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Book Details
Abstract
An excellent companion to Rodak's Hematology: Clinical Principles & Applications, this atlas is ideal for helping you accurately identify cells at the microscope. It offers complete coverage of the basics of hematologic morphology, including examination of the peripheral blood smear, basic maturation of the blood cell lines, and discussions of a variety of clinical disorders. Over 400 photomicrographs, schematic diagrams, and electron micrographs visually clarify hematology from normal cell maturation to the development of various pathologies.
- Normal Newborn Peripheral Blood Morphology chapter covers the unique normal cells found in neonatal blood.
- A variety of high-quality schematic diagrams, photomicrographs, and electron micrographs visually reinforce your understanding of hematologic cellular morphology.
- Spiral binding and compact size make this book easy to use in a laboratory setting.
- Coverage of common cytochemical stains, along with a summary chart for interpretation, aids in classifying malignant and benign leukoproliferative disorders.
- Morphologic abnormalities are presented in chapters on erythrocytes and leukocytes, along with a schematic description of each cell, to provide correlations to various disease states.
- Body Fluids chapter covers the other fluids found in the body besides blood, using images from cytocentrifuged specimens.
-
Updated information on the subtypes of chronic lymphocytic leukemia (CLL) helps you recognize variant forms of CLL you may encounter in the lab.
Table of Contents
| Section Title | Page | Action | Price |
|---|---|---|---|
| Front cover | Cover | ||
| Clinical hematology atlas | iii | ||
| Copyright | iv | ||
| Dedication | v | ||
| Reviewers | vii | ||
| Preface | ix | ||
| Organization | ix | ||
| Evolve | x | ||
| Acknowledgments | xi | ||
| Table of contents | xiii | ||
| Commonly used abbreviations in hematology | xv | ||
| 1 Introduction to peripheral blood smear examination | 1 | ||
| Wedge smear preparation | 2 | ||
| Making the peripheral blood smear | 2 | ||
| Staining of peripheral blood smears | 2 | ||
| Peripheral smear examination | 5 | ||
| 10× examination | 5 | ||
| 40× or 50× examination | 6 | ||
| 100× examination | 7 | ||
| Summary | 10 | ||
| 2 Hematopoiesis | 11 | ||
| 3 Erythrocyte maturation | 19 | ||
| Pronormoblast | 21 | ||
| Proerythroblast | 21 | ||
| Rubriblast | 21 | ||
| Size: | 21 | ||
| Nucleus: | 21 | ||
| Nucleoli: | 21 | ||
| Chromatin: | 21 | ||
| Cytoplasm: | 21 | ||
| N/c ratio: | 21 | ||
| Reference interval: | 21 | ||
| Bone marrow: | 21 | ||
| Peripheral blood: | 21 | ||
| Basophilic normoblast | 23 | ||
| Basophilic erythroblast | 23 | ||
| Prorubricyte | 23 | ||
| Size: | 23 | ||
| Nucleus: | 23 | ||
| Nucleoli: | 23 | ||
| Chromatin: | 23 | ||
| Cytoplasm: | 23 | ||
| N/c ratio: | 23 | ||
| Reference interval: | 23 | ||
| Bone marrow: | 23 | ||
| Peripheral | 23 | ||
| Polychromatic normoblast | 25 | ||
| Polychromatic erythroblast | 29 | ||
| Rubricyte | 29 | ||
| 4 Megakaryocyte maturation | 33 | ||
| Megakaryoblast (mk-i) | 35 | ||
| Promegakaryocyte (mk-ii) | 37 | ||
| Megakaryocyte (mk-iii) | 39 | ||
| Platelet | 41 | ||
| 5 Neutrophil maturation | 43 | ||
| Myeloblast | 46 | ||
| Promyelocyte (progranulocyte) | 48 | ||
| Neutrophilic myelocyte | 50 | ||
| Neutrophilic metamyelocyte | 52 | ||
| Neutrophilic band | 54 | ||
| Segmented neutrophil | 56 | ||
| Polymorphonuclear neutrophil | 56 | ||
| Size: | 56 | ||
| Nucleus: | 56 | ||
| Nucleoli: | 56 | ||
| Chromatin: | 56 | ||
| Cytoplasm: | 56 | ||
| Granules: | 56 | ||
| Primary: | 56 | ||
| Secondary: | 56 | ||
| N/c ratio: | 56 | ||
| Reference interval: | 56 | ||
| Bone marrow: | 56 | ||
| Peripheral blood: | 56 | ||
| 6 Monocyte maturation | 59 | ||
| Monoblast | 61 | ||
