BOOK
Early Diagnosis and Treatment of Cancer Series: Breast Cancer - E-Book
Lisa Jacobs | Christina Finlayson | Stephen C. Yang
(2010)
Additional Information
Book Details
Abstract
Each volume in the Early Detection and Treatment of Cancer Series is packed with practical, authoritative information designed to cover the full range of diagnostic procedures, including pathologic, radiologic, bronchoscopic, and surgical aspects. You’ll be able to determine the safest, shortest, least invasive way to reach an accurate diagnosis; stage the disease; and choose the best initial treatment for early stages. Based on current evidence in the literature, authors provide clinical, hands-on tools to help you make informed decisions on precisely what tests and imaging studies are needed to diagnose and stage each type of cancer. Practical, authoritative, and highly-illustrated, this volume in the brand new Early Detection and Treatment of Cancer series covers current protocols and the latest advances in diagnostic imaging and molecular and serologic markers for breast cancer. Apply expert advice on the best “next-step” plan for different presentations and tips for less invasive protocols. Get clinical, hands-on tools to help you make informed decisions on precisely what tests and imaging studies are needed for accurate diagnosis and staging. Clear figures, tables, and boxes illustrate step-by-step care of the full range of problems encountered. The small size and convenient format make this an ideal purchase for diagnostic reference.
- Outlines the steps after diagnosis to guide you through formulating a treatment or patient care plan.
- Emphasizes important points—such as the promising new breast cancer vaccine, sentinel node biopsy, and hormone receptor tests—with “key points” boxes at the beginning of each chapter and pedagogic features throughout.
- Summarizes the process of accurately diagnosing and staging cancer in a logical, almost algorithmic, approach for easy reference.
- Discusses the treatment of early-stage disease so you have clear options for care.
- Complements the procedures outlined in the text with full-color photographs and line drawings to reinforce your understanding of the material.
Table of Contents
| Section Title | Page | Action | Price |
|---|---|---|---|
| Front Cover | Cover | ||
| Early Diagnosis and Treatment of Cancer: Breast Cancer | iii | ||
| Copyright Page | iv | ||
| Table of Contents | xi | ||
| Dedication | v | ||
| Series Preface | vii | ||
| Preface | ix | ||
| Contributors | xiii | ||
| Chapter 1. The Normal Breast and Benign Diseases of the Breast | 1 | ||
| The Normal Breast | 1 | ||
| Abnormalities of Breast Development | 3 | ||
| Gynecomastia | 4 | ||
| Inflammatory and ReactiveBreast Lesions | 4 | ||
| Fibroepithelial Lesions | 6 | ||
| Papillary Lesions | 7 | ||
| Fibrocystic Change | 7 | ||
| Conclusion | 9 | ||
| References | 10 | ||
| Chapter 2. Ductal and Lobular Proliferations: Preinvasive Breast Disease | 11 | ||
| Introduction | 11 | ||
| Ductal Carcinoma in Situ | 12 | ||
| Atypical Ductal Hyperplasia | 16 | ||
| Ductal Hyperplasia of the Usual Type | 17 | ||
| Lobular Neoplasia | 18 | ||
| References | 20 | ||
| Chapter 3. Invasive Breast Cancer | 21 | ||
| Introduction | 21 | ||
| Biopsy Procedures | 21 | ||
| Histopathologic Appearance of Invasive Breast Cancer | 22 | ||
| Mimickers of Invasive Carcinoma | 24 | ||
| Grading | 29 | ||
| Margin Status | 30 | ||
| Invasive Carcinoma with an Extensive in Situ Component | 31 | ||
| Lymphovascular Space Invasion | 31 | ||
| Lymph Nodes | 31 | ||
| Invasive Ductal Carcinoma | 33 | ||
| Invasive Lobular Carcinoma | 33 | ||
| Invasive Tubular Carcinoma | 35 | ||
| Tubulolobular Carcinoma | 37 | ||
| Mucinous (Colloid) Carcinoma | 37 | ||
| Invasive Cribriform Carcinoma | 38 | ||
| Medullary Carcinoma | 39 | ||
