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The Human Body in Health and Illness - E-Book

The Human Body in Health and Illness - E-Book

Barbara Herlihy

(2014)

Additional Information

Book Details

Abstract

Using colorful cartoons, humorous illustrations, and an easy-to-read approach, The Human Body in Health and Illness, 5th Edition makes it fun to learn anatomy & physiology. Step-by-step explanations, clever features, and clinical examples simplify A&P concepts and relate A&P to the real world. Organized by body system, this book shows how each organ is structurally designed to perform specific physiological tasks while demonstrating what happens to the body when a system does not function properly. Written by well-known author and educator Barbara Herlihy, The Human Body in Health and Illness makes A&P concepts easy to understand even if you have a limited background in the sciences.

  • Full-color illustrations simplify difficult concepts and complex processes.
  • Colorful cartoons use humor to clarify and reinforce the content, making it more memorable, accessible, and reader-friendly.
  • Interesting analogies and examples make learning easier, especially if you’re studying A&P for the first time.
  • Key terms and objectives are listed at the beginning of every chapter, setting learning expectations and goals, with terms defined in a comprehensive glossary.
  • Did You Know boxes include brief vignettes describing clinical scenarios or historical events related to A&P.
  • Review tools include chapter summaries, Review Your Knowledge questions, and Go Figure! questions relating to figures and diagrams.
  • UPDATED illustrations and content keep A&P information current and strengthen an already popular textbook.
  • UPDATED Medical Terminology and Disorders tables include pronunciations, derivations, and word parts, along with expanded, in-depth descriptions of the most crucial information.
  • UPDATED! The Evolve website assets include practice exams, interactive activities and exercises, the Body Spectrum Online Coloring Book, and more!

Table of Contents

Section Title Page Action Price
Front Cover cover
Inside Front Cover ifc1
The Human Body in Health and Illness, 5/e i
Copyright Page ii
Pageburst ad iii
Dedication iv
Acknowledgments v
To the Instructor vi
Textbook Strengths vi
Classroom Resources vii
Study Guide vii
Evolve Instructor Learning Resources vii
TEACH Instructor Resource on Evolve vii
To the Student ix
Textbook Features ix
Key Terms ix
Objectives ix
Illustrations ix
Do You Know… ix
Ramp It Up! ix
Re-Think ix
As You Age ix
Sum It Up! ix
Medical Terminolgy and Disorders Tables ix
End-of-Chapter Features ix
Summary Outline ix
Review Your Knowledge ix
Go Figure ix
Answers to Review Your Knowledge and Go Figure Questions ix
Glossary ix
Study Guide ix
Table Of Contents x
1 Introduction to the Human Body 1
Objectives 1
Key Terms 1
Anatomy and Physiology: What They Are 1
What’s It Mean? 1
Why Do I Need to Know This? 1
The Body’s Levels of Organization 2
Major Organ Systems 2
Homeostasis: Staying the Same 6
Anatomical Terms: Talking About the Body 6
Anatomical Position 6
Relative Positions 6
Planes of the Body 7
Regional Terms 8
Cavities of the Body 9
Dorsal Cavity 9
Ventral Cavity 10
Thoracic Cavity 10
Abdominopelvic Cavity 10
Division into Quadrants 10
Division into Regions 10
Other Cavities 10
Get Ready for Exams! 12
Summary Outline 12
Review Your Knowledge 13
Matching: Directions of the Body 13
Matching: Regional Terms 13
Multiple Choice 13
Go Figure 13
2 Basic Chemistry 15
Objectives 15
Key Terms 15
Matter, Elements, and Atoms 15
Matter 15
Elements 15
Atoms 16
Atomic Structure 16
Other Characteristics of Atoms 17
Electron Shells 18
Chemical Bonds 18
Ionic Bonds 18
Covalent Bonds 18
Hydrogen Bonds 18
Polarity 18
Ions 20
Cations, Anions, and Electrolytes 20
Ion Formation 20
Ionization 20
Molecules and Compounds 20
Molecules 20
Compounds 21
Some Important Compounds and Molecules 21
Water 21
Oxygen 21
Carbon Dioxide 22
Chemical Reactions 22
Acids and Bases 22
Acids 23
Bases 23
Neutralization of Acids and Bases 23
Measurement: the pH Scale 23
Reading the pH Scale 24
pH of Body Fluids 24
Energy 24
Forms of Energy 24
Conversion of Energy 25
Energy Transfer: the Role of Adenosine Triphosphate 25
Mixtures, Solutions, Suspensions, and Precipitates 25
Mixtures 25
Solutions 26
Suspensions 26
Precipitates 27
Get Ready for Exams! 27
Summary Outline 27
Review Your Knowledge 28
Matching: Atoms and Elements 28
Matching: Structure of the Atom 28
Matching: Ions and Electrolytes 28
Matching: Acids and Bases 28
Multiple Choice 28
Go Figure 28
