BOOK
Neuromuscular Disorders: Management and Treatment E-Book
Tulio E. Bertorini | Tulio E. Bertorini
(2010)
Additional Information
Book Details
Abstract
Neuromuscular Disorders presents a multi-disciplinary approach to the management and therapeutic treatment of the full range of neuromuscular disorders and resulting complications. Dr. Tulio Bertorini and a contributing team of the world’s leading authorities in the field provide the latest tools and strategies for minimizing disability and maximizing quality of life.
- Effectively treat your patients using the latest management tools and targeted therapeutic strategies.
- Manage all neuromuscular disorders as well as resulting complications through comprehensive coverage of diagnosis and evaluations, treatments, and outcomes.
- Apply the multi-disciplinary approach of an expert in clinical neuromuscular care and a team of world-renown contributors.
- Easily refer to tools for diagnosis, treatment algorithms, and drug tables included throughout the text.
Table of Contents
| Section Title | Page | Action | Price |
|---|---|---|---|
| Front Cover | Cover | ||
| Neuromuscular Disorders: Treatment and Management | iii | ||
| Copyright Page | iv | ||
| Dedication | v | ||
| Preface | vii | ||
| Acknowledgments | ix | ||
| Contributors | xi | ||
| Contents | xv | ||
| Part I: General Principles in the Treatment and Management of Neuromuscular Disorders | 1 | ||
| Chapter 1: Introduction: Evaluation of Patients with Neuromuscular Disorders | 3 | ||
| Medical History and Symptoms | 3 | ||
| Physical Examination | 3 | ||
| Diagnostic Tests | 7 | ||
| Electrophysiologic Tests | 10 | ||
| Histologic Tests | 11 | ||
| References | 18 | ||
| Chapter 2: Respiratory Complications in Neuromuscular Disorders | 21 | ||
| Management of Neuromuscular Diseases Resulting in Chronic Respiratory Failure | 21 | ||
| Management of Neuromuscular Diseases Resulting in Acute Respiratory Failure | 30 | ||
| Acute Exacerbations of Chronic Neuromuscular Respiratory Failure | 31 | ||
| References | 31 | ||
| Chapter 3: Cardiac Complications of Neuromuscular Disorders | 33 | ||
| Duchenne Muscular Dystrophy | 33 | ||
| Becker Muscular Dystrophy | 33 | ||
| Carriers of Duchenne Muscular Dystrophy and Becker Muscular Dystrophy | 35 | ||
| X-Linked Dilated Cardiomyopathy | 35 | ||
| Limb-Girdle Muscular Dystrophy | 35 | ||
| Myotonic Dystrophy | 36 | ||
| Emery-Dreifuss Muscular Dystrophy | 36 | ||
| Facioscapulohumeral Dystrophy | 36 | ||
| Other Neuromuscular Disorders | 37 | ||
| Diagnosis and Evaluation | 37 | ||
| Pathology | 41 | ||
| Treatment | 41 | ||
| Preoperative Assessment | 45 | ||
| Experimental Therapies | 45 | ||
| Monitoring | 45 | ||
| Summary | 47 | ||
| Conclusion | 47 | ||
| References | 47 | ||
| Chapter 4: Gastrointestinal Complications of Neuromuscular Disorders | 51 | ||
| Pharynx and Esophagus | 51 | ||
| Stomach and Duodenum | 55 | ||
| Small Intestine | 56 | ||
| Large Intestine and Anal Sphincter | 57 | ||
| Peripheral Neuropathy and the Gastrointestinal System | 57 | ||
| Conclusion | 58 | ||
| References | 58 | ||
| Chapter 5: Autonomic Dysfunction in Neuromuscular Disorders | 61 | ||
| Overview of the Autonomic Nervous System | 61 | ||
| Evaluation of the Autonomic Nervous System | 63 | ||
| Types of Autonomic Neuropathy | 66 | ||
| Symptomatic Treatment of Autonomic Disorders | 71 | ||
| References | 75 | ||
| Chapter 6: A Practical Approach to the Treatment of Painful Polyneuropathies | 79 | ||
