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Principles of Neurological Surgery E-Book

Principles of Neurological Surgery E-Book

Richard G. Ellenbogen | Saleem I. Abdulrauf | Laligam N Sekhar

(2012)

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Book Details

Abstract

Principles of Neurosurgery, by Drs. Richard G. Ellenbogen, Saleem I. Abdulrauf and Laligam N Sekhar, provides a broad overview of neurosurgery ideal for anyone considering or training in this specialty. From general principles to specific techniques, it equips you with the perspectives and skills you need to succeed. Comprehensive without being encyclopedic, this new edition familiarizes you with the latest advances in the field—neuroimaging, the medical and surgical treatment of epilepsy, minimally invasive techniques, and new techniques in position and incisions—and shows you how to perform key procedures via an online library of surgical videos at www.expertconsult.com. No other source does such an effective job of preparing you for this challenging field!

  • Get comprehensive coverage of neurosurgery, including pre- and post- operative patient care, neuroradiology, pediatric neurosurgery, neurovascular surgery, trauma surgery, spine surgery, oncology, pituitary adenomas, cranial base neurosurgery, image-guided neurosurgery, treatment of pain, epilepsy surgery, and much more.
  • Gain a clear visual understanding from over 1,200 outstanding illustrations—half in full color—including many superb clinical and operative photographs, surgical line drawings, and at-a-glance tables.
  • Apply best practices in neuroimaging techniques, minimally invasive surgery, epilepsy surgery, and pediatric neurosurgery.
  • Master key procedures by watching experts perform them in a video library online at www.expertconsult.com, where you can also access the fully searchable text, an image gallery, and links to PubMed.
  • Keep up with recent advances in neurosurgery with fully revised content covering neuroimaging, the medical and surgical treatment of epilepsy, minimally invasive techniques, new techniques in position and incisions, deep brain stimulation, cerebral revascularization, and treatment strategies for traumatic brain injury in soldiers.
  • Apply the latest guidance from new chapters on Cerebral Revascularization, Principles of Modern Neuroimaging, Principles of Operative Positioning, Pediatric Stroke and Moya-Moya, Anomalies of Craniovertebral Junction, and Degenerative Spine Disease.
  • Tap into truly global perspectives with an international team of contributors led by Drs. Richard G. Ellenbogen and Saleem I. Abdulrauf.
  • Find information quickly and easily thanks to a full-color layout and numerous detailed illustrations.

Table of Contents

Section Title Page Action Price
Front Cover\r Cover
IFC\r IFC
Principles of Neurological Surgery\r iii
Copyright\r iv
