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Pharmacology - E-Book

Pharmacology - E-Book

Eugenia M. Fulcher | Robert M. Fulcher | Cathy Dubeansky Soto

(2014)

Additional Information

Book Details

Abstract

Comprehensive yet easy to read, Pharmacology: Principles and Applications, 3rd Edition introduces you to basic pharmacology, showing how to apply principles to the kinds of clinical situations you will encounter on the job. You'll learn how different drugs work in the body, how to calculate drug dosages, drug administration routes and procedures, the medications related to disorders in each body system, and much more. Written by expert authors Eugenia M. Fulcher, Robert M. Fulcher, and Cathy Dubeansky Soto, Pharmacology ensures that you master all of the pharmacology competencies required by CAAHEP and ABHES. In the book and on a companion Evolve website, a variety of exercises helps you strengthen your skills in math, dosage calculation, and critical thinking.

  • Practical coverage of basic pharmacology provides a thorough understanding of the medications most commonly used in ambulatory and inpatient settings.
  • A real-life Scenario starts each chapter with thought-provoking questions to consider as you progress through the material.
  • Procedures boxes provide step-by-step guidance for drug calculation and administration, accompanied by numerous illustrations and icons that identify OSHA-mandated protocols.
  • Common Signs & Symptoms of Diseases and Common Side Effects of Medications lists in each body system chapter help you distinguish between disease progression and medication reactions.
  • Body systems icons highlight the ways that specific drugs affect a particular body system.
  • Chapter objectives and key words at the beginning of each chapter help you focus your study efforts.
  • Check Your Understanding math review sections enable you to assess your knowledge of application and calculation concepts.
  • Critical Thinking exercises challenge you to apply what you've learned to a variety of realistic situations.
  • Important Facts and Clinical Tips boxes in each chapter highlight the key concepts for practice.
  • Patient Education for Compliance boxes help you communicate more effectively with patients about possible side effects or adverse reactions.
  • Summary tables are more concise and easier to follow.
  • New calculations exercises and quizzes are included on the companion Evolve website.
  • Expanded math and drug calculation sections in the workbook supplement the textbook with additional exercises for practice with math and dosage calculations. Available separately.

Table of Contents

Section Title Page Action Price
Front cover cover
Inside front cover ifc1
Evolve page i
Pharmacology iii
Copyright page iv
Dedication v
Reviewers vi
Preface vii
Organization of the Text viii
Section I: General Aspects of Pharmacology viii
Section II: Mathematics for Pharmacology and Dosage Calculations viii
Section III: Medication Administration viii
Section IV: Pharmacology for Multisystem Application and Section V: Medications Related to Body Systems viii
Workbook ix
Instructor’s Resource Manual with TEACH ix
Purpose of the Textbook ix
Acknowledgments ix
Table of Contents xiii
I General Aspects of Pharmacology 1
1 Introduction to Pharmacology and Its Legal and Ethical Aspects 2
Objectives 2
Key Terms 3
Pharmacology and Health Sciences 3
Why Study Pharmacology? 3
Role of Professionals in Medication Administration 4
History of Pharmacology 5
Society and the Need for Drug Regulation 7
Drug Standards and Patient Safety 7
International, Federal, and State Statutes for the Regulation of Medications 8
Federal Legislation Related to Drugs 8
The Food and Drug Administration and the Introduction of New Drugs 10
The Drug Enforcement Administration and Controlled Substances 12
The Drug Enforcement Administration and Controlled Substances in the Medical Office 12
Ordering and Securing Controlled Substances 14
Record Keeping and Inventory Control 14
Disposing of Scheduled and Nonscheduled Drugs 15
Preventing Drug Dependence and Drug Abuse 16
Role of Allied Health Professionals in Medication Administration 16
Ethics of the Health Professional in Medication Management 17
Drug Samples and Ethics 17
