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Current Therapy of Trauma and Surgical Critical Care E-Book

Current Therapy of Trauma and Surgical Critical Care E-Book

Juan A. Asensio | Donald D. Trunkey

(2008)

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Book Details

Abstract

Here’s a unified evidence-based approach to problems encountered in trauma and critical care surgical situations. Comprehensive and concise, it is ideal for a quick overview before entering the operating room or ICU, or as a review for board certification or recertification.

  • Be prepared for the unexpected with practical, concise coverage of major surgical problems in trauma and critical care.
  • Get expert practical and up-to-date guidance on ventilator management, damage control, noninvasive techniques, imaging, infection control, dealing with mass casualties, treating injuries induced by chemical and biological agents, and much more.
  • Find the information you need quickly and easily through numerous illustrations, key points boxes, algorithms, and tables.

Table of Contents

Section Title Page Action Price
Front Cover Cover
Current Therapy of Trauma and Surgical Critical Care iii
Copyright Page iv
Contributors v
Foreword xix
Preface xxi
Table of Contents xxiii
1 Trauma Systems 1
1 The Development of Trauma Systems 1
Modern Trauma System Development 2
Are Trauma Systems Effective? 3
What are the Current Problems? 4
Solutions 4
2 Trauma Center Organization and Verification 6
Trauma System and Trauma Center Organization 6
Trauma System Organization 6
Trauma Center Organization 6
Trauma Performance Improvement Process 7
Trauma Center Verification 8
3 Injury Severity Scoring: Its Definitionand Practical Application 10
Injury Description and Scoring: Conceptual Background 10
Testing a Test: Statistical Measures of Predictive Accuracy and Power 11
Measuring Anatomic Injury 12
Measuring Physiologic Injury 15
Measuring Physiologic Reserve and Comorbidity Risk 15
More Powerful Predictions: Combining Several Types of Information 16
Statistical Considerations 18
Improved Prediction in Trauma Scoring 19
How Good are Current Scoring Systems? 19
The Uses of Injury Scoring 19
Recommendations 20
Conclusions 20
4 The Role of Alcohol and Other Drugs in Trauma 21
Effects of Alcohol and Drugs on Management and Outcome 21
Alcohol and Injury Recidivism 22
Withdrawal Syndromes: Prophylaxis and Treatment 22
Definition of Alcohol Problems 22
Rationale for Brief Alcohol Interventions in Trauma Centers 23
Screening for Alcohol Problems 23
Goals of Brief Interventions 23
Brief Intervention Techniques 24
Summary 24
Key Points 24
5 The Role of Trauma Prevention in Reducing Interpersonal Violence 25
Understanding the Problem 25
Impact of Enhanced Trauma Commitment on Patient Outcomes 25
In-Hospital Prevention: Shortcomings 25
Effectiveness of a Violence Prevention Program 25
Culture of Violence 26
6 Trauma Scoring 26
Anatomic Scoring Systems 27
Abbreviated Injury Scale 27
Injury Severity Scale 27
Anatomic Profile and New Injury Severity Score 28
ICD-9 Injury Severity Score 28
Physiologic Scoring Systems 28
Glasgow Coma Scale 28
Revised Trauma Score 29
Acute Physiology and Chronic Health Evaluation 29
Physiologic Reserve 29
Risk-Adjustment Scoring Systems 29
Trauma and Injury Severity Score 29
A Severity Characterization of Trauma 29
Mechanism of Injury 30
Scoring Systems Evaluation 30
Data Collection 30
Databases 30
Outcome Measures 30
Summary 31
7 Trauma Systems and Trauma Triage Algorithms 32
Trauma Systems 33
Trauma Systems Summary 34
Support for Regionalized Trauma Care 34
Initial Approach to the Critically Injured Patient 35
Prehospital Care: Intervention at Injury Site 35
Field Triage 35
Declaration of Death at Scene 35
Guidelines for Withholding or Termination of Resuscitation in Prehospital Cardiopulmonary Arrest 35
Initial Electrocardiographic Rhythm 35
Resuscitation Duration 35
Emergency Department Thoracotomy 37
Rapid Transport versus Field Stabilization 38
Air Medical Transport 38
Exceptions 39
Prehospital Care Controversies 39
Advanced Trauma Life Support 39
Airway Management 40
Prehospital Intubation of Patients with Traumatic Brain Injury 40
Prehospital Volume Resuscitation 40
Resuscitation with Hypertonic Saline 40
Pediatric Trauma System 41
Conclusions 41
Practice Management Guidelines for Geriatric Trauma 43
Triage Issues in Geriatric Trauma 43
Predictors of Mortality in Geriatric Population 44
Complications and Outcome 45
Parameters for Resuscitation of the Geriatric Trauma Patient 45
Summary 45
Conclusion 46
2 Prehospital Trauma Care 47
8 Delivering Multidisciplinary Trauma care: Current Challenges and Furutre Directions 47
Organizing the Initial Care of Trauma Patients 48
Prehospital Communication 48
Tiered Trauma Team Activation 48
In-House Trauma Attending 49
Captain of the Ship Concept 49
Trauma Coverage by Specialists 49
Organizing Subsequent Care of Trauma Patients 49
Role of Tertiary Survey 49
Communication 50
Morning Report 50
Check-Out Rounds 50
Multidisciplinary Rounds 50
Role of Physician Extenders 50
Next Generation of Trauma Surgeons 51
Working Hours 51
Trauma as a Nonoperative Specialty 51
Operative Trauma Education 52
Other Challenges in Organizing Trauma Care 52
Alcohol and Substance Abuse 52
Social and Financial Issues 53
Rehabilitation and Further Disposition 53
Nutritional Support 53
Populations at Risk 53
Geriatric Population 53
Obstetric Trauma Patients 53
Pediatric Population 53
Funding for Educational Outreach and Research 54
Summary 54
9 Triage 55
Field Triage 55
Mass Casualty Triage 56
Comments 57
10 Prehospital Airway Management: Intubation, Devices, and Controversies 58
Who Needs an Airway? 58
Difficult Airway 58
Which Strategy should be Used? 58
Laryngeal Mask Airway 58
Combitube 58
Orotracheal Intubation 59
Confirmation of Orotracheal Tube Placement 60
Controversies in Prehospital Intubation 60
Prehospital Intubation in Traumatic Brain Injury 60
Who Should Perform Prehospital RSI? 60
Role of Capnometry in Prehospital Intubation 61
Use of Positive End-Expiratory Pressure 61
Final Comments 62
11 Prehospital Fluid Resuscitation: What Type, How Much, and Controversies 63
