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Equine Sports Medicine and Surgery E-Book

Equine Sports Medicine and Surgery E-Book

Kenneth W Hinchcliff | Andris J. Kaneps | Raymond J. Geor

(2013)

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Book Details

Abstract

Equine Sports Medicine and Surgery provides the most up-to-date, in-depth coverage of the basic and clinical sciences required for management of the equine athlete. The unique treatment of exercise physiology and training within a clinical context, together with detailed review of all diseases affecting athletic horses, makes this the most comprehensive text available.
The book will provide a thorough grounding in the basic physiology of each body system, and in particular the responses of each body system to exercise and training, that will be separate, but highly relevant to, the succeeding sections on clinical disorders of each body system.
The highly respected editors have brought together an internationally renowned team of 50 contributors, producing the ultimate reference for veterinarians, students, horse-owners, and all those involved in the world of equine athletics.

    • High quality artwork, including relevant radiographic, ultrasonographic, CAT scan, and MRI images, aid understanding and diagnosis
    • Provides a truly international perspective, including guidelines pertinent to different geographic areas, and racing jurisdictions
    • In-depth coverage of the role of the veterinarian in the management of athletic horses
    • Explores the use of complementary therapies
  • ~

Table of Contents

Section Title Page Action Price
Front cover cover
Equine Sports Medicine and Surgery i
Copyright page iv
Table of Contents v
List of contributors ix
Acknowledgments xv
Preface xvii
1 Integrative Physiology and Exercise Testing 1
1 The horse as an athlete 3
Chapter Contents 3
Origins of the horse 3
Limits to performance 4
Comparative physiology 5
Integrative physiology of exercise 7
Physiology of training 8
The adaptive response 8
Mechanisms of training effects 8
Principles of training 8
Overtraining 8
Factors limiting performance 8
References 9
2 Laboratory exercise testing 11
Chapter Contents 11
Introduction 11
Indications for laboratory exercise testing in horses 12
Preparation for exercise testing 12
Horse preparation 12
Treadmill instrumentation/equipment 12
Acclimation to treadmill exercise 13
Treadmill safety 14
Exercise test protocols 14
Validity of treadmill exercise testing 14
Treadmill reliability and sensitivity 14
Main types of exercise test protocols 15
Selecting the optimal treadmill exercise test protocol 16
Measurements that can be made during treadmill exercise testing 16
Measurements of performance capacity 16
Aerobic capacity – measurement of the maximal rate of oxygen consumption 16
Heart rate 17
Blood lactate 17
Anaerobic capacity 17
Clinical exercise testing 18
Assessment of the respiratory tract 18
Endoscopic examination 18
Respiratory sound recording and analysis 18
Respiratory function testing 18
Methods of pulmonary function testing 18
Measurement of blood gases 19
Assessment of the cardiovascular system 20
Assessment of the musculoskeletal system 20
Conclusions 20
References 20
3 Exercise testing in the field 25
Chapter Contents 25
Introduction 25
Limitations of treadmill exercise testing 26
Field exercise tests 26
Measurements during field exercise tests 28
Heart rate 28
Electrocardiography 30
Blood or plasma lactate 30
Red cell volume and hematocrit 31
Measurement of oxygen consumption in field exercise 31
Gait analysis 32
Respiratory sound analysis during exercise 32
Endoscopy during exercise 33
Field exercise tests in trotters and pacing horses 33
Field exercise tests in Thoroughbreds 35
Heart rate measurements 35
Blood lactate measurements 36
Field exercise tests in eventers 37
Field exercise tests in show jumpers and dressage horses 37
Field exercise tests in endurance horses 38
Measurements after exercise 38
Conclusion 39
References 40
4 Genetic basis of equine performance 43
Chapter Contents 43
Introduction 43
Genomics of performance 43
Genetic component of the performance traits: how to measure the heritability of the exercise variables and performance traits using phenotypic measurements 43
Heritability calculation in horse performance 44
Muscle power and fiber composition in gluteus medius muscle 44
Evaluation of cardiac and aerobic capacity 44
Gait and jump tests 44
Conformation 44
Equine genetics and genomics come of age 44
Genomic applications in gallop and trot racing 46
Short time genomic response to exercise in Thoroughbreds 46
Genotyping in Thoroughbreds for gallop racing ability 47
Gene mutation related to tölt and trot 49
Genotyping in show jumping 49
Gene expression in endurance racing 49
Genomic applications in poor performance evaluation 50
Genotyping and gene expression disorders in myopathies 50
Genotyping in osteochondrosis 53
Genotyping in respiratory diseases 55
Conclusion: genetic and genomic perspective in equine exercise 55
References 57
2 Musculoskeletal System 59
5 Epidemiology of orthopedic diseases in athletic horses 61
Chapter Contents 61
Epidemiology 61
The racehorse 61
Risk of orthopedic disease, injury, or fatality in Thoroughbred racehorses 61
The level of risk during racing 62
Risk of fracture (catastrophic or non-catastrophic fractures) 62
Risk of soft tissue injury 62
The level of risk during training 62
Risk factor studies 63
Intrinsic risk factors 63
Extrinsic risk factors 63
Racing surface 63
Exercise intensity 63
Risk of injury after rest 64
Modifiable risk factors 64
Other athletic horses 64
Osteochondrosis 64
Other injury types 65
Dressage 65
Endurance 65
Eventing 66
Team roping 66
Barrel racing 66
How does this information help? 66
References 66
6 Muscle physiology: 69
Chapter Contents 69
Muscular response to exercise 69
Overview 69
Methodology 70
Percutaneous needle biopsy technique 70
Laboratory methods 71
Other techniques 72
Muscle structure and function 72