| Invasive Papillary Carcinoma | 40 | ||
| Invasive Micropapillary Carcinoma | 40 | ||
| Invasive Apocrine Carcinoma | 41 | ||
| Adenoid Cystic Carcinoma | 42 | ||
| Metaplastic Carcinoma | 42 | ||
| Neuroendocrine Tumors | 45 | ||
| Primary Malignant Lymphoma | 45 | ||
| In. ammatory Carcinoma | 46 | ||
| Paget Disease | 46 | ||
| Microinvasive Carcinoma | 47 | ||
| Presentation as an Axillary Lymph Node Metastasis | 48 | ||
| Conclusion | 51 | ||
| References | 51 | ||
| Chapter 4. Risk Factors and Risk Assessment | 55 | ||
| Breast Cancer and Risk | 55 | ||
| Risk Factors | 56 | ||
| Risk Assessment Tools | 62 | ||
| Discussing Risk with Patients | 65 | ||
| Conclusion | 68 | ||
| References | 68 | ||
| Chapter 5. Genetics | 71 | ||
| Introduction | 71 | ||
| Genetics Review: Autosomal Dominant Inheritance | 72 | ||
| Hereditary Breast and Ovarian Cancer Syndrome (HBOC) | 72 | ||
| Genetic Testing | 75 | ||
| Management: Screening and Risk Reduction Options | 77 | ||
| Low-Penetrance Genes | 84 | ||
| Genetic Assessment | 84 | ||
| Special Considerations | 86 | ||
| Conclusion | 86 | ||
| References | 87 | ||
| Chapter 6. Strategies for Risk Reduction | 89 | ||
| Concepts of Chemoprevention | 90 | ||
| Tamoxifen Chemoprevention Studies | 90 | ||
| Raloxifene Chemoprevention Studies | 92 | ||
| International Chemoprevention Studies | 93 | ||
| Impact of Chemoprevention on Benign Breast Disease | 94 | ||
| Phytoestrogens as Chemopreventive Agents | 95 | ||
| Translation of Studies into Clinical Use of Tamoxifen | 95 | ||
| Genetic Counseling | 96 | ||
| Cost-Effectiveness of Tamoxifen and Chemoprevention | 97 | ||
| Overview of Prophylactic Mastectomy | 98 | ||
| Patient Selection | 98 | ||
| Quality of Life after Prophylactic Mastectomy | 100 | ||
| Summary | 100 | ||
| References | 102 | ||
| Chapter 7. Nutrition and Lifestyle | 105 | ||
| Introduction | 105 | ||
| Diet | 106 | ||
| Recommendations | 112 | ||
| Adiposity | 113 | ||
| Alcohol | 118 | ||
| Exposures | 119 | ||
| Summary | 121 | ||
| References | 122 | ||
| Chapter 8. Radiologic Techniques for Early Detection and Diagnosis | 125 | ||
| Film Mammography | 125 | ||
| Digital Mammography | 125 | ||
| Ultrasound | 129 | ||
| Magnetic Resonance Imaging | 129 | ||
| Nuclear Medicine Techniques | 130 | ||
| Digital Breast Tomosynthesis | 131 | ||
| Contrast-Enhanced Digital Mammography | 134 | ||
| Dedicated Breast CT | 137 | ||
| Conclusion | 137 | ||
| References | 138 | ||
| Chapter 9. Screening of High-Risk Patients | 141 | ||
| Introduction | 141 | ||
| Definition of High Risk | 141 | ||
| Mammography | 141 | ||
| Screening Recommendations | 144 | ||
| Magnetic Resonance Imaging | 145 | ||
| Whole Breast Ultrasound | 146 | ||
| Nuclear Medicine | 147 | ||
| Tomosynthesis | 147 | ||
| Breast 1H MRI Spectroscopy | 148 | ||
| Conclusion | 148 | ||
| References | 149 | ||
| Chapter 10. Minimally Invasive Breast Biopsy | 151 | ||
| Introduction | 151 | ||
| Conclusion | 173 | ||
| References | 173 | ||
| Chapter 11. Surgical Biopsy | 175 | ||
| Introduction | 175 | ||
| Evaluation of a Palpable Breast Lesion | 175 | ||
| Biopsy Techniques | 177 | ||
| Evaluation of a Nonpalpable Breast Lesion | 179 | ||
| Evaluation of Nipple Discharge | 180 | ||
| Skin Biopsy | 182 | ||
| Conclusion | 183 | ||
| References | 183 | ||
| Chapter 12. Surgical Therapy of Early Breast Cancer | 185 | ||
| Introduction | 185 | ||
| History | 185 | ||
| Mastectomy | 187 | ||
| Partial Mastectomy (Lumpectomy) | 188 | ||
| Conclusion | 190 | ||
| References | 190 | ||
| Chapter 13. Breast Reconstruction after Mastectomy | 191 | ||
| Introduction | 191 | ||
| Immediate versus Delayed Reconstruction | 193 | ||
| Prosthetic Reconstruction | 195 | ||
| Autologous Reconstruction | 196 | ||
| Surveillance after Breast Reconstruction | 201 | ||
| Conclusion | 202 | ||
| References | 202 | ||
