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Pathophysiology for the Health Professions - E- Book

Pathophysiology for the Health Professions - E- Book

Karin C. VanMeter | Robert J Hubert

(2013)

Additional Information

Book Details

Abstract

A concise, easy-to-understand introduction to the fundamentals, Gould’s Pathophysiology for the Health Professions, 5th Edition helps you learn essential concepts of major diseases/disorders and disease processes. Continuing in its well-known tradition of readability and vivid, full-color illustrations, the text is updated with the latest research and trends in human disease. Disorders are described by body system, with coverage of the interactions between systems, and special features help you apply the material to real-life situations. No matter which healthcare field you may enter, Gould’s Pathophysiology prepares you for the conditions encountered in clinical practice.

"Gould’s Pathophysiology for the Health Professions can easily be incorporated into a course as a prescribed book to students in the health care professions. The authors of this book are commended for their contribution to the literature on pathophysiology and its application to the health professions." Reviewed by: Dr Benita Olivier, University of the Witwatersrand, Date: Oct 14

  • Concise and readable approach includes the information you need without being overwhelming, even if you have a limited scientific background.
  • Unique Think About questions alert you to important points and help with self-evaluation, test preparation, and review.
  • Warning Signs boxes help you identify the pre-emptive signs of physiologic events such as strokes.
  • Emergency Treatment boxes give step-by-step instructions to follow for emergencies such as shock, cardiac arrest, and pneumothorax.
  • Apply Your Knowledge questions ask you to use what you’ve learned to predict What can go wrong with this structure or system?
  • Ready References in the appendix provide a quick lookup for anatomic terms, conversion tables, abbreviations and acronyms, diagnostic studies and tests, and more.
  • Key terms are listed at the beginning of each chapter and defined within the text, covering the scientific terminology you need to know.
  • Research boxes discuss new developments, problem areas of pathophysiology, and complications associated with research.
  • Learning objectives and bulleted chapter summaries help you focus on key concepts and information.
  • NEW Defense/Protective Mechanisms section consolidates coverage of inflammation and healing, infection, and immunity.
  • UPDATED chapters are reorganized with a building-block method that presents content in a more logical and systematic approach.
  • UPDATED format for individual disorders includes 1) background, 2) pathophysiology, 3) etiology, 4) signs and symptoms, 5) diagnoses, 6) possible related complications/disorders, and 7) treatments/research.
  • NEW! Pathophysiology of Body Systems chapters begin with a brief review of normal anatomy and physiology and show the interrelatedness and the interactions between systems.
  • NEW authors bring a fresh and contemporary approach to the content while keeping true to the integrity of Barbara Gould’s original text.

