BOOK
Sjogren's Syndrome, An Issue of Oral and Maxillofacial Surgery Clinics, E-Book
(2014)
Additional Information
Book Details
Abstract
Editor Michael Brennan highlights important areas in Sjögren’s Syndrome for all oral and maxillofacial surgeons. Topics include diagnosis and the ACR classification criteria, epidemiology and pathophysiology, salivary gland dysfunction and xerostomia, salivary gland disease: sialadenitis to lymphoma, extraglandular manifesations, oral complications, management of xerostomia, parotidectomy in Sjögren’s Syndrome, support network for Sjögren’s Syndrome patients, and much more!
Table of Contents
| Section Title | Page | Action | Price |
|---|---|---|---|
| Front Cover | Cover | ||
| Sjögren’s Syndrome | i | ||
| Copyright\r | ii | ||
| Contributors | iii | ||
| Contents | v | ||
| Forthcoming Issues | viii | ||
| Sjögren's Syndrome | ix | ||
| Sjo¨ gren’s Syndrome\rAn Update on Epidemiology and Current\rInsights on Pathophysiology\r | 1 | ||
| Key points | 1 | ||
| Introduction | 1 | ||
| Prevalence and incidence | 2 | ||
| Pathogenesis of SS | 2 | ||
| Histopathology of the Target Organ | 2 | ||
| Clinical Implications of Lymphoid Neogenesis | 3 | ||
| Local and Systemic Autoantibodies | 3 | ||
| Other autoantibodies | 3 | ||
| Cytokines and Chemokines | 3 | ||
| T Cells in pSS | 4 | ||
| Cytotoxic T cells | 5 | ||
| NKT cells | 5 | ||
| Follicular helper T cells | 5 | ||
| Th17 cells | 5 | ||
| The Treg/Th17 balance | 5 | ||
| Genetics | 6 | ||
| Risk and prediction of lymphoma | 6 | ||
| References | 7 | ||
| Diagnosis of Sjögren's Syndrome | 13 | ||
| Key points | 13 | ||
| Introduction | 13 | ||
| AECG criteria | 14 | ||
| Critique of the AECG criteria | 16 | ||
| ACR criteria | 17 | ||
| ACR criteria critique | 17 | ||
| Comparison of AECG with ACR criteria in clinical practice | 19 | ||
| Discussion | 20 | ||
| References | 21 | ||
| Salivary Gland Biopsy for Sjögren's Syndrome | 23 | ||
| Key points | 23 | ||
| Introduction | 23 | ||
| Labial salivary gland biopsy | 23 | ||
| Complications | 24 | ||
| Suitability for Diagnostic and Treatment Evaluation Purposes | 25 | ||
| Parotid gland biopsy | 25 | ||
| Complications | 27 | ||
| Suitability for Diagnostic and Treatment Evaluation Purposes | 27 | ||
| Sublingual salivary gland biopsy | 28 | ||
| Complications | 28 | ||
| Comparison of techniques | 29 | ||
| Summary | 31 | ||
| References | 31 | ||
| Salivary Gland Dysfunction and Xerostomia in Sjögren's Syndrome | 35 | ||
| Key points | 35 | ||
| Introduction | 35 | ||
| Salivary gland physiology | 35 | ||
| What is Saliva? | 35 | ||
| Saliva Secretion: The Two-Step Model | 36 | ||
| Salivary Secretion and Composition in SS | 36 | ||
| Early manifestations | 38 | ||
| Late manifestations | 38 | ||
| What can saliva tell about the progression of SS? | 39 | ||
| Pathophysiology of salivary gland dysfunction and xerostomia in SS | 40 | ||
| Clinical presentation of dry mouth | 41 | ||
| Assessment of salivary gland hypofunction and xerostomia | 42 | ||
| How to Measure Salivary Gland Hypofunction? | 42 | ||
| Collection of Resting Whole Saliva | 43 | ||
| Collection of Stimulated Whole Saliva | 43 | ||
| Collection of Parotid Saliva | 44 | ||
| Collection of SM/SL Saliva | 44 | ||
| New Developments in the Application of Saliva as a Diagnostic Tool | 45 | ||
| Diagnostic Imaging Techniques | 46 | ||
| How to Assess Xerostomia? | 48 | ||
| Impact of SS on quality of life | 51 | ||
| References | 51 | ||
| Oral Complications of Sjögren's Syndrome | 55 | ||
| Key points | 55 | ||
| Introduction | 55 | ||
| Saliva function | 55 | ||
| Changes in oral microflora | 56 | ||