Morphology 72
Development 72
Gross anatomy and muscle function 72
Histology 73
Ultrastructure 73
General muscle physiology 75
The motor unit 75
Muscle proprioception 75
Electrical and ionic properties of the sarcolemma 76
Excitation–contraction coupling 78
Force transmission 79
Oxygen availability 79
Energy provision for muscular functions 80
Aerobic pathways 80
Anaerobic pathways 80
Integration of aerobic and anaerobic pathways 81
Muscle heterogeneity 84
Muscle fiber types 85
Fiber type differentiation 85
Muscle fiber type properties 85
Muscle fiber recruitment 85
Muscle fiber type distribution between and within muscles 87
Relationship to performance 88
Control and regulation 90
Myogenic factors 90
Non-myogenic factors 91
Responses to exercise 92
Aerobic exercise 92
Anaerobic exercise 93
Lactate accumulation and pH decline 93
Nucleotide depletion 93
Glycogen depletion 94
Other muscular changes 94
Molecular responses to exercise in muscle 94
Muscular responses to training 94
Overview 94
Muscular adaptations to training 95
Muscle fiber size 95
Muscle fiber type transitions 96
Metabolic changes and increased capillary density 97
Physiological adaptations and buffering capacity 98
Other training consequences 98
Overtraining 98
Detraining 99
Possible mechanisms underlying muscular adaptations to training 99
Implications of training-induced changes to the physiologic response to exercise 100
References 103
7 Muscle disorders of equine athletes 109
Chapter Contents 109
Introduction 109
General response of muscle to trauma and disease 109
Muscle damage caused by trauma, strains and tears 111
Recognition 111
History and presenting complaint 111
Physical examination 112
Special examination 112
Laboratory examination 112
Diagnostic confirmation 112
Treatment and prognosis 112
Therapeutic aims 112
Therapy 112
Prognosis 112
Prevention 112
Exertional rhabdomyolysis syndrome 112
Recognition 113
History and presenting complaint 113
Physical examination 113
Laboratory examination 113
Blood sampling 113
Exercise testing 114
Plasma vitamin E and selenium 114
Urinalysis 114
Electrolyte clearance ratios 114
Muscle biopsy 115
Genetic testing 115
Scintigraphy 116
Additional tests 116
Necropsy examination 116
Diagnostic confirmation 117
Treatment and prognosis 117
Therapeutic aims 117
Therapy 117
Management 117
Fluid therapy 117
Diuretics 117
Analgesia 117
Other therapies 117
Prognosis 117
Prevention 117
Diet 118
Exercise 118
Electrolyte therapy 118
Lactate modifiers 118
Dantrolene 118
Antioxidant supplementation 118
Etiology, pathophysiology and pathology 118
Acquired causes 119
Overexertion 119
Eccentric contraction 119
Metabolic exhaustion 119
Oxidative injury 119
Electrolyte imbalance 120
Hormonal influence 120
Infectious causes 120
Inherited causes: recurrent exertional rhabdomyolysis 120
Etiology and pathogenesis 120
Epidemiology 121
Genomic studies 121
Pathology 121
Malignant hyperthermia 123
Polysaccharide storage myopathy type 1 (PSSM1) 123
Pathogenesis 124
Phenotypic variation 124
Pathology 125
Polysaccharide storage myopathy type 2 (PSSM2) 125
Hyperkalemic periodic paralysis 126
Recognition 126
History and presenting complaint 126
Physical examination 126
Special examinations 126
Electrocardiography 126
Endoscopy 126
Electromyography 126
Laboratory examination 126
Serum biochemistry 126
Muscle biopsy 127
Diagnostic confirmation 127
Treatment and prognosis 127
Therapeutic aims 127
Therapy 127
Emergency treatment during an attack 128
Prognosis 128
Prevention 128
Management and dietary changes 128
Prophylaxis 128
Etiology and pathophysiology 128
Transient myotonia 129
Paresis 129
Hyperkalemia can be both the consequence and the cause of an attack 129
Muscle hypertrophy 129
Exercise intolerance 129
Epidemiology 129
Myotonia 130
Recognition 130
History and presenting complaint 130
Physical examination 130
Special examinations 130
Electromyography 130
Muscle biopsy 130
Diagnostic confirmation 131
Treatment and prognosis 131
Etiology and pathophysiology 131
Myotonic dystrophy 132
Recognition 132
History and presenting complaint 132
Physical examination 132
Special examination 132
Electromyography 132
Laboratory examination 132
Hematology and biochemistry 132
Muscle biopsy 132
Diagnostic confirmation 132
Treatment and prognosis 132
Prevention 132
Etiology and pathogenesis 133
Epidemiology 133
Mitochondrial myopathy 133
Recognition 133
History and presenting complaint 133
Physical examination 133
Special examination 133
Exercise test 133
Laboratory examinations 133
Hematology and biochemistry 133
Muscle biopsy 133
Biochemical analysis of mitochondrial oxidative enzymes 134
3 Respiratory System 527
25 Upper airway function of normal horses during exercise 529
Chapter Contents 529
Introduction 529
Obligate nasal breathing 530
Basic upper airway mechanics 530
Ventilation 530
Head position 530
Neuromuscular control of upper airway function 531
Nasal occlusion 531
Muscular anatomy and function of the upper airway 532
The nose 532
The nasopharynx 533
Soft palate 533
Muscles of the hyoid apparatus 534
Dorsal pharyngeal constrictors 537
The larynx 539
Guttural pouches 540
Physiology 540
Anatomy 540
References 544
26 Abnormalities of the upper airway 549
Chapter Contents 549
Introduction 549
Redundant alar folds (alar fold collapse) 549
Recognition 550
History and presenting complaint 550
Physical examination 550
Special examination 550
Laboratory examination 550
Diagnostic confirmation 550
Treatment and prognosis 550
Therapeutic aims 550
Therapy 550
Prognosis 550
Prevention 550
4 Cardiovascular System 665
31 Heart and vessels: 667
Chapter Contents 667
Introduction 667
Role of the heart and cardiovascular system in setting aerobic capacity 669
Conductive O2 transport (lungs to muscle) 670
Diffusive O2 transport within muscle 671
Anatomy of the cardiovascular system 671
Heart size 671
Spleen 674
Systemic circulation and microcirculation 675
Pulmonary circulation and microcirculation 677
Cardiovascular physiology and responses to exercise 677
Cardiac output 677
