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Berne & Levy Physiology, Updated Edition E-Book

Berne & Levy Physiology, Updated Edition E-Book

Bruce M. Koeppen | Bruce A. Stanton

(2009)

Additional Information

Book Details

Abstract

Berne and Levy Physiology has long been respected for its scientifically rigorous approach and now includes major updates to bring you all of the latest knowledge in the field. Bruce M. Koeppen and Bruce A. Stanton present a honed and shortened edition that emphasizes the core information needed by students of physiology today and features a full-color design and artwork to enhance readability and enrich your comprehension of every concept. With access to the full contents online at Student Consult, this time-honored book delivers an in-depth understanding of physiology more powerfully and effectively than ever before.

  • Describes all of the mechanisms that control and regulate bodily function using a clear and intuitive organ system-based approach.
  • Provides a rich understanding of the body's dynamic processes through key experimental observations and examples.
  • Includes Student Consult access to the complete and searchable contents of the book online, as well as relevant bonus content from other Student Consult titles, an image gallery, 10 physiology animations, and much more.
  • Features updated coverage throughout to expand your understanding of the most current trends in physiology and medicine, including the latest cellular and molecular knowledge.
  • Includes shaded boxes that highlight and explain important clinical and molecular information.
  • Presents new section editors who ensure that you are getting the freshest, most clinically relevant information available today.
  • Summarizes need-to-know information in each chapter with Key Points sections.