3 Cells 30
Objectives 30
Key Terms 30
Typical Cell 30
Cell Membrane 30
Inside the Cell 31
Nucleus 31
Cytoplasm 32
Cytoplasmic Gel 32
Cytoplasmic Organelles 33
Mitochondria 33
Ribosomes 33
Endoplasmic Reticulum 33
Golgi Apparatus 34
Lysosomes 34
Cytoskeleton 34
Centrioles 34
On the Cell Membrane 35
Microvilli 35
Cilia 35
Flagella 35
Movement Across the Cell Membrane 36
Passive Transport Mechanisms 36
Diffusion 36
Facilitated Diffusion 37
Osmosis 38
Tonicity 39
Isotonic Solution 39
Hypotonic Solution 39
Hypertonic Solutions 40
Filtration 40
Active Transport Mechanisms 40
Active Transport Pumps 41
Endocytosis 41
Exocytosis 41
Cell Division 41
Cell Cycle 42
Interphase 42
Mitosis 42
Cell Differentiation 43
Stem Cells 43
Order, Disorder, and Death 44
Get Ready for Exams! 45
Summary Outline 45
Review Your Knowledge 46
Matching: Cell Structure 46
Matching: Transport and Tonicity 46
Multiple Choice 46
Go Figure 47
4 Cell Metabolism 48
Objectives 48
Key Terms 48
Metabolism 48
Carbohydrates 48
Monosaccharides 48
Disaccharides 49
Polysaccharides 49
Uses of Glucose 50
The Breakdown of Glucose 50
The Making of Glucose 51
Lipids (Fats) 52
Uses of Lipids 54
Metabolism of Lipids 54
Making Fat 54
Proteins 54
Amino Acids 54
Uses of Proteins 55
Breakdown of Protein and the Problem with Ammonia 55
Formation of Urea 56
Worrying About Ammonia. 56
Protein Synthesis and DNA 56
DNA Structure 57
The Genetic Code 57
Reading the Code 57
Copying the Code: mRNA 57
mRNA as Copycat 58
Steps in Protein Synthesis 59
Get Ready for Exams! 62
Summary Outline 62
Review Your Knowledge 62
Matching: Carbohydrates, Proteins, and Fats 62
Matching: Biochemistry Terms 62
Matching: Genetic Code and Protein Synthesis 63
Multiple Choice 63
Go Figure 63
5 Microbiology Basics 64
Objectives 64
Key Terms 64
What is Disease? 64
Types of Pathogens 64
Microorganisms (Microbes) 65
Other (Multicellular) Disease-Causing Organisms 67
Laboratory Identification of Pathogens 68
The Spread of Infection 69
Portals of Entry and Exit 69
How Pathogens Spread 70
Person-to-Person Contact 70
Environment-to-Person Contact 70
“Tiny Animal”-to-Person Contact 70
Five Germ-Laden Stories 70
Dr. Semmelweis Screams, “Wash Those Mitts!” 70
Flora and Her Vaginal Itch 71
Rick, Nick, and the Sick Tick 71
Why Typhoid Mary Needed to Lose Her Gallbladder 72
A Pox News Alert! 72
Get Ready for Exams! 75
Summary Outline 75
Review Your Knowledge 75
Matching: Microorganisms and Other Pathogens 75
Multiple Choice 76
Go Figure 76
6 Tissues and Membranes 77
Objectives 77
Key Terms 77
Epithelial Tissue 77
Where is It Found? 77
What Does It Do? 77
What is It Like? 77
Classification 78
Simple Epithelia 78
Stratified Epithelia 79
Glandular Epithelia 81
Connective Tissue 81
Where is It Found? 81
What Does It Look Like? 81
Connective Tissue Cells 81
Types of Connective Tissue 82
Loose Connective Tissue 82
Dense Fibrous Connective Tissue 83
Cartilage 84
Types of Cartilage 84
Bone 85
Blood and Lymph 85
Nervous Tissue 85
Neurons 85
Muscle Tissue 85
Skeletal Muscle 86
Smooth Muscle 86
Cardiac Muscle 86
Tissue Repair 86
Membranes 88
Classification of Membranes 88
Epithelial Membranes 88
Cutaneous Membrane 88
Mucous Membranes 88
Serous Membranes 88
Get Ready for Exams! 91
Summary Outline 91
Review Your Knowledge 91
Matching: Tissues 91
Matching: Membranes 91
Multiple Choice 91
Go Figure 92
7 Integumentary System and Body Temperature 93
Objectives 93
Key Terms 93
Functions of the Integumentary System 93
Structure of the Skin 94
Layers of the Skin 94
Epidermis 94
Dermis 95
The Skin Tells a Story 95
Subcutaneous Layer 95
The Skin, Drugs, and Chemicals 96
Skin Color 96
Accessory Structures of the Skin 97
Hair 97
Nails 98
Glands 99
Body Temperature 101
Heat Production 101
Heat Loss 101
Regulation 101
Newborns and Body Temperature 102
When Skin is Burned 103
Eschar 104
A Note About Skin Care 105
Get Ready for Exams! 108
Summary Outline 108
Review Your Knowledge 109
Matching: Skin 109
Matching: Glands 109
Matching: Colors 109
Multiple Choice 109
Go Figure 110
8 Skeletal System 111
Objectives 111
Key Terms 111
Arrangement and Functions of Bones 111
The Skeletal System: What It Does 111
Many Sizes and Shapes of Bones 113
Bone Tissue and Bone Formation 113
Compact and Spongy Bone 114
Long Bones 115
Ossification 115
Ossification of Flat Bones: Intramembranous Ossification 115
Ossification of Long Bones: Endochondral Ossification 115
Growing Bones 115
Growing Taller 116
The “What-Ifs” of the Epiphyseal Disc 116
Growing Thicker and Wider 116
Bumps and Grooves 116
Broken Bones 117
Divisions of the Skeletal System 117
Axial Skeleton 117
Skull 117
Cranium 118
Facial Bones 119
