
| Importance | 34 | ||
| Agents | 35 | ||
| Epidemiology and Risk Factors | 37 | ||
| Pathophysiology | 40 | ||
| Clinical Features | 40 | ||
| Laboratory Features | 41 | ||
| Histology | 42 | ||
| Diagnosis | 43 | ||
| Natural History and Outcome | 47 | ||
| Treatment | 48 | ||
| Prevention | 49 | ||
| Chapter 4 - Chronic viral hepatitis | 53 | ||
| Key points | 53 | ||
| Overview | 53 | ||
| Chronic Hepatitis B | 53 | ||
| Chronic Hepatitis C | 61 | ||
| Hepatitis D Virus (HDV) | 67 | ||
| Chronic Hepatitis E | 69 | ||
| Chapter 5 - Autoimmune hepatitis | 70 | ||
| Key Points | 70 | ||
| Definition | 70 | ||
| Diagnosis | 71 | ||
| Pathogenesis | 72 | ||
| Subclassifications | 76 | ||
| Epidemialogy | 79 | ||
| Prognosis | 79 | ||
| Clinical Features | 81 | ||
| Treatment | 83 | ||
| Chapter 6 - Alcoholic liver disease | 95 | ||
| Key Points | 95 | ||
| Epidemiology | 95 | ||
| Risk Factors for Alcoholic Liver Disease | 96 | ||
| Clinical Features | 97 | ||
| Diagnosis | 99 | ||
| Histology and Spectrum of Disease | 99 | ||
| Indices of Liver Dysfunction for Alcoholic Hepatitis | 101 | ||
| Treatment | 101 | ||
| Chapter 7 - Fatty liver and nonalcoholic steatohepatitis | 106 | ||
| Key Points | 106 | ||
| Overview | 106 | ||
| Pathogenesis | 107 | ||
| Clinical Features | 108 | ||
| Risk Factors | 108 | ||
| Diagnosis | 110 | ||
| Prognosis (Fig. 7.1) | 113 | ||
| Treatment | 113 | ||
| Chapter 8 - Drug-induced and toxic liver disease | 115 | ||
| Key Points | 115 | ||
| Overview | 115 | ||
| Clinical Presentation | 116 | ||
| Characterization of Drug-Induced Liver Injury | 116 | ||
| Pathophysiology | 118 | ||
| Biotransformation | 118 | ||
| Diagnosis of Drug-induced Liver Injury | 120 | ||
| Hepatotoxicity of Specific Medications | 120 | ||
| Chapter 9 - Cirrhosis and portal hypertension: an overview | 136 | ||
| Key Points | 136 | ||
| Cirrhosis | 136 | ||
| Portal Hypertension | 144 | ||
| Chapter 10 - Portal hypertension and gastrointestinal bleeding | 150 | ||
| Key Points | 150 | ||
| Portal Hypertension: Overview | 150 | ||
| Prevention of Initial Variceal Hemorrhage | 152 | ||
| Treatment of Acute Variceal Hemorrhage | 153 | ||
| Prevention of Recurrent Variceal Hemorrhage | 156 | ||
| Management of Nonesophageal Variceal Sources of Bleeding Related to Portal Hypertension | 157 | ||
| Chapter 11 - Ascites and spontaneous bacterial peritonitis | 159 | ||
| Key Points | 159 | ||
| Overview of Ascites | 159 | ||
| Evaluation of the Patient with Ascites | 160 | ||
| Ascitic Fluid Analysis | 162 | ||
| Treatment of Ascites in Patients with Cirrhosis | 163 | ||
| Spontaneous Bacterial Peritonitis and other Ascitic Fluid Infections | 166 | ||
| Prophylaxis of Ascitic Fluid Infection | 170 | ||
| Chapter 12 - Hepatorenal syndrome | 173 | ||
| Key Points | 173 | ||
| Overview | 173 | ||
| Definition | 173 | ||
| Pathogenesis | 173 | ||
| Pathogenesis | 176 | ||
| Diagnosis | 177 | ||
| Other Causes of Acute Kidney Injury in Cirrhosis | 177 | ||
| Clinical Features | 178 | ||
| Treatment | 178 | ||
| Prevention | 180 | ||
| Chapter 13 - Hepatic encephalopathy | 183 | ||
| Key Points | 183 | ||
| Definition and Classification | 183 | ||
| Pathophysiology | 183 | ||
| Clinical Features | 184 | ||
| Diagnosis | 185 | ||
| Covert Hepatic Encephalopathy | 186 | ||
| Overt Hepatic Encephalopathy | 187 | ||
| Laboratory Tests | 188 | ||
| Treatment | 189 | ||
| Chapter 14 - Primary biliary cirrhosis | 193 | ||
| Key Points | 193 | ||
| Epidemiology | 193 | ||
| Genetics | 194 | ||
