BOOK
Bone Grafts And Bone Substitutes: Basic Science And Clinical Applications
(2005)
Additional Information
Book Details
Abstract
This book provides the latest updates on the major challenges of bridging large bone defects, where options range from autografts, “tissue engineered bone”, biomaterials (hydroxyapatite, polycaprolactone and third generation biomaterials) to prostheses. Emphasis has been made on bone tissue engineering, the current state-of-the-art in this field, problems encountered with cell culture technology, scaffolds and bone growth factors (including genomics) and the use of gene therapy for the application of bone growth factors. Attention has also been given to the use of bone autografts. It also covers the use of biomaterials and prostheses as other options for reconstruction. Clinical applications, in addition to the basic science, are also included throughout the discussions.
Sample Chapter(s)
Chapter 1: Structure of Bone (284 KB)
Contents:
- Basic Science of Bone
- Autografts
- Allografts
- Genomics
- Bone Tissue Engineering
- Growth Factors
- Ceramics
- Prostheses
Readership: Undergraduate students, graduate students, researchers and lecturers in bone tissue engineering, bone growth factors, biomaterials, autografts, allografts, prostheses, as well as orthopaedic surgeons, plastic and reconstructive surgeons, maxillo-facial surgeons and tissue bank operators.
Table of Contents
| Section Title | Page | Action | Price |
|---|---|---|---|
| Contents | v | ||
| Preface | ix | ||
| Introduction | xi | ||
| Contributors | xiii | ||
| SECTION I: BASIC SCIENCE OF BONE | 1 | ||
| Chapter 1 Structure of Bone | 3 | ||
| Chapter 2 Fracture Healing | 19 | ||
| Chapter 3 An Introduction to Biomechanics of Bone | 31 | ||
| SECTION II: AUTOGRAFTS | 57 | ||
| Chapter 4 Autogenous Bone Grafting in Orthopaedic Surgery | 59 | ||
| Chapter 5 Vascularised Pedicular Bone Grafts | 71 | ||
| Chapter 6 Vascularised Autograft: Basic Sciences and Clinical Applications | 85 | ||
| Chapter 7 Healing of Large Non-Vascularised Cortical Autologus Bone Transplants: An Experimental Study in Adult Cats | 119 | ||
| SECTION III: ALLOGRAFTS | 137 | ||
| Chapter 8 Role of Bone Allografts in Orthopaedic Surgery | 139 | ||
| Chapter 9 Setting Up a Tissue Bank | 155 | ||
| Chapter 10 Quality Control Issues in Tissue Banking | 173 | ||
| Chapter 11 Is the Irradiation Dose of 25 kGy Enough to Sterilise Tissue Grafts? | 189 | ||
| Chapter 12 Diploma Course Training of Tissue Bank Operators: 7 Years of Experience | 213 | ||
| Chapter 13 Healing of Large Diaphyseal Deep-Frozen Cortical Allografts | 227 | ||
| Chapter 14 Bone Allotransplantation: Future Directions | 243 | ||
| SECTION IV: GENOMICS | 255 | ||
| Chapter 15 The Human Genome | 257 | ||
| Chapter 16 Genomics in Orthopaedics | 269 | ||
| Chapter 17 Gene Therapy and New Bone Formation | 277 | ||
| SECTION V: BONE TISSUE ENGINEERING | 295 | ||
| Chapter 18 Stem Cell Technology and its Commercial Potential | 297 | ||
| Chapter 19 Setting Up a Tissue Engineering Laboratory | 313 | ||
| Chapter 20 Culturing Mesenchymal Stem Cells from Bone Marrow | 321 | ||
| Chapter 21 Bone Marrow Derived Mesenchymal Stem Cells: Potential for Tissue Regeneration | 335 | ||
| Chapter 22 Scaffolds in Bone Tissue Engineering | 357 | ||
| Chapter 23 Carriers of Mesenchymal Cells | 367 | ||
| SECTION VI: GROWTH FACTORS | 377 | ||
| Chapter 24 The Role of Bone Morphogenic Proteins in Bone Incorporation | 379 | ||
| Chapter 25 Platelet-Rich Plasma in Orthopaedic Surgery: Basic Science and Clinical Applications | 387 | ||
| Chapter 26 Applications of Autogenous Platelet Rich Plasma (PRP) Gel to Enhance Bone Formation | 405 | ||
| SECTION VII: CERAMICS | 429 | ||
| Chapter 27 The Need for New Materials for Use in Bone in Man | 431 | ||
| Chapter 28 Role of Ceramics as Bone Graft Substitutes | 445 | ||
| Chapter 29 Enhancement of the Bioactivity of Orthopaedic Biomaterials: Role of Growth Factors Ion Substitution and Implant Architecture | 459 | ||
| Chapter 30 Fabrication of Granular Hydroxyapatite | 489 | ||
| Chapter 31 Role of Corals and Coralline Ceramics in Orthopaedic Surgery | 501 | ||
| Chapter 32 Biomedical Use of Corals and Coralline Hydroxyapatite in Hard Tissue Replacement | 513 | ||
| Chapter 33 Coral as Bone Graft Substitute | 533 | ||
| SECTION VIII: PROSTHESES | 545 | ||
| Chapter 34 Rapid Prototyping in Orthopaedics: Principles and Applications | 547 | ||
| Chapter 35 Custom Mega Prosthesis for Bone Reconstruction in Orthopaedic Surgery | 563 | ||
| Index | 591 |