Epidemiology 63
Causes of Significant Hemorrhage 63
Diagnosis/Assessment 63
Classes of Hemorrhagic Shock 64
Management 64
Access 64
Types of Fluid 64
Resuscitation Targets 66
Morbidity and Complications 66
Summary 66
12 Civilian Hospital Response to Mass Casualty Events 67
Key Definitions 67
Prehospital Care in Mass Casualty Event 67
Hospital Triage 67
Hospital Emergency Incident Command System 69
Disaster Preparedness through Simulation 69
Causes of Mass Casualty Events 69
Conventional Weapons/Blast Injury 69
Biological Agents 70
Chemical Agents 71
Radiation Injuries 72
Conclusion 73
13 Blast Injuries 73
Mechanisms of Injury and Injury Patterns in Explosions 73
Blast Injury: Clinical Aspects 74
Primary Blast Injury 74
Secondary Blast Injury 75
Tertiary Blast Injury 76
Quaternary Blast Injury 76
Quinary Blast Injury 76
Multidimensional Injury Pattern 76
Treatment of Blast Injuries 76
14 Prehospital Care of Biological Agent–Induced Injuries 78
15 Wound Ballistics: What Every Trauma Surgeon should Know 82
Firearm and Projectile Design 82
Handguns 83
Hunting Rifles 84
Assault Rifles 85
Shotguns 85
Protective Vests 86
Landmines and Improvised Explosive Devices 87
Red Cross Wound Classification 87
Bullet Removal 87
16 Common Prehospital Complications and Pitfalls in the Trauma Patient 88
Incidence 88
Airway 89
Breathing 89
Circulation 90
Disability 92
Transport 92
Comorbidities 92
Conclusion 93
3 Inital Assessment and Resuscititation 95
17 Airway Management: what every trauma surgeon shouls know, from intubation to cricothyroidotomy 95
Airway Anatomy 95
Assessing the Airway 97
Controlling the Airway 97
Documentation of Proper Endotracheal Tube Placement 98
Combitube© 100
Endotracheal Intubation 101
Nasal Intubation 101
Orotracheal Intubation 101
Surgical Airway 103
Needle Cricothyroidotomy 104
Cricothyroidotomy 104
Emergency Surgical Tracheostomy 104
Management of Airway When Neck is Lacerated 105
Summary 105
18 Resuscitation Fluids 106
Classes of Shock 106
Autoresuscitation 106
Vasoconstriction and Reduction of Capillary Hydrostatic Pressure 106
Hormonal Response 106
Hypotensive Resuscitation 108
Choice of Fluids 108
Crystalloid Solutions 109
Hypertonic Saline 110
Artificial Oxygen-Carrying Blood Substitutes 110
Blood Transfusions 110
Complications of Resuscitation 111
Hypothermia 111
Coagulopathy 112
Acidosis 113
Summary 114
19 Emergency Department Thoracotomy 114
Historic Perspective 114
Objectives 115
Physiology 115
Positive Effects 115
Negative Effects 115
Indications 115
Accepted Indications 115
Selective Indications 115
Rare Indications 116
Techniques for Cardiac Injury Repair 116
Incisions 116
Adjunct Maneuvers 116
Repair of Atrial Injuries 118
Repair of Ventricular Injuries 118
Coronary Artery Injuries 118
Use of Bioprosthetic and Autogenous Materials 119
Complex and Combined Injuries 119
Results 119
20 The Role of Focused Assessment with Sonography for Trauma: Indications, Limitations, and Controversies 125
Formation of an Ultrasound Image 125
Technique 125
Troubleshooting 128
Indications 128
Accuracy 130
Learning Curve and Training 130
Fluid Volume and Scoring Systems 131
Algorithm: Blunt Abdominal Trauma 131
Algorithm: Penetrating Thoracoabdominal Trauma 131
Extensions to Fast 132
Hemothorax 132
Pneumothorax 132
Sternal Fracture 132
Fast for Pediatric Trauma 133
Fast for Reproductive-Age Females 133
Limitations of Fast 134
Controversies 134
Summary 135
21 The Use of Computed Tomography in Initial Trauma Evaluation 136
History 136
Computed Tomography of Head/Brain (Cranium) 136
Computed Tomography of Face and Orbits 136
Computed Tomography of Spine 136
Computed Tomography of Neck and Great Vessels 137
Computed Tomography of Chest 137
Computed Tomography of Abdomen and Pelvis 138
Computed Tomography of Orthopedic Injuries 138
22 Interventional Radiology: Diagnosticsand Therapeutics 139
Indications 139
Blunt Cerebrovascular Injury 139
Brachiocephalic Trauma 140
Thoracic Injury 140
Abdominal Trauma 141
Pelvic Trauma 142
Extremity Trauma 142
Management of Late Complications 143
23 Endpoints of Resuscitation 143
Hemodynamic Parameters 143
Vital Signs and Clinical Endpoints 143
Invasive Monitoring 144
Metabolic Parameters 145
Lactate 145
Base Deficit 145
Regional Perfusion Endpoints 145
Summary 146
4 Head and Central Nervous System Injuries 147
24 Traumatic Brain Injury: Pathophysiology, Clinical Diagnosis, and prehospital and Emergency Center Care 147
Incidence 147
Mechanism of injury 147
Subdural Hematoma 147
Epidural Hematoma 147
Subarachnoid Hemorrhage 148
Parenchymal Lesions 148
Ischemia 148
Diffuse Axonal Injury 149
Cellular and Molecular Factors 149
Clinical Diagnosis 149
Clinical Examination 149
Initial Clinical Interventions: Prehospital and Emergency Center Care 149
Airway 149
Breathing 149
Circulation 150
Imaging Modalities: What, When, and Why 150
Computed Tomography Scanning 150
Magnetic Resonance Imaging 150
Angiography 150
Injury Grading 151
Glasgow Coma Scale 151
Marshall Computed Tomography Scale 151
Abbreviated Injury Scale 151
Mild and Moderate Traumatic Brain Injury 151
Conclusions and Algorithm 152
25 Traumatic Brain Injury: Imaging, Operativeand Nonoperative Care, and Complications 153
Surgical Management 153
Positioning 153
Bone Flap 153
Brain Swelling 153
Epidural Hematomas 154
Intraparenchymal Lesions 154
Intracranial Pressure Monitoring 154
Coagulopathy 154
Summary 154
Nonoperative Management 154
Location of Care 154
Secondary Insults 154
Ventilator Weaning and Tracheostomy 155
Sedation 155
Cerebral Monitoring 155
Nutrition 155
Fluids and Electrolytes 155
Physical, Occupational, and Speech Therapy 155
Fever 155
Deep Venous Thrombosis 155
Transfusion Thresholds 156
Treatment of Intracranial Hypertension 156
Individualization of Treatment 158
Failure of Intracranial Pressure Prophylaxis 158
Guidelines 158
Failure of Clinical Trials 158
Morbidity and Complications 158
Mortality 158
Penetrating Brain Injury 159
Conclusions and Algorithm 159
26 Spine: Spinal Cord Injury, Blunt and Penetrating, Neurogenic and Spinal Shock 160
Incidence 160
Mechanism of Injury 161
Biomechanics of the Spine 161
Mechanism of Injury 162
Penetrating Spinal Cord Injury 162