Table of Contents

Section Title Page Action Price
Front Cover Cover
Berne & Levy Physiology iii
Copyright Page iv
Table of Contents xi
Dedication v
Contributors\r vii
Preface ix
SECTION ONE: CELLULAR PHYSIOLOGY 1
CHAPTER 1. Principles of Cell Function\r 3
OVERVIEW OF EUKARYOTIC CELLS 3
THE PLASMA MEMBRANE 5
MECHANISMS OF MEMBRANE TRANSPORT 7
VESICULAR TRANSPORT 10
ELECTROCHEMICAL GRADIENT 13
OSMOSIS AND OSMOTIC PRESSURE 15
KEY CONCEPTS 18
CHAPTER 2.\r Homeostasis of Body Fluids 20
CONCEPT OF STEADY-STATE BALANCE 20
OVERVIEW OF THE INTRACELLULAR AND EXTRACELLULAR COMPARTMENTS 21
MAINTENANCE OF CELLULAR HOMEOSTASIS 23
PRINCIPLES OF EPITHELIAL TRANSPORT 28
KEY CONCEPTS 32
CHAPTER 3. Signal Transduction, Membrane Receptors, Second Messengers, and Regulation of Gene Expression\r 34
CELL-TO-CELL COMMUNICATION 34
RECEPTORS 37
RECEPTORS AND SIGNAL TRANSDUCTION PATHWAYS 40
REGULATION OF GENE EXPRESSION BY SIGNAL TRANSDUCTION PATHWAYS 47
KEY CONCEPTS 48
SECTION TWO: THE NERVOUS SYSTEM 51
CHAPTER 4. The Nervous System: Introduction to Cells and Systems\r 53
CELLULAR COMPONENTS OF THE NERVOUS SYSTEM 53
THE SUPPORTIVE MATRIX OF THE CENTRAL NERVOUS SYSTEM 55
THE CENTRAL NERVOUS SYSTEM 57
NERVOUS TISSUE REACTIONS TO INJURY 62
KEY CONCEPTS 63
CHAPTER 5. Generation and Conduction of Action Potentials\r 65
MEMBRANE POTENTIALS 65
SUPRATHRESHOLD RESPONSE: THE ACTION POTENTIAL 67
CONDUCTION OF ACTION POTENTIALS 73
SENSORY TRANSDUCTION AND CODING 77
KEY CONCEPTS 80
CHAPTER 6. Synaptic Transmission 82
ELECTRICAL SYNAPSES 82
CHEMICAL SYNAPSES 84
SYNAPTIC INTEGRATION 91
MODULATION OF SYNAPTIC ACTIVITY 92
NEUROTRANSMITTERS 95
NEUROTRANSMITTER RECEPTORS 100
KEY CONCEPTS 103
CHAPTER 7. The Somatosensory System\r 105
SUBDIVISIONS OF THE SOMATOSENSORY SYSTEM 105
THALAMIC AND CORTICAL SOMATOSENSORY AREAS 113
PAIN AND TEMPERATURE SENSATION 114
CENTRIFUGAL CONTROL OF SOMATOSENSATION 120
KEY CONCEPTS 121
CHAPTER 8. The Special Senses\r 123
THE VISUAL SYSTEM 123
THE AUDITORY AND VESTIBULAR SYSTEMS 138
THE CHEMICAL SENSES 151
KEY CONCEPTS 155
CHAPTER 9. Organization of Motor Function\r 157
PRINCIPLES OF SPINAL CORD ORGANIZATION 157
DESCENDING MOTOR PATHWAYS 168
BRAINSTEM CONTROL OF POSTURE AND MOVEMENT 173
MOTOR CONTROL BY THE CEREBELLUM 181
MOTOR CONTROL BY THE BASAL GANGLIA 188
EYE MOVEMENT 192
KEY POINTS 198
CHAPTER 10. Higher Functions of the Nervous System\r 201
THE CEREBRAL CORTEX 201
HIGHER FUNCTIONS OF THE NERVOUS SYSTEM 205
KEY CONCEPTS 216
CHAPTER 11. The Autonomic Nervous System and Its Central Control\r 218
ORGANIZATION OF THE AUTONOMIC NERVOUS SYSTEM 218
AUTONOMIC GANGLIA 222
NEUROTRANSMITTERS 222
CENTRAL CONTROL OF AUTONOMIC FUNCTION 225
KEY CONCEPTS 230
SECTION THREE: MUSCLE 231
CHAPTER 12. Skeletal Muscle Physiology\r 233
ORGANIZATION OF SKELETAL MUSCLE 233
CONTROL OF SKELETAL MUSCLE ACTIVITY 237
SKELETAL MUSCLE TYPES 243
MODULATION OF THE FORCE OF CONTRACTION 244
MODULATION OF FORCE BY REFLEX ARCS 246
SKELETAL MUSCLE TONE 246
ENERGY SOURCES DURING CONTRACTION 246
OXYGEN DEBT 247
FATIGUE 248
GROWTH AND DEVELOPMENT 248
DENERVATION, REINNERVATION, AND CROSS-INNERVATION 250
RESPONSE TO EXERCISE 252
DELAYED-ONSET MUSCLE SORENESS 252
