BOOK
Healthy Brain Aging: Evidence Based Methods to Preserve Brain Function and Prevent Dementia, An issue of Clinics in Geriatric Medicine - E-Book
(2010)
Additional Information
Book Details
Abstract
This issue examines what is a healthy aging brain and covers preventive measures for succesful cognitive aging. Topics covered include: A road map to healthy aging brain; Cardiovascular risk factors, cerebrovascular disease burden and healthy aging brain; Healthy aging brain: Impact of head injury, alcohol and environmental toxins; Healthy aging brain: What has sleep go to do with it?; Endocrine aspects of healthy aging brain; Healthy aging brain: Role of exercise and physically active lifestyle; Healthy aging brain: Role of nutrition and nutritional supplements; Healthy aging brain: Role of cognitive reserve, cognitive stimulation and cognitive exercises; Healthy aging brain: Impact of positive and negative emotions; Dementia risk predictor. Are we there yet?; Potential future neuroprotective therapies for neurodegenerative disorders and stroke; Healthy aging brain: Importance of promoting resilience and creativity.
Table of Contents
| Section Title | Page | Action | Price |
|---|---|---|---|
| Front Cover | Cover | ||
| Contributors | iii | ||
| Contents | v | ||
| Preface | xi | ||
| Chapter 1. Healthy Brain Aging: A Road Map | 2 | ||
| STEP 1: UNDERSTANDING THE DEMOGRAPHIC IMPERATIVE | 3 | ||
| STEP 2: UNDERSTANDING THE CONCEPT OF HEALTHY BRAIN AGING | 4 | ||
| STEP 3: UNDERSTANDING THAT PREVENTION OF DEMENTIA PRIMARILY INVOLVES DELAYING ONSET OF DEMENTIA | 4 | ||
| STEP 4: UNDERSTANDING THE VARIOUS EVIDENCE-BASED STRATEGIES TO PROMOTE HEALTHY BRAIN AGING | 5 | ||
| STEP 5: UNDERSTANDING WHO THE TARGET POPULATION IS, WHEN TO START APPLYING THESE INTERVENTIONS, AND WHEN TO STOP | 9 | ||
| STEP 6: UNDERSTANDING THE POTENTIAL FOR BRAIN CHANGES (NEUROPLASTICITY), THE CAPACITY OF THE BRAIN TO GENERATE NEW BRAIN CELLS (NEUROGENESIS), AND THE CONCEPT OF COGNITIVE RESERVE | 10 | ||
| STEP 7: UNDERSTANDING THE DIRECTIONS THAT FUTURE RESEARCH NEEDS TO TAKE TO MAKE HEALTHY BRAIN AGING A REALITY FOR ALL | 10 | ||
| STEP 8: UNDERSTANDING THE ROLE OF GOVERNMENT, HEALTH-INSURANCE COMPANIES, AND ACADEMIC INSTITUTIONS IN PROMOTING HEALTHY BRAIN AGING | 11 | ||
| STEP 9: UNDERSTANDING THE ROLE OF PHYSICIANS AND INDIVIDUALS IN PROMOTING HEALTHY BRAIN AGING | 12 | ||
| SUMMARY | 14 | ||
| REFERENCES | 14 | ||
| Chapter 2. Cardiovascular Risk Factors, Cerebrovascular Disease Burden, and Healthy Brain Aging | 18 | ||
| CARDIOVASCULAR RISK FACTORS AND COGNITIVE IMPAIRMENT | 18 | ||
| CARDIOVASCULAR RISK FACTORS AND DEPRESSION | 20 | ||
| POTENTIAL MECHANISMS BY WHICH CEREBROVASCULAR BURDEN INFLUENCES THE HEALTHY BRAIN | 21 | ||
| CHANGING CLINICAL PRACTICE AND PUBLIC HEALTH POLICY | 23 | ||
| KEY GAPS IN RESEARCH | 25 | ||
| SUMMARY | 25 | ||
| REFERENCES | 25 | ||
| Chapter 3. Healthy Brain Aging: Effect of Head Injury, Alcohol and Environmental Toxins | 29 | ||
| HEAD INJURY AND RISK FOR DEMENTIA | 30 | ||