Table of Contents

Section Title Page Action Price
Front cover cover
Inside front cover ifc1
Evolve page ii
Gould's Pathophysiology for the Health Professions, 5/e iii
Copyright page iv
Dedication v
Reviewers vii
Preface viii
Organization viii
Section I—Basic Concepts of Disease Processes viii
Section II—Defense/Protective Mechanisms viii
Section III—Pathophysiology of Body Systems viii
Section IV: Biological Factors Contributing to Pathophysiology viii
Section V: Environmental Factors and Pathophysiology viii
Appendices—additional information: viii
Format and Features viii
What’s New? ix
Guidelines for Users ix
Resources x
Acknowledgments xii
Table of Contents xiii
I Pathophysiology: Background and Overview 1
1 Introduction to Pathophysiology 1
Chapter Outline 1
Learning Objectives 1
Key Terms 1
What Is Pathophysiology and Why Study It? 2
Understanding Health and Disease 2
Concept and Scope of Pathophysiology and Evidenced-Based Practice 2
Beginning the Process: A Medical History 4
New Developments and Trends 5
Basic Terminology of Pathophysiology 5
The Disease Process 5
Causes of Disease 6
Characteristics of Disease 6
Disease Prognosis 7
Introduction to Cellular Changes 8
Terms Used for Common Cellular Adaptations 8
Cell Damage and Necrosis 9
Chapter Summary 12
Study Questions 13
Additional Resources 13
2 Fluid, Electrolyte, and Acid-Base Imbalances 14
Chapter Outline 14
Learning Objectives 14
Key Terms 14
Fluid Imbalance 15
Review of Concepts and Processes 15
Fluid Compartments 15
Movement of Water 15
Fluid Excess—Edema 16
Causes of Edema 16
Effects of Edema 19
Fluid Deficit—Dehydration 20
Causes of Dehydration 21
Effects of Dehydration 21
Third-Spacing: Fluid Deficit and Fluid Excess 21
Electrolyte Imbalances 21
Sodium Imbalance 21
Review of Sodium 21
Hyponatremia 22
Causes of Hyponatremia 22
Effects of Hyponatremia 23
Hypernatremia 23
Causes of Hypernatremia 23
Effects of Hypernatremia 24
Potassium Imbalance 24
Review of Potassium 24
Hypokalemia 24
Causes of Hypokalemia 24
Effects of Hypokalemia 24
Hyperkalemia 24
Causes of Hyperkalemia 25
Effects of Hyperkalemia 25
Calcium Imbalance 25
Review of Calcium 25
Hypocalcemia 26
Causes of Hypocalcemia 26
Effects of Hypocalcemia 27
Hypercalcemia 27
Causes of Hypercalcemia 27
Effects of Hypercalcemia 27
Other Electrolytes 27
Magnesium 27
Phosphate 28
Hypophosphatemia 28
Hyperphosphatemia 28
Chloride 28
Hypochloremia 28
Hyperchloremia 28
Acid-Base Imbalance 28
Review of Concepts and Processes 28
Control of Serum pH 29
Buffer Systems 29
The Bicarbonate-Carbonic Acid Buffer System and Maintenance of Serum pH 30
Respiratory System 31
Renal System 31
Acid-Base Imbalance 31
Compensation 31
Decompensation 31
Acidosis 32
Causes of Acidosis 32
Effects of Acidosis 32
Alkalosis 33
Effects of Alkalosis 33
Treatment of Imbalances 34
Case Study A Vomiting 37
Part A: Day 1 37
Part B: Days 2 to 3 37
Part C: Day 3: Admission to the Hospital 37
Case Study B Diarrhea 38
Case Study C Nephrotic Syndrome 38
Chapter Summary 38
Study Questions 39
Additional Resources 39
3 Introduction to Basic Pharmacology and Other Common Therapies 40
Chapter Outline 40
Learning Objectives 40
Key Terms 40
Pharmacology 40
Basic Principles 40
Drug Effects 41
Administration and Distribution of Drugs 42
Drug Mechanisms and Receptors 45
Drug Classifications and Prescriptions 46
Traditional Forms of Therapy 47
Physiotherapy 47
Occupational Therapy 47
Speech/Language Pathology 48
Nutrition/Diet 48
Registered Massage Therapy 48
Osteopathy 48
Chiropractic 48
Complementary or Alternative Therapies 48
Noncontact Therapeutic Touch 49
Naturopathy 49