Ethics of Medications with Medical Personnel 18
Summary 18
Critical Thinking Exercises 19
Scenario 19
Review Questions 19
2 Basics of Pharmacology 21
Objectives 21
Key Terms 21
What Is A Drug? 22
Five Basic Categories of Pharmacology 23
Pharmacognosy—Origins of Drugs 23
Pharmacokinetics—How the Body Processes Drugs 24
Absorption 25
Distribution 27
Metabolism or Biotransformation 27
Excretion or Elimination 27
Pharmacodynamics—Drug Actions in the Body 28
Pharmacotherapeutics—Indications for or Effects of Medication Use 29
Toxicology—Poisonous Effects of Drugs on the Body 30
Identifying Undesirable Effects of Drugs 31
Drugs and Their Receptor Sites 32
Mechanisms of Drug Interactions 32
Drug-Drug Interactions 32
Nutrient-Drug Interactions 33
Disease-Drug Interactions 35
Summary 35
Critical Thinking Exercises 36
Scenario 36
Review Questions 36
3 Drug Information and Drug Forms 38
Objectives 38
Key Terms 38
Drug Classifications 39
“Off-Label” Uses for Medications 39
Drug Nomenclature 39
Sources of Drug Information 40
Drug Forms and Drug Delivery Systems 41
Oral Medications 44
Solid Oral Preparations 44
Liquid Oral Preparations 44
Miscellaneous Oral Medications 44
Percutaneous Medications 47
Parenteral Medications 49
Water-Based Parenteral Medications 49
Oil-Based Parenteral Medications 50
Other Forms of Medications 50
Packaging Medications for Patient Compliance 50
Summary 51
Critical Thinking Exercises 51
Scenario 51
Review Questions 51
4 Understanding Drug Dosages for Special Populations 53
Objectives 53
Key Terms 53
Variables Affecting Drug Dosage and Actions 54
Age 54
Weight 55
Diet 55
Gender 56
Genetics 56
Diseases 56
Mental State 56
History of Previous Medications 56
Time of Administration 56
Route of Administration 56
Environment 56
Drug Dependence 56
Patient Compliance 56
Precautions and Contraindications to Medication Use in Certain Populations 57
Medication Use during Pregnancy and Lactation 57
Medication Use in Children 58
Medication Use in Older Patients 60
Polypharmacy in the Older Adult 61
Assisting the Older Adult with Medication Compliance 62
Assisting Other Special Populations with Medications 62
Medications and Cultural Differences 63
Communication and Medication Compliance 65
Summary 65
Critical Thinking Exercises 65
Scenario 65
Review Questions 66
5 Reading and Interpreting Medication Labels and Orders and Documenting Appropriately 68
Objectives 68
Key Terms 69
Reading a Label for Stock Medications 69
Parts of a Medication Label 69
A. Trade (Proprietary or Brand) Name 69
B. Generic Name 69
C. Drug Strength (Weight) 70
D. Form 70
E. Route of Administration 70
F. Total Amount of Medication in Container 71
G. Directions for Reconstitution 71
H. National Drug Code 71
I. Manufacturer’s Name 71
J. Expiration Date 71
K. Labels for Controlled Drugs 71
L. Auxiliary Labeling 71
Labeling of Over-The-Counter Medications 71
Ordering Medications 72
Common Abbreviations Used in Prescriptions and Medication Orders 72
Verbal Orders 73
Standing Orders 73
Medication Orders 73
Prescriptions 74
Prescription Preparation 74
Parts of a Prescription 74
Line A 74
Line B 75
Line C 75
Line D 75
Line E 75
Line F 75
Line G 75
Line H 75
Line I 75
Prescription Refills 76
Safeguarding Prescription Pads 77
Summary 77
Critical Thinking Exercises 78
Scenario 78
Review Questions 78
Reading and Writing Prescriptions 79
Documentation 81
II Mathematics for Pharmacology and Dosage Calculations 83
6 Math Review 84
Objectives 84
Key Terms 84
Chapter 6 Pretest 84
Fractions and Mixed Numbers 84
Decimals 85
Percents 85
Ratio and Proportion 86
Fractions 86
Proper Fractions 86
Improper Fractions 86
Equivalent Fractions 87
Simplifying Fractions to the Lowest Term 87
Check Your Understanding: Fractions Box 6-1 87
Mixed Numbers 88
Check Your Understanding: Mixed Numbers Box 6-2 89
Adding Fractions and Mixed Numbers with the Same Denominator 89
Adding Fractions and Mixed Numbers with Different Denominators 90
Check Your Understanding: Adding Fractions Box 6-3 91
Subtracting Fractions 91
Subtracting Fractions and Mixed Numbers 91
Multiplying Fractions 92
Check Your Understanding: Subtracting Fractions and Mixed Numbers Box 6-4 92
Multiplying Mixed Numbers 93
Check Your Understanding: Multiplying Fractions and Mixed Numbers Box 6-5 93
Dividing Fractions 94
Dividing Mixed Numbers 94
