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Clinical Approaches to Oral Mucosal Disorders: Part II, An Issue of Dental Clinics of North America, E-Book

Clinical Approaches to Oral Mucosal Disorders: Part II, An Issue of Dental Clinics of North America, E-Book

Thomas P. Sollecito

(2014)

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Book Details

Abstract

Part II of our important volume on oral mucosal disorders, in this issue we cover: oral herpes virus infections, recurrent aphthous stomatitis, lichen planus/lichenoid mucositis, pediatric soft tissue diagnosis, oral cancer, chemotherapy/radiation induced oral mucositis, bisphosphonate related osteonecrosis of jaws/anti-resorptive drug related osteonecrosis of the jaw, oral graft-versus-host disease, human papillomavirus, perioral lesions and dermatoses, and more!

Table of Contents

Section Title Page Action Price
Front Cover Cover
Clinical Approaches to Oral Mucosal Disorders: Part II\r i
copyright\r ii
Contributors iii
Contents vii
Dental Clinics Of North America\r x
Preface xi
Dedication xi
Update on Oral Herpes Virus Infections 265
Key points 265
Introduction 265
HSV 266
Primary herpes simplex infections 266
Recurrent herpes simplex infection 267
Diagnosis 270
Differential Diagnosis 270
Laboratory Diagnosis 271
Virologic tests 271
Cytology smears 271
Immunomorphologic tests 271
Polymerase chain reaction test 271
Serologic tests 271
VZV 272
Varicella 272
HZ 272
EBV 273
CMV 274
HHV-6 275
HHV-7 275
HHV-8 276
Summary 276
References 276
Recurrent Aphthous Stomatitis 281
Key points 281
Introduction 281
Epidemiology 282
Predisposing etiologic factors 282
Local Factors 283
Microbial Factors 284
Underlying Disease 285
Hereditary and Genetic Factors 286
Allergic Factors 287
Immunologic Factors 287
Nutritional Factors 288
Psychological Stress 288
Other Factors 288
Clinical manifestation and pathogenesis 289
Management 289
Summary 292
References 292
Oral Lichen Planus and Lichenoid Mucositis 299
Key points 299
Introduction 299
Nature of Problem and Definition 299
Prevalence/Incidence 300
Cause and Pathogenesis 300
Symptoms 301
Clinical findings 302
Physical Examination 302
Diagnostic Modalities 304
Pathology 304
Diagnostic dilemma: a premalignant lesion 305
Comorbidities 306
Lichenoid Drug Reactions 306
Hepatitis C and OLP 307
Management 307
Goals 307
Pharmacologic Strategies: Topical Medications 308
Pharmacologic Strategies: Systemic Therapies 308
Summary 310
References 310
Oral Cancer 315
Key points 315
Anatomic sites 317
Stage at diagnosis and survival 319
TNM staging 319
Cause and risk factors 320
Immune system 320
Tobacco 320
Oral lichen planus 321
Nutrition 321
Viruses 321
Clinical assessment 322
Signs and symptoms 322
Erythroleukoplakia and erythroplakia 325
Erythroplakia with ulceration 325
PVL 325
Candidiasis (candidosis), leukoplakia, and erythroplakia 325
Delay in diagnosis 326
Oral carcinogenesis, epithelial dysplasia, and malignant transformation 327
Molecular progression 328
Genomics and proteomics 328
Precancerous classification (PMDs) 329
Diagnosis and management 330
Incisional and excisional scalpel or punch biopsy 330
Diagnostic adjunctive techniques 330
Cytology and brush biopsy 330
Fine-needle aspiration 331
Toluidine blue 331
Visualization-based adjunctive techniques 331
Monoclonal antibodies 332
Imaging 332
Chemoprevention 333
Chemoprevention of Oral Leukoplakia Remains Experimental 333
Workup for patients with oral SCCs 333
Treatment 333
Follow-up 334
References 334
Chemotherapy or Radiation-Induced Oral Mucositis 341
Key points 341
Introduction, epidemiology, and pathogenesis 341
Morbidity of oral mucositis 342
Pain 342
Nutritional Compromise 342
Quality of Life 342
Impact on Cancer Therapy 342
Infection 342
Impact on Oral Health 344
Economic Impact 344
Clinical findings 344
Management of oral mucositis 345
Symptom Management 345
Targeted Therapeutic Interventions 346
Cryotherapy 346
Low-level laser therapy 347
Growth factors 347
Antiinflammatory agents 347
Antimicrobial agents 347
Summary 348
References 348
Oral Graft-Versus-Host Disease 351
Key points 351
Introduction 351
Pathobiology and incidence of GVHD 352
aGVHD 353
cGVHD 354
Oral GVHD 355
Incidence 355
Clinical Findings 355
Diagnosis and Assessment 356
Impact of GVHD 358
Overall Survival 358
Quality of Life 359
Oral GVHD 359
Prevention and management of GVHD 359
Management Principles 359
Prophylaxis 360
Systemic Therapy 360
Management of oral GVHD 361
Pharmacologic Strategies 361
Nonpharmacologic Strategies 362
Late complications of oral GVHD 363
Summary 363
References 364
Antiresorptive Drug–Related Osteonecrosis of the Jaw 369
Key points 369
Introduction 369
Antiresorptive Drugs Associated with ONJ 370
BP 370
Anti-RANK ligand: denosumab 370
Differences between BP and denosumab 371
Epidemiology 371
Worldwide incidence 372
Clinical parameters 373
Diagnostic Guidelines and Staging of ARONJ 373
Imaging 373
Pathogenicity 374
Impaired Epithelial Repair 374
Bacterial Colonization and Biofilm 375
Immunosuppression 375
Diagnostic dilemmas 376
Management strategies 377
Surgical Strategies 377
Nonsurgical and Adjunctive Strategies 379
Summary 379
References 380
The Role of Human Papillomavirus in Oral Disease 385
Key points 385
Introduction 385
The virus 386
HPV infection 387
HPV immunology 388
HPV transmission 388
Epidemiology 388
Oral clinical lesions associated with HPV 389
Verruca Vulgaris (Common Wart) 389
Multifocal Epithelial Hyperplasia (Heck Disease) 390
Condyloma Accuminatum (Venereal Wart) 390
Oral squamous papilloma 392
Potentially malignant papillomatous lesions 392
Oral leukoplakia and head and neck squamous cell carcinoma 392
Treatment of oral HPV-related clinical lesions 394
Prevention 395
Summary 395
Acknowledgments 396
References 396
Perioral Lesions and Dermatoses 401
Key points 401
Index 455