Additional Information
Book Details
Abstract
Topics that are essential to the surgical pathologist in cytopathology are included in this issue of Surgical Pathology Clinics. Topics include cytopathology of the Thyroid; Pancreas, Salivary glands; Lung; Urine; Gynecologic; Metastasis of unknown origin; and Preparation techniques and Cell transfer. Expert cytopathologist and prolific author and researcher and expert clinician Tarik Elsheikh leads this issue as Guest Editor.
Table of Contents
| Section Title | Page | Action | Price |
|---|---|---|---|
| Front Cover | Cover | ||
| Cytopathology | i | ||
| copyright\r | ii | ||
| Contributors | iii | ||
| Contents | v | ||
| Surgical Pathology Clinics | vii | ||
| Preface\r | ix | ||
| Ancillary Studies, Including Immunohistochemistry and Molecular Studies, in Pancreatic Cytology | 1 | ||
| Abstract | 1 | ||
| Overview | 1 | ||
| Ancillary studies | 1 | ||
| Ancillary Studies in Solid Pancreatic Neoplasms | 2 | ||
| Cytologic and ancillary findings in solid pancreatic neoplasms | 2 | ||
| Pancreatic Ductal Adenocarcinoma | 2 | ||
| Ancillary Studies in the Diagnosis of Pancreatic Ductal Adenocarcinoma | 4 | ||
| Immunohistochemistry | 4 | ||
| Molecular testing | 4 | ||
| Pancreatic Neuroendocrine Neoplasms | 5 | ||
| Ancillary Studies in the Diagnosis of Pancreatic Neuroendocrine Neoplasms | 6 | ||
| Immunohistochemistry | 6 | ||
| Molecular studies | 6 | ||
| Acinar Cell Carcinoma | 7 | ||
| Ancillary Studies in the Diagnosis of Acinar Cell Carcinoma | 7 | ||
| Immunohistochemistry | 7 | ||
| Molecular studies | 9 | ||
| Solid Pseudopapillary Neoplasm | 10 | ||
| Ancillary Studies in the Diagnosis of Solid Pseudopapillary Neoplasm | 10 | ||
| Immunohistochemistry and molecular studies | 10 | ||
| Pancreatoblastoma | 13 | ||
| Ancillary Studies in the Diagnosis of Pancreatoblastoma | 13 | ||
| Immunohistochemistry | 13 | ||
| Secondary Pancreatic Neoplasms | 14 | ||
| Ancillary Studies in Cystic Masses | 14 | ||
| Viscosity | 14 | ||
| Enzymes | 14 | ||
| Tumor Markers | 14 | ||
| Histochemical Stains | 15 | ||
| Immunohistochemistry | 15 | ||
| Molecular Studies | 15 | ||
| KRAS | 15 | ||
| GNAS | 15 | ||
| DNA Analysis and Other Molecular Analysis | 16 | ||
| Cytologic and ancillary features of cystic masses | 16 | ||
| Non-neoplastic Cysts | 16 | ||
| Pseudocyst | 16 | ||
| Lymphoepithelial Cyst of the Pancreas | 16 | ||
| Squamoid Cyst of Pancreatic Ducts | 18 | ||
| Neoplastic cysts | 18 | ||
| Serous Cystadenoma | 18 | ||
| Neoplastic Mucinous Cysts: Mucinous Cystic Neoplasm and Intraductal Papillary Mucinous Neoplasm | 21 | ||
| Invasive Carcinoma Arising from Intraductal Papillary Mucinous Neoplasm and Intraductal Oncocytic Papillary Neoplasm | 26 | ||
| Role of Cytology in the Management of Mucinous Cysts | 26 | ||
| Solid Neoplasms with Cystic Degeneration | 26 | ||
| Rare Pancreatic and Extrapancreatic Cysts and Neoplasms | 26 | ||
| Practical applications | 26 | ||
| Solid Masses | 26 | ||
| Cystic Masses | 29 | ||
| Prognostic and therapeutic applications of ancillary studies in solid and cystic pancreatic neoplasms | 29 | ||
| Future trends | 29 | ||
| Whole-Exome Sequencing | 29 | ||
| miRNA Sequencing | 31 | ||
| Proteomics | 31 | ||
| References | 31 | ||
| Ancillary Studies, Including Immunohistochemistry and Molecular Studies, in Lung Cytology | 35 | ||
| Abstract | 35 | ||
| Overview | 35 | ||
| Cytologic differential diagnosis | 36 | ||
| Ancillary studies, diagnostic | 38 | ||
| Special Stains | 38 | ||
| Immunocytochemistry | 38 | ||
