BOOK
Clinical Ocular Toxicology E-Book
Frederick T. Fraunfelder | Frederick W. Fraunfelder | Wiley A. Chambers
(2008)
Additional Information
Book Details
Abstract
Written by international authorities in ocular toxicology, including the Founder of The National Registry of Drug-Induced Side Effects and its current Director, this essential resource provides the clinically relevant information you need to effectively diagnose and manage herbal, chemical, and drug-related ocular problems. Comprehensive coverage of all drugs’ generic and trade drug names, primary uses, ocular and systemic side effects, and clinical significance make this book - like its best-selling predecessor, Drug-Induced Ocular Side Effects - the ideal reference for quick, on-the-spot consultation.
- Leaders in the field provide need-to-know information on all aspects of ocular toxicology—all in one concise reference.
- Data from the National Registry of Drug Induced Ocular Side-Effects (Casey Eye Institute, Portland, OR) and the World Health Organization (Uppsala, Sweden) help you recognize and avoid drug-induced ocular side effects.
- A highly templated format makes retrieval of essential knowledge quick and easy.
- A wealth of full-color photographs provide vivid, visual diagnostic guidance.
- The latest information on approved medications helps you stay up to date and provide state-of-the-art care.
- Extensive coverage of principles of therapy, ocular drug delivery, methods to evaluate drug-induced visual side effects, and the role of electrophysiology and psychophysics gives you the knowledge you need to manage any challenge in ocular toxicology
- Authoritative guidance on ocular drugs and their use in pregnancy helps you safely manage the unique needs of these patients.
- The inclusion of the WHO classification system helps you determine whether a particular side effect is certain, probable, or likely to occur.
Table of Contents
Section Title | Page | Action | Price |
---|---|---|---|
Front Cover | Cover | ||
Clinical Ocular Toxicology | iii | ||
Copyright Page | iv | ||
Contents | v | ||
Preface | vii | ||
Contributors | viii | ||
Dedication | ix | ||
Instructions to Users | x | ||
PART 1: Principles of therapy | 1 | ||
PHARMACODYNAMICS | 1 | ||
PHARMACOKINETICS | 3 | ||
PHARMACOLOGY PRINCIPLES | 4 | ||
REFERENCES AND FURTHER READING | 6 | ||
PART 2: Ocular drug delivery and toxicology | 9 | ||
TOPICAL OCULAR ADMINISTRATION | 9 | ||
BASIC PHARMOCOLOGY AND TOXICOLOGY OF TOPICAL MEDICATIONS | 9 | ||
INTRAOCULAR DISTRIBUTION | 10 | ||
PRESERVATIVES | 10 | ||
VEHICLES FOR TOPICAL OCULAR MEDICATION DELIVERY | 10 | ||
TOXICITY RESPONCES | 11 | ||
HOW TO APPLY TOPICAL OCULAR MEDICATION | 12 | ||
REFERENCES AND FURTHER READING | 13 | ||
PART 3: Methods for evaluating drug-induced visual side effects | 15 | ||
RISK | 15 | ||
SELECTING DIAGNOSTIC TESTS | 15 | ||
ORDER OF TESTING | 16 | ||
TIMING OF TESTING | 16 | ||
FUNCTIONAL TESTS | 16 | ||
OBJECTIVE ANATOMICAL METHODS | 18 | ||
NUMBER OF PATIENTS TO TEST | 19 | ||
SUMMARY | 19 | ||
REFERENCES AND FURTHER READING | 19 | ||
PART 4: The role of electrophysiology and psychophysics in ocular toxicology | 21 | ||