| Promonocyte | 63 | ||
| Monocyte | 63 | ||
| Macrophage (histiocyte) | 67 | ||
| 7 Eosinophil maturation | 69 | ||
| Eosinophilic myelocyte | 71 | ||
| Eosinophilic metamyelocyte | 73 | ||
| Eosinophilic band | 75 | ||
| Eosinophil | 75 | ||
| 8 Basophil maturation | 79 | ||
| Basophil | 79 | ||
| 9 Lymphocyte maturation | 83 | ||
| Lymphoblast | 85 | ||
| Prolymphocyte | 87 | ||
| Lymphocyte | 87 | ||
| Plasma cell | 91 | ||
| 10 Variations in size and color of erythrocytes | 93 | ||
| Variations in size | 93 | ||
| Anisocytosis | 95 | ||
| Variation in color of erythrocytes | 96 | ||
| 11 Variations in shape and distribution of erythrocytes | 97 | ||
| Acanthocyte | 98 | ||
| Spur cell | 98 | ||
| Description: | 98 | ||
| Associated with: | 98 | ||
| Schistocyte | 99 | ||
| Schizocyte | 99 | ||
| Color: | 99 | ||
| Shape: | 99 | ||
| Associated with: | 99 | ||
| Echinocyte | 100 | ||
| Burr cell | 100 | ||
| Description: | 100 | ||
| Associated with: | 100 | ||
| Spherocyte | 101 | ||
| Target cell | 102 | ||
| Codocyte | 102 | ||
| Color: | 102 | ||
| Shape: | 102 | ||
| Associated with: | 102 | ||
| Sickle cell | 103 | ||
| Drepanocyte | 103 | ||
| Color: | 103 | ||
| Shape: | 103 | ||
| Composition: | 103 | ||
| Associated with: | 103 | ||
| Hemoglobin c crystal | 104 | ||
| Hemoglobin sc crystal | 105 | ||
| Elliptocyte/ovalocyte | 106 | ||
| Tear drop cell | 107 | ||
| Dacryocyte | 107 | ||
| Description: | 107 | ||
| Associated with: | 107 | ||
| Stomatocyte | 108 | ||
| Rouleaux versus autoagglutination | 109 | ||
| 12 Inclusions in erythrocytes | 111 | ||
| Howell-jolly bodies | 112 | ||
| Basophilic stippling | 113 | ||
| Pappenheimer bodies | 114 | ||
| Siderotic granules | 114 | ||
| Color: | 114 | ||
| Shape: | 114 | ||
| Number per cell: | 114 | ||
| Composition: | 114 | ||
| Associated with: | 114 | ||
| Cabot rings | 115 | ||
| Inclusions with supravital stain | 116 | ||
| Stained with new methylene blue | 116 | ||
| 13 Diseases affecting erythrocytes | 119 | ||
| Microcytic/hypochromic anemia | 120 | ||
| Iron deficiency anemia | 120 | ||
| β-thalassemia minor | 121 | ||
| β/β + β/β 0 β/δβ 0 β/δβ lepore | 121 | ||
| β-thalassemia major | 122 | ||
| β 0 β 0 β + β + β 0 β + δβ lepore /δβ lepore | 122 | ||
| α-thalassemia**α-Thalassemia minor (−−/αα,−α/−α) has red cell morphology similar to β-thalassemia minor and ... | 122 | ||
| Hemoglobin h | 122 | ||
| −−/−α | 122 | ||
| Hemoglobin bart hydrops fetalis syndrome | 123 | ||
| −−/−− | 123 | ||
| Macrocytosis | 124 | ||
| 124 | |||
| Nonmegaloblastic | 124 | ||
| Megaloblastic anemia | 125 | ||
| Aplastic anemia | 126 | ||
| Immune hemolytic anemia | 127 | ||
| Hemolytic disease of the fetus and newborn | 128 | ||
| Hereditary spherocytosis | 129 | ||
| Hereditary elliptocytosis | 130 | ||
| Microangiopathic hemolytic anemia | 131 | ||
| Hemoglobin cc disease | 132 | ||
| Hemoglobin ss disease | 133 | ||
| Hemoglobin sc disease | 134 | ||
| 14 Nuclear and cytoplasmic changes in leukocytes | 135 | ||
| Hyposegmentation of neutrophils | 136 | ||
| Hypersegmentation of neutrophils | 137 | ||
| Vacuolation | 138 | ||
| DÖhle body | 139 | ||
| Toxic granulation | 140 | ||
| Hypogranulation/agranulation | 141 | ||
| Reactive lymphocytes | 142 | ||
| 15 Acute myeloid leukemia | 145 | ||
| Approach to acute myeloid leukemia | 146 | ||
| Acute myeloid leukemia, minimally differentiated | 147 | ||
| Fab††French-American-British classification of acute leukemia. m0 | 147 | ||
| Morphology | 147 | ||
| Peripheral blood: | 147 | ||
| Bone marrow: | 147 | ||
| Cytochemistry | 147 | ||
| Myeloperoxidase: | 147 | ||
| Sudan black b: | 147 | ||
| Nonspecific esterase: | 147 | ||
| Genetics | 147 | ||
| Immunophenotype | 147 | ||
| Acute myeloid leukemia without maturation | 148 | ||
| Fab m1 | 148 | ||
| Morphology | 148 | ||
| Peripheral blood: | 148 | ||