In Memorium\r v
Dedication\r vii
Contributors ix
Preface xix
Contents xxi
Online Video Contents xxiii
Online Cases Studies Contents xxv
Part 1 - General Overview 1
Chapter 1 - Landmarks in the History of Neurosurgery 3
PREHISTORIC PERIOD: THE DEVELOPMENT OF TREPHINATION 3
EGYPTIAN AND BABYLONIAN MEDICINE: EMBRYONIC PERIOD 3
GREEK AND EARLY BYZANTINE PERIOD: THE ORIGINS OF NEUROSURGERY 4
SIXTEENTH CENTURY: ANATOMICAL EXPLORATION 13
SEVENTEENTH CENTURY: ORIGINS OF NEUROLOGY 18
EIGHTEENTH CENTURY: ADVENTUROUS SURGEONS 20
CONCLUSION 35
SELECTED KEY REFERENCES 36
REFERENCES e1
Chapter 2 - Clinical Evaluation of the Nervous System 37
NEUROLOGICAL HISTORY 38
FOCAL CORTICAL SIGNS 38
PYRAMIDAL TRACT 39
THE EXTRAPYRAMIDAL SYSTEM 40
CRANIAL NERVES 40
CEREBELLUM 44
SPINAL CORD, NERVE ROOTS, AND MUSCLES 45
THE PEDIATRIC PATIENT 47
NEURO-OPHTHALMOLOGY 48
ANCILLARY DIAGNOSTIC TESTS 49
DIAGNOSIS AND INVESTIGATION OF CEREBRAL TUMORS 51
HEADACHE 51
VASCULAR DISEASES 51
HYSTERIA AND MALINGERING 52
SELECTED KEY REFERENCES 52
REFERENCES e1
Chapter 3 - Principles of Modern Neuroimaging 53
PRINCIPLES 54
CLINICAL IMAGING 56
SUMMARY 75
SELECTED KEY REFERENCES 75
Chapter 4 - Principles of Surgical Positioning 77
GENERAL PRINCIPLES OF PATIENT POSITIONING 77
SUPINE POSITION 80
PRONE POSITION 80
LATERAL POSITION 81
THREE-QUARTER PRONE POSITION 82
SITTING POSITION 83
SURGICAL ERGONOMICS 85
ACKNOWLEDGMENT 86
SELECTED KEY REFERENCES 86
REFERENCES e1
Part 2 - Pediatric Neurosurgery 87
Chapter 5 - Spinal Dysraphism and Tethered Spinal Cord 89
MYELOMENINGOCELE 89
OCCULT SPINA BIFIDA AND THE TETHERED CORD SYNDROME 93
LIPOMYELOMENINGOCELE 95
DIASTEMATOMYELIA AND THE SPLIT CORD MALFORMATIONS 98
ANTERIOR SACRAL MENINGOCELE 100
CONGENITAL DERMAL SINUS AND HYPERTROPHIED FILUM TERMINALE 101
SACRAL AGENESIS, MYELOCYSTOCELE, AND CLOACAL EXTROPHY 102
CONCLUSIONS 103
SELECTED KEY REFERENCES 103
REFERENCES e1
Chapter 6 - Hydrocephalus in Children and Adults 105
HISTORY 105
CEREBROSPINAL FLUID AND PATHOPHYSIOLOGY OF HYDROCEPHALUS 106
CLASSIFICATION OF HYDROCEPHALUS 109
ETIOLOGY AND CLINICAL PRESENTATION 110
DIAGNOSIS 112
TREATMENT OF HYDROCEPHALUS 115
COMPLICATIONS OF HYDROCEPHALUS TREATMENT 120
ENDOSCOPIC TREATMENT OF HYDROCEPHALUS 124
SUMMARY 127
SELECTED KEY REFERENCES 127
REFERENCES e1
Chapter 7 - Developmental Anomalies: Arachnoid Cysts, Dermoids, and Epidermoids 129
ARACHNOID CYSTS 129
DERMOID CYSTS 131
EPIDERMOID CYSTS 134
SELECTED KEY REFERENCES 135
REFERENCES e1
Chapter 8 - Diagnosis and Surgical Options for Craniosynostosis 137
HISTORY 137
EPIDEMIOLOGY 138
GENETIC AND ETIOLOGICAL FACTORS 138
ANATOMICAL AND PATHOLOGICAL CONSIDERATIONS 140
DIAGNOSTIC EVALUATION AND IMAGING 140
THERAPEUTIC CONSIDERATIONS 141
CLINICAL PRESENTATION/THERAPEUTIC CONSIDERATIONS 143
FUTURE DIRECTIONS 155
SELECTED KEY REFERENCES 155
REFERENCES e1
Chapter 9 - The Chiari Malformations and Syringohydromyelia 157