Check Your Understanding: Dividing Fractions and Mixed Numbers Box 6-6 95
Check Your Understanding: Fraction Review Box 6-7 95
Decimals 96
Rounding Decimals 96
Check Your Understanding: Rounding Decimals Box 6-8 97
Converting Fractions to Decimals 97
Check Your Understanding: Converting Fractions to Decimals Box 6-9 98
Adding and Subtracting Decimals 98
Check Your Understanding: Adding and Subtracting Decimals Box 6-10 99
Multiplying Decimals 99
Check Your Understanding: Multiplying Decimals Box 6-11 100
Dividing Decimals 100
Check Your Understanding: Dividing Decimals Box 6-12 100
Check Your Understanding: Decimal Review Box 6-13 101
Percents 101
Changing Percents to Decimals 102
Check Your Understanding: Changing Percents to Decimals Box 6-14 102
Changing Decimals to Percents 102
Check Your Understanding: Changing Decimals to Percents Box 6-15 102
Multiplying Percents 103
Check Your Understanding: Multiplying Percents Box 6-16 103
Dividing Percents 104
Check Your Understanding: Dividing Percents Box 6-17 104
Using Fractions to Figure Percentages 104
Check Your Understanding: Using Fractions to Figure Percents Box 6-18 106
Using an Equation to Figure a Percentage 106
Check Your Understanding: Percent Review Box 6-19 106
Ratio and Proportion 107
Solving for x in a Proportion 107
Check Your Understanding: Ratio and Proportion Box 6-20 108
Using Ratio and Proportion to Figure Percents 108
Check Your Understanding: Using Proportions to Figure Percents Box 6-21 110
Practical Applications 110
Check Your Understanding: Ratio and Proportion Review Box 6-22 111
7 Measurement Systems and Their Equivalents 113
Objectives 113
Key Terms 113
Chapter 7 Pretest: Measurement Systems and Their Equivalents 113
Metric System 114
Check Your Understanding: Metric System Basics Box 7-1 115
Calculation Review 116
Length Measurement and Conversion in the Metric System 116
Check Your Understanding: Metric Length Conversions Box 7-2 117
Practical Application 118
Volume Measurement and Conversion in the Metric System 118
Check Your Understanding: Metric Volume Conversions Box 7-3 119
Practical Application 119
Weight Measurement and Conversion in the Metric System 119
Check Your Understanding: Metric Weight Conversions Box 7-4 120
Practical Application 120
Apothecary System 121
Household Measurement System 121
Check Your Understanding: Household System Box 7-5 122
Practical Application 122
Units 122
Milliequivalents 123
Current Trends for Symbols and Abbreviations 123
Summary 123
Critical Thinking Exercises 123
Review Questions 124
8 Converting Between Measurement Systems 126
Objectives 126
Key Terms 126
Chapter 8 Pretest—Converting between Measurement Systems 126
Time Conversions 127
Check Your Understanding: Time Conversion 8-1 129
Measuring Temperature 129
Temperature Conversions 130
Method 1 130
Method 2 130
Check Your Understanding: Temperature Conversions 8-2 131
Practice Problems 131
Converting Between Measurement Systems Using Ratio and Proportion 131
Check Your Understanding: Ratio and Proportion 8-3 132
Calculation Review 132
System Conversions 132
Volume 132
Converting Volume Measurement Units between Systems 133
Check Your Understanding: Volume Conversion 8-4 134
Calculation Review 134
Practical Application 135
Weight 135
Converting Weight Measurement Units between Systems 136
Check Your Understanding: Weight Conversions 8-5 139
Calculation Review 139
Practical Application 139
Length 140
Converting Length Measurement Units between Systems 140
Check Your Understanding: Length Conversions 8-6 141
Calculation Review 141
Practical Application 141
Summary 142
Critical Thinking Exercises 142
Review Questions 143
Practical Application 143
9 Calculating Doses of Nonparenteral Medications 145
Objectives 145
Key Words 145
Chapter 9 Pretest—Calculating Doses of Nonparenteral Medications 145
Introduction to Methods of Dosage Calculation 147
Dosage Forms for Nonparenteral Medications 148
Check Your Understanding: Dosage Measurements Box 9-1 148
Calculation Review 148
Three Methods of Calculating Doses 149
Calculating Doses Using Ratio and Proportion 149
Check Your Understanding: Ratio and Proportion Box 9-2 151
Calculation Review 151
Practical Application 151
Calculating Doses Using the Formula Method 151
Check Your Understanding: Formula Method Box 9-3 153
Practical Application 154