| Practical Applications of Immunocytochemistry | 39 | ||
| Molecular Testing | 42 | ||
| Therapeutic and prognostic applications | 42 | ||
| Practical applications | 44 | ||
| Future trends | 45 | ||
| References | 45 | ||
| Ancillary Studies in Thyroid Cytopathology | 47 | ||
| Abstract | 47 | ||
| Overview | 47 | ||
| Differential diagnosis associated with BSRTC categories | 48 | ||
| Ancillary studies | 50 | ||
| Immunohistochemistry | 50 | ||
| Molecular Testing | 51 | ||
| Molecular Panel of Common Genetic Alterations in Thyroid Neoplasms | 52 | ||
| BRAF | 52 | ||
| RAS | 52 | ||
| RET/PTC | 52 | ||
| PAX 8/PPARγ | 52 | ||
| Other Molecular Alterations | 53 | ||
| Practical Application of Molecular Panel Testing | 53 | ||
| Therapeutic and Prognostic Applications of Molecular Panel | 55 | ||
| Afirma Gene Expression Classifier | 57 | ||
| Practical Applications of the Afirma GEC Test | 57 | ||
| Future trends | 58 | ||
| References | 58 | ||
| Cytology of the Salivary Glands | 61 | ||
| Abstract | 61 | ||
| Introduction | 61 | ||
| Differential diagnosis | 61 | ||
| Ancillary studies | 67 | ||
| Special Stains | 67 | ||
| Immunohistochemistry | 67 | ||
| Molecular Testing | 67 | ||
| Therapeutic and prognostic applications | 69 | ||
| Practical applications | 69 | ||
| Future trends | 72 | ||
| References | 72 | ||
| Urine Cytopathology and Ancillary Methods | 77 | ||
| Abstract | 77 | ||
| Introduction | 77 | ||
| Cytologic differential diagnosis | 78 | ||
| Ancillary studies | 79 | ||
| Immunology-based methods | 79 | ||
| Molecular testing | 81 | ||
| FISH | 81 | ||
| Practical applications | 82 | ||
| Therapeutic and prognostic applications | 86 | ||
| Future trends | 86 | ||
| References | 87 | ||
| Ancillary Diagnostics in Gynecologic Cytology | 89 | ||
| Abstract | 89 | ||
| Introduction | 89 | ||
| Cytologic differential diagnosis | 89 | ||
| Ancillary studies | 90 | ||
| Immunocytochemistry and In-Situ Hybridization | 90 | ||
| P16INK4A\r | 90 | ||
| Therapeutic and prognostic applications of p16INK4a | 92 | ||
| Practical applications of p16INK4a | 93 | ||
| Ki-67 (MIB-1) | 93 | ||
| CINtec+: dual p16/Ki-67 staining | 93 | ||
| Therapeutic and prognostic applications of CINtec+ (dual p16/Ki-67 staining) | 93 | ||
| Practical applications of CINtec | 94 | ||
| Minichromosome maintenance protein 2 and DNA topoisomerase IIα (ProEx C) | 94 | ||
| Therapeutic and prognostic applications of ProEx C | 95 | ||
| Practical applications of ProEx C | 95 | ||
| In Situ Hybridization | 95 | ||
| Therapeutic and prognostic applications of HPV in situ hybridization | 97 | ||
| Practical applications of in situ hybridization | 97 | ||
| Hybrid Capture | 97 | ||
| Hybrid Capture Diagnostic Assays | 97 | ||
| Digene HC2 | 97 | ||
| Cervista HPV high-risk test | 98 | ||
| Therapeutic and prognostic applications of hybrid capture | 98 | ||
| Practical applications of hybrid capture | 98 | ||
| Genotyping | 99 | ||
| Genotyping diagnostic assays | 99 | ||
| Therapeutic and prognostic applications of genotyping | 100 | ||
| Practical applications and challenges of genotyping | 100 | ||
| Future trends | 100 | ||
| References | 100 | ||
| Metastatic Tumors of Unknown Origin | 105 | ||
| Abstract | 105 | ||
| Overview | 105 | ||
| Cytomorphologic assessment | 106 | ||
| Ancillary studies in diagnosis | 110 | ||
| Immunocytochemistry | 110 | ||
| In Situ Hybridization | 117 | ||
| Molecular Profiling | 118 | ||
| Therapeutic and prognostic applications | 122 | ||
| Practical applications | 123 | ||
| Future trends | 126 | ||
| References | 127 | ||
| Index | 131 |