| ALCOHOL AND HEALTHY AGING BRAIN | 33 | ||
| HEALTHY AGING BRAIN AND ENVIRONMENTAL TOXINS | 36 | ||
| REFERENCES | 39 | ||
| Chapter 6. Healthy Brain Aging: What Has Sleep Got To Do With It? | 45 | ||
| SLEEP AND ITS EFFECT ON COGNITION | 46 | ||
| OBSTRUCTIVE SLEEP APNEA AND THE HEALTHY AGING BRAIN | 48 | ||
| SLEEP AND SLEEP DISORDERS IN THE ELDERLY | 49 | ||
| COGNITIVE IMPAIRMENT/IMPROVEMENT FROM MEDICATIONS USED FOR SLEEP | 50 | ||
| RESEARCH GAPS | 51 | ||
| SUMMARY | 52 | ||
| REFERENCES | 52 | ||
| Chapter 7. Endocrine Aspects of Healthy Brain Aging | 57 | ||
| DIABETES MELLITUS AND INSULIN RESISTANCE | 57 | ||
| HYPERLIPIDEMIA | 58 | ||
| GROWTH HORMONE AND IGF-I | 59 | ||
| LEPTIN | 59 | ||
| METABOLIC SYNDROME | 60 | ||
| TESTOSTERONE AND COGNITIVE FUNCTION | 60 | ||
| ESTROGEN AND HORMONE THERAPY IN WOMEN | 62 | ||
| DEHYDROEPIANDROSTERONE AND PREGNENOLONE | 62 | ||
| CORTISOL | 63 | ||
| VITAMIN D | 63 | ||
| GONADOTROPIN | 64 | ||
| MELATONIN | 64 | ||
| SUMMARY | 65 | ||
| REFERENCES | 65 | ||
| Chapter 8. Healthy Brain Aging: Role of Exercise and Physical Activity | 75 | ||
| PHYSICAL ACTIVITY AND THE PREVENTION OF DEMENTIA, AD, OR COGNITIVE DECLINE | 76 | ||
| SUMMARY | 82 | ||
| REFERENCES | 83 | ||
| Chapter 9. Nutrition and the Brain | 89 | ||
| THE GUT-BRAIN AXIS | 89 | ||
| FAT-BRAIN AXIS | 90 | ||
| DIABETES MELLITUS AND MEMORY | 90 | ||
| VITAMIN B12 DEFICIENCY | 91 | ||
| VITAMIN D DEFICIENCY | 92 | ||
| FREE RADICALS AND OXIDATIVE DAMAGE | 92 | ||
| DIETARY PATTERNS AND DEMENTIA | 92 | ||
| MEMORY SHAKES | 93 | ||
| SUMMARY | 94 | ||
| REFERENCES | 94 | ||
| Chapter 10. Healthy Brain Aging: Role of Cognitive Reserve, Cognitive Stimulation, and Cognitive Exercises | 99 | ||
| KEY TERMS, CONCEPTS, AND HYPOTHESES | 100 | ||
| COGNITIVELY STIMULATING LIFESTYLES: WHAT IS KNOWN? | 101 | ||
| COGNITIVE TRAINING INTERVENTIONS: WHAT IS KNOWN? | 103 | ||
| POTENTIAL MECHANISMS FOR NEUROPROTECTIVE EFFECTS OF COGNITIVE STIMULATION AND TRAINING | 105 | ||
| IMPLICATIONS FOR CLINICAL PRACTICE AND PUBLIC HEALTH POLICY | 106 | ||
| KEY GAPS IN RESEARCH AND SUGGESTIONS ON HOW TO FILL THESE GAPS | 108 | ||
| REFERENCES | 108 | ||
| Chapter 11. Dementia Risk Prediction: Are We There Yet? | 113 | ||
| RISK FACTORS | 113 | ||
| PREVIOUS DEMENTIA RISK PREDICTOR STUDIES | 118 | ||
| SUMMARY | 119 | ||
| REFERENCES | 120 | ||
| Chapter 12. Potential Future Neuroprotective Therapies for Neurodegenerative Disorders and Stroke | 125 | ||
| TARGETING SPECIFIC MECHANISMS OF DISEASE PATHOGENESIS | 126 | ||
| AD | 127 | ||
| HD | 127 | ||
| PD | 128 | ||
| SUMMARY | 139 | ||
| REFERENCES | 139 | ||
| Chapter 13. Healthy Aging Persons and Their Brains: Promoting Resilience Through Creative Engagement | 149 | ||
| CREATIVITY, RESILIENCE, AND AGING: LEO AND MRS G | 151 | ||
| WHAT’S GOOD FOR THE PERSON IS USUALLY GOOD FOR THE BRAIN | 154 | ||
| IMPLICATIONS FOR RESEARCH, PRACTICE, AND POLICY | 155 | ||
| SUMMARY OF KEY POINTS | 159 | ||
| ACKNOWLEDGMENTS | 159 | ||
| REFERENCES | 159 | ||
| Index | 163 |