Homeopathy 49
Herbal Medicine 49
Aromatherapy 49
Asian Concepts of Disease and Healing 49
Acupuncture 49
Shiatsu 50
Yoga 50
Reflexology 50
Craniosacral Therapy 50
Ayurveda 50
Emergency Assessment and Aid 51
Case Study A Therapies for Pain 51
Chapter Summary 51
Study Questions 51
Additional Resources 52
Web Sites 52
4 Pain 53
Chapter Outline 53
Learning Objectives 53
Key Terms 53
Etiology and Sources of Pain 53
Structures and Pain Pathways 54
Physiology of Pain and Pain Control 55
Characteristics of Pain 57
Signs and Symptoms 57
Young Children and Pain 57
Referred Pain 57
Phantom Pain 58
Pain Perception and Response 59
Basic Classifications of Pain 59
Acute Pain 59
Chronic Pain 59
Headache 59
Central Pain 61
Neuropathic Pain 61
Ischemic Pain 61
Cancer-Related Pain 61
Pain Control 61
Methods of Managing Pain 61
Anesthesia 62
Case Study A Acute Pain 63
Case Study B Chronic Pain 63
Chapter Summary 64
Study Questions 64
Additional Resources 64
Web Sites 64
II Defense/Protective Mechanisms 65
5 Inflammation and Healing 65
Chapter Outline 65
Learning Objectives 65
Key Terms 66
Review of Body Defenses 66
Mechanical Barriers 66
Nonspecific Mechanisms 66
Specific Mechanisms 66
Review of Normal Capillary Exchange 66
Physiology of Inflammation 66
Definition 67
Causes 67
Steps of Inflammation 69
Acute Inflammation 69
Pathophysiology and General Characteristics 69
Local Effects 70
Systemic Effects 71
Diagnostic Tests 72
Potential Complications 72
Chronic Inflammation 72
Pathophysiology and General Characteristics 72
Potential Complications 73
Treatment of Inflammation 73
Drugs 73
First Aid Measures 75
Other Therapies 75
Healing 75
Types of Healing 75
The Healing Process 76
Factors Affecting Healing 77
Complications due to Scar Formation 77
Loss of Function 77
Contractures and Obstructions 78
Adhesions 78
Hypertrophic Scar Tissue 78
Ulceration 78
Example of Inflammation and Healing 78
Burns 78
Classifications of Burns 79
Effects of Burn Injury 82
Shock 82
Respiratory Problems 82
Pain 83
Infection 83
Metabolic Needs 83
Healing of Burns 83
Children 84
Case Study A Trauma 86
Case Study B Burns 86
Chapter Summary 86
Study Questions 86
Inflammation 86
Healing 87
Burns 87
Additional Resources 87
Web Sites 87
6 Infection 88
Chapter Outline 88
Learning Objectives 88
Key Terms 88
Review of Microbiology 89
Microorganisms 89
Types of Microorganisms 90
Bacteria 90
Viruses 92
Chlamydiae, Rickettsiae, and Mycoplasmas 93
Fungi 96
Protozoa 96
Other Agents of Disease 98
Helminths 98
Prions 98
Algae 98
Resident Flora (Indigenous Normal Flora, Resident Microbiota) 98
Principles of Infection 99
Transmission of Infectious Agents 99
Host Resistance 100
Virulence and Pathogenicity of Microorganisms 101
New Issues Affecting Infections and Transmission 101
Control of Transmission and Infection 102
Physiology of Infection 104
Onset and Development 104
Patterns of Infection 105
Signs and Symptoms of Infection 105
Local Signs 105
Systemic Signs 105
Methods of Diagnosis 106
Treatment and Antimicrobial Drugs 106
Guidelines for Use 106
Classification 107
Mode of Action 107
Example of Infection: Influenza (Flu) 109
Case Study A Viral Gastroenteritis 111
Case Study B Upper Respiratory Infection 111
Chapter Summary 111
Study Questions 112
Additional Resources 112
Web Sites 112
7 Immunity 113
Chapter Outline 113
Learning Objectives 113
Key Terms 113
Review of the Immune System 114
Components of the Immune System 114
Elements of the Immune System 114
Antigens 114
Cells 114
Antibodies or Immunoglobulins 117
Complement System 117
Chemical Mediators 118
The Immune Response 118
Diagnostic Tests 118