INTRODUCTION | 21 | ||
THE VISUAL SYSTEM | 21 | ||
THE ROLE OF NON-INVASIVE ELECTROPHYSIOLOGY IN DRUG TESTING | 26 | ||
VISUAL ELECTROPHYSIOLOGY IN DRUG DEVELOPMENT | 31 | ||
COMPLEMENTARY TESTS | 32 | ||
ENSURING QUALITY | 34 | ||
CONCLUSION | 36 | ||
REFERENCES AND FURTHER READING | 36 | ||
PART 5: National registry of drug-induced ocular side effects | 39 | ||
RATIONALE | 39 | ||
OBJECTIVES OF THE NATIONAL REGISTRY | 39 | ||
HOW TO REPORT A SUSPECTED REACTION | 39 | ||
REFERENCES AND FURTHER READING | 40 | ||
PART 6: Herbal medicines and dietary supplements– an overview | 41 | ||
REGULATORY ISSUES AND CLASSIFICATION | 41 | ||
REFERENCES AND FURTHER READING | 43 | ||
PART 7: Drug-induced ocular side effects | 45 | ||
SECTION 1: ANTI-INFECTIVES | 45 | ||
CLASS: AIDS-RELATED AGENTS | 45 | ||
REFERENCES AND FURTHER READING | 45 | ||
SECTION 2: AGENTS AFFECTING THE CNS | 85 | ||
CLASS: ANALEPTICS | 85 | ||
REFERENCES AND FURTHER READING | 86 | ||
SECTION 3: ANALGESICS, NARCOTIC ANTAGONISTS AND AGENTS USED TO TREAT ARTHRITIS | 111 | ||
CLASS: AGENTS USED TO TREAT GOUT | 111 | ||
REFERENCES AND FURTHER READING | 112 | ||
SECTION 4: AGENTS USED IN ANESTHESIA | 128 | ||
CLASS: ADJUNCTS TO ANESTHESIA | 128 | ||
REFERENCES AND FURTHER READING | 129 | ||
SECTION 5: GASTROINTESTINAL AGENTS | 138 | ||
CLASS: AGENTS USED TO TREAT ACID PEPTIC DISORDERS | 138 | ||
REFERENCES AND FURTHER READING | 139 | ||
SECTION 6: CARDIAC, VASCULAR AND RENAL AGENTS | 146 | ||
CLASS: AGENTS USED TO TREAT MIGRAINE | 146 | ||
REFERENCES AND FURTHER READING | 146 | ||
SECTION 7: HORMONES AND AGENTS AFFECTING HORMONAL MECHANISMS | 169 | ||
CLASS: ADRENAL CORTICOSTEROIDS | 169 | ||
REFERENCES AND FURTHER READING | 172 | ||
SECTION 8: AGENTS AFFECTING BLOOD FORMATION AND COAGULABILITY | 181 | ||
CLASS: AGENTS USED TO TREAT DEFICIENCY ANEMIAS | 181 | ||
REFERENCES AND FURTHER READING | 181 | ||
SECTION 9: HOMEOSTATIC AGENTS | 188 | ||
CLASS: AGENTS USED TO TREAT HYPERGLYCEMIA | 188 | ||
REFERENCES AND FURTHER READING | 189 | ||
SECTION 10: AGENTS USED TO TREAT ALLERGIC AND NEUROMUSCULAR DISORDERS | 192 | ||
CLASS: AGENTS USED TO TREAT MYASTHENIA GRAVIS | 192 | ||
REFERENCES AND FURTHER READING | 192 | ||
SECTION 11: ONCOLYTIC AGENTS | 199 | ||
CLASS: ANTINEOPLASTIC AGENTS | 199 | ||
REFERENCES AND FURTHER READING | 200 | ||
SECTION 12: HEAVY METAL ANTAGONIST AND MISCELLANEOUS AGENTS | 223 | ||
CLASS: AGENTS TO TREAT ALCOHOLISM | 223 | ||
REFERENCES AND FURTHER READING | 223 | ||
SECTION 13: DRUGS USED IN OPHTHALMOLOGY | 245 | ||
CLASS: AGENTS USED TO TREAT AGE-RELATED MACULAR DEGENERATION | 245 | ||
REFERENCES AND FURTHER READING | 246 | ||
PART 8: Chemical-induced ocular side effects | 289 | ||
CLASS: ACIDS | 289 | ||
CLASS: AEROSOLS | 290 | ||
CLASS: ALCOHOLS | 291 | ||
CLASS: ALKALI | 295 | ||
CLASS: BLEACHES | 298 | ||
CLASS: DETERGENTS | 300 | ||
CLASS: GLUES | 301 | ||
CLASS: HERBICIDES AND INSECTICIDES | 302 | ||
CLASS: HYDROCARBONS | 304 | ||
CLASS: MISCELLANEOUS | 305 | ||
PART 9: Herbal medicine and dietary supplement induced ocular side effects | 307 | ||
REFERENCE AND FURTHER READING | 307 | ||
Index of Side Effects | 315 | ||
Subject index | 359 |