Sinuses 121
How the Skull Bones Are Held Together 121
The Infant Skull 121
Hyoid Bone 122
Bones of the Middle Ear 122
Vertebral Column 122
The Back and Its Stack of Bones 122
Two Special Vertebrae: Atlas (C1) and Axis (C2) 123
Characteristics of Vertebrae 123
Some Vertebral Column Concerns 123
Curvatures 124
Thoracic Cage 125
Sternum 125
Ribs 125
Other Thoracic Cage Structures 125
Appendicular Skeleton 126
Shoulder Girdle 127
Clavicle 128
Scapula 128
Upper Limbs 128
Humerus 128
Radius 128
Ulna 128
Hand 128
Pelvic Girdle 129
Pelvis 130
Male and Female Differences. 130
Coxal Bone 130
Ilium. 130
Ischium. 130
Pubis. 130
Lower Limbs 130
Femur 130
Patella 130
Tibia and Fibula 131
Foot 131
Joints (Articulations) 132
Joint Classification 133
Immovable Joints 133
Slightly Movable Joints 133
Freely Movable Joints 133
Naming Joints 134
Moving Synovial Joints 134
Hinge Joint 134
Ball-and-Socket Joint 135
Pivot Joint 135
Saddle Joint 135
Gliding Joint 135
Condyloid Joint 135
Clinically “Big” Synovial Joints 135
Knee 135
Peas for the Knees and More Disease 135
Shoulder 137
Elbow 137
Hip 137
Types of Joint Movements 137
Get Ready for Exams! 139
Summary Outline 139
Review Your Knowledge 139
Matching: Long Bone 139
Matching: Names of Bones 139
Matching: Joints and Joint Movement 140
Multiple Choice 140
Go Figure 140
9 Muscular System 142
Objectives 142
Key Terms 142
Types and Functions of Muscles 142
Skeletal Muscle 142
Smooth Muscle 142
Cardiac Muscle 143
Structure of the Whole Muscle 143
Muscle 143
Layers of Connective Tissue 144
Muscle Attachments 145
Structure and Function of a Single Muscle Fiber 145
How Muscles Contract 145
Sliding Filament Mechanism 145
The Role of Calcium and Adenosine Triphoshate 145
Skeletal Muscles and Nerves 147
Somatic Motor Neuron 147
The Motor Unit 147
The Neuromuscular Junction 147
The Stimulated Muscle Membrane 147
Disorders of the Neuromuscular Junction 148
Myasthenia Gravis 148
Neuromuscular Blockade Caused by Curare 149
Effects of Neurotoxins on Muscle Function 149
Force of Muscle Contraction 150
Contractile Force of a Single Muscle Fiber 150
More about Tetanus 151
Contractile Force of a Whole Muscle 151
Muscle Tone 151
Energy Source for Muscle Contraction 151
Muscle Fatigue 152
Muscle Terms 152
Origin and Insertion 152
Prime Mover, Synergist, and Antagonist 152
Muscle Overuse and Underuse Terms 153
Hypertrophy 153
Atrophy 153
Contracture 153
How Skeletal Muscles are Named 153
Size 153
Shape 153
Orientation of Fibers 153
Location 153
Number of Origins 153
Origin and Insertion 153
Muscle Action 153
Muscles From Head to Toe 154
Muscles of the Head 154
Facial Muscles 154
Chewing Muscles 154
Muscles of the Neck 160
Sternocleidomastoid 160
Trapezius 160
Muscles of the Trunk 160
Muscles Involved in Breathing 160
Muscles That Form the Abdominal Wall 161
Muscles That Move the Vertebral Column 161
Muscles That Form the Pelvic Floor 161
Muscles of the Shoulder (Pectoral) Girdle and Arm 162
Muscles That Move the Forearm 163
Muscles That Move the Wrist, Hand, and Fingers 163
The Carpal Tunnel 163
Muscles That Move the Thigh, Leg, and Foot 164
Muscles That Move the Femur (Thigh Bone) 164
Muscles That Move the Leg 164
Muscles That Move the Foot 165
Get Ready for Exams! 169
Summary Outline 169
Review Your Knowledge 169
Matching: Muscle Terms 169
Matching: Names of Muscles 170
Multiple Choice 170
Go Figure 170
10 Nervous System: 172
Objectives 172
Key Terms 172
The Nervous System: Structure and Function 172
Divisions of the Nervous System 172
Functions of the Nervous System 172
Sensory Function 172
Integrative Function 172
Motor Function 173
Cells That Make Up the Nervous System 173
Neuroglia 173
Neuron 173
Parts of a Neuron 173
Three Parts 173
The Axon: A Special Structure 174
Types of Neurons 174
White Matter Versus Gray Matter 175
The Neuron Carrying Information 175
The Nerve Impulse: What It Is 175
11 Nervous System: 200
Objectives 200
Key Terms 200
What the Spinal Cord Is 200
Location and Size 200
Gray on the Inside, White on the Outside 201
Gray Matter 201
White Matter 201
Decussation 202
Spinal Nerves Attached to the Spinal Cord 203
What the Spinal Cord Does 203
Reflexes 204
What Reflexes Are 204
The Reflex Arc 205
Many, Many Reflexes 205
Ouch! the Withdrawal Reflex 205
Organ Reflexes 205
Peripheral Nervous System 206
Nerves 206
Classifying the Peripheral Nervous System 206
Structural Classification of the Peripheral Nervous System 206
Cranial Nerves 207
Names and Numbers of Cranial Nerves. 207
Functions of Cranial Nerves. 207
Spinal Nerves 210
Names and Numbers of Spinal Nerves 210
Spinal Nerve Plexuses 210
What a Dermatome Is 214