| Dental manifestations | 56 | ||
| Caries | 56 | ||
| Gingivitis/Periodontal Disease | 57 | ||
| Oral mucosal manifestations | 58 | ||
| Fungal Infection | 58 | ||
| Oral Lesions | 58 | ||
| Orofacial pain | 58 | ||
| Burning Mouth | 58 | ||
| Neurologic | 59 | ||
| Headaches | 59 | ||
| Temporomandibular Disorder | 59 | ||
| Other oral manifestations | 59 | ||
| Dysphagia/Dysguesia | 59 | ||
| Swollen Salivary Glands | 59 | ||
| Gastroesophageal Reflux | 59 | ||
| Summary | 60 | ||
| References | 60 | ||
| Management of Xerostomia and Other Complications of Sjögren's Syndrome | 63 | ||
| Key points | 63 | ||
| Methods | 63 | ||
| Search Strategy | 63 | ||
| Data Abstraction and Evidence Grading | 64 | ||
| Results | 64 | ||
| Xerostomia and Salivary Hypofunction | 64 | ||
| Sialagogues | 65 | ||
| Local interventions | 65 | ||
| Immune modulators | 65 | ||
| Oral Lesions | 67 | ||
| Sensory Complaints | 67 | ||
| Oral burning | 67 | ||
| Dysphagia | 67 | ||
| Dysgeusia (taste disorders) | 68 | ||
| Fungal Infections | 68 | ||
| Discussion | 68 | ||
| Limitations | 69 | ||
| Summary | 69 | ||
| References | 70 | ||
| Appendix 1 Search strategy | 72 | ||
| Xerostomia AND Sjogren Syndrome | 72 | ||
| Salivary Hypofunction AND Sjogren Syndrome | 72 | ||
| Salivary Gland Disease in Sjögren's Syndrome | 75 | ||
| Key points | 75 | ||
| Introduction | 75 | ||
| Genetic predisposition | 76 | ||
| Aberrant cellular function | 76 | ||
| Clinical progression | 77 | ||
| Enlargement of the parotid glands and sialoadenitis | 77 | ||
| Lymphoma | 78 | ||
| Summary | 79 | ||
| References | 79 | ||
| The Role of Parotidectomy in Sjögren's Syndrome | 83 | ||
| Key points | 83 | ||
| Introduction | 83 | ||
| Clinical findings | 84 | ||
| Diagnosis and surgery | 85 | ||
| Management of symptoms and surgery | 86 | ||
| Indications for Parotidectomy | 86 | ||
| Anatomic and Technical Considerations | 87 | ||
| Complications | 87 | ||
| Summary | 88 | ||
| References | 89 | ||
| Extraglandular Manifestations of Primary Sjögren's Syndrome | 91 | ||
| Key points | 91 | ||
| Nervous system | 91 | ||
| Peripheral Nervous System | 91 | ||
| Sensory Ataxic Neuropathy | 92 | ||
| Axonal Sensorimotor Polyneuropathy | 92 | ||
| Trigeminal Neuralgia | 92 | ||
| Autonomic Neuropathy | 92 | ||
| Central Nervous System Involvement | 93 | ||
| Psychiatric Involvement | 93 | ||
| Pulmonary Involvement | 94 | ||
| Musculoskeletal manifestations | 95 | ||
| Vasculitis | 96 | ||
| Summary | 97 | ||
| References | 97 | ||
| Management of Extraglandular Manifestations of Primary Sjögren's Syndrome | 101 | ||
| Key points | 101 | ||
| Musculoskeletal manifestations | 101 | ||
| Fatigue | 103 | ||
| Neurologic manifestations | 104 | ||
| Cutaneous manifestations | 105 | ||
| Other major organ system involvement | 105 | ||
| Future directions | 106 | ||
| Rituximab | 107 | ||
| Epratuzumab | 107 | ||
| Belimumab | 107 | ||
| Abatacept | 107 | ||
| Summary | 107 | ||
| References | 107 | ||
| Coping Strategies and Support Networks for Sjögren’s Syndrome Patients | 111 | ||
| Key points | 111 | ||
| Introduction | 111 | ||
| Strategies for coping | 111 | ||
| Types of coping strategies | 112 | ||
| Emotion Focused | 112 | ||
| Problem Focused | 112 | ||
| Avoidance | 112 | ||
| Alternative coping strategies | 112 | ||
| Web-Based Coping | 112 | ||
| Social Coping with Friends and Family | 113 | ||
| Coping with Sjögren’s syndrome | 113 | ||
| Support groups for Sjögren’s syndrome | 113 | ||
| Pros and Cons with Support Groups | 113 | ||
| How a Support Group Functions | 114 | ||
| Information through Sjögren's Syndrome Foundation | 114 | ||
| References | 115 | ||
| Index | 117 |