Blunt Spinal Cord Injury 162
Severity/Grading of Spinal Cord Injuries 162
Neurological and Functional Outcome Scales 162
Spinal Cord Syndromes 163
Diagnosis 164
Management of Acute Spinal Cord Injury 164
Prehospital Care 166
Acute Emergency Department Evaluation/Management 166
Surgical Intervention 166
Thoracolumbar Fractures 167
Optimal Timing of Surgical Intervention in Spinal Cord Injuries 167
Surgery in Penetrating Spinal Cord Injuries 167
Nonoperative Acute Interventions 169
Pharmacotherapy and Spinal Cord Injury 169
Institution of Blood Pressure Parameters 170
Subacute Management of SCI 170
Morbidity and Complications Management in Spinal Cord Injury 171
Neurogenic Shock 171
Spinal Shock 171
Pulmonary Complications 171
Thromboembolism 171
Genitourinary Complications 172
Gastrointestinal Complications 172
Skin Care 172
Post-Traumatic Syringomyelia 172
Mortality 172
Conclusion 172
5 Maxillofacial and Ocular Injuries 175
27 Maxillofacial Injuries 175
Airway and breathing 175
Circulation and Control of Hemorrhage 175
Epistaxis 175
Scalp Lacerations 176
Tongue Lacerations 176
Hemorrhage from LeFort Fractures 176
History and Physical Exam 176
Radiographs 176
Soft Tissue Injuries 176
General Considerations 176
Local Anesthesia 176
Antibiotics 177
Abrasions 177
Foreign Bodies 177
Treatment of Lacerations—General Concepts 177
Lip Lacerations 177
Nasal Lacerations 177
Ear Lacerations 178
Orbital Soft Tissue Injuries 178
Lacrimal System Injuries 178
Parotid Duct Injuries 178
Facial Nerve Injuries 178
Intraoral Injuries 179
Facial Fractures 179
General Principles 179
Frontal Sinus/Frontobasilar Fractures 179
Naso-Orbital-Ethmoid Fractures 179
Orbital Fractures 179
Zygoma Fractures 180
Maxillary LeFort Fractures 180
Nasal Fractures 180
Mandibular Fractures 180
28 Trauma to the Eye and Orbit 181
Incidence 181
Mechanism of Injury 182
Diagnosis 184
Orbital Trauma 184
Ocular Trauma 185
Anatomic Location of Injury and Injury Grading—Ocular Trauma Classification Group 191
Medical and Surgical Management 193
Trauma to the Orbit 193
Conclusions and Algorithm 194
6 Neck Injuries 197
29 Penetrating Neck Injuries: Diagnosis and Selective Management 197
Anatomy of the Neck 197
Initial Evaluation 197
Aero-Digestive Injury 197
Soft Tissue Injury 199
Thoracic Duct Injury 199
Vascular Injury in the Neck 199
Treatment of Carotid Artery Injuries 201
Conclusion 202
30 Carotid, Vertebral Artery, and Jugular Venous Injuries 203
Carotid Artery Injuries 203
Incidence 203
Mechanism of Injury 203
Diagnosis 203
Treatment 204
Vertebral Artery Injuries 205
Incidence 205
Mechanism of Injury 205
Associated Injuries 205
Diagnosis 205
Treatment 205
Jugular Venous Injuries 206
31 Blunt Cerebrovascular Injuries 207
Signs and Symptoms 207
Mechanism and Patterns of Injury 207
Diagnostic Imaging 207
Injury Grading Scale 209
Incidence of blunt Cerebrovascular Injuries 210
Antithrombotic Treatment 211
Role of Endovascular Stents 213
Long-Term Follow-Up and Outcome 213
Conclusions 213
32 Tracheal, Laryngeal, and Oropharyngeal Injuries 215
Anatomy of Upper Airway 215
Oral Cavity 215
Pharynx 215
Pharyngeal Injury 217
Incidence 217
Mechanism of Injury 217
Diagnosis 217
Larynx 218
Surgical Anatomy 218
Laryngeal Injury 219
Trachea 219
Surgical Anatomy 219
Tracheal Injury 219
Surgical Management 222
Nonoperative Management 222
Operative Management 222
Morbidity 223
Early Complications 223
Late Complications 224
Other Potentially Life-Threatening Complications 225
Mortality 225
7 Thoracic Injuries 227
33 Pertinent Surgical Anatomy of the Thorax and Mediastinum 227
Chest wall 227
Muscles of the Chest Wall 229
Intercostal Space 232
Pleural Space 232
Diaphragm 232
Pericardium 234
Subxiphoid Space 236
Heart 237
Body Surface Markings for Heart 237
External Features 237
Coronary Arteries and Veins 239
Conduction System 239
Internal Features of Heart Chambers 241
Anatomy of Pulmonary Artery/ Swan-Ganz Catheter Placement 241
Hilum of Lung 246
Right Hilum 246
Left Hilum 247
Lung Anatomy 248
Aorta,Trachea, Esophagus, and Thoracic Duct 249
Aorta 249
Trachea 249
Esophagus 250
Thoracic Duct 251
34 Thoracic Wall Injuries: Ribs, Sternal Scapular Fractures, Hemothoraces, and Pneumothoraces 252
Incidence 252
Mechanism 252
Diagnosis 252
Physical Examination 252
Radiographic Studies 253
Aast-Ois Grading 255
Management of Specific Injuries to Chest Wall 255
Chest Wall Defects 255
Rib Fractures and Flail Chest 256
Narcotics 256
Regional Anesthesia 256
Pneumothorax and Hemothorax 257
Tube Thoracostomy: Technique and Management 257
Sternal Fractures 258
Scapular Fractures 258
Scapulothoracic Dissociation 258
Clavicular Fractures 259
Complications of Hemopneumothorax 259
Empyema 259
Pneumatocele 259
Persistent Air Leaks and Bronchopleural Fistula 259
Complications of Bony Injuries 260
Conclusions 260
35 Diagnostic and Therapeutic Roles of Bronchoscopy 261
Incidence 261
Diagnostic and Therapeutic Roles of Vats in Chest Trauma 262
Indications and Patient Selection 262
Surgical Approach 263
Morbidity and Complication Management 264
Diagnostic and Therapeutic Role of Bronchoscopy 264
Basic Technique of Flexible Fibroptic Bronchoscopy 264
Diagnostic Role of Flexible Fibroptic Bronchoscopy 265
Therapeutic Role of Flexible Fibroptic Bronchoscopy 266
Conclusion 268
36 Pulmonary Contusion and Flail Chest 269
Incidence 269
Physical Mechanisms of Injury 269
Mechanisms of Physiologic Injury 270
Diagnosis 271
Physical Examination 271
Chest X-Rays 271
Chest Computed Tomography 271
Physiologic Studies 272
Anatomic Location of Injury and Injury Grading 273
Management 273
Immediate Management 273
Intensive Care Unit Management 273
General Principles of Ventilator Management 273
Pain Management 275
Steroids 276
Tracheostomy 276
Operative Stabilization of Flail Chest 276
Mortality 276
Conclusion 276
37 Tracheal and Tracheobronchial Tree Injuries 278
Incidence and Mechanisms of Injury 278
Diagnosis 278
Presentation 278
Evaluation 279
Management 280
Initial Management 280
Nonoperative Management 280
Operative Management 280
Outcomes 281
38 Operative management of pulmonary injuries: lung-sparing and formal resections 282
Incidence 283
Etiology 284
Classification 284