Functional Classification of the Peripheral Nervous System 215
Get Ready for Exams! 215
Summary Outline 215
Review Your Knowledge 216
Matching: Reflexes 216
Matching: Nerves 216
Multiple Choice 216
Go Figure 216
12 Autonomic Nervous System 218
Objectives 218
Key Terms 218
Autonomic (Visceral) Reflexes 218
What They Do 218
Pathway 218
Organization and Function of the Autonomic Nervous System 219
Division of the Autonomic Nervous System 219
Sympathetic Nervous System: Fight or Flight 219
Parasympathetic Nervous System: Feed and Breed 220
Autonomic Terminology and Pharmacology 220
Autonomic Tone and Vasomotor Tone 221
Autonomic Nervous System Neurons 221
Numbers and Ganglia 221
Neurons of the Sympathetic Nervous System 221
Neurons of the Parasympathetic Nervous System 222
Running with Cranial Nerves 223
Oculomotor Nerve (CN III) 223
Facial Nerve (CN Vll) 223
Glossopharyngeal Nerve (CN lX) 223
Vagus Nerve (CN X) 223
Naming Fibers and Neurotransmitters 223
Neurotransmitters: Termination of Activity 223
Receptors of the Autonomic Nervous System 224
Cholinergic Receptors 224
Adrenergic Receptors 225
Autonomic Terminology: “Doing” Autonomic Pharmacology 226
Get Ready for Exams! 228
Summary Outline 228
Review Your Knowledge 229
Matching: Sympathetic or Parasympathetic 229
Matching: Norepinephrine or Acetylcholine 229
Multiple Choice 229
Go Figure 230
13 Sensory System 231
Objectives 231
Key Terms 231
Receptors and Sensation 231
Cells That Detect Stimuli 231
What Sensation Is 231
Experiencing a Sensation 231
Four Components 231
Two Characteristics of Sensation 232
The General Senses 233
Pain 233
Touch and Pressure 235
Temperature 235
Proprioception 236
The Special Senses 236
Sense of Smell: the Nose 236
What a Smell Can Tell 236
Sense of Taste: the Tongue 237
Some Tasteful Comments 237
Sense of Sight: the Eye 238
Visual Accessory Organs 238
Eyebrows 238
Eyelids 238
Conjunctiva 239
Eyelashes 239
Lacrimal Apparatus: It’s Tearing Me Up! 239
Extrinsic Eye Muscles 239
The Eyeball 239
Layers of the Eyeball 241
Sclera. 241
Choroid. 241
Retina. 241
Cavities and Fluids 242
Muscles of the Eye 242
Extrinsic Eye Muscles 242
Intrinsic Eye Muscles 243
Muscles of the Iris. 243
Photopupillary Reflex. 245
Ciliary Muscle. 245
Refraction and Accommodation 245
Stimulation of the Photoreceptors 246
Night Vision 246
Color Vision 246
Informing the Brain: the Visual Pathway 246
Seeing Happens When… 247
Seeing Doesn’t Happen When… 247
Sense of Hearing: the Ear 248
Structure of the Ear 248
External Ear 248
Middle Ear 248
Inner Ear 249
Hearing Happens When… 250
Hearing Doesn’t Happen When… 250
Sense of Balance: the Ear 251
Get Ready for Exams! 255
Summary Outline 255
Review Your Knowledge 256
Matching: Senses 256
Matching: Structures of the Eye 256
Matching: Structures of the Ear 256
Multiple Choice 256
Go Figure 257
14 Endocrine System 259
Objectives 259
Key Terms 259
Endocrine Glands 259
Hormones 259
Classification of Hormones 261
Targets 261
Hormone Receptors 261
Control of Hormone Secretion 262
Negative Feedback Loop, or “Enough is Enough” 262
Positive Feedback Loop, or “Give Me More” 262
Biorhythms 262
Control by the Central Nervous System 263
Pituitary Gland 263
Pituitary Gland and Hypothalamus 263
Anterior Pituitary Gland 263
Growth Hormone 265
Prolactin 266
Tropic Hormones 266
Posterior Pituitary Gland 266
Antidiuretic Hormone 266
Oxytocin 266
A Tiny Third Lobe … a Fetal Structure 267
Melanocyte-Stimulating Hormone 267
Thyroid Gland 267
Thyroid Follicle 268
What Thyroid Hormones (T3 and T4) Do 268
Hypothyroidism 268
Hyperthyroidism 268
Regulation of Secretion 268
The Need for Iodine 268
Synthesis of Thyroid Hormone 268
Iodine Deficiency 269
Calcitonin 269
Parathyroid Glands 269
Blood Calcium REGULATION: Imbalances 269
Hypocalcemia 269
Hypercalcemia 270
Adrenal Glands 271
Adrenal Medulla 271
Adrenal Cortex 271
Glucocorticoids 271
Control of Cortisol Secretion 272
Mineralocorticoids 273
Sex Hormones 273
Hyposecretion and Hypersecretion 273
Hyposecretion 273
Hypersecretion 273
The Case of the Lazy Gland (Acute Adrenal Cortical Insufficiency) 273
Pancreas 274
Insulin 275
Secretion and Effects 275
Insulin and Blood Glucose 275
Diabetes Mellitus: “a Melting Down of the Flesh and Limbs Into Urine” 275
Insulin Receptors and the Diabetic State 276
Glucagon 276
Glucagon, Infection, and Diabetes 276
Gonads 277
Thymus Gland 277
Pineal Gland 277
Other Hormones 277
Organ-Specific Hormones 277
Prostaglandins 277
Adipose Tissue Hormones 278
The Tab of Ab Flab 278
Heart and Blood Vessels 278
Diabetes Mellitus 278
Cancer 278
Joint Disease 278
Get Ready for Exams! 281
Summary Outline 281
Review Your Knowledge 282