Heart rate 678
Stroke volume 679
Arterial O2 content (CaO2) and O2 delivery ( × CaO2 = ) 679
Determinants of O2 loading 680
Pulmonary circulation 680
Exercise-induced arterial hypoxemia 682
Alveolar–capillary O2 diffusion limitation (~70% of alveolar-to-capillary O2 pressure gradient) 682
Alveolar hypoventilation 682
Mild ventilation-to-perfusion () mismatch 682
Exercise-induced pulmonary hemorrhage 682
Systemic circulation 683
Muscle blood flow () and O2 delivery () across the rest–exercise transition 684
Determinants of O2 exchange within skeletal muscle: the microcirculation 685
Exercise training 687
Mechanistic bases for training-induced stroke volume (SV) increase 687
Mechanistic bases for increased muscle vascular conductance and O2-diffusing capacity (and increased Cao2 − Cvo2) after training 689
Conclusions 689
References 689
32 Diseases of the heart and vessels 695
Chapter Contents 695
Introduction 695
General approach to equine cardiology 695
Overall approach 695
Clinical history 696
Cardiac auscultation 696
Technique 696
Rules 696
Location of valve areas 696
Left hemithorax 696
Right hemithorax 696
Abnormalities of cardiac rhythm 697
General principles 697
Atrial fibrillation (AF) and atrial flutter (AFL) 699
Recognition 701
History 701
Physical examination 701
Special examination 702
Laboratory tests 703
Treatment and prognosis 703
Treatment of atrial fibrillation with quinidine sulfate 704
Regime 704
Other pharmacological treatments for atrial fibrillation 705
Transvenous electrical cardioversion of atrial fibrillation 705
Aftercare 707
Prognosis 708
Etiology and pathophysiology 709
Epidemiology 709
Supraventricular premature depolarizations 710
Recognition 710
History 710
Physical examination 710
Special examination 710
Other tests 710
Treatment and prognosis 710
Therapeutic aim 710
Therapy 710
Prognosis 711
Etiology and pathophysiology 711
Ventricular premature depolarizations 712
Recognition 712
History 712
Physical examination 713
Special examination 713
Other tests 717
Treatment and prognosis 717
Therapeutic aim 717
Therapy 717
Prognosis 717
Etiology and pathophysiology 717
Bradydysrhythmias 718
Recognition 718
History 718
Physical examination 718
Special tests 718
Treatment and prognosis 718
Therapeutic aims 718
Therapy 718
Prognosis 719
Etiology and pathology 721
Epidemiology 721
Cardiac murmurs 721
General principles 721
Physiological murmurs 721
Systolic ejection murmurs 721
Functional diastolic murmurs: diastolic filling murmurs 722
Murmurs associated with cardiac dysfunction 722
Tricuspid regurgitation 722
Recognition 722
History 722
Physical examination 722
Special examination 722
Treatment and prognosis 723
Treatment 723
Prognosis 723
Etiology and pathophysiology 723
Epidemiology 723
Mitral regurgitation 723
Recognition 724
History 724
Physical examination 724
Special examination 726
Treatment and prognosis 726
Treatment 726
Prognosis 726
Etiology and pathophysiology 727
Epidemiology 727
Ventricular septal defect 727
Recognition 728
History 728
Presenting signs 728
Special tests 729
Treatment and prognosis 729
Treatment 729
Prognosis 729
Etiology and pathophysiology 729
Epidemiology 729
Aortic insufficiency 729
Recognition 729
History 729
Presenting signs 729
Special examination 730
Treatment and prognosis 730
Treatment 730
Prognosis 731
Etiology and pathophysiology 731
Epidemiology 731
Complex congenital lesions 731
Diseases of the myocardium 731
Recognition 732
History 732
Physical examination 732
Special examination 733
Treatment and prognosis 733
Therapeutic aim 733
Therapy 733
Prognosis 733
Etiology and pathophysiology 733
Epidemiology 734
Diseases of the pericardium 734
Recognition 734
History 734
Presenting signs 734
Special tests 734
Therapeutic aims 734
Treatment and prognosis 734
Treatment 734
Prognosis 734
Etiology and pathophysiology 735
Epidemiology 735
Diseases of the vessels 735
General 735
Aortic and great vessel rupture 735
Recognition 735
History and presenting signs 735
Treatment and prognosis 737
Treatment 737
Prognosis 737
Large vessel rupture 737
Sinus of Valsalva aneurysm 737
Etiology and pathogenesis 737
Epidemiology 737
Aortoiliacofemoral thrombosis 737
Recognition 737
Presenting signs 737
Special tests 737
5 Metabolism and nutrition 745
33 Metabolic responses to exercise and training 747
Chapter Contents 747
Introduction 747
Physiological response to exercise 747
Overview 747
Integration of various body systems 747
Sources of metabolic fuel 748
Major pathways for energy transduction 749
Glycolysis 750
β-Oxidation of free fatty acids 750
Degradation of amino acids 751
Tricarboxylic acid cycle 751
The electron transfer system 751
Other pathways 751
Methods of assessing metabolic response to exercise and training 751
Samples and measurements to study the effects of exercise 752
Whole-body level measurements 752
Metabolic evaluation at the organ level 754
Metabolic responses and mechanisms 754
Responses in metabolite concentrations in plasma 755
Changes in muscle 755
Effects of warm-up 757
Mechanisms of fatigue 757
Metabolism during recovery from exercise 758
Lactate removal 758
Glycogen synthesis 758
Physiological response to training 760
Overview 760
Metabolic responses and mechanisms 760
Responses in metabolite concentrations in plasma 760
Changes in muscle 760
Training intensity and duration 761
Detraining 761
References 761
34 Endocrine function during exercise and response to training 769
Chapter Contents 769
Introduction 769
Growth hormone 770
Major actions of growth hormone 770
Regulation of GH secretion 770
Effects of exercise and training on secretion and circulating GH concentrations 770
Actions of growth hormone during exercise 771
Glucose tolerance 771
Insulin 771
Major actions of insulin 771
Regulation of insulin secretion 771
Effects of exercise and training on secretion and circulating insulin concentrations 771
Actions during exercise and training 773
Insulin sensitivity and resistance 773
Assessment of insulin sensitivity 774