The Process of Acquiring Immunity 118
Outcome of Infectious Disease 120
Emerging and Re-emerging Infectious Diseases and Immunity 120
Bioterrorism 120
Tissue and Organ Transplant Rejection 120
Rejection Process 121
Treatment and Prevention 121
Hypersensitivity Reactions 121
Type I: Allergic Reactions 122
Causative Mechanism 122
Clinical Signs and Symptoms 122
Hay Fever or Allergic Rhinitis 122
Food Allergies 122
Atopic Dermatitis or Eczema 123
Asthma 123
Anaphylaxis or Anaphylactic Shock 124
■ Pathophysiology 124
■ Signs and Symptoms 124
■ Treatment 124
Type II: Cytotoxic Hypersensitivity 124
Type III: Immune Complex Hypersensitivity 125
Type IV: Cell-Mediated or Delayed Hypersensitivity 126
Autoimmune Disorders 127
Mechanism 127
Example: Systemic Lupus Erythematosus 127
■ Pathophysiology 128
■ Clinical Signs and Symptoms 128
■ Diagnostic Tests 128
■ Treatment 128
Immunodeficiency 130
Causes of Immunodeficiency 130
Effects of Immunodeficiency 130
■ Treatment 131
Acquired Immunodeficiency Syndrome 131
History 131
The Agent 133
Transmission 134
■ Diagnostic Tests 135
■ Clinical Signs and Symptoms 135
Women with AIDS 136
Children with AIDS 136
People over 50 with HIV/AIDS 136
■ Treatment 137
Case Study A Hypersensitivity 138
Case Study B Anaphylaxis 138
Case Study C Systemic Lupus Erythematosus 138
Case Study D HIV and AIDS 139
Chapter Summary 139
Study Questions 140
Additional Resources 140
Web Sites 140
Information on Vaccinations or on HIV/AIDS 140
III Pathophysiology of Body Systems 141
8 Skin Disorders 141
Chapter Outline 141
Learning Objectives 141
Key Terms 141
Review of the Skin 142
Skin Lesions 143
■ Diagnostic Tests 144
■ General Treatment Measures 145
Inflammatory Disorders 145
Contact Dermatitis 145
Urticaria 145
Atopic Dermatitis 146
Psoriasis 147
Pemphigus 147
Scleroderma 147
Skin Infections 148
Bacterial Infections 148
Cellulitis 148
Furuncles 148
Impetigo 148
Acute Necrotizing Fasciitis 149
Leprosy 149
Viral Infections 150
Herpes Simplex 150
Verrucae 150
Fungal Infections 150
Tinea 150
Other Infections 152
Scabies 152
Pediculosis 153
Skin Tumors 153
Keratoses 153
Squamous Cell Carcinoma 154
Malignant Melanoma 155
Kaposi’s Sarcoma 155
Case Study A Atopic Dermatitis 156
Case Study B Malignant Melanoma 156
Chapter Summary 156
Study Questions 157
Additional Resources 157
Web Sites 157
9 Musculoskeletal System Disorders 158
Chapter Outline 158
Learning Objectives 158
Key Terms 158
Review of the Musculoskeletal System 159
Bone 159
Skeletal Muscle 161
Joints 163
Diagnostic Tests 164
Trauma 164
Fractures 164
■ Pathophysiology 165
Factors Affecting the Healing of Bone 166
■ Signs and Symptoms 167
■ Diagnostic Tests 167
■ Treatment 167
Dislocations 167
Sprains and Strains 168
Other Injuries 168
Muscle Tears 168
Repetitive Strain Injury 169
Bone Disorders 169
Osteoporosis 169
■ Pathophysiology 169
■ Etiology 169
IV Biological Factors Contributing to Pathophysiology 548
20 Neoplasms and Cancer 548
Chapter Outline 548
Learning Objectives 548
Key Terms 548
Review of Normal Cells 549
Benign and Malignant Tumors 549
Nomenclature 550
Characteristics of Benign and Malignant Tumors 550
Malignant Tumors: Cancer 550
Pathophysiology 550
Effects of Malignant Tumors 552
Local Effects of Tumors 552
Systemic Effects of Malignant Tumors 552
Diagnostic Tests 553
Spread of Malignant Tumors 554
Staging of Cancer 556
Etiology 556
Carcinogenesis 556
Risk Factors and Prevention 557
Host Defenses 557
Treatment 559
Surgery 559
Radiation Therapy 559
Chemotherapy 561
Other Drugs 563
Nutrition 563
Complementary Therapies 564
Prognosis 564
Examples of Malignant Tumors 564