Matching: Glands 282
Matching: Hormones 282
Multiple Choice 282
Go Figure 283
15 Blood 284
Objectives 284
Key Terms 284
What Blood Does 284
Composition of Blood 284
Characteristics 284
Blood Has Two Parts 285
Origin of Blood Cells 286
Hemopoiesis and Red Bone Marrow 286
Bone Marrow Misery 286
Bone Marrow Depression 286
Bone Marrow Overactivity 286
Blood Cells 287
Red Blood Cells 287
“Retics” 287
Shape and Contents 288
Hemoglobin 288
Why Blood Changes Its Color 289
Substances Essential for Hemoglobin Production 289
Regulation of RBC Production 290
Removal and Breakdown of Red Blood Cells 290
Recycle! 290
The Anemias … as a Summary of Red Blood Cell Requirements and Conditions 291
White Blood Cells 291
Types of White Blood Cells 292
Neutrophils 292
Naming the Neutrophil 293
Polys, Polymorphs, or Polymorphonuclear Leukocytes. 293
Segs. 293
Band Cells, Staff Cells, and Stab Cells. 293
What Is a “Shift to the Left”? 293
Basophils 294
Eosinophils 294
Agranulocytes 294
Good News, Bad News 294
Platelets 294
Blood Counts 295
Differential Count 295
Hemostasis: Prevention of Blood Loss 295
Blood Vessel Spasm 295
Formation of a Platelet Plug 295
Antiplatelet Drugs and Bleeding 295
Blood Clotting 296
Formation of the Blood Clot 296
Anticoagulants 297
Endothelium 297
Secretion of Heparin 297
Anticoagulant Medications 298
Clot Retraction 298
Clot Busting: Fibrinolysis 298
Blood Types 299
Antigens and Blood Types 299
Antibodies and Blood Type 300
Antigen–Antibody Interaction 300
Compatibility and Incompatibility of Blood Types 300
Rh Classification System 301
Get Ready for Exams! 305
Summary Outline 305
Review Your Knowledge 306
Matching: Blood Cells 306
Matching: Blood Clots 306
Matching: Blood Types 306
Multiple Choice 306
Go Figure 307
16 Anatomy of the Heart 308
Objectives 308
Key Terms 308
Function, Location, and Size of the Heart 308
Layers and Covering of the Heart 308
Endocardium 308
Myocardium 309
Epicardium 309
Pericardium 310
A Double Pump and Two Circulations 310
The Heart’s Chambers and Great Vessels 311
Right Atrium 311
Right Ventricle 312
Left Atrium 312
Left Ventricle 312
Great Vessels of the Heart 313
Heart Valves 313
Atrioventricular Valves 313
Semilunar Valves 314
Pulmonic Valve 314
Aortic Valve 314
Heart Sounds 315
Pathway of Blood Flow Through the Heart 315
Blood Flow and Shunts 315
Shunts 315
Left-to-Right Shunt 315
Right-to-Left Shunt 315
Blood Supply to the Myocardium 316
Ischemia and Infarction 317
Cardiac Enzymes and Leaky Cells 318
Cardiac Conduction System 318
Parts of the Cardiac Conduction System 318
Sinoatrial Node 318
Atrial Conducting Fibers 319
Atrioventricular Node 319
His-Purkinje System 319
Automaticity and Rhythmicity 320
Normal, Slow, and Slower 320
Electrocardiogram 320
Get Ready for Exams! 322
Summary Outline 322
Review Your Knowledge 323
Matching: Structures of the Heart 323
Matching: Valves 323
Multiple Choice 323
Go Figure 324
17 Function of the Heart 325
Objective 325
Key Terms 325
The Coordinated and Adaptable Pump 325
Cardiac Cycle 325
Autonomic Control of the Heart 326
Why the Autonomic Nervous System? 326
Autonomic Wiring 326
Autonomic Firing 326
Sympathetic Stimulation 326
Parasympathetic (Vagus Nerve) Stimulation 327
Cardiac Output 328
Heart Rate 328
Stroke Volume 329
How to Change Stroke Volume 329
Starling’s Law of the Heart. 329
Inotropic Effect. 329
Changing Cardiac Output 329
Heart Talk 330
Heart Talk: Clinical Terms 330
End-Diastolic Volume 330
Preload 330
Ejection Fraction 330
Afterload 331
Inotropic Effect 331
Chronotropic Effect 331
Dromotropic Effect 331
Heart Talk: Receptor Language 331
Beta1-Adrenergic Receptor Activation 331
Beta1-Adrenergic Receptor Blockade 331
Muscarinic (Cholinergic) Receptor Activation 331
Muscarinic (Cholinergic) Receptor Blockade 332
The Failing Heart: When the Heart Can’t Pump 332
Left Heart Failure 332
Backward Failure 332
Forward Failure 332
Right Heart Failure 333
Get Ready for Exams! 337
Summary Outline 337
Review Your Knowledge 338
Matching: Cardiac Function Terms 338
Matching: Loads and Effects 338
Multiple Choice 338
Go Figure 338
18 Anatomy of the Blood Vessels 340
Objective 340
Key Terms 340
Circles, Circuits, and Circulations 340
Blood Vessels 341
Naming the Blood Vessels 341
Arteries 341
Capillaries 341
Veins 341
Blood Vessel Walls: the Layered Look 341
Blood Vessels: What They Do 342
Arteries 342
Arterioles 342
Capillaries 342
Veins and Venules 343
Major Arteries of the Systemic Circulation 343
Aorta 343
Branches of the Aorta 344
Branches of the Ascending Aorta 344
Branches of the Aortic Arch 344
Branches of the Descending Aorta (Thoracic Aorta) 345