Effects of exercise and physical conditioning on insulin sensitivity 774
Glucagon 775
Major actions of glucagon 775
Regulation of glucagon secretion 775
Effects of exercise and training on secretion and circulating glucagon concentrations 775
Actions of glucagon during exercise 775
The steroid hormones (specifically testosterone and cortisol) 775
Testosterone 776
Effects of exercise and training on secretion and circulating testosterone concentrations 776
Actions during exercise/training 776
The hypothalamic–pituitary–adrenocortical axis and cortisol 776
Major actions of cortisol 776
Regulation of cortisol secretion 776
Effects of exercise and training on secretion and circulating cortisol concentrations 777
Actions of cortisol during exercise 777
The dual steroid response 777
β-endorphin 778
Adrenaline 778
Major actions of adrenaline 778
Regulation of adrenaline secretion 778
Effects of exercise and training on secretion and circulating adrenaline concentrations 778
Actions of adrenaline during exercise 778
Thyroid hormones 778
Major actions of thyroid hormones 779
Regulation of thyroid hormone secretion 779
Effects of exercise and training on secretion and circulating thyroid hormone concentrations 779
Actions of thyroid hormones during exercise 779
Adipocyte hormones 779
Fluid-regulating hormones 780
Conclusions 780
References 780
35 Endocrine and metabolic disorders of the equine athlete 787
Chapter Contents 787
Introduction 787
Exhausted horse syndrome 787
Recognition 787
History and presenting complaint 787
Physical examination 787
Laboratory examination 788
Necropsy examination 788
Diagnosis 788
Treatment and prognosis 788
Therapeutic aims 788
Therapy 788
Prognosis 789
Etiology and pathophysiology 789
Epidemiology 790
Prevention 790
Overtraining syndrome 791
Recognition 792
History and presenting complaint 792
Physical examination 792
Bodyweight and heart rate 792
Hematological findings 792
Clinicopathological findings 793
Endocrine signs 793
Behavioral signs 793
Diagnostic confirmation 794
Treatment and prognosis 794
Therapeutic aims 794
Prognosis 794
Etiology and pathophysiology 794
Epidemiology 794
Prevention 795
References 795
36 Nutrition for the equine athlete: 797
Chapter Contents 797
Introduction 797
What nutrients does an athletic horse need? 797
Building a ration for an individual horse 797
Which units and requirements to use? 797
Calculation of energy requirements 804
Sources of dietary energy 804
Forage 804
Accounting for pasture forage intake 807
Cereals and cereal by-products 807
Highly digestible fibers 807
Oils 809
Amounts of forage and concentrate feed in the ration 809
Forage 809
Is there a maximum or minimum forage intake? 810
Concentrate or complementary feeds (including oil) 810
Balancing the ration for protein and amino acids 811
Other nutrients 811
Minerals 811
Iron 813
Selenium 813
Chelated/organic sources 813
Dietary cation-anion balance (DCAB) 814
Vitamins 814
Antioxidant vitamins E and C 814
Water 814
References 815
37 Nutrition for the equine athlete: 819
Chapter Contents 819
Introduction 819
Time of feeding before exercise 819
Electrolyte supplementation 821
Dietary manipulation of muscle glycogen content 822
Muscle glycogen and exercise performance 822
Post-exercise muscle glycogen synthesis 822
Diet and muscle glycogen storage 823
Feeding management for horses at risk for specific conditions 825
Equine gastric ulcer syndrome (EGUS) 825
What about the use of supplements? 826
Equine rhabdomyolysis syndrome 826
Effects of oil-supplemented diets in athletic horses 827
Metabolic responses to exercise 827
Athletic performance 827
Thermal load 828
Behavior 828
Free fatty acid (FFA) profile 828
Putative ergogenic supplements 828
Creatine 828
L-carnitine 829
Amino acids 830
Carnosine 830
References 831
6 Fluids and Electrolytes 835
38 Body fluids and electrolytes: 837
Chapter Contents 837
Introduction 837
Body fluid compartments 837
Plasma osmolality and the concentration of key electrolytes 840
Plasma concentration versus plasma content 841
Effects of acute exercise on fluid and electrolyte balance 841
Intercompartmental fluid shifts at the onset of exercise 841
Fluid and electrolyte losses associated with longer acute exercise 843
Sweat losses and the combined effects of exercise and environment 843
Thirst, drinking, and electrolyte intake 844
Renal function during exercise 845
Effects of exercise on renal blood flow 845
Effect of exercise on glomerular filtration rate, filtration fraction 846
Renal tubular function and excretion during exercise 846
Post-exercise changes in renal function 848
Adaptive response to repeated exercise (training) 848
Training-induced hypervolemia 848
Effects of aging on the acute and chronic response to exercise 851
Summary 851
References 851
39 Acid-base physiology at rest, during exercise and in response to training 855
Chapter Contents 855
Introduction 855
Acid-base balance in resting horses 856
Overview of acid-base balance 856
Acidosis and skeletal muscle fatigue 857
Assessment of acid-base balance and factors that affect acid-base regulation 858
Physicochemical determinants of acid-base balance 858
Strong ions and strong ion difference 859
Weak acids and bases, and [Atot] 861
The carbon dioxide system 861
Solving equations to determine acid-base balance 861
Contracting skeletal muscle: proton generating and removing reactions 862
Muscle characteristics and acid-base 862
Physicochemical origins of [H+] changes in skeletal muscle during exercise 863
Muscle [SID] during exercise 863
Muscle [Atot] during exercise 864
Muscle CO2 during exercise 865
Draught exercise 865
Changes in plasma acid-base state during exercise and recovery 865
Incremental steady state exercise 866
High intensity sprint exercise 866
Steady state submaximal exercise 867
Endurance exercise 868
Simulated racing: Standardbred racehorses 869
Other types of exercise 869
Clinical notes 869
Exercise summary 870
Responses to training 870
Endurance training 870
Sprint training 870
High altitude 871
Diet and acid-base balance 871
