BOOK
PET in the Aging Brain, An Issue of PET Clinics - E-Book
Andrew B. Newberg | Abass Alavi
(2010)
Additional Information
Book Details
Abstract
PET imaging has shown its value in diagnosing diseases affecting older people. Most significantly this has been with regard to the diagnosis of Alzheimer’s disease and other forms of dementia. Parkinson’s disease is another condition in which PET has proved valuable. This issue also included articles on the uses of PET for diagnosing cerebrovascular disease and for assessing neuroplasticity.
Table of Contents
| Section Title | Page | Action | Price |
|---|---|---|---|
| Front Cover | Cover | ||
| Contributors | iii | ||
| Contents | v | ||
| PET Clinics | viii | ||
| Preface | xi | ||
| Chapter 1. Normal Patterns and Variants in PET Brain Imaging | 1 | ||
| NORMAL VARIANTS IN FUNCTIONAL NEUROIMAGING STUDIES | 2 | ||
| NEUROIMAGING IN THE STUDY OF NORMAL AGING FROM INFANCY TO ADULTHOOD | 4 | ||
| NEUROTRANSMITTER FUNCTION IN NORMAL AGING | 8 | ||
| OTHER BIOCHEMICAL CHANGES IN NORMAL AGING | 10 | ||
| SUMMARY | 10 | ||
| REFERENCES | 10 | ||
| Chapter 2. Evaluation of Early Dementia (Mild Cognitive Impairment) | 15 | ||
| FDG-PET STUDIES | 16 | ||
| ‘‘AT RISK’’ POPULATIONS | 17 | ||
| AMYLOID PET IMAGING | 20 | ||
| PIB | 20 | ||
| FDDNP | 22 | ||
| COMPARATIVE STUDIES | 22 | ||
| LIMITATIONS | 24 | ||
| SUMMARY | 26 | ||
| REFERENCES | 27 | ||
| Chapter 3. Amyloid PET Ligands for Dementia | 33 | ||
| ALZHEIMER’S DISEASE AND OTHER DEMENTIAS | 33 | ||
| AMYLOID LIGANDS | 34 | ||
| AMYLOID IMAGING IN DEMENTIA | 38 | ||
| AMYLOID IMAGING AND OTHER MARKERS OF DISEASE | 40 | ||
| SPECIFIC BIOMARKERS OF DISEASE | 41 | ||
| SUMMARY | 43 | ||
| REFERENCES | 44 | ||
| Chapter 4. 18F-Fluorodeoxyglucose PET in the Evaluation of Parkinson Disease | 55 | ||
| METABOLIC NETWORKS IN PARKINSONISM | 56 | ||
| METABOLIC PATTERNS IN ATYPICAL PARKINSONIAN SYNDROMES | 57 | ||
| DIFFERENTIAL DIAGNOSIS USING PET | 58 | ||
| CHANGES IN NETWORK ACTIVITY WITH DISEASE PROGRESSION IN PD | 59 | ||
| NETWORK MODULATION WITH PD THERAPY | 60 | ||
| SUMMARY | 62 | ||
| ACKNOWLEDGMENTS | 62 | ||
| REFERENCES | 63 | ||
| Chapter 5. SPECT and PET in Atypical Parkinsonism | 65 | ||
| THE SPECTRUM OF MOVEMENT DISORDERS | 65 | ||
| DOPAMINERGIC IMAGING IN THE DIAGNOSIS OF PARKINSONISM AND RELATED DISORDERS | 66 | ||
| NONDOPAMINERGIC IMAGING IN THE DIFFERENTIAL DIAGNOSIS OF MOVEMENT DISORDERS | 70 | ||
| IDENTIFYING NEW TARGETS AND IMAGING BIOMARKERS IN PARKINSON SPECTRUM DISORDERS | 71 | ||
| SUMMARY | 72 | ||
| REFERENCES | 73 | ||
| Chapter 6. 18F-AV-133: A Selective VMAT2-binding Radiopharmaceutical for PET Imaging of Dopaminergic Neurons | 75 | ||
| APPROACHES TO DA NEURON IMAGING | 75 | ||
| VMAT2 AS PET IMAGING TARGET | 76 | ||
| REFERENCES | 80 | ||
| Chapter 7. PET in Cerebrovascular Disease | 83 | ||
| NORMAL CEREBRAL HEMODYNAMICS AND ENERGY METABOLISM | 83 | ||
| CEREBROVASCULAR CONTROL | 84 | ||
| HEMODYNAMIC EFFECTS OF ARTERIAL OCCLUSIVE DISEASE | 86 | ||
| EVOLUTION OF ACUTE INFARCTION | 89 | ||
| IDENTIFICATION OF PREVENTABLE INFARCTION | 90 | ||
| CAROTID ARTERY ATHEROSCLEROSIS | 92 | ||
| REMOTE METABOLIC EFFECTS OF CEREBRAL INFARCTION | 92 | ||
| VASCULAR DEMENTIA | 94 | ||
| INTRACEREBRAL HEMORRHAGE | 94 | ||
| ANEURYSMAL SUBARACHNOID HEMORRHAGE | 94 | ||
| SUMMARY | 97 | ||
| REFERENCES | 97 | ||
| Chapter 8. Imaging Pathophysiology and Neuroplasticity After Stroke | 107 | ||
| CEREBROVASCULAR DISEASE | 107 | ||
| EVALUATION OF CBF, METABOLISM, AND RECEPTORS USING PET TRACERS | 108 | ||
| METABOLISM, OEF, AND CEREBROVASCULAR REACTIVITY MEASUREMENTS OF PERIINFARCTION TISSUE HEMODYNAMICS | 109 | ||
| EVALUATION OF ISCHEMIA BY PET | 109 | ||
| PET MEASURES OF CBF AND OEF | 109 | ||
| TIME-DEPENDENT PROGRESSIVELY EVOLVING STROKE PENUMBRA | 110 | ||
| PET MEASURES OF CEREBRAL TISSUE VIABILITY STATUS IN ISCHEMIC BRAIN | 111 | ||
| RECOVERY FROM STROKE: DIASCHISIS RESOLUTION AND CEREBRAL REORGANIZATION | 112 | ||
| CEREBRAL DIASCHISIS AS A RESULT OF STROKE | 112 | ||
| IMPROVEMENT OF STROKE-INDUCED NEUROLOGIC DEFICITS ATTRIBUTABLE TO CEREBRAL DIASCHISIS RESOLUTION | 114 | ||
| CEREBRAL REORGANIZATION | 115 | ||
| IMPROVEMENT OF STROKE-INDUCED NEUROLOGIC DEFICITS ATTRIBUTABLE TO CEREBRAL REORGANIZATION | 116 | ||
| ADAPTIVE PLASTICITY IN STROKE RECOVERY | 117 | ||
| EXPANSION OF CORTICAL REPRESENTATION AREAS AND ROLE OF THE CONTRALESIONAL HEMISPHERE | 118 | ||
| TASK-DEPENDENT CORTICAL ACTIVATION STUDIES | 119 | ||
| SUMMARY | 123 | ||
| ACKNOWLEDGMENTS | 123 | ||
| REFERENCES | 123 | ||
| Index | 127 |