Branches of the Descending Aorta (Abdominal Aorta) 346
Major Veins of the Systemic Circulation 346
Venae Cavae 346
Veins That Empty Into the Superior Vena Cava 346
Veins That Empty Into the Inferior Vena Cava 348
Special Circulations 348
Blood Supply to the Head and Brain 348
Arteries of the Head and Neck 349
Venous Drainage of the Head and Brain 350
Blood Supply to the Liver and the Hepatic Portal Circulation 350
Hepatic Blood Vessels 350
Hepatic Portal Circulation: a Part of the Splanchnic Circulation 350
Fetal Circulation 351
Pulse 353
What is a Pulse? 353
What Can You Learn About a Patient by Feeling the Pulse? 353
Get Ready for Exams! 354
Summary Outline 354
Review Your Knowledge 355
Matching: Blood Vessels: Structure and Function 355
Matching: Names of Blood Vessels 355
Matching: Fetal Circulation 355
Multiple Choice 355
Go Figure 356
19 Functions of the Blood Vessels 357
Objective 357
Key Terms 357
Blood Vessels Deliver 357
Blood Vessels Regulate Blood Pressure 357
Measurement of Blood Pressure 357
116/72 mm Hg: What It Means 357
Normal and Abnormal 358
“Taking” a Blood Pressure 358
Blood Pressure in Different Blood Vessels 359
Blood Pressure and Venous Return 359
Skeletal Muscle Action 359
Respiratory Movements 360
Constriction of the Veins 360
What Determines Blood Pressure? 360
Heart and Blood Pressure 360
Blood Vessels and Blood Pressure 360
How Blood Pressure Stays Within Normal Limits 362
Rapidly Acting Mechanisms 362
Slower Acting Mechanisms and Long-Term Regulation of Blood Pressure 364
Blood Vessels Act as Exchange Vessels 364
What is an Exchange Vessel? 364
Why Capillaries are Good Exchange Vessels 365
Thin Capillary Walls 365
Millions of Capillaries 365
Slow Velocity of Blood Flow 365
Capillary Forces: Exchange 365
Exchange Involving Diffusion 365
Exchange Involving Filtration-Osmosis 365
Mechanisms of Edema Formation 365
Heart Failure 365
Severe Burn 366
Kidney Disease 366
Blocked Lymphatic Drainage 366
Blood Vessels Distribute Blood 367
Blood Vessels Regulate Body Temperature 367
Get Ready for Exams! 370
Summary Outline 370
Review Your Knowledge 371
Matching: Blood Pressure Terms 371
Matching: Blood Pressure Readings 371
Matching: Changes in Blood Pressure 371
Multiple Choice 371
Go Figure 372
20 Lymphatic System 373
Objective 373
Key Terms 373
The Lymphatic System 373
Lymph: What It is, Where It Comes From 373
Lymphatic Vessels 373
Movement Through the Lymphatic Vessels 374
Lymphoid Organs 374
Lymph Nodes 375
Tonsils 376
Thymus Gland 376
Spleen 378
Get Ready for Exams! 380
Summary Outline 380
Review Your Knowledge 380
Matching: Lymph Terms 380
Multiple Choice 380
Go Figure 381
21 Immune System 382
Objective 382
Key Terms 382
Classification of the Immune System 382
Nonspecific Immunity 382
First Line of Defense 383
Second Line of Defense 384
Phagocytosis 384
What Does a Phagocyte Do? 384
Inflammation 384
Fever 385
Protective Proteins 385
Natural Killer Cells 386
Specific Immunity: Third Line of Defense 386
Antigens 386
Self and Nonself: is That Me? 386
Lymphocytes 387
Why the Names “T” and “B” Cells? 387
Cell-Mediated Immunity: T-Cell Function 387
Antibody-Mediated Immunity: B-Cell Function 388
Antibodies 389
What Antibodies Are 389
What Antibodies Do 390
Remember Me? Primary and Secondary Responses 390
Types of Immunity 390
Genetic Immunity 391
Acquired Immunity 391
Naturally Acquired Immunity 391
Artificially Acquired Immunity 391
Other Immune Responses 392
Allergic Reactions 392
Autoimmune Disease 393
Organ Rejection 393
Get Ready for Exams! 396
Summary Outline 396
Review Your Knowledge 397
Matching: Nonspecific Immunity 397
Matching: Specific Immunity 397
Matching: Active and Passive Immunity 397
Multiple Choice 397
Go Figure 398
22 Respiratory System 399
Objective 399
Key Terms 399
Structure: Organs of the Respiratory System 399
Upper and Lower Respiratory Tracts 399
Nose and Nasal Cavities 399
Pharynx 401
Larynx 401
Where and What is Your Voice Box? 401
Vocal Cords 401
True or False 401
Down the Wrong Way 403
From Boy to Young Man 403
Trachea 404
Where It Sits and Where It Splits 404
Keeping It Open 404
Bronchial Tree: Bronchi, Bronchioles, and Alveoli 404
Bronchi 404
Bronchioles 406
Alveoli 406
Lungs 406
Right and Left 406
Pleural Membranes 407
Pleura 407
Pleural Cavity: a Potential Space 407
Collapsed and Expanded Lungs 407
Why Lungs Collapse 408
Elastic Recoil 408
Surface Tension 408
Why Lungs Expand 409
Saying It Another Way: Compliance 410
Respiratory Function 411
Three Steps in Respiration 411
Step 1: Ventilation or Breathing 411
What It Is 411
Boyle’s Law: Pressure and Volume 411
Boyle’s Law and Breathing 411
The Muscles of Respiration 412