BIOPHYSICAL PROPERTIES OF SKELETAL MUSCLE 252
KEY CONCEPTS 254
CHAPTER 13. Cardiac Muscle\r 256
BASIC ORGANIZATION OF CARDIAC MUSCLE CELLS 256
CONTROL OF CARDIAC MUSCLE ACTIVITY 259
REGULATION OF THE FORCE OF CONTRACTION 261
CARDIAC MUSCLE METABOLISM 264
CARDIAC MUSCLE HYPERTROPHY 264
KEY CONCEPTS 266
CHAPTER 14. Smooth Muscle\r 268
OVERVIEW OF SMOOTH MUSCLE 268
STRUCTURE OF SMOOTH MUSCLE CELLS 268
CONTROL OF SMOOTH MUSCLE ACTIVITY 273
INNERVATION OF SMOOTH MUSCLE 273
REGULATION OF CONTRACTION 274
REGULATION OF MYOPLASMIC CALCIUM CONCENTRATION 277
DEVELOPMENT AND HYPERTROPHY 281
SYNTHETIC AND SECRETORY FUNCTIONS 282
BIOPHYSICAL PROPERTIES OF SMOOTH MUSCLE 283
KEY CONCEPTS 285
SECTION FOUR: THE CARDIOVASCULAR SYSTEM 287
CHAPTER 15. Overview of Circulation\r 289
THE HEART 289
THE CARDIOVASCULAR CIRCUIT 289
BLOOD VESSELS 289
KEY CONCEPTS 291
CHAPTER 16.\r Elements of Cardiac Function 292
ELECTRICAL PROPERTIES OF THE HEART 292
CONDUCTION IN CARDIAC FIBERS 299
CARDIAC EXCITABILITY 301
EFFECTS OF CYCLE LENGTH 301
NATURAL EXCITATION OF THE HEART AND THE ELECTROCARDIOGRAM 302
ELECTROCARDIOGRAPHY 310
ARRHYTHMIAS 313
THE CARDIAC PUMP 317
KEY CONCEPTS 328
CHAPTER 17. Properties of the Vasculature\r 330
HEMODYNAMICS 330
THE ARTERIAL SYSTEM 336
THE VENOUS SYSTEM 342
MICROCIRCULATION AND LYMPHATICS 343
CORONARY CIRCULATION 353
CUTANEOUS CIRCULATION 358
REGULATION OF SKIN BLOOD FLOW 358
SKELETAL MUSCLE CIRCULATION 360
CEREBRAL CIRCULATION 362
INTESTINAL CIRCULATION 363
HEPATIC CIRCULATION 364
FETAL CIRCULATION 366
KEY CONCEPTS 368
CHAPTER 18. Regulation of the Heart and \rVasculature 370
REGULATION OF HEART RATE AND CONTRACTILITY 370
NERVOUS CONTROL OF THE HEART RATE 370
REGULATION OF MYOCARDIAL PERFORMANCE 375
REGULATION OF THE PERIPHERAL CIRCULATION 383
KEY CONCEPTS 390
CHAPTER 19. Integrated Control of the Cardiovascular \rSystem 393
REGULATION OF CARDIAC OUTPUT AND BLOOD PRESSURE 393
VASCULAR FUNCTION CURVE 393
RELATING THE CARDIAC FUNCTION CURVE TO THE VASCULAR FUNCTION CURVE 397
A MORE COMPLETE THEORETICAL MODEL: THE TWO-PUMP SYSTEM 401
ROLE OF THE HEART RATE IN CONTROL OF CARDIAC OUTPUT 403
ANCILLARY FACTORS THAT AFFECT THE VENOUS SYSTEM AND CARDIAC OUTPUT 404
INTERPLAY OF CENTRAL AND PERIPHERAL FACTORS IN CONTROL OF THE CIRCULATION 405
KEY CONCEPTS 414
SECTION FIVE: THE RESPIRATORY SYSTEM 415
CHAPTER 20. Structure and Function of the Respiratory System\r 417
LUNG ANATOMY 417
BLOOD SUPPLY TO THE LUNG—PULMONARY AND BRONCHIAL CIRCULATIONS 421
INNERVATION 423
MUSCLES OF RESPIRATION—DIAPHRAGM, EXTERNAL INTERCOSTALS, SCALENE 425
FLUIDS LINE THE LUNG EPITHELIUM AND PLAY IMPORTANT PHYSIOLOGICAL ROLES 426
THE LYMPHATIC SYSTEM 428
LUNG DEVELOPMENT, GROWTH, AND AGING 428
KEY CONCEPTS 429
CHAPTER 21. Mechanical Properties of the Lung and Chest Wall: Static and Dynamic\r 430
STATIC LUNG MECHANICS 430
DYNAMIC LUNG MECHANICS 435
WORK OF BREATHING 441
KEY CONCEPTS 443
CHAPTER 22. Ventilation (V.), Perfusion (Q.), and V./Q. Relationships\r 444
VENTILATION 444
ALVEOLAR VENTILATION 444
DEAD SPACE 447
PERFUSION 448
PULMONARY VASCULAR RESISTANCE 451
DISTRIBUTION OF PULMONARY BLOOD FLOW 451
ACTIVE REGULATION OF BLOOD FLOW 452
VENTILATION-PERFUSION RELATIONSHIPS 453