| Bone marrow: | 149 | ||
| Cytochemistry | 149 | ||
| Myeloperoxidase: | 149 | ||
| Sudan black b: | 149 | ||
| Nonspecific esterase: | 149 | ||
| Genetics | 149 | ||
| Immunophenotype | 149 | ||
| Acute myeloid leukemia with maturation | 150 | ||
| Fab m2 | 150 | ||
| Morphology | 150 | ||
| Peripheral blood: | 150 | ||
| Bone marrow: | 150 | ||
| Cytochemistry | 151 | ||
| Myeloperoxidase: | 151 | ||
| Sudan black b: | 151 | ||
| Genetics | 151 | ||
| Immunophenotype | 151 | ||
| Acute promyelocytic leukemia | 152 | ||
| Acute promyelocytic leukemia—microgranular variant | 152 | ||
| Acute myelomonocytic leukemia | 154 | ||
| Fab m4 | 154 | ||
| Morphology | 155 | ||
| Peripheral blood: | 155 | ||
| Bone marrow: | 155 | ||
| Cytochemistry | 155 | ||
| Myeloperoxidase: | 155 | ||
| Specific esterase: | 155 | ||
| Nonspecific esterase: | 155 | ||
| Genetics | 155 | ||
| Immunophenotype | 155 | ||
| Acute myeloid leukemia with inv(16) (p13.1q22) or t(16;16)(p13.1;q22); cbfb-myh11 | 156 | ||
| Fab m4eo | 156 | ||
| Morphology | 157 | ||
| Peripheral blood: | 157 | ||
| Bone marrow: | 157 | ||
| Cytochemistry | 157 | ||
| Myeloperoxidase: | 157 | ||
| Nonspecific esterase: | 157 | ||
| Specific esterase: | 157 | ||
| Genetics | 157 | ||
| Immunophenotype | 157 | ||
| Acute monoblastic and monocytic leukemia | 158 | ||
| Acute erythroid leukemia | 160 | ||
| Fab m6a | 160 | ||
| (erythroid/myeloid leukemia) | 160 | ||
| 16 Precursor lymphoid neoplasms | 163 | ||
| Acute lymphoblastic leukemia, small blasts | 165 | ||
| Acute lymphoblastic leukemia, large blasts | 166 | ||
| 17 Myeloproliferative neoplasms | 167 | ||
| Chronic myelogenous leukemia, bcr-abl1 positive | 170 | ||
| Leukocyte alkaline phosphatase | 172 | ||
| Polycythemia vera | 174 | ||
| Essential thrombocythemia | 175 | ||
| Primary myelofibrosis | 176 | ||
| 18 Myelodysplastic syndromes | 177 | ||
| Dyserythropoiesis | 179 | ||
| Dysmyelopoiesis | 182 | ||
| Dysmegakaryopoiesis | 184 | ||
| 19 Mature lymphoproliferative disorders | 187 | ||
| Chronic lymphocytic leukemia | 188 | ||
| B cell prolymphocytic leukemia | 190 | ||
| Morphology | 190 | ||
| Peripheral blood: | 190 | ||
| Bone marrow: | 190 | ||
| Immunophenotype | 190 | ||
| Hairy cell leukemia | 191 | ||
| Plasma cell myeloma | 192 | ||
| Burkitt leukemia/lymphoma | 194 | ||
| Lymphoma | 194 | ||
| Morphology | 195 | ||
| 20 Morphologic changes after myeloid hematopoietic growth factors | 197 | ||
| 21 Microorganisms | 201 | ||
| Plasmodium species | 202 | ||
| Babesia species | 203 | ||
| Loa loa | 204 | ||
| Trypanosomes | 205 | ||
| Fungi | 206 | ||
| Bacteria | 207 | ||
| 22 Miscellaneous cells | 209 | ||
| Hematologic manifestations of systemic disorders | 210 | ||
| Cells occasionally seen in bone marrow | 213 | ||
| Artifacts in peripheral blood smears | 216 | ||
| 23 Normal newborn peripheral blood morphology | 219 | ||
| 24 Body fluids | 223 | ||
| Cells commonly seen in cerebrospinal fluid | 226 | ||
| Cells sometimes found in cerebrospinal fluid | 227 | ||
| Cells sometimes found in cerebrospinal fluid after central nervous system hemorrhage | 227 | ||
| Organisms sometimes found in cerebrospinal fluid | 231 | ||
| Cells sometimes found in serous body fluids (pleural, pericardial, and peritoneal) | 232 | ||
| Mesothelial cells | 234 | ||
| Multinucleated mesothelial cells | 235 | ||
| Malignant cells sometimes seen in serous fluids | 237 | ||
| Crystals sometimes found in synovial fluid | 239 | ||
| Other structures sometimes seen in body fluids | 244 | ||
| Index | 245 | ||
| A | 245 | ||
| B | 245 | ||
| C | 246 | ||
| D | 246 | ||
| E | 246 | ||
| F | 247 | ||
| G | 248 | ||
| H | 248 | ||
| I | 248 | ||
| L | 248 | ||
| M | 249 | ||
| N | 250 | ||
| O | 251 | ||
| P | 251 | ||
| R | 252 | ||
| S | 252 | ||
| T | 252 | ||
| U | 253 | ||
| V | 253 | ||
| W | 253 | ||
| Y | 253 |