Calculating Doses Using Dimensional Analysis 154
Choosing a Calculation Method 156
Check Your Understanding: Dimensional Analysis Box 9-4 156
Practical Application 157
Check Your Understanding: Dosage Calculations Box 9-5 157
Calculation Review 157
Reconstituting a Powder 158
Check Your Understanding: Reconstituting a Powder Box 9-6 159
Practical Application 159
Special Calculations 160
Calculations Using the Body Surface Area Method 160
Using Body Surface Area 162
Check Your Understanding: Using A Nomogram Box 9-7 162
Calculation Review 162
Check Your Understanding: Body Surface Area Box 9-8 163
Calculation Review 163
Calculating Dose Using Milligrams per Kilogram 163
Check Your Understanding: Milligrams per Kilogram Box 9-9 164
Other Nonparenteral Medications 164
Summary 164
Critical Thinking Exercises 165
Calculation Review 167
Review Questions 168
10 Calculating Doses of Parenteral Medications 169
Objectives 169
Key Terms 169
Chapter 10 Pretest 169
Calculating Doses of Parenteral Medications 169
Parenteral Medications 170
Reading Syringes for Parenteral Drug Administration 171
Check Your Understanding: Reading Syringes Box 10-1 172
Calculation Review 172
Calculating Parenteral Medications Using the Metric System 174
Calculating Dose Using the Ratio and Proportion Method 174
Calculating Dose Using the Formula Method 174
Calculating Dose Using the Dimensional Analysis Method 174
Check Your Understanding: Calculating Doses in the Metric System Box 10-2 175
Calculation Review 175
Calculating Doses of Parenteral Drugs in Units 176
Check Your Understanding: READING Insulin and Noninsulin Doses in Units Box 10-3 176
Calculation Review 176
Calculating a Parenteral Medication Available in Units 178
Calculating Units Using the Ratio and Proportion Method 178
Calculating Units Using the Formula Method 178
Calculating Units Using the Dimensional Analysis Method 178
Calculating Heparin Doses in Units 178
Calculating Heparin Units Using Ratio and Proportion 178
Calculating Heparin Units Using the Formula Method 179
Calculating Heparin Units Using Dimensional Analysis 179
Measuring Insulin in Units 179
Check Your Understanding: Calculating Insulin and Noninsulin Doses in Units Box 10-4 179
Calculation Review 179
Summary 181
Check Your Understanding: Review Box 10-5 181
Calculation Review 181
Critical Thinking Exercises 182
Review Questions 183
III Medication Administration 185
11 Safety and Quality Assurance 186
Objectives 186
Key Terms 186
Safety with Medications Taken by Patients 187
Medication Administration 188
Occupational Safety and Health Administration Standards in Medication Administration 188
Quality Assurance in Medication Delivery 189
Medication Administration for Patient Safety 190
Reducing Medication Errors Using 3 + 7 191
Three Befores 191
Seven Rights 191
Sources of Medication Errors 193
Delivery of Medications 193
Summary 194
Critical Thinking Exercises 194
Scenario 194
Review Exercises 195
Documentation of Medications 195
Review Questions 195
12 Enteral Routes 196
Objectives 196
Key Terms 196
Oral Administration of Medications 197
Rectal Administration of Medications 197
Summary 201
Critical Thinking Exercises 203
Scenario 203
Review Questions 204
13 Percutaneous Routes 205
Objectives 205
Key Terms 205
Topical Medications 206
Applying Topical Medications 206
Powders 206
Soaks, Compresses, and Wet Dressings 206
Creams, Ointments, Gels, and Lotions 206
Patches, Disks, and Transdermal Dots 207
Sprays and Aerosols 208
Special Considerations for Topical Medications in Geriatric Patients 208
Buccal and Sublingual Medications 209
Ophthalmic Medications 210
Otic Medications 210
Nasal Medications 210
Vaginal Medications 212
Inhaled Medications 214
Summary 216
Critical Thinking Exercises 216
Scenario 216
Review Questions 216
14 Parenteral Routes 218
Objectives 218
Key Terms 218
Advantages of Parenteral Administration 219
Disadvantages of Parenteral Administration 219
Special Precautions with Parenteral Medications 219
Equipment Selection for Injectable Medications 220
Medication Containers 220
Syringes 220
Needles 221
Containers for Injectable Medications 222
Ampules 222
Vials 223
Prefilled Syringe 223
Disposable Injection Units 223
Preparation of Medication for Injection 223
Reconstitution of Powder Forms of Medication 223