| Chapter 14. Oncoplastic Surgical Techniques for the Partial Mastectomy | 205 | ||
| Introduction to Oncoplastic Surgery | 205 | ||
| Anatomic Distribution of Cancer in the Breast | 206 | ||
| Preoperative Assessment of Disease Distribution | 208 | ||
| Oncoplastic Partial Mastectomy | 209 | ||
| Conclusions | 214 | ||
| References | 214 | ||
| Chapter 15. Axillary Management | 217 | ||
| Introduction | 217 | ||
| Noninvasive Axillary Assessment | 219 | ||
| Management of the Clinically Negative Axilla | 221 | ||
| Management of the Clinically Positive Axilla | 231 | ||
| Complications of Axillary Surgery | 234 | ||
| References | 236 | ||
| Chapter 16. Radiation Oncology | 241 | ||
| Introduction | 241 | ||
| Breast-Conserving Therapy | 242 | ||
| Alternative Breast-Conserving Therapies | 243 | ||
| Radiation Toxicity | 251 | ||
| Primary Radiation Therapy | 255 | ||
| Conclusion | 256 | ||
| References | 256 | ||
| Chapter 17. Neoadjuvant Therapy | 261 | ||
| Historical Perspective | 261 | ||
| Neoadjuvant Treatment | 266 | ||
| Multidisciplinary Management of Patients Receiving Neoadjuvant Therapy | 271 | ||
| What If Neoadjuvant Therapy Doesn’t Work? | 276 | ||
| Recommendations for Neoadjuvant Therapy | 276 | ||
| Open Questions and Ongoing Studies | 277 | ||
| References | 277 | ||
| Chapter 18. Cost-Effective Staging of Breast Cancer | 281 | ||
| Overview | 281 | ||
| Local Staging of Newly Diagnosed Breast Cancer | 284 | ||
| Evaluating for Distant Metastasis | 286 | ||
| Summary | 288 | ||
| References | 289 | ||
| Chapter 19. Adjuvant Systemic Therapy | 291 | ||
| Types of Breast Cancer | 291 | ||
| Molecular Subtypes of Breast Cancer | 291 | ||
| Risk of Breast Cancer Recurrence and Mortality | 291 | ||
| Adjuvant Chemotherapy | 292 | ||
| Adjuvant Hormone Therapy | 297 | ||
| References | 304 | ||
| Chapter 20. Surveillance and Detection of Recurrence of Breast Cancer | 307 | ||
| Introduction | 307 | ||
| The Evidence Behind Current Surveillance Guidelines in Breast Cancer | 307 | ||
| Detecting Locoregional Recurrences | 308 | ||
| Detecting Asymptomatic Systemic Metastases | 311 | ||
| Symptom-Directed Workup | 312 | ||
| Long-Term Complications of Adjuvant Chemotherapy for Breast Cancer | 314 | ||
| Coordinating Medical Care | 315 | ||
| Conclusions | 316 | ||
| References | 317 | ||
| Chapter 21. The Use of Molecular Pro. les in the Management of Breast Cancer | 319 | ||
| Introduction | 319 | ||
| Prognostic Profiles | 321 | ||
| Predictive Profiles | 323 | ||
| Conclusion | 325 | ||
| References | 325 | ||
| Chapter 22. Partial Breast Irradiation | 327 | ||
| Background | 327 | ||
| Challenging Whole Organ Therapy | 327 | ||
| The Case for WBI | 328 | ||
| Patient Selection | 329 | ||
| Impact of Technologic Advances and Techniques | 330 | ||
| Interstitial Multicatheter Brachytherapy | 331 | ||
| MammoSite Radiation Therapy System | 332 | ||
| Other Intracavitary Devices | 333 | ||
| External-Beam Radiation Therapy | 334 | ||
| Fractionation | 336 | ||
| Ipsilateral Breast Tumor Control | 338 | ||
| Toxicity and Complications | 339 | ||
| Cosmesis | 339 | ||
| Conclusions | 340 | ||
| References | 341 | ||
| Chapter 23. Breast Cancer and Pregnancy | 343 | ||
| Epidemiology | 343 | ||
| Presentation | 343 | ||
| Pathology | 344 | ||
| Imaging | 344 | ||
| Biopsy | 345 | ||
| Staging | 346 | ||
| Treatment | 346 | ||
| Summary | 352 | ||
| References | 352 | ||
| Chapter 24. Mammary Ductoscopy | 355 | ||
| Introduction | 355 | ||
| Technical Aspects of Performing MD | 357 | ||
| Clinical Features with Use of MD | 358 | ||
| Methods of Increasing the Sensitivity of MD Sample Analysis | 359 | ||
| Indications for MD | 359 | ||
| Conclusion | 361 | ||
| Future Perspective | 362 | ||
| References | 362 | ||
| Chapter 25. Conclusion | 363 | ||
| References | 365 | ||
| Index | 367 |