Skin Cancer 564
Ovarian Cancer 565
Brain Cancer 565
Cancer Incidences 566
Case Study A Lung Cancer 567
Case Study B Breast Cancer 567
Chapter Summary 567
Study Questions 567
Additional Resources 568
Web Sites 568
21 Congenital and Genetic Disorders 569
Chapter Outline 569
Learning Objectives 569
Key Terms 569
Review of Genetic Control 569
Congenital Anomalies 571
Genetic Disorders 574
Single-Gene Disorders 574
Autosomal Recessive Disorders 575
Autosomal Dominant Disorders 575
X-Linked Dominant Disorders 575
X-Linked Recessive Disorders 575
Chromosomal Disorders 576
Multifactorial Disorders 576
Developmental Disorders 577
Diagnostic Tools 578
Genetic Technology 579
Genetic Engineering and Gene Therapy 579
Genetic Diagnosis and DNA Testing 579
Proteomic Research and Designer Drugs 579
Down Syndrome 580
Case Study A Retinoblastoma 580
Chapter Summary 580
Study Questions 582
Additional Resources 582
Web Sites 582
22 Complications of Pregnancy 583
Chapter Outline 583
Learning Objectives 583
Key Terms 583
Embryonic and Fetal Development 583
Physiological Changes During Pregnancy 584
Diagnosis of Pregnancy 584
Physiological Changes and Their Implications 585
Hormonal Changes 585
Reproductive System Changes 585
Weight Gain and Nutrition 586
Digestive System Changes 586
Musculoskeletal Changes 586
Cardiovascular Changes 586
Potential Complications of Pregnancy 587
Ectopic Pregnancy 587
Preeclampsia and Eclampsia: Pregnancy-Induced Hypertension 587
Gestational Diabetes Mellitus 587
Placental Disorders 588
Blood Clotting Disorders 588
Thrombophlebitis and Thromboembolism 588
Disseminated Intravascular Coagulation 588
Rh Incompatibility 588
Infection 589
Adolescent Pregnancy 590
Case Study A Gestational Diabetes Mellitus* 590
Chapter Summary 590
Study Questions 591
Additional Resources 591
Web Sites 591
23 Complications of Adolescence 592
Chapter Outline 592
Learning Objectives 592
Key Terms 592
Review of Changes During Adolescence 592
Obesity and Metabolic Syndrome 593
Musculoskeletal Abnormalities 594
Kyphosis and Lordosis 594
Scoliosis 595
Osteomyelitis 595
Juvenile Rheumatoid Arthritis 597
Eating Disorders 598
Anorexia Nervosa 598
Bulimia Nervosa 598
Skin Disorders 599
Acne Vulgaris 599
Infection 599
Infectious Mononucleosis 599
Disorders Affecting Sexual Development 600
Chromosomal Disorders 600
Tumors 600
Menstrual Abnormalities 600
Case Study A Obesity 601
Chapter Summary 601
Study Questions 601
Additional Resources 602
Web Sites 602
24 Complications of Aging 603
Chapter Outline 603
Learning Objectives 603
Key Terms 603
The Aging Process 603
Physiological Changes with Aging 604
Hormonal Changes 604
Reproductive System Changes 604
Changes in the Skin and Mucosa 605
Cardiovascular System Changes 605
Musculoskeletal System Changes 606
Osteoporosis 606
Osteoarthritis 607
Herniated Intervertebral Disc 607
Other Changes 607
Respiratory System Changes 607
Nervous System Changes 607
Digestive System Changes and Nutrition 608
Urinary System Changes 609
Other Factors 609
Multiple Disorders 609
Case Study A Complications of Aging 610
Case Study B Alzheimer’s Disease 610
Case Study C Multiple Disorders of Aging 610
Chapter Summary 610
Study Questions 611
Additional Resources 611
Web Sites 611
V Environmental Factors and Pathophysiology 612
25 Immobility and Associated Problems 612
Chapter Outline 612
Learning Objectives 612
Key Terms 612
Factors Involving Immobility 613
Musculoskeletal System Effects 613
Cutaneous Effects 614
Cardiovascular System Effects 614
Respiratory System Effects 615
Digestive System Effects 615
Urinary System Effects 615
