BOOK
Pathology of the Medical Kidney, An Issue of Surgical Pathology Clinics, E-Book
(2014)
Additional Information
Book Details
Abstract
Non-neoplastic diseases are the focus of coverage in this issue of Surgical Pathology Clinics. Topics include: Non-neoplastic diseases in kidney cancer; Nephrectomy for non-neoplastic causes; Autopsy renal pathology; Practical approach to kidney donation workup; Kidney allograft pathology; Renal infections; Amyloidosis - all subtypes; Histologic classifications in renal pathology - pros and cons; Renal molecular pathology; Emerging concepts and controversies in renal pathology. This issue is intended for surgical pathologists and those with clinical practices in diagnostic renal pathology and kidney research. Anthony Chang, whose clinical practice and research is focused on renal pathology, leads this issue.
Table of Contents
| Section Title | Page | Action | Price |
|---|---|---|---|
| Front Cover | Cover | ||
| Pathology of theMedical Kidney | i | ||
| Copyright\r | ii | ||
| Contributors | iii | ||
| Contents | v | ||
| Surgical pathology clinics | viii | ||
| Preface | ix | ||
| Non-neoplastic Pathology in Tumor Nephrectomy Specimens | 291 | ||
| Abstract | 291 | ||
| Overview | 291 | ||
| Chronic kidney disease after nephrectomy procedure | 291 | ||
| Evaluation of non-neoplastic pathology in tumor nephrectomy specimens | 293 | ||
| Practical recommendations | 294 | ||
| Common non-neoplastic renal parenchymal lesions seen in tumor nephrectomy specimens | 295 | ||
| Changes Related to Neoplastic Growth | 297 | ||
| Changes Related to Medical Kidney Disease, Independent of Tumor Growth | 299 | ||
| Vascular Sclerosing Disease | 299 | ||
| Diabetic Renal Disease | 300 | ||
| Tubulointerstitial Disease | 302 | ||
| Other Medical Renal Diseases | 303 | ||
| References | 304 | ||
| Nephrectomy for Non-neoplastic Kidney Diseases | 307 | ||
| Abstract | 307 | ||
| Overview | 307 | ||
| Chronic pyelonephritis | 307 | ||
| Gross Features of Chronic Pyelonephritis | 308 | ||
| Microscopic Features | 308 | ||
| Reflux nephropathy | 310 | ||
| Autopsy Renal Pathology | 321 | ||
| Abstract | 321 | ||
| Approach to gross dissection | 321 | ||
| Tissue Allocation | 321 | ||
| Postmortem Alterations | 321 | ||
| Medical Renal Diseases | 322 | ||
| Dissection and Examination of the Kidneys | 323 | ||
| Adults | 323 | ||
| Children | 323 | ||
| Common pathologic changes of kidneys at autopsy | 324 | ||
| Congenital Anomalies of the Kidney and Urinary Tract | 324 | ||
| Donor Kidney Evaluation | 357 | ||
| Abstract | 357 | ||
| Overview | 357 | ||
| Classification of donors | 358 | ||
| ECD | 358 | ||
| SCD | 358 | ||
| DBD | 358 | ||
| DCD | 358 | ||
| Clinical and laboratory evaluation of donors | 358 | ||
| Donor biopsy assessment | 358 | ||
| Donor Biopsy Pathology Evaluation and Report | 359 | ||
| Glomerular Changes | 360 | ||
| Vascular Changes | 361 | ||
| Tubulointerstitial Changes | 361 | ||
| Living donor biopsies | 361 | ||
| Clinical and histopathologic scoring systems for donor biopsies | 362 | ||
| Molecular evaluation of donor biopsies | 363 | ||
| References | 363 | ||
| The Basics of Renal Allograft Pathology | 367 | ||
| Abstract | 367 | ||
| Overview | 367 | ||
| Allograft biopsy laboratory preparation | 368 | ||
| Acute rejection: T-cell mediated | 368 | ||
| Overview | 368 | ||
| Microscopic Description | 371 | ||
| Differential Diagnosis | 371 | ||
| Diagnosis | 373 | ||
| Clinical Correlation, Treatment, and Prognosis | 373 | ||
| Acute rejection: antibody-mediated (humoral rejection) | 373 | ||
| Overview | 373 | ||
| Microscopic Description | 373 | ||
| C4d Studies | 374 | ||
| Differential Diagnosis | 374 | ||
| Diagnosis | 374 | ||
| Clinical Correlation, Treatment, and Prognosis | 376 | ||
| Polyomavirus nephropathy | 376 | ||
| Overview | 376 | ||
| Microscopic Description | 376 | ||
| Differential Diagnosis | 376 | ||
| Diagnosis | 376 | ||
| Prognosis | 377 | ||
| Drug toxicities | 377 | ||
| Overview: Calcineurin Inhibitors | 377 | ||
| Microscopic Description: Calcineurin Inhibitors | 378 | ||
| Differential Diagnosis: Calcineurin Inhibitors | 378 | ||