ARTERIAL BLOOD GAS ABNORMALITIES 454
VENTILATION-PERFUSION IN A SINGLE ALVEOLUS 454
VENTILATION-PERFUSION MISMATCHING: LOW V./Q.\r 455
ALVEOLAR HYPOVENTILATION 456
DIFFUSION ABNORMALITIES 456
MECHANISMS OF HYPERCAPNIA 456
EFFECT OF 100% OXYGEN ON ARTERIAL BLOOD GAS ABNORMALITIES 457
EFFECT OF CHANGING CARDIAC OUTPUT 457
REGIONAL DIFFERENCES 457
KEY CONCEPTS 457
CHAPTER 23. Oxygen and Carbon Dioxide Transport\r 459
GAS DIFFUSION 459
OXYGEN TRANSPORT 461
CO2 TRANSPORT 464
REGULATION OF H+ ION CONCENTRATION AND ACID-BASE BALANCE 465
THE CO2 DISSOCIATION CURVE 466
KEY CONCEPTS 466
CHAPTER 24. Control of Respiration\r 468
VENTILATORY CONTROL: AN OVERVIEW 468
RESPONSE TO CO2 468
CONTROL OF VENTILATION: THE DETAILS 469
EXERCISE 474
ABNORMALITIES IN THE CONTROL OF BREATHING 474
KEY CONCEPTS 476
CHAPTER 25. Nonrespiratory Functions of the Lung\r 477
MUCOCILIARY CLEARANCE SYSTEM 477
PERICILIARY FLUID 477
METABOLIC FUNCTIONS OF THE LUNG 479
IMMUNE DEFENSE SYSTEM 479
CLINICAL MANIFESTATIONS ASSOCIATED WITH ABNORMALITIES IN INNATE AND ADAPTIVE IMMUNITY 483
KEY CONCEPTS 483
SECTION SIX: GASTROINTESTINAL PHYSIOLOGY 485
CHAPTER 26. Functional Anatomy and General Principles of Regulation in the Gastrointestinal Tract\r 487
FUNCTIONAL ANATOMY 487
REGULATORY MECHANISMS IN THE GASTROINTESTINAL TRACT 489
RESPONSE OF THE GI TRACT TO A MEAL 493
KEY CONCEPTS 495
CHAPTER 27. The Cephalic, Oral, and Esophageal Phases of the Integrated Response to a Meal\r 496
CEPHALIC AND ORAL PHASES 496
ESOPHAGEAL PHASE 502
KEY CONCEPTS 502
CHAPTER 28. The Gastric Phase of the Integrated Response to a Meal 504
FUNCTIONAL ANATOMY OF THE STOMACH 504
GASTRIC SECRETION 505
DIGESTION IN THE STOMACH 511
GASTROINTESTINAL MOTILITY 511
GASTRIC MOTILITY 513
KEY CONCEPTS 514
CHAPTER 29. The Small Intestinal Phase of the Integrated Response to a Meal\r 516
GASTRIC EMPTYING IN THE SMALL INTESTINAL PHASE 516
CARBOHYDRATE ASSIMILATION 522
PROTEIN ASSIMILATION 523
UPTAKE OF PEPTIDES AND AMINO ACIDS 526
LIPID ASSIMILATION 526
WATER AND ELECTROLYTE SECRETION AND ABSORPTION 528
MOTOR PATTERNS OF THE SMALL INTESTINE 530
KEY CONCEPTS 531
CHAPTER 30. The Colonic Phase of the Integrated Response to a Meal 533
OVERVIEW OF THE LARGE INTESTINE 533
KEY CONCEPTS 541
CHAPTER 31. Transport and Metabolic Functions of the Liver\r 542
OVERVIEW OF THE LIVER AND ITS FUNCTIONS 542
STRUCTURAL FEATURES OF THE LIVER AND BILIARY SYSTEM 543
BILE FORMATION AND SECRETION 545
AMMONIA HANDLING BY THE LIVER 551
CLINICAL ASSESSMENT OF LIVER FUNCTION 552
KEY CONCEPTS 552
SECTION SEVEN: THE RENAL SYSTEM 555
CHAPTER 32. Elements of Renal Function\r 557
OVERVIEW OF RENAL FUNCTION 557
FUNCTIONAL ANATOMY OF THE KIDNEYS 558
ASSESSMENT OF RENAL FUNCTION 566
GLOMERULAR FILTRATION 568
RENAL BLOOD FLOW 571
REGULATION OF RENAL BLOOD FLOW AND THE GLOMERULAR FILTRATION RATE 573
KEY CONCEPTS 576
CHAPTER 33. Solute and Water Transport along the Nephron: Tubular Function\r 578
SOLUTE AND WATER REABSORPTION ALONG THE NEPHRON 578
REGULATION OF NaCl AND WATER REABSORPTION 589
KEY CONCEPTS 592
CHAPTER 34. Control of Body Fluid Osmolality and Volume\r 594
CONTROL OF BODY FLUID OSMOLALITY: URINE CONCENTRATION AND DILUTION 594