| Immunologic Abnormalities | 194 | ||
| Pathogenesis | 195 | ||
| Pathology | 197 | ||
| Clinical Features | 199 | ||
| Diagnosis | 202 | ||
| Treatment | 203 | ||
| Chapter 15 - Primary sclerosing cholangitis | 208 | ||
| Key Points | 208 | ||
| Overview | 208 | ||
| Terminology and Diagnostic Criteria | 208 | ||
| Clinical Features | 209 | ||
| Diseases Associated with Primary Sclerosing Cholangitis | 211 | ||
| Epidemiology | 212 | ||
| Etiology and Pathogenesis | 213 | ||
| Natural History | 214 | ||
| Treatment | 215 | ||
| Complications and Their Treatment | 216 | ||
| Acknowledgment | 218 | ||
| Chapter 16 - Hemochromatosis | 219 | ||
| Key Points | 219 | ||
| Epidemiology | 219 | ||
| Genetics | 219 | ||
| Classification | 220 | ||
| Pathophysiology | 221 | ||
| Clinical Features | 222 | ||
| Natural History and Prognosis | 224 | ||
| Diagnosis | 224 | ||
| Differential Diagnosis | 227 | ||
| Treatment | 227 | ||
| Screening | 228 | ||
| Chapter 17 - Wilson disease and related disorders | 230 | ||
| Key Points | 230 | ||
| Copper Metabolism (Figs 17.1 and 17.2) | 230 | ||
| Genetics | 231 | ||
| Pathogenesis | 233 | ||
| Clinical Features | 233 | ||
| Diagnosis | 236 | ||
| Treatment | 238 | ||
| Other Copper-Related Disorders | 243 | ||
| Chapter 18 - Alpha-1 antitrypsin deficiency and other metabolic liver diseases | 245 | ||
| Key Points | 245 | ||
| Overview | 245 | ||
| Alpha-1 Antitrypsin Deficiency (α-1 ATD) | 246 | ||
| Hereditary Tyrosinemia | 248 | ||
| Gaucher’s Disease | 250 | ||
| Glycogen Storage Disease (GSD) | 251 | ||
| Cystic Fibrosis (CF) | 252 | ||
| Porphyria | 254 | ||
| Other Inborn Errors of Metabolism | 256 | ||
| Chapter 19 - Budd–Chiari syndrome and other vascular disorders | 259 | ||
| Key Points | 259 | ||
| Budd–Chiari Syndrome | 259 | ||
| Portal Vein Thrombosis | 263 | ||
| Sinusoidal Obstruction Syndrome | 265 | ||
| Chapter 20 - The liver in heart failure | 268 | ||
| Key Points | 268 | ||
| Overview | 268 | ||
| Hepatic Circulation | 268 | ||
| Liver Architecture | 269 | ||
| Pathophysiology | 270 | ||
| Pathology | 271 | ||
| Etiology (Table 20.1) | 274 | ||
| Frequency | 275 | ||
| Clinical Features | 275 | ||
| Laboratory Features | 277 | ||
| Radiologic Features | 279 | ||
| Treatment | 280 | ||
| Prognosis | 280 | ||
| Chapter 21 - The liver in pregnancy | 282 | ||
| Key Points | 282 | ||
| Overview | 282 | ||
| Approach to the Pregnant Patient | 283 | ||
| Liver Disorders Unique to Pregnancy | 285 | ||
| Pregnancy in Patients with Chronic Liver Disease | 291 | ||
| Viral Hepatitis and Herpes Simplex Virus Infections in Pregnant Women (see also Chapters 3 and 4) | 293 | ||
| Budd–Chiari Syndrome (see also Chapter 19) | 295 | ||
| Cholelithiasis and Cholecystitis in Pregnant Women (see also Chapter 32) | 295 | ||
| Chapter 22 - The liver in systemic disease | 297 | ||
| Key Points | 297 | ||
| Cardiac Disease (see Chapter 20) | 297 | ||
| Connective Tissue Diseases | 299 | ||
| Endocrine and Metabolic Disorders | 301 | ||
| Granulomatous Disease and Sarcoidosis (see Chapter 26) | 301 | ||
| Lymphoma and Hematologic Diseases | 302 | ||
| Infections (see Chapter 29) | 303 | ||
| Gastrointestinal and Nutritional Disorders | 304 | ||
| Amyloidosis | 306 | ||
| Chapter 23 - Pediatric liver disease | 308 | ||
| Key Points | 308 | ||
| Consequences of Physiologic Immaturity of the Liver | 308 | ||
| Hyperbilirubinemia | 309 | ||
| Hepatomegaly | 312 | ||
| Acute Liver Disease | 316 | ||