Diagnosis 284
Physical Examination 284
Adjunctive Diagnostic Modalities 284
Associated Injuries 285
Anatomic Location of Injury 286
Management 286
Surgical Decisions 286
Operative Management 287
Surgical Techniques of Repair and Resection 291
Tissue-Sparing Procedures 291
Resectional Procedures 292
Prognostic Factors and Outcomes 293
Mechanism of Injury and Type of Wounding Agents 293
Prehospital Transport Time 293
Presence of Shock at Scene or upon Arrival 293
Loss of Airway 294
Presence of Associated Injuries 294
Complexity of Surgical Procedure 294
Location of Injury 294
Morbidity 294
Intraoperative Complications 294
Short-Term Postoperative Complications 294
Long-Term Postoperative Complications 294
Mortality 295
Conclusions 295
39 Complications of Pulmonary and Pleural Injury 298
Pulmonary 298
Persistent Air Leak 298
Pneumatocoele/Hematoma 299
Pneumonia 299
Necrotizing Lung Infection 299
Bronchial Stricture 300
Pulmonary Torsion 300
Retained Parenchyma Missiles 300
Pleural 301
Retained Hemothorax 301
Empyema 301
Chylothorax 303
Fibrothorax 303
40 Cardiac Injuries 304
Penetrating Cardiac Injury 304
Historical Perspective 304
Incidence 304
Etiology 304
Clinical Presentation 304
Diagnosis 305
Management 305
Techniques for Cardiac Injury Repair 306
Anatomic Location of Injury 309
Associated Injuries 309
Prognostic Factors 309
Blunt Cardiac Injury 309
Historical Perspective 309
Mechanism, Pathophysiology, and Incidence 311
Clinical Presentation 311
Diagnosis 311
Spectrum of Blunt Cardiac Injury 311
Myocardial Contusion 312
Conclusions 313
41 Thoracic Vascular Injury 315
Incidence 316
Mechanism of Injury 316
Diagnosis 316
American Association for The Surgery of Trauma, Organ Injury Scale 318
Surgical Management 318
Morbidity and Management Complications 320
Mortality 320
Conclusions 320
42 Treatment of Esophageal Injury 321
Incidence 321
Diagnosis 322
Surgical Treatment 322
Cervical Esophagus 323
Thoracic Esophagus 323
Abdominal Esophagus 323
Devastating Injuries 324
Management of Complications 325
Conclusions 326
43 Diaphragmatic Injury 326
Anatomy and Physiology 326
Incidence of Diaphragmatic Injuries 328
Mechanism and Location of Injury 329
Severity of Injury 330
Diagnosis of Diaphragmatic Injury 330
Management of Diaphragmatic Injury 331
Mortality 333
Morbidity 333
Complicated Diaphragmatic Repair with Thoracic Injury 334
Combined Chest Wall and Abdominal Defect with Diaphragmatic Rupture 335
8 Abdominal Injuries 341
44 Surgical Anatomy of the Abdomen and Retroperitoneum 341
Making the Incision 341
Exploring the Abdomen 341
Exploring the Retroperitoneum 343
Future Challenges 346
Summary 347
45 Diagnostic Peritoneal Lavage and Laparoscopy in Evaluation of Abdominal Trauma 347
Laparoscopy in Trauma 350
46 Nonoperative Management of Blunt and Penetrating Abdominal Injuries 352
Blunt Abdominal Injury 352
Incidence 352
Mechanism of Injury 352
Diagnosis 353
Anatomic Location of Injury and AAST-OIS Grading 353
Management 353
Morbidity and Complications Management 356
Mortality 357
Conclusions 357
Penetrating Abdominal Injury 357
Incidence 358
Mechanism of Injury 358
Diagnosis 358
Anatomic Location of Injury and AAST-OIS Grading 359
Management 359
Morbidity and Complications Management 360
Mortality 360
Conclusions and Algorithm 361
47 Gastric Injuries 362
Incidence 362
Mechanism of Injury 362
Diagnosis 362
Surgical Management 363
Mortality 364
Morbidity 364
Conclusion 364
48 Small Bowel Injury 365
Incidence 365
Mechanism of Injury 365
Diagnosis 365
Injury Grading 368
Surgical Management 368
Complications 370
Mortality 371
Conclusions 372
49 Duodenal Injuries 372
Determinants of Outcome 372
Anatomy and Physiology 373
Diagnostic Adjuvants 373
Treatment 374
Duodenal Hematoma 377
50 Pancreatic Injuries 379
Anatomy 379
Physiology 379
Diagnosis 380
Classification of Pancreatic Injuries 381
Surgical Management of Pancreatic Injuries 381
Morbidity and Complications Management 384
Conclusions 384
51 Liver Injury 385
Incidence 385
Mechanism of Injury 385
Blunt Hepatic Injury 385
Penetrating Hepatic Injury 385
Diagnosis 386
Hemodynamically Unstable Patients 386
Hemodynamically Stable Patients 386
Anatomic Location of Injury and Injury Grading—Aast-Ois 387
Management 387
Nonoperative Management/Blunt Hepatic Trauma 387
Contrast “Blush” on CT 388
Nonoperative Management/Penetrating Hepatic Trauma 388
Operative Management/General Principles 388
Operative Management/Minor Injuries (Grades I and II) 389
Operative Management/Complex Injuries (Grades III to V) 389
Juxtahepatic Venous Injuries (Grade V) 391
Portal Triad Injuries 395
Damage Control/Perihepatic Packing and Planned Re-Exploration 395
Adjuncts to Operative Management 395
Morbidity and Complications Management 396
Failure of Nonoperative Management 396
Hemorrhage 396
Perihepatic Sepsis/Abscess 397
Bile Collections/Fistula 397
Hemobilia 397
Injury to the Intrahepatic Bile Ducts and Late Stricture 397
Postobservational CT Scanning 397
Resumption of Normal Activities 397
Mortality 397
Conclusions/Algorithm 398
52 Splenic Injuries 400
Incidence and Mechanism of Injury 400
Diagnosis 401
Anatomic Location of Injury and Injury Grading: American Association for the Surgery of Trauma Organ Injury Scale 402
Management 403
Nonoperative Management 403
Transcatheter Embolization 405
Operative Management 405
Morbidity and Complications of Management 407
Mortality 407
Conclusions and Algorithm: 408
53 Abdominal Vascular Injuries 410
Epidemiology 410
Initial Resuscitation 410
General Operative Maneuvers 411
Classification of Injuries 411
Injuries in Supramesocolic Region of Zone 1 411
Injuries in Inframesocolic Region of Zone 1 412
Injuries in Zone 2 413
Injuries in Zone 3 413
Injuries in Porta Hepatis or to Retrohepatic Inferior Vena Cava 413
Injury Grading 413
Conclusions 414
54 Colon and Rectal Injuries 416
Incidence and Mechanism 416
Diagnosis 416
Anatomic Location and Injury Grading 416
Surgical Management 416
Morbidity and Complications Management 419
Mortality 419
Conclusions and Algorithm 419
55 Genitourinary Tract Injury 420
Kidney Injury 420
Ureteral Injury 421
Bladder Injury 422
Urethral Injury 422
Genital Injury 423