Mixing Two Medications for Administration 228
Administering Injectable Medications 229
Routes of Administration and the Common Indications 229
Administering Intradermal Injections 229
Administering Medications Subcutaneously 231
Administering Medications Intramuscularly 231
Sites for Intramuscular Injections 233
Deltoid Site. 233
Dorsogluteal Site. 233
Ventrogluteal Site. 234
Vastus Lateralis and Rectus Femoris Sites. 234
Summary 236
Critical Thinking Exercises 237
Scenario 237
Review Questions 237
IV Pharmacology for Multisystem Application 239
15 Analgesics and Antipyretics 240
Objectives 240
Key Terms 240
What is Pain? 241
Pain and Emotional Responses 241
Pain and Medications 242
Types of Analgesics 243
Opioid and Opiate Analgesics 243
Uses of Opioids and Opiates 245
Opioid and Opiate Analgesic Precautions 245
Nonopioid Analgesics 246
Salicylate Analgesics 246
Non-salicylates for Pain 246
Nonsteroidal Antiinflammatory Drugs 247
Combination Nonopioid Medications 248
Combining Analgesics for Greater Effectiveness 248
Adjuvant Medications for Analgesia 250
Children and Analgesics 250
The Elderly and Analgesics 252
Summary 252
Critical Thinking Exercises 253
Scenario 253
Drug Calculations 253
Review Questions 254
16 Immunizations and the Immune System 255
Objectives 255
Key Terms 255
Role of Lymphocytes in Immunity 257
Inborn Versus Acquired Immunity 258
Natural Passive Immunity 258
Natural Active Immunity 258
Artificial Active Immunity 259
Artificial Passive Immunity 260
Types of Active and Passive Immunizing Agents 260
Vaccines 260
Toxoids 261
Immune Globulins 261
Antitoxins 261
Who Should Be Immunized? 261
Indications for Immunizations 262
Contraindications to Immunizations 262
Adverse Reactions to Immunizations 262
Documentation of Immunizations 263
Agents for Artificial Active Immunity 263
Vaccines for Diphtheria, Tetanus, and Pertussis (DTaP, Tdap, Td) 263
Tetanus Toxoid (TT) 267
Vaccines for Measles (Rubeola), Mumps, and Rubella (MMR) 267
Poliomyelitis Vaccines (IPV, OPV) 267
Vaccine for Haemophilus Influenzae Type B 267
Vaccines for Hepatitis A and B 267
Vaccine for Chickenpox 267
Vaccines for Influenza 268
Vaccine for Pneumonia 268
Vaccine for Tuberculosis 268
Vaccine for Rotavirus 268
Vaccine for Meningitis 268
Vaccine for Human Papillomavirus 268
Vaccine for Shingles 269
“Super Shots” 269
Vaccines for Specific Populations 269
Vaccine for Rabies 269
Patient Safety with Agents for Active Immunization 269
Safety with Vaccines 269
Agents for Artificial Passive Immunity 271
Antitoxins 271
Immune Globulins 272
Immune Globulins for Specific Conditions 272
Respiratory Syncytial Virus Immune Globulin 272
Education Concerning Immunizations 272
Immunosuppressants 274
Immunostimulants 275
Summary 277
Critical Thinking Exercises 277
Scenario 277
Drug Calculations 278
Review Questions 278
17 Antimicrobials, Antifungals, and Antivirals 280
Objectives 280
Key Terms 280
What is an Antibiotic? 281
Classification of Microorganisms 282
Identification of Microorganisms 282
Shape 282
Gram Staining 282
Need for Oxygen 282
Antimicrobials Versus Antibiotics 282
Bactericidal Versus Bacteriostatic 283
Factors in the Choice of Antibiotics 283
Drug Sensitivity 283
Patient Factors 283
Antibiotic Resistance 284
Superinfection and Antibiotic Use 284
Prophylactic Use of Antibiotics 284
Misuse of Antibiotics 284
Antibacterial Drugs 285
Penicillins 285
Narrow-Spectrum Penicillins 286
Narrow-Spectrum Antistaphylococcal (Penicillin-Resistant) Penicillins 286
Broad-Spectrum Penicillins (Aminopenicillins) 286
Extended-Spectrum Penicillins 286
Cephalosporins 288
Carbapenems 288
Macrolides 288
Tetracyclines 290
Aminoglycosides 292
Quinolones 292
Other Antibiotics 293
Chloramphenicol 293
Lincomycin and Derivatives 293
Oxazolidinones 293
Ketolides 295
Vancomycin 295
Metronidazole 295
Tigecycline 295
Topical Over-the-Counter Antibiotics 295
Sulfonamides (Sulfa Drugs) 295
Sulfonamides in Combinations 295
Topical Sulfonamide Preparations 296
Drugs to Treat Tuberculosis 297
Drugs to Treat Fungal Infections 298
Topical Antifungals 299
Systemic Antifungals 299
Drugs to Treat Viral Infections 300
Classification of Antiviral Drugs 300
Non-HIV Antiviral Medications 300
HIV Antivirals 300
Drugs to Treat Malaria 303
Chemical Agents Used As Antiseptics and Germicides and Disinfectants 303