CHIARI I MALFORMATION 158
CHIARI II MALFORMATION 162
SYRINGOHYDROMYELIA 164
SUMMARY 168
SELECTED KEY REFERENCES 168
REFERENCES e1
Chapter 10 - Posterior Fossa and Brainstem Tumors in Children 169
CLINICAL PRESENTATION 170
GENERAL DIAGNOSTIC IMAGING FEATURES 170
INDIVIDUAL POSTERIOR FOSSA TUMOR TYPES 171
SURGICAL MANAGEMENT OF POSTERIOR FOSSA TUMORS 181
BRAINSTEM GLIOMAS 182
REFERENCES e1
Chapter 11 - Causes of Nontraumatic Hemorrhagic Stroke in Children: Pediatric Moyamoya Syndrome 187
PEDIATRIC ISCHEMIC STROKE 187
MOYAMOYA SYNDROME 189
CONCLUSIONS 194
SELECTED KEY REFERENCES 194
REFERENCES e1
Part 3 - Vascular Neurosurgery 195
Chapter 12 - Cerebrovascular Occlusive Disease and Carotid Surgery 197
REVIEW OF CLINICAL ANATOMY 198
ATHEROSCLEROTIC CEREBROVASCULAR OCCLUSIVE DISEASE 199
NONATHEROSCLEROTIC OCCLUSIVE DISEASE 203
REFERENCES e1
Chapter 13 - Intracranial Aneurysms 209
EPIDEMIOLOGY 210
PATHOGENESIS 210
NATURAL HISTORY 211
CLINICAL PRESENTATION 212
SUBARACHNOID HEMORRHAGE 214
TREATMENT OF INTRACRANIAL ANEURYSMS 215
CONCLUSION 228
SELECTED KEY REFERENCES 228
REFERENCES e1
Chapter 14 - Vascular Malformations (Arteriovenous Malformations and Dural Arteriovenous Fistulas) 229
CLASSIFICATION AND DEFINITIONS 229
DIAGNOSTIC RADIOLOGY 230
GRADING SYSTEMS 233
PATHOLOGICAL SEQUELAE 234
DEVELOPMENT 235
MOLECULAR BIOLOGY AND GENETICS 235
PHYSIOLOGY 236
EPIDEMIOLOGY AND NATURAL COURSE 237
TREATMENT 239
DURAL ARTERIOVENOUS FISTULAS 244
SUMMARY 246
SELECTED KEY REFERENCES 246
REFERENCES e1
Chapter 15 - Cavernous Malformations Management Strategies 249
DESCRIPTION 249
NATURAL HISTORY 250
MANAGEMENT OPTIONS 250
MANAGEMENT DECISIONS 251
SPECIAL CONSIDERATIONS 254
CONCLUSION 254
SELECTED KEY REFERENCES 255
REFERENCES e1
Chapter 16 - Spontaneous Intracerebral Hemorrhage 257
BACKGROUND AND EPIDEMIOLOGY 257
PATHOPHYSIOLOGY 257
ETIOLOGY 259
SIGNS AND SYMPTOMS 261
NATURAL HISTORY 262
DIAGNOSIS 262
TREATMENT 263
SELECTED KEY REFERENCES 264
REFERENCES e1
Chapter 17 - Endovascular Neurosurgery 265
INTRODUCTION (BOX 17.1) 265
GENERAL PRINCIPLES 266
ISCHEMIC STROKE INTERVENTION 268
INTRACRANIAL ATHEROSCLEROSIS TREATMENT 271
CAROTID ANGIOPLASTY AND STENTING 274
INTRACRANIAL ANEURYSM TREATMENT 276
PARENT VESSEL SACRIFICE 284
INTRACRANIAL ARTERIOVENOUS MALFORMATION EMBOLIZATION 285
ENDOVASCULAR THERAPY FOR VASOSPASM 287
TUMOR EMBOLIZATION 287
EPISTAXIS 288
CONCLUSION 288
SELECTED KEY REFERENCES 289
REFERENCES e1
Chapter 18 - Cerebral Revascularization for Giant Aneurysms of the Transitional Segment of the Internal Carotid Artery 291
NATURAL HISTORY 291
TREATMENT OF GIANT INTERNAL CAROTID ARTERY ANEURYSMS 292
CONCLUSIONS 308
SELECTED KEY REFERENCES 308
REFERENCES e1
Part 4 - \rTrauma 309
Chapter 19 - Intracranial Hypertension 311
ACUTE INTRACRANIAL HYPERTENTION 312
SUBACUTE TO CHRONIC INTRACRANIAL HYPERTENSION 320
NOVEL ADJUNCTIVE THERAPIES 322
SELECTED KEY REFERENCES 323
REFERENCES e1