Resting horses 871
Exercise 871
Dietary protein 871
Dietary starch 871
Dietary fat 872
Selected clinically relevant issues for seemingly ‘normal’ horses 872
Age 872
Idiopathic laryngeal hemiplegia 872
Administration of alkalinizing substances and other purported ergogenic aids 872
Alkalinizing substances 872
Time course 873
Mechanism for enhanced lactate efflux 873
Creatine supplementation 873
Furosemide 873
References 874
40 Abnormalities of body fluids and electrolytes in athletic horses 881
Chapter Contents 881
Introduction 881
Exercise-associated dehydration/exhaustion 882
Recognition 882
History and presenting complaint 882
Physical examination 882
Laboratory examination 882
Treatment and prognosis 884
Intravenous fluid therapy 885
Volume of intravenous fluids and rate of administration 886
Prevention 886
Strategies of water and electrolyte replacement/supplementation before, during, and immediately after exercise 887
Before exercise 887
During exercise 887
Rehydration after exercise 888
Diet, fiber content and the large intestine as a fluid and electrolyte reservoir 888
Electrolyte requirements in athletic horses 889
Etiology and pathophysiology 891
Epidemiology 891
Complications associated with exercise-induced dehydration and electrolyte imbalance 892
Cardiac dysrhythmias 892
Laminitis 893
Colic/ileus 893
Synchronous diaphragmatic flutter (thumps) 893
Recognition 894
History and presenting complaint 894
Physical examination 894
Laboratory examination 894
Treatment and prognosis 894
Prevention 894
Etiology and pathophysiology 894
Epidemiology 895
Acute renal failure 895
Recognition 896
History and presenting complaint 896
Physical examination 896
Laboratory examination 896
Urinalysis and urine sediment evaluation 896
Treatment and prognosis 897
Fluid therapy 897
Adjunctive medications 897
Diuretics 897
Renal vasodilators 897
Prevention 897
Etiology and pathophysiology 897
Epidemiology 898
References 898
41 Thermoregulation and exercise-associated heat illnesses 901
Chapter Contents 901
Introduction 901
Heat production and dissipation 901
Heat production 902
Mechanisms of heat transfer 902
Mechanisms of sweat formation 903
Thermoregulation during exercise 905
Effects of environmental heat load on exercise responses 905
Physiologic factors affecting thermoregulatory capacity 906
Conditioning 907
Heat acclimatization 907
Hydration state 908
Old age 909
Recommendations for preparation for exercise or competition in hot conditions 910
Diseases caused by inadequate thermoregulation 911
Anhidrosis (‘dry coat’) 911
Recognition 911
History and presenting complaint 911
Physical examination 911
Diagnosis 911
Treatment and prognosis 911
Therapy 911
Prognosis 912
Etiology and pathophysiology 912
Epidemiology 912
Prevention 912
Heat exhaustion/heat stroke 912
Recognition 913
History and presenting complaint 913
Physical examination 913
Diagnosis 913
Treatment and prognosis 913
Therapy 913
Prognosis 914
Etiology and pathophysiology 914
Epidemiology 914
Prevention 915
References 915
7 Hematology and Immunology 919
42 Hematology and serum biochemistry of the equine athlete 921
Chapter Contents 921
Introduction 921
Methods 921
Hematology: structure and function 923
Erythrocytes and gas exchange 923
Leukocytes 924
Platelets 924
Hematologic responses to exercise 924
Hematologic responses to training 925
Plasma or serum biochemistry overview 926
Changes in plasma or serum biochemistry associated with exercise 926
Plasma proteins 926
Liver-derived enzymes 926
Muscle-derived enzymes 926
Electrolytes and minerals 926
Changes in plasma or serum biochemistry associated with training 927
Conclusion 927
References 927
43 Biochemical abnormalities of athletic horses 931
Chapter Contents 931
Introduction 931
Clinical chemistry as an indicator of disease 931
Plasma proteins 931
Muscle enzyme activities 933
Cardiac troponin I 935
Liver enzymes 935
Renal variables and urinary fractional excretion 935
Serum and plasma electrolytes and minerals 936
Conclusion 936
References 936
44 Abnormalities of the erythron 939
Chapter Contents 939
Anemia 939
Diagnosis of anemia 940
Recognition 940
Clinical signs 940
Hematology 940
Blood smears 942
Bone marrow evaluation 942
Serum biochemistry 944
Urinalysis 944
Blood gas analysis and lactate 944
Assessment of minerals, trace elements, and vitamins 945
Iron 945
Copper 946
Folic acid and vitamin B12 (cobalamin) 946
Specific causes of anemia 946
Acute blood loss anemia 947
Recognition 947
History and presenting complaint 947
Physical examination 947
Special examination 947
Laboratory examination 947
Diagnostic confirmation 947
Treatment and prognosis 947
Therapeutic aims 947
Therapy 947
Prognosis 949
8 Gastrointestinal System 983
46 Effects of exercise on gastrointestinal function 985
Chapter Contents 985
Introduction 985
Digestion 986
Absorption 986
Secretion 986
Motility 986
Maintenance of mucosal barrier integrity 986
Liver specific functions 987
Available methodologies to document the effects of exercise on the equine gastrointestinal system 987
Methods that have been used in horses 987
Transit markers 987
Apparent digestibility of diet 987
Barostat 988
Blood flow measurement 988
Continuous pH monitoring 989
Measurement of GI regulatory peptides and steroids 989
Methods that could potentially be useful in horses, based upon experience in other species 990
Gastric motility and emptying 990
Gastric secretion 990
Gastric blood flow 990
Intestinal transit and motility 990
Mucosal permeability and absorption 991
Exercise and gastrointestinal function: what is known in other species that is pertinent to horses 991
Gastric motility and emptying 991
Intestinal motility and transit 992
Gastrointestinal blood supply 992
Mechanical factors 993
Mucosal barrier integrity 993
Clinical implications of exercise-associated changes in gastrointestinal function 993
Anatomical considerations 993
Physiological considerations 993
References 995
47 Gastrointestinal diseases of athletic horses 999
Chapter Contents 999
Introduction 999
