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Hepatobiliary Imaging, An Issue of Magnetic Resonance Imaging Clinics of North America, E-Book

Hepatobiliary Imaging, An Issue of Magnetic Resonance Imaging Clinics of North America, E-Book

Peter S. Liu

(2014)

Additional Information

Abstract

This issue, edited by Drs. Peter Liu and Richard Abramson, will comprehensively review imaging of the hepatobiliary system. Articles will include: Hepatic MRI Techniques, Optimization, and Artifacts, MR Contrast Agents for Liver Imaging, Focal Liver Lesion Characterization in Noncirrhotic Patients: An MR Approach, MRI in Cirrhosis and Hepatocellular Carcinoma, Understanding LI-RADS: A Primer for Practical Use, MRI of the Liver after Locoregional and Systemic Therapy, Diffusion Weighted Imaging of the Liver: Techniques and Applications, Hepatic Iron and Fat Quantification Techniques, Perfusion Imaging in Liver MRI, MR Elastography, Treatment Planning Before Hepatobiliary Surgery: Clinical and Imaging Considerations, MRI/MRCP of Benign and Malignant Biliary Conditions, and more!

Table of Contents

Section Title Page Action Price
Front Cover Cover
Hepatobiliary Imaging i
Copyright\r ii
Contributors iii
Contents vii
Magnetic Resonance Imaging Clinics of North America \r x
Foreword Hepatobiliary Imaging\r xiii
Preface Hepatobiliary Imaging\r xv
Hepatic MR Imaging Techniques, Optimization, and Artifacts 263
Key points 263
Introduction 263
The basic hepatic MR imaging examination 264
Individual pulse sequences 264
Localizer Images 264
Magnetic Resonance Contrast Agents for Liver Imaging 283
Key points 283
Introduction 283
Contrast agent properties 283
Relaxivity 284
Biodistribution 285
Extracellular contrast agents 285
Hepatobiliary agents 285
Blood pool agents 286
Adverse events and toxicity 287
Gadolinium-based Agents 288
Iron-based Agents 289
Injection protocol and arterial phase acquisition 289
Summary 290
References 290
Appendix 1 292
Pregnancy 293
Breast-feeding Mothers 293
MR Characterization of Focal Liver Lesions 295
Key points 295
Pearl 1: the T1 pearl: a focal lesion that is isointense to hyperintense to liver on T1-weighted images is hepatocellular i ... 295
FNH 296
IHCA 298
The exceptions 299
Nonhepatocellular Focal Liver Lesions in a Liver Containing Background Moderate or Marked Steatosis 299
Hemorrhagic Metastases to the Liver 299
Hemorrhagic Cysts of the Liver 300
Pearl 2: the chemical shift pearl: focal liver lesions that lose signal intensity on opposed-phase imaging contain lipid an ... 300
RN and HCC 301
HNF-1α Hepatic Adenoma 302
Nodular Steatosis 302
The exceptions 303
Clear Cell Renal Cell Carcinoma 303
Liposarcoma and Germ Cell Neoplasms 303
Ethiodized Oil 304
Hepatic Angiomyolipoma 305
Pearl 3 (in 3 parts): the iron pearls 305
Pearl 4 (in 3 parts): the T2 pearls 307
The exceptions 309
Hepatic Adenomas and FNH Can Have Components That Are Isointense to Spleen 309
Mucinous Adenocarcinoma Metastases Can Be Hyperintense to Spleen on Heavily T2-Weighted Images and Can Mimic Nonsolid Benig ... 309
Summary 309
References 310
MR Imaging in Cirrhosis and Hepatocellular Carcinoma 315
Key points 315
Introduction 315
Surveillance 316
Technique 316
Cirrhosis 316
Findings of Cirrhosis 316
RNs 318
Dysplastic Nodules 319
Hepatocellular carcinoma 320
Key imaging features of HCC 320
Arterial Phase Hyperenhancement 320
Washout 321
Capsular Enhancement 321
Other findings of HCC 322
T1W Signal 322
Fatty Metamorphosis 322
T2W Signal 322
DWI 322
Hepatocyte-specific Contrast Agents 323
Mosaic Pattern 325
Nodule Within a Nodule Appearance 325
Vascular Invasion 326
HCC subtypes 327
Diffuse HCC 327
Scirrhous HCC 327
Combined Hepatocellular Cholangiocarcinomas 328
HCC mimics and other masses in cirrhotic livers 328
Intrahepatic Mass-forming Cholangiocarcinoma 328
Metastases 328
Large RNs in Budd-Chiari Syndrome 329
Confluent Hepatic Fibrosis 329
Nodules less than 20 mm with atypical enhancement patterns 329
Small (<20 mm) Arterially Hyperenhancing Nodules 329
Small (<20 mm) Hypovascular Nodules 330
Summary 330
References 330
Understanding LI-RADS 337
Key points 337
Introduction 337
Observations 338
Categories 338
Algorithm 339
Major features 341
LI-RADS table 346
Ancillary features 348
Tie-breaking rules 349
Other features of LI-RADS 349
Future directions 351
Summary 351
References 351
Magnetic Resonance Imaging of the Liver After Loco-Regional and Systemic Therapy 353
Key points 353
Introduction 353
Loco-regional and systemic therapy 354
Transarterial Embolization 354
Transarterial Chemotherapy with and Without Embolization 355
TACE with Drug-Eluting Beads 355
Transarterial Radioembolization 355
Tissue Ablation 356