Chapter 20 - Closed Head Injury 325
CLASSIFICATION 326
EVALUATION 330
MANAGEMENT OF SEVERE TRAUMATIC BRAIN INJURY 332
GUIDELINES FOR TREATMENT 338
MEDICAL THERAPY 338
SURGICAL THERAPY 345
PROGNOSIS 346
SELECTED KEY REFERENCES 347
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Chapter 21 - Penetrating Brain Injury 349
HISTORICAL BACKGROUND 349
PROGNOSIS 350
PATHOPHYSIOLOGY 352
MECHANISMS OF PENETRATING BRAIN INJURY 352
MANAGEMENT RECOMMENDATIONS IN THE SETTING OF PENETRATING BRAIN INJURIES 354
CONCLUSION 360
SELECTED KEY REFERENCES 364
REFERENCES e1
Chapter 22 - Traumatic Skull and Facial Fractures 365
SKULL FRACTURES 365
MAXILLOFACIAL INJURIES 372
SELECTED KEY REFERENCES 393
REFERENCES e1
Part 5 - Spine 395
Chapter 23 - Injuries to the Cervical Spine 397
NEUROLOGICAL INJURY 397
MANAGEMENT 401
CONCLUSIONS 411
SELECTED KEY REFERENCES 411
REFERENCES e1
Chapter 24 - Thoracolumbar Spine Fractures 413
BIOMECHANICS 413
RADIOGRAPHIC EVALUATION 414
CLASSIFICATION OF THORACOLUMBAR FRACTURES 415
FRACTURE MANAGEMENT 416
SUMMARY 418
SELECTED KEY REFERENCES 419
REFERENCES e1
Chapter 25 - Intradural Extramedullary and Intramedullary Spinal Cord Tumors 421
INTRADURAL EXTRAMEDULLARY TUMORS 421
INTRAMEDULLARY SPINAL CORD TUMORS 425
CONCLUSIONS 436
SELECTED KEY REFERENCES 436
REFERENCES e1
Chapter 26 - Treatment of Spinal Metastatic Tumors 437
PRESENTATION 438
DIAGNOSIS 438
MANAGEMENT 439
ADJUVANT THERAPIES 442
CONCLUSIONS 443
REFERENCES e1
Chapter 27 - Spinal Cord Injury 445
PATHOPHYSIOLOGY 446
TRANSLATIONAL RESEARCH 448
CELLULAR TRANSPLANTATION STRATEGIES 449
CLINICAL MANAGEMENT 450
CONCLUSIONS 454
SELECTED KEY REFERENCES 454
REFERENCES e1
Chapter 28 - Syringomyelia 455
EPIDEMIOLOGY 459
PATHOPHYSIOLOGY OF SYRINGOMYELIA 459
CLINICAL FEATURES 462
DIAGNOSIS 463
CONTROVERSIES IN MANAGEMENT 464
NATURAL HISTORY 464
SURGERY 464
INTRACRANIAL HYPERTENSION AND SYRINGOMYELIA 467
SYRINGOMYELIA WITH CHIARI II MALFORMATION 467
SELECTED KEY REFERENCES 469
REFERENCES e1
Chapter 29 - Craniovertebral Junction: A Reappraisal 471
CRANIOVERTEBRAL ANOMALIES 471
ATLANTOAXIAL DISLOCATION 471
BASILAR INVAGINATION 475
DEGENERATIVE ARTHRITIS 481
RHEUMATOID ARTHRITIS AFFECTING CRANIOVERTEBRAL JUNCTION 483
TUBERCULOSIS OF CRANIOVERTEBRAL JUNCTION 484
SELECTED KEY REFERENCES 485
REFERENCES e1
Chapter 30 - Degenerative Spine Disease 487
ANATOMY AND PHYSIOLOGY OF SPINE DEGENERATION 487
CLINICAL PRESENTATION 489
DIAGNOSTIC FINDINGS 490
TREATMENT OPTIONS 491
SELECTED KEY REFERENCES 495
REFERENCES e1
Chapter 31 - Pediatric and Adult Scoliosis 497
PART I. SCOLIOSIS IN THE PEDIATRIC PATIENT 497
SELECTED KEY REFERENCES 507
REFERENCES e1
Chapter 32 - Acute Nerve Injuries 509
EVALUATING THE PATIENT WITH AN ACUTE PERIPHERAL NERVE INJURY 509
SURGICAL NERVE REPAIR/RECONSTRUCTION 513
CONCLUSION 514
REFERENCES e1
Chapter 33 - Entrapment Neuropathies 515
PATHOLOGY OF NERVE COMPRESSION7 515
DOUBLE CRUSH SYNDROME 517