Antiseptics versus Disinfectants and Germicides 304
Antiseptics 304
Iodine Preparations 304
Alcohol 304
Hexachlorophene 305
Hydrogen Peroxide 305
Silver Preparations 305
Disinfectants 305
Summary 305
Critical Thinking Exercises 307
Scenario 307
Drug Calculations 307
Review Questions 308
18 Antineoplastic Agents 309
Objectives 309
Key Terms 309
What is Cancer? 310
Classifying Tumors 311
Antineoplastic Agents 312
Side Effects of Antineoplastics 313
Factors to Consider with Chemotherapy 314
Classes of Antineoplastic Agents 314
Alkylating or Alkylating-Like Agents 314
Antimetabolites 314
Mitotic Inhibitors (Plant Alkaloids) 314
Hormones and Hormone Antagonists 314
Antitumor Antibiotics 319
Immunosuppressants 319
Radioisotopes 319
Newer Drugs and Drug Delivery Systems 319
Handling and Administering Antineoplastic Agents 320
Summary 321
Critical Thinking Exercises 321
Scenario 321
Drug Calculations 321
Review Questions 322
19 Nutritional Supplements and Alternative Medicines 323
Objectives 323
Key Terms 323
Vitamins 324
Classification of Vitamins 325
Fat-Soluble Vitamins 325
Water-Soluble Vitamins 325
Use of Vitamin Supplements in the Elderly 330
Minerals 330
Use of Mineral Supplements 331
Alternative Medications 331
Cultural Differences in Using Alternative Medicine 331
Safety and Regulation of Herbal Supplements 336
Summary 340
Critical Thinking Exercises 340
Scenario 340
Drug Calculations 341
Review Questions 341
V Medications Related to Body Systems 343
20 Endocrine System Disorders 344
Objectives 344
Key Terms 344
What are Hormones? 346
Pituitary Gland Hormones 347
Anterior Pituitary Gland 347
Posterior Pituitary Gland 349
Thyroid Gland Hormones 350
Antithyroid Medications 351
Calcitonin 351
Parathyroid Hormone 352
Corticosteroids/Steroids 353
Adrenal Cortex Hormones 353
Administration Techniques with Steroid Therapy 355
Drugs Used as Antidiabetic Agents 355
Diabetes Mellitus 356
Administration of Insulin in Type 1 Diabetes Mellitus 357
Mixing Insulins 358
Insulin Delivery Systems 361
Adverse Reactions to Insulin 363
Drugs Used as Oral Antidiabetic Agents 363
Other Injectables for Type 2 and Type 1 Diabetes Mellitus 364
Hyperglycemic Agents 365
Summary 365
Critical Thinking Exercises 366
Scenario 366
Drug Calculations 367
Review Questions 367
21 Eye and Ear Disorders 369
Objectives 369
Key Terms 369
Eye 370
Antiinfective and Antiinflammatory Agents 372
Agents for Glaucoma 375
Mydriatics and Cycloplegics 376
Local Ophthalmic Anesthetic Agents 377
Immunomodulators 378
Artificial Tears and Lubricants 378
Ophthalmic Antiallergic and Decongestant Agents 379
Ophthalmic Staining Agents 379
Ear 380
Otic Preparations 380
Vertigo and Ototoxicity 381
Storage of Eye and Ear Preparations 383
Summary 383
Critical Thinking Exercises 384
Scenario 384
Dosage Calculations 384
Review Questions 384
22 Drugs for Skin Conditions 385
Objectives 385
Key Terms 385
Classification of Dermatologic Preparations 387
Dermatologic Preparations and Absorption 387
Types of Preparations for the Skin 388
Antiinfective and Antiinflammatory Topicals 388
Acne Preparations 393
Keratolytic Agents 394
Treatments for Seborrheic Dermatitis 395
Medications for Psoriasis 395
Topical Anesthesia and Antipruritics 395
Topical Treatment of Burns and Chronic Wounds 397
Prophylactic Agents 398
Medications for Scabies and Pediculosis 399
Other Dermatologic Preparations 399
Summary 400
Critical Thinking Exercises 400
Scenario 400
Drug Calculations 400
Review Questions 401
23 Musculoskeletal System Disorders 402
Objectives 402
Key Terms 402
Osteoporosis and Medications for Treatment 404
Joint Diseases and Their Treatment 406
Gouty Arthritis 411
Diseases Involving Muscles 413
Diseases with Muscle Spasticity 413
Fibromyalgia 415
Summary 415
Critical Thinking Exercises 415
Scenario 415
Drug Calculations 416
Review Questions 416
24 Gastrointestinal System Disorders 418
Objectives 418
Key Terms 418
Gastrointestinal System and How Drugs Act 420
Drugs Used in the Mouth 421
Agents Used for Mouth Conditions 421
Drugs Used for Gastric Conditions 422
Other Medications for Peptic Ulcers 424
Drugs Used to Treat Hepatitis B and Hepatitis C 428
Drugs Used as Pancreatic Enzyme Replacements 428
Drugs Used with Gallbladder Disease 428
Drugs for Emesis 430
Drugs Used for Intestinal Conditions 432