| Systemic Diseases Affecting the Liver (see Chapter 22) | 317 | ||
| Chapter 24 - Liver disease in the elderly | 320 | ||
| Key Points | 320 | ||
| Cellular and Biochemical Aspects | 320 | ||
| Pathophysiology of the Aging Liver | 321 | ||
| Hepatic Diseases in the Elderly | 322 | ||
| Chapter 25 - Hepatobiliary complications of HIV | 332 | ||
| Key Points | 332 | ||
| Viral Hepatitis and Other Viral Infections | 332 | ||
| Other Infections (see also Chapter 29) | 336 | ||
| Malignant Diseases | 337 | ||
| Nonalcoholic Fatty Liver Disease | 338 | ||
| Antiretroviral-Induced Hepatotoxicity | 338 | ||
| AIDS-Related Biliary Tract Diseases | 339 | ||
| Chapter 26 - Granulomatous liver disease | 342 | ||
| Key Points | 342 | ||
| Pathogenesis of Granulomas | 342 | ||
| Causes of Hepatic Granulomas | 343 | ||
| Clinical Features | 343 | ||
| Specific Types of Granulomatous Liver Disease | 346 | ||
| Therapy | 351 | ||
| Chapter 27 - Hepatic tumors | 352 | ||
| Key Points | 352 | ||
| Benign Tumors of the Liver | 352 | ||
| Malignant Tumors of the Liver | 355 | ||
| Diagnostic Approach to Liver Masses or Tumors | 360 | ||
| Chapter 28 - Hepatic abscesses and cysts | 363 | ||
| Key Points | 363 | ||
| Amebic Liver Abscess | 363 | ||
| Pyogenic Liver Abscess | 369 | ||
| Hepatic Cysts | 372 | ||
| Hydatid Disease of the Liver (Fig. 28.3) | 373 | ||
| Diagnostic Approach to Hepatic Abscesses and Cysts | 377 | ||
| Chapter 29 - Other infections involving the liver | 380 | ||
| Key Points | 380 | ||
| Bacterial Infections Involving the Liver | 380 | ||
| Spirochetal Infections of the Liver | 384 | ||
| Parasitic Diseases that Involve the Liver (Table 29.1) | 385 | ||
| Fungal Liver Disease | 400 | ||
| Chapter 30 - Surgery in the patient with liver disease and postoperative jaundice | 403 | ||
| Key Points | 403 | ||
| Effects of Anesthesia and Surgery on the Liver | 403 | ||
| Estimation of Operative Risk in Patients with Liver Disease | 405 | ||
| Obstructive Jaundice (see Chapters 33 and 34) | 411 | ||
| Hepatic Resection (see Chapter 27) | 412 | ||
| Preoperative Evaluation and Preparation | 413 | ||
| Postoperative Jaundice | 416 | ||
| Chapter 31 - Liver transplantation | 420 | ||
| Key Points | 420 | ||
| Overview | 420 | ||
| Selection of Candidates | 421 | ||
| Donor Selection | 425 | ||
| Major Diseases Considered for Transplantation | 426 | ||
| Exceptional Conditions in Transplant Listing | 428 | ||
| Immunosuppression | 430 | ||
| Post-transplant Complications | 431 | ||
| Chapter 32 - Cholelithiasis and cholecystitis | 434 | ||
| Key Points | 434 | ||
| Classification of Gallstones | 434 | ||
| Pathogenesis | 435 | ||
| Diagnosis | 436 | ||
| Natural History | 436 | ||
| Surgical Treatment | 438 | ||
| Medical Treatment | 438 | ||
| Acute Cholecystitis | 439 | ||
| Acute Acalculous Cholecystitis | 441 | ||
| Postcholecystectomy Problems | 442 | ||
| Biliary Sludge | 442 | ||
| Other Less Common Syndromes Associated with Gallstones | 443 | ||
| Chapter 33 - Diseases of the bile ducts | 445 | ||
| Key Points | 445 | ||
| Bile Duct Stones | 445 | ||
| Postcholecystectomy Problems | 451 | ||
| Postoperative Bile Duct Injuries and Leaks | 452 | ||
| Recurrent Pyogenic Cholangitis | 454 | ||
| Choledochal Cysts | 455 | ||
| Chapter 34 - Tumors of the biliary tract | 460 | ||
| Key Points | 460 | ||
| Benign Tumors of the Gallbladder | 460 | ||
| Benign Tumors of the Bile Duct | 461 | ||
| Carcinoma of the Gallbladder | 461 | ||
| Carcinoma of the Bile Duct (Cholangiocarcinoma) | 466 | ||
| Index | 475 |