Neurological/Psychological Effects 616
Effects of Immobility on Children 616
Case Study A Trauma and Immobility 616
Chapter Summary 616
Study Questions 617
Additional Resources 617
Web Sites 617
26 Stress and Associated Problems 618
Chapter Outline 618
Learning Objectives 618
Key Terms 618
Review of the Stress Response 618
Stress and Disease 619
Potential Effects of Prolonged or Severe Stress 621
Coping with Stress 622
Case Study A Situational Stress Response 622
Chapter Summary 623
Study Questions 623
Additional Resources 623
Web Sites 623
27 Substance Abuse and Associated Problems 624
Chapter Outline 624
Learning Objectives 624
Key Terms 624
Terminology 625
Predisposing Factors 626
Environmental/Behavioral Risk Factors 626
Indications/Recognition of Abuse 627
Potential Complications of Substance Abuse 627
Overdose 627
Withdrawal 628
Effects on Pregnancy 628
Cardiovascular Problems 628
Infection 628
Neurological/Psychological Effects 628
Alcohol 628
Cirrhosis (Laënnec’s Cirrhosis) 628
Nervous System Damage 629
Treatment for Substance Abuse 629
Case Study A Alcohol Abuse 629
Chapter Summary 629
Study Questions 630
Additional Resources 630
Web Sites 630
28 Environmental Hazards and Associated Problems 631
Chapter Outline 631
Learning Objectives 631
Key Terms 631
Chemicals 632
Heavy Metals 633
Acids/Bases 633
Inhalants 633
Asbestos 634
Pesticides 634
Physical Agents 634
Temperature Hazards 634
Hyperthermia 634
Hypothermia 635
Radiation Hazards 635
Ionizing Radiation 635
Light Energy 635
Noise Hazards 636
Food and Waterborne Hazards 636
Biological Agents 636
Bites and Stings 636
Case Study A Occupational Hazards of Fighting Forest Fires 637
Chapter Summary 637
Study Questions 637
Additional Resources 638
Web Sites 638
Appendices 639
Ready Reference 1 639
Body Planes, Cavities, Regions, and Fluid Compartments 639
Body Planes 639
Body Cavities 639
Body Regions 639
Body Fluid Compartments 639
Common Body Movements 641
Ready Reference 2 641
Anatomic Terms 641
Prefix or Root (Combining Form) Used in Anatomic Terms 641
Directional Terms 641
Ready Reference 3 643
Conversion Tables 643
Ready Reference 4 643
Common Abbreviations and Acronyms 643
Common Pharmaceutical Abbreviations 645
Ready Reference 5 645
Common Diagnostic Studies and Tests 645
Endoscopic Examination 645
Imaging Studies 645
Radiograph or X-ray Film 645
Computed Tomography (CT scan, formerly computerized axial tomography or CAT scan) 645
Ultrasonography (ultrasound) 645
Magnetic Resonance Imaging (MRI) 645
Nuclear Scanning 647
Positron Emission Tomography (PET) 647
Determinations of Electrical Activity 647
Electrocardiogram (ECG, EKG) 647
Stress test (exercise electrocardiography) 647
Electroencephalogram (EEG) 647
Pulmonary Function Tests 648
Blood Tests 648
Hematology testing 648
Blood chemistry tests 648
Immunodiagnostic Tests 648
Chromosomal and Genetic Analysis 648
Therapeutic Drug Monitoring 649
Urine Tests 649
Cerebrospinal Fluid Tests 649
Fecal Tests or Stool Analysis 649
Microbiologic Tests 649
Ready Reference 6 649
Example of a Medical History 649
Ready Reference 7 653
Disease Index 653
Ready Reference 8 658
Drug Index 658
Ready Reference 9 660
Additional Resources 660
Textbooks 660
Anatomy and Physiology 660
Pathophysiology 660
Medicine 660
Pharmacology 660
Other Topics 660
Dictionaries and Medical Terminology 660
Journals 661
Journals Published by Professional Groups 661
Web Sites 661
Glossary 662
Index 671
A 671
B 673
C 674
D 677
E 678
F 680
G 680
H 681
I 683
J 684
K 684
L 684
M 685
N 686
O 687
P 687
Q 689
R 689
S 690
T 692
U 693
V 694
W 694
X 694
Z 694
Inside back cover ibc1