56 Gynecologic Injuries 423
Trauma in Pregnancy 423
Incidence 424
Mechanism of Injury 424
Diagnosis 424
Surgical Treatment 426
Morbidity and Mortality 427
Conclusions 427
Trauma to Nongravid Uterus and Female Genitalia 427
Incidence 428
Mechanism of Injury 428
Diagnosis 428
Surgical Management 429
Morbidity and Mortality 429
Conclusions 429
57 Multidisciplinary Management of Pelvic Fractures: Operative and Nonoperative Hemostasis 430
Pelvic Bleeding: Making the Diagnosis 430
Pelvic Fracture Classifications 431
Treating Pelvic Fracture Bleeding 432
Management of Open Pelvic Fractures 435
Summary 436
9 Special Issues in Major Torso Trauma 437
58 Current Concepts in the Diagnosis and Management of Hemorrhagic Shock 437
Epidemiology of Severe Hemorrhagic Shock 437
Clinical Perspective: Length and Depth of Hypotension 437
Discrepancies between Clinical Syndrome of Shock and Animal Models Used to Study Shock 438
Diagnosis of Shock 438
Assessment of Tissue Perfusion 438
Management of Shock 439
Hemorrhage Control 439
Local Hemorrhage Control 439
Systemic Hemorrhage Control 439
Factor VIIa 439
Fluids 439
Vascular Access for Patients with Severe Hemorrhage 440
Timing and Volume of Resuscitation Fluid Therapy 440
Type of Fluid 440
Pharmacotherapy 442
Vasopressin 442
New Therapeutic Possibilities 442
Hypothermia and Hemorrhagic Shock 443
Summary 443
59 Exsanguination: Reliable Models to Indicate Damage Control 445
History 445
Metabolic Failure 446
Models for Damage Control 446
Patient Selection 447
Technique of Damage Control 447
Conclusions 448
60 Surgical Techniques for Thoracic, Abdominal, Pelvic, and Extremity Damage Control 449
Predisposing Factors 449
Initial Resuscitation Concerns 449
Phase I: Damage Control Operation 450
Damage Control Laparotomy 450
Damage Control Thoracotomy 451
Damage Control Orthopedics 451
Phase 2: Resuscitation in Intensive Care Unit 452
Phase 3: Definitive Operative Management 452
Complications Following Damage Control Surgery 452
Immediate 452
Delayed 453
Summary 453
Table 3: Indications for Early Return to Operating Room 453
61 Abdominal Compartment Syndrome, Damage Control, and the Post-Traumatic Open Abdomen 454
Abdominal Compartment Syndrome 454
Damage Control 455
Temporary Abdominal Closure 457
Planned Ventral Hernia and Delayed Abdominal Wall Reconstruction 463
Conclusion 464
10 Peripheral Vascular Injury 467
62 Vascular Anatomy of the Extremities 467
Diagnosis 467
Management 467
Vascular Anatomy of Upper Extremity 467
Axillary Artery 467
Axillary Vein 468
Surgical Exposure of Axillary Vessels 468
Brachial Artery 468
Surgical Exposure of Brachial Artery 468
Radial Artery 469
Ulnar Artery 469
Surgical Exposure of Ulnar and Radial Arteries 469
Veins of Upper Extremity 469
Basilic Vein 469
Cephalic Vein 469
Axillary Vein 469
Nerves of Upper Extremity 469
Median Nerve 470
Ulnar Nerve 470
Radial Nerve 470
Vascular Anatomy of Lower Extremity 470
Femoral Artery 470
Profunda Femoris Artery 470
Superficial Femoral Artery 470
Surgical Exposure of Femoral Artery 471
Popliteal Artery 471
Anterior Tibial Artery 471
Tibioperoneal Trunk 471
Posterior Tibial Artery 471
Peroneal Artery 471
Surgical Exposure of Vessels in Leg 472
Veins of Lower Extremity 472
Long Saphenous Vein 472
Short Saphenous Vein 472
63 The Diagnosis of Vascular Trauma 473
DIAGNOSIS 473
History 473
Physical Examination 473
Hard and Soft Signs of Vascular Injury 474
Additional Ancillary Tests 474
Specific Areas of Injury 475
Acknowledgment 476
64 Upper Extremity Vascular Trauma 477
Incidence 478
Mechanism of Injury 478
Diagnosis 479
Anatomic Location of Injury and Injury Grading 480
Surgical Management 481
Morbidity and Complications Management 483
Mortality 483
Conclusions and Algorithm 483
65 Lower Extremity Vascular Injuries: Femoral, Popliteal, and Shank Vessel Injury 484
Incidence and Mechanism of Injury 484
Diagnosis 485
Operative Management for all Peripheral Vascular Injury 485
Preoperative Management 485
Intraoperative Management 486
Approach to Specific Vascular Injuries 486
Postoperative Management 488
Morbidity and Complications 488
Outcome 488
Conclusion 488
66 Compartment Syndromes 489
Incidence 489
Mechanism of Injury 489
Diagnosis 489
Physical Examination 489
Compartment Measurements 490
Noninvasive Methods 490
Laboratory Studies 490
Anatomic Location and Grading of Injury 491
Surgical Management 492
Morbidity and Complication Management 494
Mortality 494
Conclusions and Algorithms 494
11 Musculoskeletal and Peripheral Central Nervous System Injuries 497
67 Upper Extremity Fractures: Orthopedic Management 497
Open Fractures 497
Dislocations 497
Gunshot Wounds 497
Imaging Studies 498
Injuries to Shoulder Girdle and Humerus 498
Scapula Fractures 498
Scapulothoracic Dissociation 499
Glenohumeral Dislocation 499
Proximal Humerus Fractures 499
Humeral Shaft Fractures 500
Elbow 500
Distal Humerus Fractures 500
Elbow Dislocation 502
Radial Head Fractures 503
Coronoid Fractures 503
Olecranon Fractures 503
Forearm 503
Monteggia Fracture 503
Radial and/or Ulnar Shaft Fractures 505
Galeazzi Fractures 505
Wrist 505
Distal Radius Fracture 505
Perilunate Dislocations 506
Carpal Fractures and Ligamentous Injuries 506
Conclusion 507
68 Lower Extremity and Degloving Injury 508
Radiologic Evaluation 508
Fractures 509
Early Care of Musculoskeletal Injuries 509
Open Fractures 509
Identification and Classification 509
Management 509
Compartment Syndromes 511
Degloving Injuries 512
Mangled Extremities: Delayed Amputation 512
69 Cervical, Thoracic, and Lumbar Fractures 513
Neurologic Injury 513
Classification of Neurologic Injury 513
Incomplete Spinal Cord Syndromes 513
Spinal Cord Injury 514
Cervical Spine Trauma 514
Evaluation 514
Anatomy 514
Cervical Spinal Ligamentous Instability 514
Occipital Condyle Fracture 515
Occipitocervical Dissociation 515
Atlas Fractures 515
Dens Fractures 516
Traumatic Spondylolisthesis of Axis 516
Subaxial Spine Fractures 516
Subaxial Spine Dislocations 517
Special Considerations 517
Thoracic and Lumbar Spine Trauma 517
Anatomy 517
Fractures 518
Important Considerations 519
70 Pelvic Fractures 520
Anatomy 520
Radiology 520
Classification 520
Acute Patient Management 520