Antiflatulents 432
Laxatives and Cathartics 432
Types of Laxatives 435
Drugs Used for Relief of Diarrhea 437
Lower GI Antiinflammatory Agents 438
Anorectal Preparations 438
Drugs Used for Intestinal Parasites 438
Drugs Used to Suppress Appetite 439
Summary 440
Critical Thinking Exercises 441
Scenario 441
Drug Calculations 441
Review Questions 442
25 Respiratory System Disorders 443
Objectives 443
Key Terms 443
How Respiration Controls Body Functions 444
Oxygen Therapy 445
Upper Respiratory Tract Conditions 446
Treatment of Nasal Congestion 446
Antihistamines 446
Decongestants 448
Cromolyn Sodium 449
Glucocorticoids 449
OTC Products for Upper Respiratory Conditions 450
Combination OTC Products 450
Zinc-Based OTC Products 451
Herbal Cold Prophylactic Products 451
Drugs Used for Coughs 451
Antitussives 451
Opioid Cough Suppressants 451
Nonopioid Cough Suppressants 452
Understanding Lower Respiratory Tract Disorders 453
Drugs for Conditions of the Lower Respiratory Tract 453
Mucokinetic Agents 453
Expectorants 453
Inhalation Medications Used As Bronchodilators 454
Epinephrine, Ephedra, and Beta2-Adrenergic Drugs 454
Xanthine Derivatives 456
Anticholinergic Medications 456
Glucocorticoids 456
Prophylactic Medications for Asthma 457
Influenza A and B 458
Medications for Inhibition of Influenza 458
Medications for Respiratory Syncytial Virus Infection 459
Summary 460
Critical Thinking Exercises 460
Scenario 460
Drug Calculations 461
Review Questions 461
26 Circulatory System and Blood Disorders 463
Objectives 463
Key Terms 463
Function of the Circulatory System 464
How Drugs Affect the Cardiac Electrical Conduction System 465
Drugs for Angina Pectoris 467
Nitrates 467
Beta-Adrenergic Blockers 468
Calcium Channel Blockers 468
Combining the Medications for Angina 468
Congestive Heart Failure and Its Treatment 470
Medications for Treating Congestive Heart Failure 471
Cardiac Dysrhythmias and Their Treatment 472
Hypertension and Its Treatment 474
Antihypertensive Therapy 475
Antihypertensive Therapy and Lifestyle Changes 475
Adding Medications for Treatment of Hypertension 475
Categories of Antihypertensive Medications 477
Diuretics 477
Adrenergic-Inhibiting Agents 480
Vasodilators 480
Calcium Channel Blockers 482
Diseases of the Blood Vessels and Their Treatment 483
Hyperlipidemia and Its Treatment 483
Treatment of Hyperlipidemia 484
Medications that Affect Coagulation 486
Anticoagulants 486
Warfarin 487
Antiplatelet Medications 488
Thrombolytic Medications 488
Topical Hemostatics 488
Medications Used As Hematopoietics and Erythropoietics 489
Summary 489
Critical Thinking Exercises 490
Scenario 490
Drug Calculations 491
Review Questions 491
27 Urinary System Disorders 493
Objectives 493
Key Terms 493
Fluid and Electrolyte Balance 495
Replacement Therapy 495
Treating Urinary Tract Infections 497
Drugs to Treat Urinary Tract Infections 497
Antiinfectives 497
Urinary Tract Antiseptics 500
Miscellaneous Urinary Tract Medications 500
Urinary Tract Analgesics 500
Urinary Tract Antispasmodics and Drugs for Overactive Bladder 500
Drugs for Enuresis 500
Summary 501
Critical Thinking Exercises 501
Scenario 501
Drug Calculations 502
Review Questions 502
28 Reproductive System Disorders 503
Objectives 503
Key Terms 503
Influence of Hormones on the Reproductive System 505
Drugs that Affect the Male Reproductive System 506
Androgens 506
Testosterone 506
Anabolic Steroids 507
Medications for Benign Prostatic Hypertrophy 508
Drugs that Affect the Female Reproductive System 509
Estrogens 509
Forms of Estrogen Preparations 510
Progesterone 511
Forms of Contraception 513
Oral Contraceptives 513
Taking Oral Contraceptives Effectively 514
Other Forms of Contraception 516
Implants and Transdermal Patches 516
Contraception by Injection 517
Intrauterine Devices 517
Spermicides 517
Barrier Devices 517
Postcoital Contraception 518
RU-486 (Abortion Pill) 519
Forms of Contraception on the Horizon 519
Drugs for Premenstrual Syndrome and Dysmenorrhea 519
Medications for Infertility 520
Treatment by Follicular Stimulation 520
Treatment of Amenorrhea 520
Male Infertility 520
Medications for Miscellaneous Reproductive Conditions 521
Medications for Erectile Dysfunction 521
Medications that Impair or Enhance Libido as a Side Effect 522
Summary 523
Critical Thinking Exercises 524