Systemic Therapy 357
Role of MR imaging in the assessment of treatment response 357
Anatomic MR Imaging Metrics 357
Functional Volumetric MR Imaging Metrics 358
DWI 358
Quantitative Contrast-Enhanced MR Imaging 358
Perfusion Fraction MR Imaging 361
Multiparametric Volumetric Functional MR Imaging 362
Imaging of hepatic tumors after LRT and systemic therapy 362
HCC 362
Cholangiocarcinoma 364
Colorectal Liver Metastases 366
Neuroendocrine Liver Metastases 366
Islet Cell Tumor Metastases 367
Summary 368
References 368
Diffusion-Weighted Imaging of the Liver 373
Key points 373
Introduction 373
DWI technique 374
Concepts 374
Principles of molecular diffusion 374
DWI physics 374
Quantification of diffusion properties in tissues 374
Quality control 375
Reproducibility and repeatability 375
Diffusion Acquisition 375
Imaging strategy 375
Control of physiologic motion 375
Parallel imaging 376
Effect of magnetic field strength: 1.5 T versus 3.0 T 376
Liver applications 376
Lesion Detection 376
Liver metastases 376
HCC 378
Cholangiocarcinoma 380
Lesion Characterization 381
Qualitative assessment 381
Quantitative assessment 382
Common pitfalls in using DWI for lesion characterization 382
Tumor Treatment Response 383
Liver Fibrosis and Cirrhosis 385
Limitations 385
Future directions 387
IVIM in the Clinic 387
Noninvasive detection of liver fibrosis 387
Liver lesion characterization 388
Combination and Comparison with Positron Emission Tomography/MR Imaging 388
New DWI Sequences 388
Summary 389
References 389
Quantification of Hepatic Fat and Iron with Magnetic Resonance Imaging 397
Key points 397
Introduction 397
NAFLD 398
NASH and cryptogenic cirrhosis 399
HCC 399
Hepatic iron overload 400
Treatment of fatty liver disease and iron overload 401
Methods of assessing of hepatic fat and iron 402
Ultrasound 402
Computed Tomography 403
Nontargeted Liver Biopsy 403
Phlebotomy 403
Qualitative MR Imaging Techniques 404
MR imaging as a quantitative biomarker 406
Hepatic Fat 406
Hepatic Iron 409
Summary 412
References 412
Perfusion Imaging in Liver MRI 417
Key points 417
Introduction 417
Qualitative explanation of dynamic clinical MR imaging 418
Qualitative explanation of DCE-MRI tracer kinetic modeling 418
Single-compartment versus dual-compartment 421
Single versus dual input 422
Conventional compartment model versus distributed parameter model 422
Model-free approaches 423
Initial Area Under the Curve 423
Hepatic Perfusion Index 423
Choice of method 423
DCE-MRI technique 425
Clinical applications 426
Predicting Liver Micrometastases 426
Predicting Response to Therapy 426
Assessing Liver Fibrosis and Cirrhosis 427
Summary 430
References 430
Magnetic Resonance Elastography of Liver 433
Key points 433
Introduction 433
Elastography 434
Magnetic resonance elastography 434
Principle of MRE 434
Technique of Liver MRE 434
Generating mechanical shear waves in liver 435
Imaging the propagating shear waves (MRE sequence) 435
Generation of stiffness map (elastogram) 436
Calculating Liver Stiffness 436
Clinical applications of liver MRE 437
Detection and Staging of Liver Fibrosis 439
Differentiation of Simple Steatosis from Nonalcoholic Steatohepatitis 439
Other Applications 440
Evaluation of focal lesions 440
Clinical follow-up and treatment response assessment 440
Emerging applications 440
Limitations of MRE 440
Future directions 443
Summary 443
References 443
Presurgical Planning for Hepatobiliary Malignancies 447
Key points 447
Introduction 447
MR imaging protocols 448
Hepatic parenchymal, vascular, and biliary anatomy 448
Functional considerations 450
HCC 453
Colorectal metastases 456
Cholangiocarcinoma 458
Summary 463
References 463
MR Imaging of Benign and Malignant Biliary Conditions 467
Key points 467
Introduction 467
MR imaging methodology 468
MR Cholangiopancreatography 468
Soft Tissue Imaging 469
T2W and steady-state free precession imaging 469
T1W imaging 469
Hepatobiliary-Specific Contrast Agents 470
The evolving role of MR imaging and endoscopic retrograde cholangiopancreatography 471
Benign hepatobiliary pathology 471
Biliary Obstruction 471
Choledocholithiasis 471
Portal biliopathy 471
Cystic Disease of the Bile Ducts 472
Inflammatory Diseases of the Bile Ducts 474
Bile stasis 474
Infectious cholangitis 474
Primary sclerosing cholangitis 475
IgG4-related sclerosing cholangitis 476
Acquired immunodeficiency cholangiopathy 476
Primary biliary cirrhosis 480
Surgical Complications 480
Bile duct injury 480
Post liver transplant biliary complications 480
Malignant hepatobiliary pathology 480
Cholangiocarcinoma 480
Lymphoma 483
Metastatic Disease 484
Intraductal Papillary Neoplasms of the Bile Duct 484
Summary 486
References 486
Index 489