Hemodynamic Instability 523
Modalities for Initial Treatment 523
Pelvic Binders 523
Angiography 523
External Fixation 523
C-Clamp 523
Surgical Management of Pelvic Bleeding 523
Treatment and Outcomes 523
Summary 525
71 Hand Fractures 525
Incidence 525
Mechanism of Injury 525
Diagnosis 526
Metacarpal Fractures 526
Metacarpal Shaft Fractures 526
Metacarpal Neck Fractures 527
Metacarpal Head Fractures 528
Thumb Metacarpal Fractures 528
Bennett’s Fracture 528
Rolando Fracture 529
Phalangeal Fractures 529
Distal Phalangeal Fractures 529
Proximal and Middle Phalangeal Fractures 530
Dislocations 530
Proximal Interphalangeal Joint Dislocation 530
Distal Interphalangeal Joint Dislocation 530
Metacarpophalangeal Joints 530
Thumb Metacarpophalangeal Joints 533
Complications 533
72 Scapulothoracic Dissociation and Degloving Injuries of the Extremities 533
Incidence 533
Mechanism of Injury 533
Diagnosis 534
Injury Grading 534
Management 534
Morbidity and Complications 535
Mortality 536
Conclusions and Algorithm 536
73 Extremity Replantation: Indications and Timing 537
Incidence 537
Classification 537
Indications 537
Timing 538
Conclusion 540
74 Techniques in the Management Complex Musculoskeletal Injury: Roles Muscle, Musculocutaneous, and Fasciocutaneous Flaps 541
Diagnosis 541
Anatomy 541
Surgical Management: Primary Flaps 541
Head and Neck 541
Upper Extremity 542
Chest Wall and Trunk 542
Abdominal Wall and Groin 544
Lower Extremity 544
Complications Management 545
12 Special Issues and Situations in Trauma Management 547
75 Airway Management in the Trauma Patient: How to Intubate and Manage Neuromuscular Paralytic Agents 547
Airway Considerations in the Trauma Patient 547
Evaluation of Airway and Respiratory Function 548
Indications for Intubation and Controlled Ventilation 549
Induction Agents And Muscle Relaxants 550
Intubation Techniques 551
Summary 552
76 Pediatric Trauma 553
Incidence of Pediatric Trauma 553
Mechanisms of Pediatric Trauma 553
Initial Assessment, Stabilization, and Management of Injured Child 553
Airway Management 553
Vascular Access 554
Circulatory Management 554
Diagnostic Assessment 555
Management of Specific Injuries 556
Head and Central Nervous System Injury 556
Thoracic Injuries 557
Abdominal Injuries 557
Acknowledgment 558
77 Trauma in Pregnancy 559
Incidence 559
Mechanism of Injury 559
Blunt Trauma 559
Penetrating Trauma 559
Intimate Partner Violence 559
Physiologic Alterations of Pregnancy 560
Second Trimester 560
Third Trimester 560
Diagnosis 561
Primary Survey 561
Secondary Survey 561
Initial Evaluation of the Fetus 561
Exposure to Radiation from Diagnostic Radiographs 561
Surgical Management 561
Blunt Trauma 562
Penetrating Trauma 562
Cesarean Section 562
Morbidity and Complications Management 563
Fetomaternal Hemorrhage 563
Premature Labor 563
Pre-eclampsia and Eclampsia 563
Placental Abruption 563
Amniotic Fluid Embolization 563
Venous Thromboembolism 563
Intra-Abdominal Infection 564
Mortality 564
Conclusions 564
78 Trauma in the Elderly 565
Physiology 565
Mechanism of Injury 566
Outcomes 567
Management of Specific Organ Injuries 567
Conclusions 568
79 Burns 569
INCIDENCE 569
Mechanism of Injury 569
Pathophysiology 569
Local Effects 569
Systemic Response 570
Grading of Burn Wound Depth 571
Resuscitation Priorities 571
Fluid Administration 571
Ventilatory Support 573
Initial Wound Care 574
Burn Wound Excision and Grafting 575
Specialized Injuries: Electrical Burns 576
Specialized Injuries: Chemical Injuries 576
Specialized Injuries: Cold Injuries 576
Morbidity and Complications Management 577
Early Complications 577
Metabolic and Nutritional Support 577
Transportation and Transfer 578
Mortality 578
80 Soft Tissue Infections 579
Superficial Infections 579
Deep Infection 579
Clinical Presentation 579
Diagnostic Imaging 580
Pathophysiology 580
Surgical Treatment 580
Bacteriology 582
Pharmacologic Therapy 582
Hyperbaric Oxygen 582
Mortality, Morbidity, and Complications Management 582
Conclusions 582
81 Common Errors in Trauma Care 583
Missed Diaphragmatic Injury 583
Failure to Recognize Extremity Compartment Syndrome 584
Abdominal Compartment Syndrome 584
The Myth of Mandatory Colostomy 585
Delayed Damage-Control Laparotomy 586
Missed Hollow Viscus Injury 586
Failure to Perform Tertiary Survey 587
Futile Resuscitative Thoracotomy 587
Summary 588
13 Critical Care I, Management of Organ Failures 589
82 Cardiac Hemodynamics: The Pulmonary Artery Catheter and the Meaning of its Readings 589
History of Controversy 589
Pulmonary Artery Catheter Use and Insertion: What it is and How it Works 590
Insertion Tips and Guidelines 590
Interpretation:What Does it Measure and What Does it Mean? 591
Initial Warnings and Potential Measurement Problems 591
Pressure,Volume, and Work Measures 591
Goal-Directed Therapy Using Pulmonary Artery Catheter 592
Mixed Venous Saturation: Monitoring Tissue Metabolism 593
Right Ventricle End-Diastolic Pressure as Measure of Cardiac Index and Cardiac Function 593
Conclusions: Use the Pulmonary Artery Catheter Wisely 593
83 Oxygen Transport 595
Energy Generation in the Cell 595
Microcirculation and Oxygen Delivery 595
Hemoglobin, the Ultimate Oxygen Carrier 595
Heart as Oxygen Delivery Pump 596
Putting it all Together: Measuring Cellular Oxygen Consumption and Extraction in Patients 596
Relationship of Oxygen Consumption and Oxygen Delivery during Pathologic States 596
Characteristic Oxygen Transport Variables in States of Shock 597
Conclusions 597
84 Pharmacologic Support of Cardiac Failure 598
Pathophysiology 598
Treatment 599
Diuretics 599
Vasodilators 599
Inotropes and Vasopressors 599
Special Circumstances 601
Heart Failure in Septic Shock 601
Right Ventricular Failure 601
Blunt Cardiac Injury 601
Summary 602
85 The Diagnosis and Management of Cardiac Dysrhythmias 602
Incidence 602
Bradyarrythmias 603
Sinus Node 603
Atrioventricular Node 603
Tachyarrhythmias 604
Sinus Tachycardia 604
Paroxysmal Supraventricular Tachycardia 605
Multifocal Atrial Tachycardia 605
Atrial Flutter 606
Atrial Fibrillation 606
Ventricular Tachyarrhythmias 607
Premature Ventricular Contractions 607
Monomorphic Ventricular Tachycardia 607
Polymorphic Ventricular Tachycardia 608