Equine gastric ulcer syndrome 999
Recognition 999
Physical examination 1000
Laboratory examination and diagnosis 1000
Treatment and prognosis 1000
Therapy 1000
Prognosis 1001
Etiology and pathophysiology 1001
Epidemiology 1002
Right dorsal colitis (RDC) 1004
Recognition 1004
Physical examination 1004
Laboratory examination 1004
Diagnosis 1004
Treatment and prognosis 1004
Therapy 1004
9 Veterinary Management of The Performance Horse 1011
48 Veterinary aspects of training Thoroughbred racehorses 1013
Chapter Contents 1013
Introduction 1013
Demographics and wastage 1013
Provision of services 1015
General disease and injury management concepts 1016
Prophylactic measures 1016
General management of disease 1016
Specific disease and injury management 1017
Musculoskeletal diseases 1017
Exercise modification 1017
Bandages and bandaging 1018
Cold therapy 1018
Joint diseases and injuries 1018
Medical management of joint injuries and disease 1018
Surgical management of joint injury and disease 1019
Osteoarthritis 1019
Bone-related injuries and diseases 1020
Training modifications 1020
Dorsal metacarpal disease 1020
Third metacarpal dorsal cortical stress fractures 1020
Stress fractures at other sites 1020
Subchondral bone injuries 1021
Breakdown Injury 1021
Tendon- and ligament-related injuries and diseases 1021
Tendon injuries 1021
Injuries of the suspensory ligament and its insertions 1021
Suspensory branch desmitis and sesamoiditis 1022
Suspensory branch and body 1022
Proximal suspensory and its attachment 1022
Foot-related injuries and shoeing 1022
Interference injuries 1023
Muscle-related injuries and disease 1024
Recurrent exertional rhabdomyolysis (RER) 1024
Muscle strains and tears 1024
Back and wither injuries 1024
Infections of the musculoskeletal system 1024
Respiratory diseases 1025
Lower respiratory diseases 1025
Coughing horses and inflammatory airway disease (IAD) 1025
Exercise-induced pulmonary haemorrhage (EIPH) 1025
Upper respiratory diseases 1025
Over-ground dynamic respiratory endoscopy 1026
Left recurrent laryngeal neuropathy (RLN) 1027
Intermittent dorsal displacement of the soft palate (IDDSP) 1027
Arytenoid chondritis 1028
Other upper respiratory problems 1028
Gastrointestinal diseases 1028
Gastric ulceration 1028
Colic 1029
Diarrhea 1029
Cardiovascular diseases 1029
Veins (septic and non-septic thrombophlebitis) 1029
Cardiac abnormalities 1029
References 1029
49 Veterinary aspects of racing and training horses used for harness racing (trotters and pacers) 1037
Chapter Contents 1037
The breed and racing 1037
Origins of the breeds 1037
Performance and its determinants 1038
Race times 1038
Effect of age and sex 1038
Effect of age at first race 1038
Heritability 1038
Racing statistics 1039
Relationship of physiologic variables with performance 1040
Gait and racing 1040
Gait 1040
Gait abnormalities – interference 1041
Equipment 1041
Training the Standardbred 1043
General principles 1043
Training programs 1043
Traditional training programs 1043
Phase 1: The initial or foundation phase 1043
Phase 2: Preparation phase 1043
Phase 3: Competition or racing phase 1043
Phase 4: Rest or lay-off phase 1043
Interval and tapered training programs 1044
Overtraining syndrome (OTS) 1047
Treatment and prevention of overtraining 1048
Veterinary problems of Standardbreds 1049
Respiratory abnormalities 1049
Upper airway abnormalities 1049
Lower airway abnormalities 1049
Musculoskeletal disorders 1050
Recognition of lameness 1050
Breed and gait differences 1050
Muscle diseases 1050
Forelimb lameness 1051
Foot 1051
Pastern and fetlock 1051
Desmitis and tendonitis 1051
Carpus 1052
Hindlimb lameness 1052
The hind digits 1053
Metatarsophalangeal joint 1053
Metatarsal region 1053
Tarsus 1053
Stifle 1053
References 1054
50 Veterinary aspects of training event horses 1057
Chapter Contents 1057
Definitions and background 1057
Equestrian sports governance 1060
Demographics 1060
Veterinary services 1060
Common diseases and conditions 1061
Skeletal 1061
Muscular 1061
Respiratory 1062
Gastrointestinal 1063
Cardiovascular 1063
Neurological 1064
Endocrine 1065
Dermatological 1066
Ocular 1066
Behavioral 1066
Metabolic/heat-related 1066
Medications during competition 1067
References 1069
51 Veterinary aspects of training dressage horses 1071
Chapter Contents 1071
Definitions and background 1071
A brief history of dressage 1072
Demographics 1072
Common diseases and conditions 1073
Skeletal 1073
Muscular 1075
Endocrine 1076
Gastrointestinal 1076
Respiratory 1076
Upper airway problems 1076
Lower airway disease 1077
Cardiovascular 1078
Neurological 1079
Medications during competition 1079
References 1079
52 Veterinary aspects of training and racing endurance horses 1083
Chapter Contents 1083
Overview of the sport 1083
History and evolution 1084
Description of the sport 1084
Veterinarians and officials for endurance events 1085
Veterinary controls 1085
Physiology of endurance exercise 1086
Metabolism 1086
Thermoregulation 1086
Electrolyte losses 1086
Acid–base disorders 1086
Substrate depletion 1087
Oxidative stress 1087
Specific diseases 1087
Prevalence 1087
Prevention and risk factors 1087
Metabolic conditions 1088
Pathophysiology and prevalence 1088
Exhausted horse syndrome (EHS) 1089
Synchronous diaphragmatic flutter (SDF) 1089
Exertional myopathy 1090
Colic 1090
Metabolic encephalopathy 1091
Laminitis 1091
General management of metabolic conditions 1092
Correction of fluid and electrolyte disorders 1092
Sedation and pain control 1093
Prognosis 1093
Musculoskeletal disorders 1093
Injuries of the suspensory apparatus and its insertions 1093
Tendonitis 1094
Joint diseases and injury 1094
Polysynovitis 1095
Foot-related injuries 1095
Fractures 1095
Back and wither injuries 1096
Nutrition and prophylactic measures 1096
Energy and protein requirements 1096
Feeding management during endurance training 1096
Feeding management before and during endurance races 1097
Water and electrolyte replacement during endurance races 1098
Prophylactic measures 1098
Parasite prophylaxis 1098