| Definitions and Overview | 80 | ||
| Nerve Anatomy | 81 | ||
| Overview of Peripheral Neuropathic Pain Pathophysiology | 81 | ||
| Modification of Sensory and Nociceptive Afferents | 84 | ||
| Evidence-Based Medicine | 87 | ||
| Approved and \"Off-Label\" Medication Uses | 89 | ||
| Previous Treatment Recommendations | 89 | ||
| General Approach to the Patient with Painful Neuropathy | 90 | ||
| First-Line\" Neuropathic Pain Treatments | 92 | ||
| Second-Line\" Neuropathic Pain Treatments | 95 | ||
| Ancillary Treatments | 96 | ||
| Conclusion | 96 | ||
| References | 97 | ||
| Chapter 7: Principles and Guidelines of Immunotherapy in Neuromuscular Disorders | 101 | ||
| Basics of the Immune Response | 101 | ||
| Autoimmunity | 102 | ||
| Immunotherapy | 103 | ||
| Evidence-Based Medicine and Treatment of Autoimmune Neuromuscular Disorders | 109 | ||
| References | 111 | ||
| Chapter 8: Rehabilitation in Neuromuscular Disorders | 115 | ||
| Management of Muscle Weakness | 116 | ||
| Orthoses and Mobility Aids | 119 | ||
| Assistive Devices for Activities of Daily Living | 124 | ||
| Environmental Evaluations and Modifications | 125 | ||
| Orthopedic Considerations | 126 | ||
| Respiratory Failure | 127 | ||
| Dysarthria | 127 | ||
| Dysphagia | 128 | ||
| Pain | 129 | ||
| Mood Disorders | 130 | ||
| Cognitive Dysfunction | 131 | ||
| Quality of Life | 132 | ||
| Roles of the Caregiver and Family | 133 | ||
| Palliative Care | 134 | ||
| References | 134 | ||
| Chapter 9: Orthopedic Surgery in Neuromuscular Disorders | 137 | ||
| Muscular Dystrophy | 137 | ||
| Hereditary Motor and Sensory Neuropathies | 144 | ||
| References | 151 | ||
| Chapter 10: Perioperative Managementof Patients withNeuromuscular Disorders | 155 | ||
| Perioperative Management in Specific Neuromuscular Disorders | 155 | ||
| Malignant Hyperthermia Syndrome | 157 | ||
| Complications of Major Surgery and Organ Transplantation | 159 | ||
| Neuromuscular Disorders Acquired in the Intensive Care Unit | 161 | ||
| References | 164 | ||
| Part II: Treatment and Management of Specific Neuromuscular Disorders | 167 | ||
| Chapter 11: Treatment and Management of Adult Motor Neuron Diseases | 169 | ||
| Diagnosis and Evaluation | 169 | ||
| Treatment and Management | 174 | ||
| References | 177 | ||
| Chapter 12: Treatment and Management of Spinal Muscular Atrophy and Congenital Myopathies | 179 | ||
| Diagnosis and Evaluation | 179 | ||
| Treatment and Management | 182 | ||
| Novel Therapies | 185 | ||
| Conclusion | 187 | ||
| References | 187 | ||
| Chapter 13: Treatment and Management of Hereditary Neuropathies | 191 | ||
| Hereditary Motor and Sensory Neuropathies | 195 | ||
| Hereditary Motor Neuropathy | 199 | ||
| Hereditary Sensory and Autonomic Neuropathies | 199 | ||
| Familial Amyloidic Polyneuropathy | 200 | ||
| Friedreich Ataxia and Other Spinocerebellar Ataxias | 202 | ||
| Inherited Dyslipidemic Neuropathies | 203 | ||
| Lysosomal Storage Diseases: Fabry Disease | 204 | ||
| Lysosomal Leukodystrophies: Metachromatic Leukodystrophy and Krabbe Disease | 206 | ||
| Peroxisomal Disorders: Adrenomyeloneuropathy and Refsum Disease | 207 | ||
| Porphyric Neuropathy | 208 | ||
| Conclusion | 211 | ||
| Acknowledgments | 211 | ||
| References | 211 | ||
| Chapter 14: Treatment and Management of Autoimmune Neuropathies | 215 | ||
| Guillain-Barré Syndrome | 215 | ||