NERVE COMPRESSION SYNDROME IN DIABETICS 517
THE ENTRAPMENT SYNDROMES 517
SELECTED KEY REFERENCES 524
REFERENCES e1
Part 6 - Tumors 525
Chapter 34 - Low-Grade and High-Grade Gliomas 527
LOW-GRADE GLIOMAS 527
HIGH-GRADE GLIOMAS 533
CONCLUSIONS 534
SELECTED KEY REFERENCES 534
REFERENCES e1
Chapter 35 - Metastatic Brain Tumors 535
CLINICAL PRESENTATION AND DIAGNOSTIC STUDIES 536
TREATMENT OPTIONS AND OUTCOMES 536
CONCLUSION 539
SELECTED KEY REFERENCES 539
REFERENCES e1
Chapter 36 - Meningiomas 541
EPIDEMIOLOGY 541
GENERAL CLINICAL PRESENTATION 542
IMAGING 542
PATHOLOGY 543
CLASSIFICATION 543
DECISION MAKING 544
CONSERVATIVE TREATMENT 544
SURGICAL TREATMENT 544
RADIATION THERAPY 563
CHEMOTHERAPY 563
SELECTED KEY REFERENCES 564
REFERENCES e1
Chapter 37 - Tumors of the Pineal Region 565
HISTORY 565
ANATOMY 566
HISTOLOGY 567
FUNCTION 567
PATHOLOGY 568
GERM CELL TUMORS 568
PINEAL PARENCHYMAL TUMORS 571
NON-NEOPLASTIC TUMOR-LIKE CONDITIONS 573
METASTASES TO THE PINEAL REGION 574
SIGNS AND SYMPTOMS 574
DIAGNOSTIC STUDIES 574
CHOICE OF TREATMENTS 577
SURGICAL APPROACHES 578
OTHER THERAPEUTIC MODALITIES 581
CONCLUSION 583
SELECTED KEY REFERENCES 584
REFERENCES e1
Chapter 38 - Cerebellopontine Angle Tumors 585
HISTORY OF CEREBELLOPONTINE ANGLE SURGERY 585
CEREBELLOPONTINE ANGLE ANATOMY 586
TUMORS OF THE CEREBELLOPONTINE ANGLE 586
IMAGING 586
SURGICAL APPROACHES TO THE CEREBELLOPONTINE ANGLE 588
VESTIBULAR SCHWANNOMAS 590
COMPLICATIONS 593
MENINGIOMAS 594
EPIDERMOIDS 595
SELECTED KEY REFERENCES 595
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Chapter 39 - Craniopharyngiomas and Suprasellar Tumors 597
CRANIOPHARYNGIOMAS 597
CYSTS OF THE SUPRASELLAR REGION 613
GLIOMAS OF THE CHIASM AND HYPOTHALAMUS 614
GERMINOMAS 618
HYPOTHALAMIC HAMARTOMAS 618
PITUICYTOMAS (TUMORS OF THE NEUROHYPOPHYSIS) 619
SELECTED KEY REFERENCES 620
REFERENCES e1
Chapter 40 - Pituitary Tumors: Diagnosis and Management 621
THE PITUITARY GLAND 621
EPIDEMIOLOGY 623
CLASSIFICATION 623
NONFUNCTIONING PITUITARY ADENOMAS 624
FUNCTIONING PITUITARY ADENOMAS 628
PITUITARY APOPLEXY 643
PEDIATRIC ADENOMAS 643
CONCLUSION 644
SELECTED KEY REFERENCES 644
REFERENCES e1
Chapter 41 - Endoscopic Approaches to Ventricular Tumors and Colloid Cysts 645
HISTORY 645
EQUIPMENT 645
ENDOSCOPIC PRINCIPLES 646
INTRAVENTRICULAR ENDOSCOPY FOR CYSTS 647
INTRAVENTRICULAR ENDOSCOPY FOR TUMORS 648
CONCLUSION AND FUTURE DIRECTIONS 650
SELECTED KEY REFERENCES 650
REFERENCES e1
Chapter 42 - Microsurgical Approaches to the Ventricular System 651
MICROSURGICAL ANATOMY 652
PATHOLOGICAL ENTITIES 654
PREOPERATIVE PLANNING AND GENERAL SURGICAL CONSIDERATIONS 654
CRANIOTOMY FLAP AND CORTICAL INCISIONS 655
ANTERIOR TRANSCORTICAL APPROACHES 656
APPROACH TO THE TEMPORAL HORN 658
POSTERIOR TRANSCORTICAL APPROACHES 659
APPROACH TO THE FOURTH VENTRICLE 662
POSTOPERATIVE DEFICITS AND COMPLICATION AVOIDANCE 663
FUTURE DIRECTIONS 665