Gastric ulceration 1098
Vaccination 1098
General management of training and riding 1099
Preliminary steps 1099
Endurance training 1099
Resistance and speed training 1099
Standard training programs 1099
Shoeing the endurance horse 1100
Fitness and poor performance investigation 1101
Blood monitoring in endurance horses 1101
Resting values 1101
Effects of exercise 1102
Biomarkers 1102
Heart rate monitoring 1102
Standardized exercise test 1102
Subclinical diseases underlying poor performance 1103
References 1104
53 Veterinary aspects of competing and training polo horses 1107
Chapter Contents 1107
History 1107
Organization of the sport 1107
Polo federation 1107
Polo match rules 1107
Doping regulation 1108
Match organization 1108
Management of horses during game 1109
Training of polo ponies (made pony) 1109
Type of effort sustained 1109
Exercise effort during a match and warm-up 1109
Common medical conditions 1110
EIPH 1110
Myositis 1110
Ligament injury and fetlock injuries 1111
Direct trauma 1111
References 1112
54 Veterinary aspects of training and competing western performance horses 1113
Chapter Contents 1113
Introduction 1113
Overview of the sport 1113
Demographics 1113
Wastage 1115
Training 1115
Arena footing 1116
Farriery and protective legwear 1116
Common conditions in selected western disciplines 1117
Reining 1117
Cutting 1118
Working/reined cow horse 1119
Team roping and calf roping 1119
Barrel racing 1119
Specific veterinary conditions and their management 1120
Musculoskeletal diseases 1120
Rhabdomyolysis 1120
Palmar heel pain 1120
Coronary band trauma and quarter cracks 1121
Pedal osteitis 1121
Splints 1121
Superficial digital flexor tendonitis 1121
Suspensory desmitis 1121
Hock lameness 1122
Distal tarsitis (DT) 1122
Hock osteochondrosis dessicans (OCD) 1122
Stifle lameness 1122
Lameness of the fetlock and pastern 1122
Fetlock and pastern osteoarthritis 1122
Fetlock osteochondrosis 1122
P2 fractures 1123
Skin conditions 1123
Fetlock and hock abrasions 1123
Pastern dermatitis 1123
Respiratory diseases 1123
Upper respiratory diseases 1123
Non-infectious upper respiratory diseases 1123
Lower respiratory diseases 1123
Exercise-induced pulmonary hemorrhage 1123
Inflammatory airway disease (IAD) and recurrent airway obstruction (RAO) 1123
References 1123
55 Veterinary aspects of training the show jumping horse 1127
Chapter Contents 1127
Introduction 1127
Features of the sport 1127
Exercise demands 1127
Biomechanics of jumping 1128
Type of horse 1129
Nutrition 1129
Horse clothing/tack 1129
Clinical evaluation of the jumping horse 1130
Subclinical lameness 1130
Specific injuries 1130
Orthopedic problems 1130
Foot pain 1131
Digital flexor tendons 1131
Suspensory ligament 1131
Tarsal pain 1131
Fetlock injury 1132
Stifle injury 1132
Back pain 1132
Non-orthopedic health problems 1132
Respiratory 1132
Gastrointestinal problems 1132
Gastric ulcers 1132
Cardiac 1133
Training for prevention of injury 1133
Training program 1133
Training session 1134
References 1134
56 Veterinary aspects of the aged equine athlete 1137
Chapter Contents 1137
Introduction 1137
Definition and demographics of the aged equine athlete 1137
Physiological alterations associated with aging 1137
Cardiorespiratory changes 1138
Thermoregulatory changes 1138
Changes in the musculoskeletal system 1138
Hematological, biochemical and endocrine parameters 1139
Age-related immunological alterations: immunosenescence and inflamm-aging 1139
Common conditions affecting the aged equine athlete 1139
Dental disease 1139
Musculoskeletal disorders and lameness 1140
Osteoarthritis 1140
Cardiac disorders 1140
Respiratory disease 1140
Pituitary pars intermedia dysfunction (PPID) 1140
Treatment 1141
Preventive health care and management for the aged equine athlete 1141
References 1141
57 Anesthesia of the equine athlete 1145
Chapter Contents 1145
Introduction 1145
History 1145
Physical examination 1146
Cardiovascular system 1146
Respiratory system 1146
Nervous and musculoskeletal systems 1146
Pre-anesthetic hematologic evaluation 1147
Pre-anesthetic medications 1147
Timing of anesthesia and animal preparation 1148
Induction of anesthesia 1148
Padding and positioning 1150
Maintenance of anesthesia 1150
Monitoring anesthesia 1150
The postoperative period 1151
Emergency sedation and anesthesia of the exhausted horse 1153
References 1154
58 Emergency procedures and first aid for the equine athlete 1157
Chapter Contents 1157
Introduction 1157
Fractures and luxations 1157
Initial assessment 1157
History 1157
Physical examination 1157
Special examination 1158
Laboratory examination 1158
Emergency treatment 1158
Therapeutic aims 1158
Therapy 1158
Bandage and splint application 1159
Classification of injuries 1159
Immobilization of level 1 injuries 1159
Forelimb 1159
Hindlimb 1159
Use of the Kimzey apparatus 1160
Extensor tendon injuries 1160
Immobilization of level 2 injuries 1160
Forelimb 1160
Hindlimb 1160
Immobilization of level 3 injuries 1161
Forelimb 1161
Hindlimb 1161
Immobilization of level 4 injuries 1161
Guidelines for safe transportation 1161
Wounds and lacerations 1162
Assessment of wounds and lacerations 1162
Location 1162
Hemorrhage 1162
Wound configuration 1162
Penetration of a body cavity 1162
Determination of synovial structure involvement 1163
Determination of tendon involvement 1163
Emergency treatment of limb wounds and lacerations 1163
Wound care 1163
Limb immobilization 1163
Emergency treatment of wounds involving the chest or abdominal cavity 1163
Pneumothorax 1163
Penetrating abdominal wound 1164
Head injuries 1164
Basisphenoid fractures 1164
Rectus and longus capitis muscle rupture 1164
Treatment of acute head injuries 1165
Ocular injuries 1165
Acute rhabdomyolysis 1166
Recognition 1166
History and presenting complaint 1166
Physical examination 1166
Treatment 1166
Therapeutic aims 1166
Therapy 1166
Emergency fluid therapy in the athletic horse 1166
Designing a fluid therapy regimen 1166
Calculating the volume of fluid to give 1167
Deciding the type of fluids to give 1167