Nerves That Supply the Respiratory Muscles 414
Step 2: Exchange of Oxygen and Carbon Dioxide 414
Why the Lungs Are Good Gas Exchangers 414
Partial Pressures and the Diffusion of Gases 415
What Causes the Respiratory Gases to Diffuse? 415
Partial Pressures within the Lungs. 415
Partial Pressure at the Cells. 416
Step 3: Transport of Oxygen and Carbon Dioxide 416
Oxygen Transport 416
Carbon Dioxide Transport 416
Amounts of Air 416
Lung Volumes 416
Lung Capacities 417
Dead Space 418
Control of Breathing 418
Neural Control of Respiration 418
Chemical Control of Respiration 420
Get Ready for Exams! 424
Summary Outline 424
Review Your Knowledge 425
Matching: Structures of the Respiratory Tract 425
Matching: Thoracic Cavity and Ventilation 426
Multiple Choice 426
Go Figure 426
23 Digestive System 428
Objectives 428
Key Terms 428
Overview of the Digestive System 428
Digestion and Absorption 429
Layers, Nerves, and Membranes 429
Mucosa 429
Submucosa 430
Muscle Layer 430
Serosa 430
Innervation 430
Peritoneal Membranes 431
Structures and Organs 431
Mouth 431
Teeth 431
Tongue 431
Salivary Glands 433
Other Structures Within the Mouth 433
Pharynx 433
Esophagus 434
Stomach 434
What It Does 434
Regions of the Stomach 434
Muscles of the Stomach 434
Glands of the Stomach 434
Vomiting 435
When the Stomach is Not Working Right 436
Small Intestine 437
Location and Parts 437
Segments of the Small Intestine 437
Functions of the Small Intestine 438
Peristalsis and Absorption in the Small Intestine 438
Large Intestine 438
Segments of the Large Intestine 438
Functions of the Large Intestine 439
Peristalsis and Absorption 439
Bacterial Action 440
Intestinal Gas 442
When the Large Intestine is Not Working Right 442
Accessory Digestive Organs 443
Liver 443
What the Liver Does 443
Blood Supply to the Liver 443
Blood Supply and the Hepatic Portal System 443
Liver Lobules 443
Bile 443
Biliary Tree 445
Gallbladder 445
Pancreas 445
When Accessory Digestive Organs are Not Working Right 446
Digestion and Absorption 448
Carbohydrates and Carbohydrate-Splitting Enzymes 448
Proteins and Protein-Splitting Enzymes 449
Fats, Bile, and Fat-Splitting Enzymes 449
Nutrition: Concepts to Know 449
Carbohydrates 450
Proteins 450
Fats (Lipids) 451
Vitamins 451
Minerals 452
Health and a Balanced Diet 452
A Balanced Diet 452
Poorly Balanced Diet and Disease 453
Appetite Control and the Couch Potato 453
Body Energy 453
Measurement of Energy 453
Energy Balance 453
Energy Expenditure 454
Get Ready for Exams! 457
Summary Outline 457
Review Your Knowledge 458
Matching: Structures: Making the Connections 458
Matching: Enzymes, Hormones, and Digestive Aids 458
Multiple Choice 458
Go Figure 459
24 Urinary System 460
Objectives 460
Key Terms 460
Excretion 460
Organs of Excretion 460
Urinary System Organs 460
Urinary System Terms 461
Kidneys 461
Location 461
Structure 461
Blood Supply 461
Nerve Supply 461
Functions of the Kidneys 461
Urine Making: the Nephron Unit 462
Structures 462
Renal Tubules 463
Renal Blood Vessels (Vascular Structures) 463
Urine Formation 463
Glomerular Filtration 463
Why Filtration Occurs 463
What Substances Are Filtered 463
Tubular Reabsorption 465
Tubular Secretion 465
Hormones That Work on the Kidneys 465
Aldosterone 465
Antidiuretic Hormone 466
Natriuretic Peptides 467
Parathyroid Hormone 467
Composition of Urine 467
Uremia and Dialysis 468
Your Plumbing 469
Ureters 470
Urinary Bladder 470
Urination 472
Urethra 472
An Autonomic Moment 473
Get Ready for Exams! 475
Summary Outline 475
Review Your Knowledge 476
Matching: Plumbing … More or Less 476
Matching: Nephron Unit 476
Matching: Hormones and Enzymes 476
Multiple Choice 476
Go Figure 477
25 Water, Electrolyte, and Acid–Base Balance 478
Objectives 478
Key Terms 478
Body Fluids: Distribution and Composition 478
Fluid Compartments 478
Composition of Body Fluids 478
Water Balance 479
Water Intake 479
Water Output 479
Water Imbalances 479
Dehydration 479
Edema 480
Why Does Fluid Shift? 480
Daily Weights and Fluid Balance 481
Fluid Spacing—in Other Words 481
Electrolyte Balance 481
Quick Reference: Electrolytes 481
Most Important Ions 481
Sodium (Na+) 481
Potassium (K+) 482
Calcium (Ca2+) 482
Magnesium (Mg2+) 482
Chloride (Cl−) 482
Bicarbonate (HCO3−) 483
Other Ions 483
Acid–Base Balance 483
Quick Reference: Acids and Bases 483
Where the Acid (H+) Comes From 483
How the Body Regulates pH 483
Buffers 483
Lungs 483
How Decreasing the Respiratory Rate Decreases pH 483
How Increasing the Respiratory Rate Increases pH 484
How the Respiratory System Knows 484
Kidneys 484
Acid–Base Imbalances 484
Acidosis 485
Alkalosis 485
Get Ready for Exams! 488
