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FDG PET/CT Imaging: Normal Variations and Benign Findings – Translation to PET/MRI, An Issue of PET Clinics, E-Book

FDG PET/CT Imaging: Normal Variations and Benign Findings – Translation to PET/MRI, An Issue of PET Clinics, E-Book

Mohsen Beheshti

(2014)

Abstract

This issue of PET Clinics examines normal variations and benign findings in FDG PET/CT Imaging. Topics include Standardization and quantification in FDG PET /CT imaging for staging and restaging of disease, dynamic changes in FDG update in normal tissues, as well as normal variations in the brain, head and neck, thorax, abdomen, pelvis, and in pediatrics.

Table of Contents

Section Title Page Action Price
Front Cover Cover
FDG PET/CT Imaging:Normal Variations and Benign Findings i
copyright\r ii
Contributors iii
Contents vii
Pet Clinics\r x
Preface\r xiii
Standardization and Quantification in FDG-PET/CT Imaging for Staging and Restaging of Malignant Disease 117
Key points 117
Introduction 117
Quantification with SUV measurements in FDG-PET/CT studies 118
Assessment of treatment response in oncology with FDG-PET/CT using SUV measurements 118
Quantification in FDG-PET: the requisites 120
Standardization 120
QC Procedures 120
Qualification of Personnel 121
Errors in quantification in FDG-PET/CT: what can we do? 122
Technical Errors: What Can We Do? 122
Physical Errors: What Can We Do? 123
Biological Errors: What Can We Do? 124
FDG-PET/CT in multicentric clinical trials 124
Summary and next steps 124
Acknowledgments 125
References 125
Brain Normal Variations and Benign Findings\rin Fluorodeoxyglucose-PET/Computed\rTomography Imaging\r 129
Key points 129
Introduction 129
Imaging technique 130
Normal anatomy 130
Imaging findings 131
Scanning Time 131
Age 132
Gender 134
Substances/Medications 134
Therapy Procedures 136
Artifacts 136
Summary 137
References 137
Head and Neck Normal Variations and Benign Findings in\rFDG Positron Emission Tomography/\rComputed Tomography Imaging\r 141
Key points 141
Introduction 141
PET/CT scanning protocols 141
FDG 142
Radiation Doses 142
Scanning Protocol 142
Patient Positioning 142
Acquisition Protocol 142
Image Reconstruction 142
PET/CT image interpretation 142
Physiologic FDG uptake 142
Benign findings 144
Artifacts 145
Summary 145
References 145
Thorax Normal and Benign Pathologic Patterns\rin FDG-PET/CT Imaging 147
Key points 147
Introduction 147
Patterns of FDG biodistribution in the normal thorax 148
Patterns of FDG uptake in benign pathologic processes of the thorax 155
Infection 155
Interstitial Lung Disease, Connective Tissue Disease, and Vasculitides 157
Pneumoconiosis 158
Acute Respiratory Distress Syndrome 158
Treatment-Related Sources of Abnormal FDG Uptake 158
Sarcoidosis 161
Cystic Fibrosis 162
Pulmonary Nodules 162
Chest Trauma 162
Myocardium and Great Vessels 163
Esophagitis, Barrett Esophagus, and Benign Esophageal Masses 164
Benign Conditions Affecting the Trachea 164
Elastofibroma Dorsi 164
Amyloidosis 165
Summary 165
References 165
Abdomen Normal Variations and Benign Conditions\rResulting in Uptake on FDG-PET/CT 169
Key points 169
Introduction 169
Variations in physiologic FDG activity in the abdomen on FDG-PET/CT 170
GI Tract 170
GU Tract 171
Solid Organs 173
Patient preparation to reduce physiologic activity in the GI and GU tracts 174
The effect of medication on variations in FDG activity in the abdomen 176
GI Tract 176
Spleen and Bone Marrow 177
Metabolically active brown adipose tissue, skeletal muscle uptake, and artifacts 177
Benign conditions resulting in uptake on FDG-PET/CT 178
Liver and Biliary Tract 179
Pancreas 180
GI Tract 180
GU Tract 180
Summary 180
References 181
Pelvis Normal Variants and Benign Findings in\rFDG-PET/CT Imaging 185
Key points 185
Introduction 185
Bone Benign Pathology 186
Colon Benign Pathology 186
Bladder Benign Pathology 188
FDG Uptake in Vascular Structures 188
Male pelvis 188
Prostate Benign Pathology 188
Male Reproductive System 189
Female pelvis 189
Normal Variants 189
Uterine Benign Pathology 190
Adnexal Benign Pathology 191
References 191
Normal Variations and Benign Findings in Pediatric 18F-FDG-PET/CT 195
Key points 195
Introduction 195
Patient preparation for pediatric 18F-FDG PET and 18F-FDG PET/CT 196
PET acquisition 201
Special pediatric concerns 202
Image coregistration 203
PET/CT 203
Normal patterns of 18F-FDG uptake in pediatrics 204
Summary 207
References 207
Differential Background Clearance of Fluorodeoxyglucose Activity in Normal Tissues and its Clinical Significance 209
Key points 209
Introduction 209
Subjects and methods 210
Patients 210
Imaging 210
Data Analysis 210
Results 210
Tissues with Decreased FDG Uptake on Delayed Images 210
Tissues with Increased FDG Uptake on Delayed Images 212
Tissues with Nonsignificant Changes in FDG Uptake on Delayed Images 213
RI and Implication for Clinical Practice: An Example 213
Discussion 214
Summary 215
Acknowledgments 216
References 216
Postradiation Changes in Tissues Evaluation by Imaging Studies with\rEmphasis on Fluorodeoxyglucose-PET/\rComputed Tomography and Correlation\rwith Histopathologic Findings 217
Key points 217
Introduction 217
External radiotherapy 218
Central Nervous System 218
Brain 218
Histopathologic features 218
Imaging (non-PET) 218
FDG-PET 219
Spinal cord 220
Fluorodeoxyglucose Positron Emission Tomography/Magnetic Resonance Imaging Current Status, Future Aspects 237
Key points 237
Introduction 237
PET/MR camera basics 238
Index 253