Conclusion 608
86 Fundamentals of Mechanical Ventilation 609
Noninvasive Ventilation 609
Contraindications to Noninvasive Ventilation 609
Complications of Noninvasive Ventilation 610
Pressure Support Ventilation 610
Heliox 611
Modes of Mechanical Ventilation 611
Assist Control Ventilation 611
Synchronized Intermittent Mandatory Ventilation 611
Positive End-Expiratory Pressure 611
Ventilator “Bundle” 612
Routine Settings 612
Sedation 613
Monitoring 613
Blood Gases 613
Capnography 613
Invasive Hemodynamic Monitoring 615
Arterial Catheterization 615
Central Venous Pressure Monitoring 616
Pulmonary Artery Catheterization 616
Clinical Use Of The Pulmonary Artery Catheter 616
Liberation From Mechanical Ventilation 617
Special Airway Considerations 618
Unplanned Extubation 618
Reintubation 618
Tracheostomy 618
87 Advanced Techniques in Mechanical Ventilation 621
Improving Oxygenation and Preventing Acute Lung Injury 621
Ventilator-Associated Lung Injury 621
Alternatives to Conventional Mechanical Ventilation 621
Proportional Assist Ventilation 621
Pressure-Controlled Ventilation 621
Inverse-Ratio Ventilation 622
Mandatory Minute Ventilation 622
Airway Pressure Release Ventilation 622
High-Frequency Ventilation 623
Permissive Hypercapnia 623
Pharmacotherapy 624
Liquid Ventilation 624
Surfactant Administration 624
Inhaled Nitric Oxide 624
Unconventional Methods of Pulmonary Support 625
Independent Lung Ventilation 625
Extracorporeal Membrane Oxygenation 625
Prone Positioning 625
The Future 626
88 The Management of Renal Failure: Replacement Therapy and Dialysis 627
Incidence 627
Mechanism of Injury/Etiology 627
Diagnosis 627
Water and Fluid Homeostasis 627
Assessment of Renal Function 627
Creatinine Clearance 628
Urine Production and Output 628
Management of Patients 628
Conservative Management 628
Nonpharmacologic Strategies for Acute Renal Failure Prevention 628
Pharmacologic Strategies for Acute Renal Failure Prevention 628
Indications for Renal Replacement Therapy in Acute Renal Failure 629
Volume Overload 629
Hyperkalemia 629
Metabolic Acidosis 629
Other Electrolyte Disturbances 629
Timing of Initiation of Renal Replacement Therapy 630
Acute Renal Failure 630
Principles of Renal Replacement Therapy 630
Classification of Renal Replacement Therapies 630
Intermittent Hemodialysis 630
Continuous Renal Replacement Therapy 631
Advantages and Disadvantages 631
Intermittent Hemodialysis versus Continuous Renal Replacement Therapy: Outcomes 632
Sustained Low-Efficiency Dialysis or Extended Daily Dialysis 632
Summary 632
89 Management of Coagulation Disorders in the Surgical Intensive Care Unit 633
Incidence 633
Congenital Bleeding Disorders 633
Acquired Bleeding Disorders 634
Diagnosis 636
Clinical Evaluation 636
Laboratory Tests of Coagulation 638
Management 639
Blood Product Transfusion 639
Conclusions 640
90 Management of Endocrine Disorders in the Surgical Intensive Care Unit 641
Brain Problems:Abnormalities in Hypothalamic/Pituitary Response 641
Diabetes Insipidus 642
SIADH and Cerebral Salt Wasting 643
Abnormalities in Thyroid Response 643
Thyroid Excess 643
Thyroid Deficit 644
Sick Euthyroid Syndrome 644
Abnormalities of Adrenal Function 644
Pheochromocytoma 644
Adrenal Insufficiency 645
Problems with Hyperglycemia 645
91 Transfusion: Management of Blood and Blood Products in Trauma 648
Incidence:Who Needs Blood Transfusion in Trauma? 648
Risks of Blood Transfusion 650
Transfusion-Related Acute Lung Injury 650
Massive Transfusion 651
Blood Component Therapy: Fresh Frozen Plasma, Platelets, and Cryoprecipitate 651
Management of Complications Related to Blood Transfusion 652
Thrombocytopenia 653
Coagulation Factor Depletion 653
Hypocalcemia 653
Hypokalemia and Hyperkalemia 653
Acid/Base Disturbances 653
Hypothermia 653
Blood Transfusion and Postinjury Multiple-Organ Failure 653
Blood Transfusion and SIRS/Mortality 653
Blood Transfusion and Mortality 653
Blood Transfusion and Infection 654
Potential Mechanisms For Transfusion-Associated Adverse Outcome 655
Decreased Red Blood Cell Deformability 655
Hemoglobin-Based Oxygen Carriers 655
Conclusions 656
14 Critical Care II, Special Issues and treatments 659
92 Acute respiratory distress syndrom 659
Epidemiology 659
Definition and clinical diagnosis 659
Pathophysiology 660
Treatment 660
Alternative Therapies 661
Conclusions 661
93 Systemic Inflammatory Response Syndrome and Multiple-Organ Dysfunction Syndrome: Definition, Diagnosis,Management 663
Incidence 663
Mechanisms of Mods 663
Diagnosis 664
Management 665
Resuscitative Phase 665
Operative Intervention 666
Intensive Care Unit Management Phase 667
Conclusions and Algorithm 668
94 Sepsis, Septic Shock, and Its Treatment 670
Incidence 670
Mechanism of Infection 670
Diagnosis 670
Staging 671
Medical and Surgical Management 671
Morbidity and Complications Management 673
Septic Shock 673
Multiple Organ Dysfunction Syndrome 675
Conclusions 676
95 The Immunology of Trauma 677
Two-Hit Model 677
Systemic Inflammatory Response Syndrome 677
Compensatory Anti-Inflammatory Response Syndrome 677
Cytokine Response 677
Cell-Mediated Response 677
Leukocyte Recruitment 679
Proteases and Reactive Oxygen Species 679
Complement, Kinins, and Coagulation 680
Acute-Phase Reaction 680
Summary 680
96 Nosocomial Pneumonia 682
Incidence/Morbidity and Mortality 682
Risk Factors and Preventive Measures 682
Nonmodifiable versus Modifiable Risk Factors 682
Mechanical Ventilation 682
Impaired Host Defenses 682
Oropharyngeal Colonization 683
Aspiration 683
Gastrointestinal Tract Bacterial Overgrowth 683
Resistant Organisms 683
Putting All Risk Factors Together 683
General Prophylaxis 684
Effectiveness of Preventive Measures 684
Diagnosis 684
Diagnostic Strategies 684
Methods of Obtaining Sputum Cultures 685
Impact of Prior Antibiotic Use on Diagnosis 685
Value of Clinical Pulmonary Infection Score in Trauma Patients 685
Management 685
Adequate Initial Antibiotics 685
De-Escalation of Antibiotics 687
Duration of Therapy 687
Antibiotic Prophylaxis and Tube Thoracostomy 687
Prophylactic Antibiotics for Chest Tube Placement 687
97 Antibacterial Therapy: The Old, the New, and the Future 689
Principles of Pharmacokinetics 688