| Chronic Inflammatory Demyelinating Polyradiculoneuropathy | 218 | ||
| Multifocal Motor Neuropathy | 220 | ||
| Lewis-Sumner Syndrome | 221 | ||
| Paraproteinemic Neuropathies: Chronic Inflammatory Demyelinating Polyradiculoneuropathy Associated with Monoclonal Gammopathy of Undetermined Significance | 221 | ||
| Paraproteinemic Neuropathies: Primary Systemic Amyloidosis | 223 | ||
| Paraproteinemic Neuropathies: POEMS Syndrome (Osteosclerotic Myeloma) | 224 | ||
| Vasculitis | 224 | ||
| Cryoglobulinemia | 225 | ||
| Nonvasculitic Neuropathies Associated with Connective Tissue Disease | 226 | ||
| Autoimmune Lumbosacral Plexopathy | 226 | ||
| Autoimmune Brachial Plexopathy | 227 | ||
| Celiac Disease | 228 | ||
| Paraneoplastic Sensory Neuronopathy | 228 | ||
| References | 229 | ||
| Chapter 15: Treatment and Management of Infectious, Granulomatous, and Toxic Neuromuscular Disorders | 237 | ||
| Infections of Nerve and Muscle | 237 | ||
| Granulomatous Diseases of Nerve and Muscle | 246 | ||
| Toxic Neuropathies and Myopathies | 247 | ||
| References | 257 | ||
| Chapter 16: Treatment and Management of Segmental Neuromuscular Disorders | 261 | ||
| Radiculopathy | 261 | ||
| Plexopathies | 269 | ||
| Focal Neuropathies | 275 | ||
| Focal Neuropathy Syndromes | 276 | ||
| References | 282 | ||
| Chapter 17: Treatment and Management of Disorders of Neuromuscular Hyperexcitability | 285 | ||
| Central Disorders | 285 | ||
| Disorders of Peripheral Nerve Hyperexcitability | 290 | ||
| Primary Disorders of Muscle | 293 | ||
| References | 300 | ||
| Appendix 17-1.. Exercise Tests for Periodic Paralysis | 306 | ||
| Chapter 18: Treatment and Management of Disorders of the Neuromuscular Junction | 307 | ||
| Myasthenia Gravis | 307 | ||
| Lambert-Eaton Myasthenic Syndrome | 322 | ||
| Botulism | 326 | ||
| Congenital Myasthenic Syndromes | 331 | ||
| Tick Paralysis | 334 | ||
| Snakebite Myasthenic Syndrome | 335 | ||
| Organophosphate Intoxication | 337 | ||
| Hypermagnesemia-Induced Paralysis | 339 | ||
| References | 340 | ||
| Chapter 19: Treatment and Management of Muscular Dystrophies | 343 | ||
| Dystrophinopathies | 343 | ||
| Limb-Girdle Muscular Dystrophies | 354 | ||
| Other Distal Muscular Dystrophies | 356 | ||
| Emery-Dreifuss Muscular Dystrophy | 356 | ||
| Facioscapulohumeral Muscular Dystrophy | 358 | ||
| Myotonic Dystrophy | 359 | ||
| Oculopharyngeal Muscular Dystrophy | 361 | ||
| Congenital Muscular Dystrophy | 362 | ||
| References | 364 | ||
| Chapter 20: Neuromuscular Manifestations of Acquired Metabolic, Endocrine, and Nutritional Disorders | 373 | ||
| Endocrine Disorders | 373 | ||
| Neuromuscular Complications of Uremia | 383 | ||
| Malnutrition and Vitamin Deficiencies | 384 | ||
| Acknowledgment | 389 | ||
| References | 389 | ||
| Chapter 21: Treatment and Management of Autoimmune Myopathies | 395 | ||
| Dermatomyositis | 395 | ||
| Polymyositis | 396 | ||
| Inclusion Body Myositis | 397 | ||
| Eosinophilic Syndromes and Fasciitis | 397 | ||
| Diagnosis and Evaluation | 398 | ||
| Treatment and Management of Inflammatory Myopathies | 402 | ||
| References | 405 | ||
| Chapter 22: Treatment and Management of Hereditary Metabolic Myopathies | 409 | ||
| Muscle Disorders of Glycogen Metabolism | 409 | ||
| Muscle Disorders of Lipid Metabolism | 417 | ||
| Mitochondrial Myopathies | 421 | ||
| Rhabdomyolysis | 426 | ||
| Conclusion | 426 | ||
| Suggested Reading | 427 | ||
| References | 427 | ||
| Index | 431 |