Crystalloids 1167
Colloids 1167
Products used for resuscitation 1168
Materials for fluid therapy 1169
Epidemiology 1169
References 1170
59 Reproductive management of the athletic horse 1171
Chapter Contents 1171
Introduction 1171
The mare 1171
Normal estrus 1171
Suppression of estrus in mares 1171
Pharmacologic suppression of estrus 1172
Progestagens 1173
Pregnancy 1174
Intrauterine balls 1174
Oxytocin 1174
Intrauterine oil 1174
hCG (diestrous ovulation) 1174
Follicular downregulation 1174
Ovariectomy 1175
Anabolic steroids 1175
Control of reproductive behavior in the stallion 1175
Surgical castration 1175
Pharmacologic modification of male behavior 1176
Immunomodulation of male fertility and behavior 1176
Combining breeding and athletic careers 1176
Stallion 1176
Mares 1177
Pregnancy 1177
Embryo transfer 1177
Other assisted reproductive techniques 1177
Management of performance horses to optimize future reproductive potential 1177
References 1178
60 Examination of the equine athlete prior to purchase 1181
Chapter Contents 1181
Introduction 1181
Aim and philosophy 1181
Requirements for the prepurchase examination 1182
Examination procedure 1183
Stage 1. Preliminary examination 1183
Stage 2. Examination during walking, trotting, turning and backing 1183
Stage 3. Examination during and immediately after strenuous exercise 1183
Stage 4. Examination during the period after exercise 1183
Stage 5. The final examination during walking, trotting, turning and backing 1183
Avoiding problems in the prepurchase examination 1183
Special considerations and ancillary tests 1184
Conformation assessment 1184
Laboratory evaluation 1184
Examination of the cardiovascular system 1184
What are we looking for on prepurchase radiographs that may result in a reduced capacity to perform as an athlete? 1185
Limitations and problems associated with prepurchase radiographs 1189
Other imaging modalities 1190
Endoscopic examination of the upper respiratory tract and trachea 1191
Examination of the Thoroughbred racehorse 1191
Prepurchase examination of yearlings at public auction sales 1192
Examination of the mature horse 1192
Examination of the Standardbred racehorse 1193
Clinical examination 1193
Conformation 1193
Skin conditions 1193
Common injuries 1193
Stage 3 exercise 1193
Ancillary tests 1193
Electrocardiographic examination 1193
Upper airway endoscopic examination 1193
Radiography 1193
Examination of the proven racehorse 1194
Examination at yearling sales 1194
Examination of the sport horse prior to purchase 1194
Examination of the three-day event horse prior to purchase 1194
Examination of dressage horses and showjumpers prior to purchase 1195
Examination of the western performance horse prior to purchase 1196
References 1196
60 Appendix 1199
60 Buyer’s statement 1199
61 International movement of athletic horses: 1205
Chapter Contents 1205
Introduction 1205
International spread of equine diseases 1206
Economic, biological, political and ecological factors 1206
Disease and horse-related factors 1206
Country factors 1206
Impact of exotic disease outbreaks 1206
International regulatory framework 1207
The World Trade Organization 1207
Office Internationale des Epizooties 1207
OIE Terrestrial Animal Health Code 1207
OIE Manual of Diagnostic Tests and Vaccines for Terrestrial Animals 1207
Diseases listed by OIE 1207
Import risk analysis 1208
Zoning and compartmentalization 1208
Role and responsibilities of government officials, shipping agents and veterinarians 1208
Government officials 1208
Shipping agents 1209
Equine veterinarians 1209
Welfare legislation and standards 1209
Role of horse industry organizations 1210
Passports 1210
Vaccinations 1210
Racing authorities 1210
Federation Equestre Internationale 1210
Overview of quarantine controls of major equine sporting nations 1211
Certification of origin from a disease-free source 1211
Separation and biosecurity 1211
Diagnostic testing 1211
Vaccination 1211
Treatment 1212
Restrictions on destination, activity and season of import 1212
Protection of health status during international travel 1212
Restrictions on duration of temporary residency 1212
Contact information for major regulatory agencies 1212
Government animal health and quarantine authorities 1212
Other organizations 1212
References 1213
10 Physical Therapy and Rehabilitation 1215
62 Manual therapy and exercise for athletic horses 1217
Chapter Contents 1217
Manual therapy 1217
Background 1217
Mechanism of action 1217
Efficacy 1217
Indications and contraindications 1218
Massage 1218
Background and mechanism of action 1218
Efficacy 1218
Indications 1219
Stretching 1219
Background and efficacy 1219
Mechanism of action 1219
Indications and therapeutic application 1219
Outcome measures for manual therapy, massage and stretching 1220
Exercise therapy 1221
Neuromotor control 1221
Background 1221
Mechanism of action and efficacy 1221
Measurement outcomes 1221
Therapeutic protocol 1221
Hydrotherapy 1222
Background 1222
Therapeutic protocol 1223
References 1223
63 Equine rehabilitation: 1225
Chapter Contents 1225
Chiropractic treatment 1225
Background 1225
Mechanism of action 1225
Indications 1225
Contraindications 1226
Therapeutic protocol 1226
Outcome measures 1228
References 1228
64 Physical treatment of the equine athlete 1231
Chapter Contents 1231
Introduction 1231
Thermotherapy 1231
Cryotherapy 1231
Background 1231
Indications and contraindications 1231
Mechanisms of action 1232
Therapeutic protocol 1232
Outcome measures 1232
Heat therapy 1232
Background 1232
Appendices 1243
Appendix 1a Reference ranges for red cell variables in athletic horses 1245
References 1246
Appendix 1b Reference ranges for the leukogram of athletic horses 1249
References 1251
Appendix 2 Reference ranges for serum biochemical variables in athletic horses 1253
References 1258
Index 1259
A 1259
B 1262
C 1263
D 1266
E 1268
F 1271
G 1273
H 1274
I 1276
J 1278
K 1278
L 1278
M 1281
N 1283
O 1284
P 1286
Q 1288
R 1288
S 1290
T 1294
U 1297
V 1297
W 1298
X 1299
Y 1299
Z 1299