Scenario 524
Drug Calculations 524
Review Questions 524
29 Drugs for Neurologic System Disorders 526
Objectives 526
Key Terms 526
Effects of Long-Term Drug Use on the Central Nervous System 530
Analgesics 530
Classes of Analgesics: Narcotics and Nonnarcotics 530
Anesthetics 531
General Anesthetics 531
Preanesthetic Medications 531
Midazolam for Conscious Sedation 531
Local Anesthetics 531
Procaine 532
Lidocaine 532
Cocaine 532
Sedatives and Hypnotics 533
Treatment of Sleep Disorders 535
Barbiturates 535
Benzodiazepines 536
Other Medications Used as Sedatives and Hypnotics 536
Other Products Available OTC for Insomnia 536
Antiseizure Medications 537
Drugs for Parkinson’s Disease 540
Drugs for Restless Legs Syndrome 543
Drugs for Headaches 543
Migraine Headaches 543
Treatment of Migraines 543
Prevention of Migraine Headaches 543
Treatment of Additional Types of Headaches 544
Cluster Headaches 544
Tension Headaches 545
Drugs for Spasticity 545
Central Nervous System Stimulants 545
Autonomic Nervous System Drugs 546
Cholinergic or Parasympathomimetic Medications 548
Anticholinergic or Parasympatholytic Medications 549
Adrenergic Agonists or Sympathomimetic Drugs 550
Adrenergic Blocking Agents or Sympatholytic Drugs 551
Beta-Adrenergic Receptor Blockers (Beta Blockers) 551
Drugs Specific for Stroke Prevention 554
Summary 554
Critical Thinking Exercises 555
Scenario 555
Drug Calculations 556
Review Questions 556
30 Drugs for Mental Health and Behavioral Disorders 558
Objectives 558
Key Terms 558
What Is Mental Health? 559
What Is A Mentally Healthy Person? 559
Anxiety and Daily Living 560
Role of Medication Therapy in Psychotherapy 560
Neurosis Versus Psychosis 560
Anxiolytics or Drugs for Anxiety (Minor Tranquilizers) 561
Benzodiazepines 561
Neuroleptics or Drugs for Psychosis (Major Tranquilizers) 563
Uses for Antipsychotics or Neuroleptics 564
Potency and Neuroleptics 564
Side Effects of Neuroleptics 564
Treatment of Psychosis with Parenteral Medications 567
Treatment of Schizophrenia 567
Depression and Its Treatment 568
Antidepressant Medications 569
Tricyclic Antidepressants 569
Atypical Antidepressants 569
Monoamine Oxidase Inhibitors 569
Selective Serotonin Reuptake Inhibitors 571
Selective Norepinephrine Reuptake Inhibitors 573
Natural Reuptake Inhibitors 573
Antimanic Medications 573
Drugs for Alzheimer’s Disease 574
Drugs Used for Attention-Deficit/Hyperactivity Disorder 575
Summary 577
Critical Thinking Exercises 578
Scenario 578
Drug Calculations 578
Review Questions 579
31 Misused, Abused, and Addictive Drugs 580
Objectives 580
Key Terms 580
What Is Drug Misuse? Abuse? 581
Factors that Contribute to Drug Misuse and Abuse 582
Behaviors Found with Drug Abuse 582
Drugs of Abuse Not Requiring a Prescription 583
Nicotine 583
Smoking Cessation Products 584
Ethyl Alcohol or Ethanol 586
Drug Interactions with Alcohol 586
Drugs Used to Treat Alcoholism 587
Other Alcohol Preparations 587
Prescription Drug Abuse 588
Opiates and Opioids 588
Signs and Symptoms of Opioid and Opiate Withdrawal 588
Abused Central Nervous System Stimulants 589
Amphetamines 589
Cocaine 589
Abused Central Nervous System Depressants 590
Barbiturates 590
Benzodiazepines 591
Marijuana and Hashish 591
Hallucinogens, Psychedelics, and PsychoTOmimetics 591
Inhalants 593
Anabolic Steroids 593
Caring for Patients with Drug Misuse and Abuse Problems 594
Summary 595
Critical Thinking Scenario 595
Review Questions 596
Appendixes 597
Appendix A Check Your Understanding Answers 597
Chapter 6 597
6-1 597
6-2 597
6-3 597
6-4 597
6-5 597
6-6 597
6-7 597
6-8 597
6-9 597
6-10 597
6-11 598
6-12 598
6-13 598
6-14 598
6-15 598
6-16 598
6-17 598
6-18 598
6-19 598
6-20 598
6-21 598
6-22 598
Chapter 7 598
7-1 598
7-2 598
7-3 598
7-4 598
7-5 598
Chapter 8 599
8-1 599
8-2 599
8-3 599
8-4 599
8-5 599
8-6 599
Chapter 9 599
9-1 599
9-2 599
9-3 599
9-4 599
9-5 599
9-6 599
9-7 599
9-8 599
9-9 599
Chapter 10 599
10-1 599
10-2 599
10-3 600
10-4 600
10-5 600
Appendix B Drug-Nutrient and Drug-Drug Interactions 601
Drug-Nutrient Interactions 601
Clinically Significant Drug-Drug Interactions 601
Glossary 602
Index 619
A 619
B 622
C 622
D 624
E 627
F 627
G 628
H 628
I 629
J 631
K 631
L 631
M 631
N 633
O 634
P 635
Q 637
R 637
S 638
T 640
U 641
V 641
W 642
X 642
Z 642
Inside back cover ibc1