CONTROL OF EXTRACELLULAR FLUID VOLUME AND REGULATION OF RENAL NaCl EXCRETION 607
KEY CONCEPTS 618
CHAPTER 35. Potassium, Calcium, and Phosphate Homeostasis\r 619
K+ HOMEOSTASIS 619
REGULATION OF PLASMA [K+] 620
ALTERATIONS IN PLASMA [K+] 620
K+ EXCRETION BY THE KIDNEYS 622
CELLULAR MECHANISM OF K+ SECRETION BY PRINCIPAL CELLS IN THE DISTAL TUBULE AND COLLECTING DUCT 623
REGULATION OF K+ SECRETION BY THE DISTAL TUBULE AND COLLECTING DUCT 623
FACTORS THAT PERTURB K+ EXCRETION 626
OVERVIEW OF CALCIUM AND INORGANIC PHOSPHATE HOMEOSTASIS 628
KEY CONCEPTS 635
CHAPTER 36. Role of the Kidneys in the Regulation of Acid-Base Balance\r 636
THE HCO3 BUFFER SYSTEM\r 636
OVERVIEW OF ACID-BASE BALANCE 636
NET ACID EXCRETION BY THE KIDNEYS 637
RESPONSE TO ACID-BASE DISORDERS 645
SIMPLE ACID-BASE DISORDERS 647
KEY CONCEPTS 650
SECTION EIGHT: THE ENDOCRINE AND REPRODUCTIVE SYSTEMS 651
CHAPTER 37. Introduction to the Endocrine System\r 653
CONFIGURATION OF FEEDBACK LOOPS WITHIN THE ENDOCRINE SYSTEM 653
CHEMICAL NATURE OF HORMONES 656
TRANSPORT OF HORMONES IN THE CIRCULATION 661
CELLULAR RESPONSES TO HORMONES 662
KEY CONCEPTS 663
CHAPTER 38. Hormonal Regulation of Energy Metabolism\r 664
OVERVIEW OF ENERGY METABOLISM 664
ATP SYNTHESIS 665
STORAGE FORMS OF ENERGY 668
GLUCONEOGENESIS: SYNTHESIZING GLUCOSE FROM GLYCEROL, LACTATE, AND AMINO ACIDS 674
SUMMARY OF KEY METABOLIC PATHWAYS 675
KEY HORMONES INVOLVED IN METABOLIC HOMEOSTASIS 675
METABOLIC HOMEOSTASIS: THE INTEGRATED OUTCOME OF HORMONAL AND SUBSTRATE/PRODUCT REGULATION OF METABOLIC PATHWAYS 680
RELEASE OF ENERGY DURING THE INTERDIGESTIVE PERIOD OR AN EXTENDED FAST 688
RELEASE OF ENERGY DURING EXERCISE 688
LEPTIN AND ADIPOSE TISSUE 690
KEY CONCEPTS 694
CHAPTER 39. Hormonal Regulation of Calcium and Phosphate Metabolism\r 696
CRUCIAL ROLES OF CALCIUM AND PHOSPHATE IN CELLULAR PHYSIOLOGY 696
PHYSIOLOGICAL REGULATION OF CALCIUM AND PHOSPHATE: PARATHYROID HORMONE AND 1,25-DIHYDROXYVITAMIN D 696
REGULATION OF [CA++] AND [PI] BY THE SMALL INTESTINE AND BONE 700
PHYSIOLOGY OF BONE 702
INTEGRATED PHYSIOLOGICAL REGULATION OF CA++/PI METABOLISM 704
KEY CONCEPTS 705
CHAPTER 40. The Hypothalamus and Pituitary Gland\r 706
ANATOMY 706
THE NEUROHYPOPHYSIS 706
THE ADENOHYPOPHYSIS 709
KEY CONCEPTS 724
CHAPTER 41. The Thyroid Gland\r 725
ANATOMY AND HISTOLOGY OF THE THYROID GLAND 725
PRODUCTION OF THYROID HORMONES 725
TRANSPORT AND METABOLISM OF THYROID HORMONES 728
PHYSIOLOGICAL EFFECTS OF THYROID HORMONE 731
REGULATION OF THYROID FUNCTION 734
KEY CONCEPTS 736
CHAPTER 42. The Adrenal Gland\r 738
ANATOMY 738
ADRENAL MEDULLA 738
ADRENAL CORTEX 742
KEY CONCEPTS 757
CHAPTER 43. The Male and Female Reproductive Systems\r 758
THE TESTIS 758
FATES AND ACTIONS OF ANDROGENS 762
HYPOTHALAMIC-PITUITARY-TESTICULAR AXIS\r 765
THE MALE REPRODUCTIVE TRACT 765
ANDROPAUSE 769
THE OVARY 769
THE OVIDUCT 778
THE UTERUS 779
HORMONAL REGULATION OF THE UTERINE ENDOMETRIUM DURING THE MENSTRUAL CYCLE 779
THE CERVIX 782
THE VAGINA 783
THE EXTERNAL GENITALIA 783
BIOLOGY OF ESTRADIOL-17β AND PROGESTERONE 783
ONTOGENY OF THE REPRODUCTIVE SYSTEMS 784
PREGNANCY 785
MAMMOGENESIS AND LACTATION 793
MENOPAUSE 796
KEY CONCEPTS 796
INDEX 799