Principles of Pharmacodynamics 689
Empiric Antibiotic Therapy 689
Duration of Therapy 690
Choice of Antibiotic 690
Development of Bacterial Resistance 690
Antibiotic Spectrum of Activity 691
Cell-Wall–Active Agents: b-lactam Antibiotics 691
Penicillins 691
Cephalosporins 692
Second-Generation Cephalosporins 692
Third-Generation Cephalosporins 692
Fourth-Generation Cephalosporins 693
Monobactams 693
Carbapenems 693
Cell-Wall–Active Agents 693
Protein Synthesis Inhibitors 694
Aminoglycosides 694
Tetracyclines 694
Oxazolidinones 695
Chloramphenicol 695
The Macrolide-Lincosamide-Streptogramin Family 695
Drugs that Disrupt Nucleic Acids 696
Quinolones 696
Rifampin 696
Cytotoxic Antibiotics 697
Metronidazole 697
Trimethoprim-Sulfamethoxazole 697
Antibiotic Toxicities 697
Beta-Lactam Allergy 697
“Red Man” Syndrome 698
Nephrotoxicity 698
Ototoxicity 698
Metronidazole Toxicity 699
Quinolone Toxicity 699
Tetracycline Toxicity 699
Trimethoprim-Sulfamethoxazole Toxicity 699
Avoiding Toxicity 699
Adjustment of Antibiotic Therapy in Hepatic Insufficiency 699
Adjustment of Antibiotic Therapy in Renal Insufficiency 699
98 Fungal Infections and Antifungal Therapy in the Surgical Intensive Care Unit 702
Predictors of Fungal Infections 702
Diabetes Mellitus 702
Neutropenia 702
Organ Transplantation and Immunosuppression 703
Solid and Hematological Malignant Tumors 703
Long-Term Use of Central Venous Catheters 703
Candida Colonization 703
Use of Broad-Spectrum Antibiotics 703
Duration of ICU Care and Invasive Mechanical Ventilation 704
Pathogenic Organisms 704
Candida albicans 704
Non–albicans Candida 705
Aspergillus 705
Other Emerging Fungal Pathogens 705
Principles of Therapy 705
Neutropenic Patients and Preemptive Therapy 707
Antifungal Prophylaxis in Solid Organ Transplant Recipients 708
Acquired Immunodeficiency Syndrome and Empiric Antifungal Therapy 708
Therapy Tailored to Specific Risk Factors and Likely Offending Organisms 708
Fungi as an Epiphenomenon 709
Summary 710
99 Preoperative and Postoperative Nutritional Support: Strategies for Enteral and Parenteral Therapies 710
Malnutrition 710
Metabolic Stress 711
Preoperative Nutrition 711
Preoperative Total Parenteral Nutrition 712
Preoperative Enteral Nutrition 712
Postoperative Nutrition 714
Postoperative Parenteral Nutrition 715
Postoperative Enteral Nutrition 715
Technical Aspects of Parenteral and Enteral Access 716
Central Venous Access 716
Gastrointestinal Access 716
Morbidity and Complications Management 716
Metabolic Complications 716
Complications of Enteral Nutrition 717
Complications of Parenteral Nutrition 717
Summary and Algorithms 717
100 Diagnosis and Treatment of Deep Venous Thrombosis: Drugs and Filters 718
Current Therapies 718
Sequential Compression Devices 718
Low-Dose Heparin 718
Low-Molecular-Weight Heparin 718
Inferior Vena Cava Filters 719
Surveillance 719
Recommendation 719
101 Hypothermia and Trauma 721
Incidence 721
Mechanism of Injury 721
Effects on Coagulation 721
Effects on Vascular Phase of Coagulation 721
Effects on Platelet Count and Function 721
Effect on Clotting Factor Levels and Function 722
Effects on Other Organs 722
Management 723
Passive Rewarming 724
Active External Rewarming 724
Active Core Rewarming 724
Mortality 725
Conclusions 726
102 Surgical Procedures in the Surgical Intensive Care Unit 727
Historical Perspective 727
Surgical Procedures 727
Bedside Tracheostomy 727
Percutaneous Feeding Catheters 729
Inferior Vena Caval Filter Placement 730
Diagnostic Peritoneal Lavage and Laparoscopy 730
Intra-Abdominal Pressure Monitoring, Decompressive Laparotomy, and the Open Abdomen 731
Management of Extremity Trauma and Vascular Injuries 732
Conclusions 732
103 Anesthesia in the Surgical Intensive Care Unit—Beyond the Airway: Neuromuscular Paralysis and Pain Management 733
Muscle Relaxants 733
Historic Perspective 733
Current Epidemiology 733
Indications 733
Mode of Action 733
Monitoring of Neuromuscular Blockade 735
Sedation and Analgesia in Critical Care Setting 737
Analgesic Agents and Their Advantages 737
Indications and Patient-Controlled Analgesia 737
Bispectral Index Monitoring 740
Benefits of Bispectral Index in Critical Care Setting 740
Computing the Bispectral Index 740
Limitations 741
Prospective Uses 741
Conclusion 742
Summary 742
104 Palliative Care in the Trauma Intensive Care Unit 744
When to Start Palliative Care in ICU 744
What is Palliative Care in the ICU? 745
Communication and Shared Decision Making 745
Withholding and Withdrawal of Life Support 746
Pain and Symptom Management 746
Family and Bereavement Support 747
105 Death from Trauma—Management of Grief and Bereavement and the Role of the Surgeon 748
Incidence 748
Grief 748
Traumatic Grief 748
Grieving Across the Life Span 748
Management of Acute Grief after Traumatic Death 749
Complicated Grief 750
106 Trauma Rehabilitation 751
Trauma Rehabilitation Team 751
Assessment of Patients with Spinal Cord Injury 751
Epidemiology of Traumatic Spinal Cord Injury in the United States 751
Neurological Classification 753
Acute Medical Management 753
Assessment of Patients with Traumatic Brain Injury 754
Epidemiology of Traumatic Brain Injury in the United States 754
Pathophysiology of Traumatic Brain Injury 754
Initial Physiatric Consultation and Early Rehabilitation Intervention 754
Medical Considerations and Complications in Traumatic Brain Injury 754
Assessment of Patients with Peripheral Nerve Injury 755
Epidemiology of Peripheral Nerve Injuries 755
Electrodiagnostic Testing and Classification of Peripheral Nerve Injury 755
Rehabilitation of Nerve Injuries 756
Assessment of Patients with Multiple Orthopedic Injuries: The Polytrauma Patient 756
Acute Hospital Care 756
Levels of Care After Acute Trauma Hospital Stay 757
Conclusions 757
107 Trauma Outcomes 758
Outcomes 758
Evidence-Based Medicine 758
Performance Improvement and Patient Safety 758
National Trauma Data Bank 759
National Surgical Quality Improvement Program 761
Summary and Future Direction 761
Index 763
A 763
B 765
C 766
D 769
E 770
F 771
G 772
H 772
I 773
J 774
K 774
L 774
M 775
N 776
O 777
P 777
Q 779
R 779
S 780
T 782
U 783
V 784
W 784
X 785
Y 785
Z 785