CONCLUSION 665
REFERENCES e1
Chapter 43 - Skull Base Approaches 667
PREOPERATIVE DECISION MAKING 668
ANTERIOR SKULL BASE APPROACHES 668
ANTEROLATERAL SKULL BASE APPROACHES 672
LATERAL AND POSTEROLATERAL SKULL BASE APPROACHES 674
COMPLICATIONS OF SKULL BASE APPROACHES 678
CONCLUSIONS 678
REFERENCES 680
Chapter 44 - Endoscopic Approaches to Skull Base Lesions, Ventricular Tumors, and Cysts 681
HISTORY 681
EQUIPMENT 682
ENDOSCOPIC PRINCIPLES 682
ENDOSCOPIC INTRAVENTRICULAR SURGICAL TECHNIQUES 683
ENDOSCOPIC ENDONASAL SKULL BASE SURGICAL TECHNIQUE 685
COMPLICATION AVOIDANCE DURING THE EXPANDED ENDONASAL APPROACH 692
OUTCOME AFTER THE EXPANDED ENDONASAL APPROACH 693
CONCLUSION AND FUTURE DIRECTIONS 693
SELECTED KEY REFERENCES 694
REFERENCES e1
Part 7 - Radiosurgery 695
Chapter 45 - Application of Current Radiation Delivery Systems and Radiobiology 697
PHYSICS OF RADIOTHERAPY 697
BIOLOGY OF RADIATION THERAPY 699
HISTORY OF RADIOSURGERY 701
CONTEMPORARY RADIATION DELIVERY SYSTEMS 701
SUMMARY 706
REFERENCES e1
Chapter 46 - Radiosurgery of Central Nervous System Tumors 707
RADIOSURGERY OR RADIOTHERAPY? 707
VESTIBULAR SCHWANNOMAS 708
MENINGIOMAS 708
PITUITARY ADENOMAS 709
MALIGNANT CRANIAL BASE TUMORS 710
BRAIN METASTASES 710
GLIAL NEOPLASMS 712
SELECTED KEY REFERENCES 713
REFERENCES e1
Chapter 47 - Stereotactic Radiosurgery of Vascular Malformations 715
ARTERIOVENOUS MALFORMATIONS 715
DURAL ARTERIOVENOUS FISTULAS 723
CAVERNOUS MALFORMATIONS 724
CONCLUSIONS 725
SELECTED KEY REFERENCES 725
REFERENCES e1
Part 8 - Functional/Pain 727
Chapter 48 - Trigeminal Neuralgia 729
CLINICAL FEATURES 730
DIAGNOSIS 731
TREATMENT 732
CONCLUSION 735
ACKNOWLEDGMENT 735
SELECTED KEY REFERENCES 735
REFERENCES e1
Chapter 49 - Surgical Therapy for Pain 737
LESIONAL SURGERY 738
NEUROMODULATION PROCEDURES 746
SELECTED KEY REFERENCES 755
REFERENCES e1
Chapter 50 - Spasticity: Classification, Diagnosis, and Management 757
CAUSES 757
CLASSIFICATION 758
PATHOPHYSIOLOGY 758
DIAGNOSIS 758
TREATMENT 759
CONCLUSIONS 763
SELECTED KEY REFERENCES 763
REFERENCES e1
Chapter 51 - Surgery for Temporal Lobe Epilepsy 765
GENERAL FEATURES 765
EVALUATION FOR SURGERY 766
SURGICAL TECHNIQUES 769
RESULTS 770
FUTURE PERSPECTIVES 771
CONCLUSION 771
SELECTED KEY REFERENCES 772
REFERENCES e1
Chapter 52 - Extratemporal Procedures and Hemispherectomy for Epilepsy 773
UNIQUE CHALLENGES IN EXTRATEMPORAL LOBE EPILEPSY 773
SURGICAL INDICATIONS 774
SURGICAL PROCEDURES 776
COMPLICATION AVOIDANCE 780
CONCLUSION 780
REFERENCES e1
Chapter 53 - Basic Principles of Deep Brain Stimulation for Movement Disorders, Neuropsychiatric Disorders, and New Frontiers 783
HISTORICAL BACKGROUND 783
DEEP BRAIN STIMULATION SURGERY: INDICATIONS, TARGET, AND OUTCOMES 786
SURGICAL TECHNIQUE 787
SPECIFIC DISORDERS: INDICATIONS AND EFFICACY 790
EMERGING INDICATIONS 793
CONCLUSION (TABLE 53.3) 794
SELECTED KEY REFERENCES 795
REFERENCES e1
Index 797