Summary Outline 488
Review Your Knowledge 488
Matching: Water Compartments 488
Matching: Ions 488
Multiple Choice 489
Go Figure 489
26 Reproductive Systems 490
Objectives 490
Key Terms 490
Male Reproductive System 490
Testes 490
Location, Location, Location 491
Lobules 491
Sperm Cells 491
Spermatogenesis 491
Genital Ducts 491
Epididymis 492
Vas Deferens and Ejaculatory Ducts 492
Urethra 494
Accessory Glands 494
Seminal Vesicles 494
Prostate Gland 494
Bulbourethral Glands 494
Semen 494
External Genitals 494
Male Sexual Response: Erection, Emission, Ejaculation, and Orgasm 494
Male Sex Hormones 495
Effects of Testosterone 495
Hormonal Control of Male Reproduction 495
Female Reproductive System 496
Ovaries 496
Egg Development: the Ovarian Follicle 496
Ovulation 496
Ovarian Hormones 498
Estrogen 498
Progesterone 498
Genital Tract 498
Fallopian Tubes 498
Tube Troubles 498
Uterus 499
Vagina 499
External Genitals 500
Female Sexual Response 500
Hormonal Control of the Reproductive Cycles 501
Two Reproductive Cycles 501
Ovarian Cycle 501
Follicular Phase 501
Luteal Phase 503
Uterine Cycle 503
Menstrual Phase 503
Proliferative Phase 503
Secretory Phase 503
Implantation: Keeping the Corpus Luteum Alive 503
Menarche, Menses, and Menopause 504
Methods of Birth Control 504
Barrier Methods of Birth Control 504
Hormonal Contraceptives 504
Surgical Methods of Birth Control 504
Intrauterine Devices 504
Behavioral Methods of Birth Control 504
Emergency Contraception 505
Get Ready for Exams! 508
Summary Outline 508
Review Your Knowledge 509
Matching: Female Structures 509
Matching: Male Structures 509
Matching: Hormones 509
Multiple Choice 510
Go Figure 510
27 Human Development and Heredity 511
Objectives 511
Key Terms 511
Fertilization 511
When Fertilization Occurs 511
Where Fertilization Occurs 512
How Fertilization Occurs 512
Human Development 512
Prenatal Development 512
Early Embryonic Period 512
From Zygote to Blastocyst … or From Zygote to Eggplant 512
Seeing Double: Twins 514
Embryonic Period 514
Extraembryonic Membranes 514
Placenta 514
Formation of the Placenta 516
Functions of the Placenta 516
Hook Up: the Umbilical Cord 517
Organogenesis 517
Be Careful: Teratogens 517
Fetal Period 518
Changes in the Mother’s Body during Pregnancy 519
Birth of Baby 520
Labor 520
Hormonal Basis of Labor 520
Stages of Labor 521
Female Breast and Lactation 522
Structure of a Breast: the Mammary Glands 522
Got Milk? 522
Hormones of Lactation 522
Postnatal Changes and Developmental Stages 522
Immediate Adjustments 522
Development as a Lifelong Process 524
Heredity 524
DNA, Genes, and Chromosomes 524
Genetic Art: the Karyotype 525
Dominant, Recessive, and Codominant Genes 525
Too Many or Too Few Chromosomes 525
Genetic Expression 526
Genetic Mutations 526
It’s a Boy, It’s a Girl: How the Sex of the Child is Determined 527
Xs and Ys 527
Sex Determination: a Male Thing 527
Sex-Linked Traits 527
Congenital and Hereditary Disease 527
Get Ready for Exams! 528
Summary Outline 528
Review Your Knowledge 529
Matching: Fertilization and Development 529
Matching: Hormones 529
Matching: Heredity 529
Multiple Choice 530
Go Figure 530
Answers to Review Your Knowledge and Go Figure Questions 531
Chapter 1: Introduction to the Human Body 531
Chapter 2: Basic Chemistry 531
Chapter 3: Cells 531
Chapter 4: Cell Metabolism 531
Chapter 5: Microbiology Basics 531
Chapter 6: Tissues and Membranes 531
Chapter 7: Integumentary System and Body Temperature 531
Chapter 8: Skeletal System 531
Chapter 9: Muscular System 532
Chapter 10: Nervous System: Nervous Tissue and Brain 532
Chapter 11: Nervous System: Spinal Cord and Peripheral Nerves 532
Chapter 12: Autonomic Nervous System 532
Chapter 13: Sensory System 532
Chapter 14: Endocrine System 532
Chapter 15: Blood 532
Chapter 16: Anatomy of the Heart 532
Chapter 17: Function of the Heart 532
Chapter 18: Anatomy of the Blood Vessels 533
Chapter 19: Functions of the Blood Vessels 533
Chapter 20: Lymphatic System 533
Chapter 21: Immune System 533
Chapter 22: Respiratory System 533
Chapter 23: Digestive System 533
Chapter 24: Urinary System 533
Chapter 25: Water, Electrolyte, and Acid–Base Balance 533
Chapter 26: Reproductive Systems 533
Chapter 27: Human Development and Heredity 534
Glossary 535
A 535
B 536
C 536
D 537
E 538
F 538
G 538
H 539
I 539
J 539
K 539
L 540
M 540
N 540
O 541
P 541
R 542
S 542
T 543
U 544
V 544
W 544
Z 544
Index 545
A 545
B 546
C 547
D 549
E 550
F 551
G 551
H 551
I 553
J 553
K 553
L 554
M 554
N 555
O 556
P 556
Q 558
R 558
S 559
T 560
U 561
V 561
W 562
X 562
Y 562
Z 562
Evolve page IBC1
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