| Diagnosis: Calcineurin Inhibitors | 381 | ||
| Sirolimus | 381 | ||
| Prognosis: Drug Toxicities | 381 | ||
| Acute tubular necrosis and related injury | 381 | ||
| Overview: ATN | 381 | ||
| Microscopic Description: ATN | 381 | ||
| Differential Diagnosis: ATN | 381 | ||
| Diagnosis: ATN | 381 | ||
| Tubulointerstitial Calcification | 381 | ||
| Prognosis: Tubular Injury | 382 | ||
| Chronic rejection and chronic allograft injury | 382 | ||
| Overview | 382 | ||
| Microscopic Description | 382 | ||
| Differential Diagnosis | 382 | ||
| Diagnosis | 384 | ||
| Prognosis | 384 | ||
| Posttransplant lymphoproliferative disorder | 384 | ||
| Other allograft biopsy findings | 384 | ||
| Summary | 385 | ||
| Acknowledgments | 385 | ||
| References | 385 | ||
| Renal Infections | 389 | ||
| Abstract | 389 | ||
| Overview | 389 | ||
| Acute bacterial pyelonephritis | 389 | ||
| Gross Features | 389 | ||
| Microscopic Features | 390 | ||
| Differential Diagnosis | 390 | ||
| Chronic pyelonephritis | 390 | ||
| Gross Features | 391 | ||
| Microscopic Features | 392 | ||
| Xanthogranulomatous pyelonephritis | 392 | ||
| Gross Features of XGP | 392 | ||
| Microscopic Features of XGP | 392 | ||
| Differential Diagnosis of XGP | 394 | ||
| Malacoplakia | 394 | ||
| Gross Features of MCP | 394 | ||
| Microscopic Features of MCP | 396 | ||
| Differential Diagnosis of MCP | 396 | ||
| Viral infections in the kidney | 396 | ||
| Polyomavirus Nephropathy | 396 | ||
| Gross Features | 398 | ||
| Microscopic Features | 398 | ||
| Differential Diagnosis | 399 | ||
| Adenovirus Infection of the Kidney | 400 | ||
| Microscopic Features | 400 | ||
| Differential Diagnosis | 400 | ||
| Cytomegalovirus | 401 | ||
| Microscopic Features | 402 | ||
| Differential Diagnosis | 402 | ||
| Fungal and mycobacterial infections of the kidney | 403 | ||
| Mycobacterial Infection of the Kidney | 403 | ||
| Gross Findings | 403 | ||
| Microscopic Findings | 403 | ||
| Fungal Infections of the Kidney | 403 | ||
| Renal Candidiasis | 404 | ||
| Aspergillosis in the Kidney | 405 | ||
| Renal Infection by Cryptococcus | 406 | ||
| References | 406 | ||
| Renal Amyloidosis | 409 | ||
| Abstract | 409 | ||
| Overview | 409 | ||
| Amyloidosis types that affect the kidney | 409 | ||
| Clinical presentation | 410 | ||
| Pathogenesis | 411 | ||
| Renal biopsy | 412 | ||
| Light Microscopy | 412 | ||
| Immunofluorescence | 415 | ||
| Electron Microscopy | 416 | ||
| Differential diagnosis | 417 | ||
| Amyloid typing (classification) | 420 | ||
| Proteomics | 421 | ||
| Treatment and outcome | 422 | ||
| References | 423 | ||
| Classification Systems in Renal Pathology | 427 | ||
| Abstract | 427 | ||
| Overview | 427 | ||
| Pathologic classification: goals and general limitations | 427 | ||
| Lupus nephritis | 428 | ||
| Renal allograft rejection | 430 | ||
| Focal segmental glomerulosclerosis | 431 | ||
| IgA nephropathy | 433 | ||
| Diabetic nephropathy | 434 | ||
| ANCA-associated glomerulonephritis | 436 | ||
| Summary | 437 | ||
| References | 438 | ||
| Renalomics | 443 | ||
| Abstract | 443 | ||
| Overview: molecular pathology in kidney biopsies | 443 | ||
| Techniques, platforms, analytical methods, and pitfalls | 443 | ||
| Molecular pathology and genetic alterations of native kidney diseases | 445 | ||
| Molecular pathology of renal allograft biopsies | 446 | ||
| Molecular Pathology of the Donor Biopsy | 446 | ||
| Molecular Pathology of Cell-Mediated Rejection | 447 | ||
| Molecular Pathology of Allograft Urine | 449 | ||
| Molecular Pathology of Chronic Allograft Damage | 449 | ||
| Molecular Pathology of Antibody-Mediated Rejection | 450 | ||
| Molecular Pathology of Polyomavirus Nephropathy (PVN) | 451 | ||
| Summary | 451 | ||
| References | 451 | ||
| Emerging Concepts and Controversies in Renal Pathology | 457 | ||
| Abstract | 457 | ||
| Introduction | 457 | ||
| C4d-negative antibody-mediated rejection | 458 | ||
| Role of antibody in arterial lesions | 460 | ||
| Revised (2013) Banff criteria for antibody-mediated rejection | 464 | ||
| Acknowledgments | 465 | ||
| References | 465 | ||
| Index | 469 |